Online process monitoring of a batch distillation by medium field NMR spectroscopy

Medium field NMR spectrometers are attractive for online process monitoring. Therefore, in the present work, a single-stage laboratory batch distillation still was coupled online with a medium field NMR spectrometer. This enables quantitative non-invasive measurements without calibration. The technique was used for studying isobaric and isothermal residue curves in two ternary systems: (dimethyl sulfoxide + acetonitrile + ethyl formate) and (ethyl acetate + acetone + diethyl ether) and boiling curves and high-boiling azeotropes in two binary systems: (acetic acid + pyridine) and (methanol + diethylamine). The results of the online NMR spectroscopic analysis were compared to results from offline analysis as well as to results from thermodynamic modeling using NRTL parameters that were parametrized with literature data. The new method for online process monitoring gives reliable results and is well-suited for fast and robust measurements of residue curves.

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Online process monitoring of a batch distillation by medium field NMR spectroscopy

Chemical Engineering Science ◽

10.1016/j.ces.2020.115561 ◽

2020 ◽

Vol 219 ◽

pp. 115561 ◽

Cited By ~ 4

Author(s):

Anne Friebel ◽

Erik von Harbou ◽

Kerstin Münnemann ◽

Hans Hasse

Keyword(s):

Nmr Spectroscopy ◽

Process Monitoring ◽

Batch Distillation ◽

Online Process Monitoring ◽

Online Process

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Online Process Monitoring Based on Vibration-Surface Quality Map for Robotic Grinding

IEEE/ASME Transactions on Mechatronics ◽

10.1109/tmech.2020.2996939 ◽

2020 ◽

Vol 25 (6) ◽

pp. 2882-2892

Author(s):

Hao Lu ◽

Xingwei Zhao ◽

Bo Tao ◽

Zhouping Yin

Keyword(s):

Surface Quality ◽

Process Monitoring ◽

Robotic Grinding ◽

Online Process Monitoring ◽

Quality Map ◽

Online Process

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Application of Near-Infrared Spectroscopy Analysis Technology to Total Nucleosides Quality Control in the Fermented Cordyceps Powder Production Process

Journal of Analytical Methods in Chemistry ◽

10.1155/2020/8850437 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Tiannv Shi ◽

Yongmei Guan ◽

Lihua Chen ◽

Shiyu Huang ◽

Weifeng Zhu ◽

...

Keyword(s):

Quality Control ◽

Infrared Spectroscopy ◽

Production Process ◽

Process Monitoring ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Powder Preparation ◽

Spectroscopy Analysis ◽

Online Process Monitoring ◽

Online Process

Product quality control is a prerequisite for ensuring safety, effectiveness, and stability. However, because of the different strain species and fermentation processes, there was a significant difference in quality. As a result, they should be clearly distinguished in clinical use. Among them, the fermentation process is critical to achieving consistent product quality. This study aims to introduce near-infrared spectroscopy analysis technology into the production process of fermented Cordyceps powder, including strain culture, strain passage, strain fermentation, strain filtration, strain drying, strain pulverizing, and strain mixing. First, high performance liquid chromatography (HPLC) was used to measure the total nucleosides content in the production process of 30 batches of fermented Cordyceps powder, including uracil, uridine, adenine, guanosine, adenosine, and the process stability and interbatch consistency were analyzed with traditional Chinese medicine (TCM) fingerprinting, followed by the near-infrared spectroscopy (NIRS) combined with partial least squares regression (PLSR) to establish a quantitative analysis model of total nucleosides for online process monitoring of fermented Cordyceps powder preparation products. The model parameters indicate that the established model with good robustness and high measurement precision. It further clarifies that the model can be used for online process monitoring of fermented Cordyceps powder preparation products.

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