scholarly journals Immunohistochemical Evaluation of PARP and Caspase-3 as Prognostic Markers in Prostate Carcinomas

2021 ◽  
Vol 19 (4) ◽  
pp. 183-191
Author(s):  
Vitoria Acar ◽  
Fabio Leite Couto Fernandez ◽  
Fabio Fabian Buscariolo ◽  
Adriana Alonso Novais ◽  
Roseli Aparecida Matheus Pereira ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Prognostic Markers ◽  
Prostate Carcinomas

Telomerase RNA Expression and DNA Ploidy as Prognostic Markers of Prostate Carcinomas

2009 ◽  
Vol 95 (6) ◽  
pp. 744-752 ◽  
Author(s):  
Athanassios Bantis ◽  
Efstratios Patsouris ◽  
Maria Gonidi ◽  
Nikolaos Kavantzas ◽  
Angelos Tsipis ◽  
...  
Keyword(s):  
Prognostic Markers ◽  
Dna Ploidy ◽  
Rna Expression ◽  
Telomerase Rna ◽  
Prostate Carcinomas

Interleukin-1beta and Caspase-3 expression serve as independent prognostic markers for metastasis and survival in oral squamous cell carcinoma

2019 ◽  
Vol 26 (1) ◽  
pp. 109-122
Author(s):  
Preeti Singh ◽  
Dominic Augustine ◽  
Roopa S. Rao ◽  
Shankargouda Patil ◽  
Samudrala Venkatesiah Sowmya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Caspase 3 ◽  
Prognostic Markers ◽  
Interleukin 1Beta

scholarly journals Gene expression profiles of some prognostic markers in a human breast cell line (MCF7) exposed to Curcumin nanoparticles and nanocapsules

2022 ◽  
Author(s):  
Emad Shaker ◽  
Ghada M. Nasr ◽  
Mahmoud Moawad
Keyword(s):  
Breast Cancer ◽  
Mrna Expression ◽  
Cell Lines ◽  
Molecular Mechanisms ◽  
Caspase 3 ◽  
Prognostic Markers ◽  
Expression Profiles ◽  
Public Health Problem ◽  
Breast Cancer Cell Lines ◽  
Curcumin Nanoparticles

Introduction: Worldwide, cancer is a significant public health problem. Curcumin exhibits anti-inflammatory, antiproliferative, and anticancer properties when used in medicine. Investigated study for Curcumin's chemopreventive mechanism against human malignancies, this research examined the cellular and molecular alterations generated by curcumin modified compound in breast cancer (MCF-7) cell lines. Oncogenic EGFR and VEGFR2 mutations lead to the formation, invasion, and maintenance of malignant phenotypes in humans, including breast cancer. Studied prognostic markers such as C-myc and Ki67 in breast cancer, and the apoptotic gene as Caspase-3 have been done. Aim of the work: The purpose of this study is to determine the therapeutic efficacy of curcumin nanoparticles and nanocapsules in breast cancer cell lines (MCF7). Materials and methods: We used real-time PCR to assess the expression of the C-myc, Ki67, EGFR, VEGFR2, and Caspase-3 genes in MCF7 cells treated with Curcumin nanoparticles and nanocapsules. Results: Curcumin nanoparticles and nanocapsules boosted apoptotic cell populations considerably regardless of the nanotechnology used. Additionally, the mRNA expression analysis results indicated that the mechanism activated by curcumin nanocapsules involved the upregulation of the oncogenes EGFR and VEGFR2. In comparison to curcumin nanoparticles, curcumin nanocapsules significantly reduced the expression of Ki67 and c-myc mRNAs in breast cancer cells. The mRNA expression study revealed that curcumin nanocapsules produce an increase in the apoptotic Caspase-3 gene production compared to cells treated with curcumin nanoparticles. Conclusion: This work demonstrates that curcumin nanoparticles created using a novel mechanical process can be employed successfully as an anticancer agent. These findings add to our understanding of the molecular mechanisms behind curcumin nanocapsules' anticancer activity in breast cancer.

372: Identification of Molecular Subtypes and Prognostic Markers in Renal Cell Carcinomas Using CDNA Microarray

2005 ◽  
Vol 173 (4S) ◽  
pp. 102-102 ◽  
Author(s):  
Hongjuan Zhao ◽  
Eric Bair ◽  
Robert Tibshirani ◽  
Börje Ljungberg ◽  
James D. Brooks
Keyword(s):  
Cdna Microarray ◽  
Renal Cell ◽  
Prognostic Markers ◽  
Molecular Subtypes ◽  
Renal Cell Carcinomas

743: Methylation of the E-Cadherin and the TIMP-3 Genes are Positive Prognostic Markers for Patients with Non-Muscle Invasive Bladder Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 197-197
Author(s):  
Martin G. Friedrich ◽  
Gangning Liang ◽  
Marieta I. Toma ◽  
Daniel J. Weisenberger ◽  
Jonathan C. Cheng ◽  
...  
Keyword(s):  
Bladder Carcinoma ◽  
Prognostic Markers ◽  
Muscle Invasive ◽  
E Cadherin
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