Item-specific overlap between hallucinatory experiences and cognition in the general population: A three-step multivariate analysis of international multi-site data

2021 ◽  
Author(s):  
Abhijit Mahesh Chinchani ◽  
Mahesh Menon ◽  
Meighen Roes ◽  
Heungsun Hwang ◽  
Paul Allen ◽  
...  

Cognitive mechanisms hypothesized to underlie hallucinatory experiences (HEs) include dysfunctional source monitoring, heightened signal detection, or impaired attentional processes. HEs can be very pronounced in psychosis, but similar experiences also occur in nonclinical populations. Using data from an international multisite study on nonclinical subjects (N = 419), we described the overlap between two sets of variables - one measuring cognition and the other HEs - at the level of individual items, allowing extraction of item-specific signal which might considered off-limits when summary scores are analyzed. This involved using a statistical hypothesis test at the multivariate level, and variance constraints, dimension reduction, and split-half reliability checks at the level of individual items. The results showed that (1) modality-general HEs involving sensory distortions (hearing voices/sounds, troubled by voices, everyday things look abnormal, sensations of presence/movement) were associated with more liberal auditory signal detection, and (2) HEs involving experiences of sensory overload and vivid images/imagery (viz., HEs for faces and intense daydreams) were associated with other-ear distraction and reduced laterality in dichotic listening. Based on these results, it is concluded that the overlap between HEs and cognition variables can be conceptualized as modality-general and bi-dimensional: one involving distortions, and the other involving overload or intensity.

2019 ◽  
Vol 19 (2) ◽  
pp. 134-140
Author(s):  
Baek-Ju Sung ◽  
Sung-kyu Lee ◽  
Mu-Seong Chang ◽  
Do-Sik Kim

Computation ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 59 ◽  
Author(s):  
Giovanni Delnevo ◽  
Silvia Mirri ◽  
Marco Roccetti

As we prepare to emerge from an extensive and unprecedented lockdown period, due to the COVID-19 virus infection that hit the Northern regions of Italy with the Europe’s highest death toll, it becomes clear that what has gone wrong rests upon a combination of demographic, healthcare, political, business, organizational, and climatic factors that are out of our scientific scope. Nonetheless, looking at this problem from a patient’s perspective, it is indisputable that risk factors, considered as associated with the development of the virus disease, include older age, history of smoking, hypertension and heart disease. While several studies have already shown that many of these diseases can also be favored by a protracted exposure to air pollution, there has been recently an insurgence of negative commentary against authors who have correlated the fatal consequences of COVID-19 (also) to the exposition of specific air pollutants. Well aware that understanding the real connection between the spread of this fatal virus and air pollutants would require many other investigations at a level appropriate to the scale of this phenomenon (e.g., biological, chemical, and physical), we propose the results of a study, where a series of the measures of the daily values of PM2.5, PM10, and NO2 were considered over time, while the Granger causality statistical hypothesis test was used for determining the presence of a possible correlation with the series of the new daily COVID19 infections, in the period February–April 2020, in Emilia-Romagna. Results taken both before and after the governmental lockdown decisions show a clear correlation, although strictly seen from a Granger causality perspective. Moving beyond the relevance of our results towards the real extent of such a correlation, our scientific efforts aim at reinvigorating the debate on a relevant case, that should not remain unsolved or no longer investigated.


2015 ◽  
Vol 117 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Michael Baltaxe ◽  
Peter Meer ◽  
Michael Lindenbaum

2021 ◽  
Vol 11 (3) ◽  
pp. 697-702
Author(s):  
S. Jayanthi ◽  
C. R. Rene Robin

In this study, DNA microarray data is analyzed from a signal processing perspective for cancer classification. An adaptive wavelet transform named Empirical Wavelet Transform (EWT) is analyzed using block-by-block procedure to characterize microarray data. The EWT wavelet basis depends on the input data rather predetermined like in conventional wavelets. Thus, EWT gives more sparse representations than wavelets. The characterization of microarray data is made by block-by-block procedure with predefined block sizes in powers of 2 that starts from 128 to 2048. After characterization, a statistical hypothesis test is employed to select the informative EWT coefficients. Only the selected coefficients are used for Microarray Data Classification (MDC) by the Support Vector Machine (SVM). Computational experiments are employed on five microarray datasets; colon, breast, leukemia, CNS and ovarian to test the developed cancer classification system. The obtained results demonstrate that EWT coefficients with SVM emerged as an effective approach with no misclassification for MDC system.


2014 ◽  
Vol 970 ◽  
pp. 172-176 ◽  
Author(s):  
Parinya Chakartnarodom ◽  
Nutthita Chuankrerkkul

The aim of this paper is to propose the approach for applying statistical methods (linear regression and statistical hypothesis testing) to study the behavior of binder during binder removing (debinding) step in powder injection molding (PIM) and also the parameters that affect the binder removing rate. In this work, the binder system under the investigation is the composite binder of 85wt% polyethylene glycol (PEG) and 15 wt% poly (methyl methacrylate) (PMMA) where PEG can be removed from the green product by using warm water while PMMA is removed later during sintering. At 0.05 level of significance, the linear regression method and the statistical hypothesis test prove that the dissolution behavior of PEG can be described using Avarami equation. Furthermore, the dissolution rates of PEG were independent of all parameters used in this study including binder contents in the green products, temperatures, and powder sizes.


2013 ◽  
Vol 43 (12) ◽  
pp. 2465-2475 ◽  
Author(s):  
M. L. Brookwell ◽  
R. P. Bentall ◽  
F. Varese

BackgroundCognitive models have postulated that auditory hallucinations arise from the misattribution of internally generated cognitive events to external sources. Several experimental paradigms have been developed to assess this externalizing bias in clinical and non-clinical hallucination-prone samples, including source-monitoring, verbal self-monitoring and auditory signal detection tasks. This meta-analysis aims to synthesize the wealth of empirical findings from these experimental studies.MethodA database search was carried out for reports between January 1985 and March 2012. Additional studies were retrieved by contacting authors and screening references of eligible reports. Studies were considered eligible if they compared either (i) hallucinating and non-hallucinating patients with comparable diagnoses, or (ii) non-clinical hallucination-prone and non-prone participants using source-monitoring, verbal self-monitoring or signal detection tasks, or used correlational analyses to estimate comparable effects.ResultsThe analysis included 15 clinical (240 hallucinating patients and 249 non-hallucinating patients) and nine non-clinical studies (171 hallucination-prone and 177 non-prone participants; 57 participants in a correlation study). Moderate-to-large summary effects were observed in both the clinical and analogue samples. Robust and significant effects were observed in source-monitoring and signal detection studies, but not in self-monitoring studies, possibly due to the small numbers of eligible studies in this subgroup. The use of emotionally valenced stimuli led to effects of similar magnitude to the use of neutral stimuli.ConclusionsThe findings suggest that externalizing biases are important cognitive underpinnings of hallucinatory experiences. Clinical interventions targeting these biases should be explored as possible treatments for clients with distressing voices.


2017 ◽  
Vol 34 (7) ◽  
pp. 925-939
Author(s):  
Bahram Sadeghpour Gildeh ◽  
Sedigheh Rahimpour ◽  
Fatemeh Ghanbarpour Gravi

Purpose The purpose of this paper is to construct a statistical hypotheses test for process capability indices and compare the pairs of them with a fixed sample size. Design/methodology/approach Since the sampling distribution of the estimators of pairs of two process capability indices (PCIs) is very complex, an exact statistical hypothesis test for them cannot be constructed. Therefore, the authors have proposed a bootstrap method to construct the hypothesis test for them on the basis of p-value. Findings The authors have shown that by increasing n, the bootstrap method has better output relative to other methods and it can be easily implemented. The authors have also demonstrated that sometimes an exact hypotheses test cannot be constructed and need some assumptions. Originality/value In the present paper, several methods to test of hypotheses about the difference between two process capability indices have been compared.


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