The Hedgehog transcription factor GLI3 is differentially expressed in the tumors of breast cancer patients treated with trastuzumab.
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Trastuzumab, a monoclonal antibody that targets HER2, is utilized for the treatment of breast cancer (1). While the mechanism of action of trastuzumab function in breast cancer is ascribed to trastuzumab binding to the extracellular region of HER2 (2), the transcriptional consequences that follow this binding event are less well understood. We report here, using analysis of published microarray and gene expression data (3, 4), that the transcription factor GLI3 (5) is differentially expressed in the tumors of patients with breast cancer treated with trastuzumab.
2020 ◽
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2020 ◽
2020 ◽
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