Neural Oscillations and Networks in Processes Specific to Auditory Imagery

Mapping Intimacies ◽

10.31234/osf.io/ny2zv ◽

2021 ◽

Author(s):

Shu Sakamoto ◽

Atsushi Aoyama

Keyword(s):

Memory Retrieval ◽

Critical Role ◽

Neural Oscillations ◽

Auditory Imagery ◽

Neural Activities ◽

Gamma Power ◽

Phase Amplitude ◽

External Stimuli ◽

With Memory

Auditory imagery is a cognitive process for generating sound in our mind. Despite the absence of external stimuli, neuroimaging studies have found overlapping neural activities within perception and imagery. While neuroimaging studies have revealed activities unique to auditory imagery, namely memory retrieval and mental manipulation, little is known about the functional oscillatory networks associated with these processes. Therefore, in this study, we aimed to distinguish between neural oscillations for memory retrieval and mental manipulation processes by building a novel experimental paradigm containing multiple imagery conditions with the goal of enabling the effective investigation of different oscillatory processes. We found that frontal and temporal gamma power was associated with mental manipulation, while frontotemporal delta phase coupling and delta-gamma phase-amplitude coupling were each associated with memory retrieval during auditory imagery. Moreover, we found that oscillations reflecting auditory-motor communication were associated with memory retrieval. Our results suggest the critical role of neural oscillations associated with imagery-specific processes and present evidence supporting the long-debated role of motor functions in auditory imagery. Our work thus adds dimension to the state of knowledge regarding functional networks within auditory imagery.

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SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology

International Journal of Molecular Sciences ◽

10.3390/ijms22126613 ◽

2021 ◽

Vol 22 (12) ◽

pp. 6613

Author(s):

Fernando C. Baltanás ◽

Rósula García-Navas ◽

Eugenio Santos

Keyword(s):

Expression Patterns ◽

Critical Role ◽

Ras Signaling ◽

Epidermal Stem Cell ◽

Functional Specificity ◽

Functional Roles ◽

Signaling Axis ◽

Therapy Target ◽

External Stimuli

The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their similar structures and expression patterns, early studies of constitutive KO mice showing that SOS1-KO mutants were embryonic lethal while SOS2-KO mice were viable led to initially viewing SOS1 as the main Ras-GEF linking external stimuli to downstream RAS signaling, while obviating the functional significance of SOS2. Subsequently, different genetic and/or pharmacological ablation tools defined more precisely the functional specificity/redundancy of the SOS1/2 GEFs. Interestingly, the defective phenotypes observed in concomitantly ablated SOS1/2-DKO contexts are frequently much stronger than in single SOS1-KO scenarios and undetectable in single SOS2-KO cells, demonstrating functional redundancy between them and suggesting an ancillary role of SOS2 in the absence of SOS1. Preferential SOS1 role was also demonstrated in different RASopathies and tumors. Conversely, specific SOS2 functions, including a critical role in regulation of the RAS–PI3K/AKT signaling axis in keratinocytes and KRAS-driven tumor lines or in control of epidermal stem cell homeostasis, were also reported. Specific SOS2 mutations were also identified in some RASopathies and cancer forms. The relevance/specificity of the newly uncovered functional roles suggests that SOS2 should join SOS1 for consideration as a relevant biomarker/therapy target.

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Context Retrieval as a Critical Component in Selective Memory Retrieval

Current Directions in Psychological Science ◽

10.1177/0963721419827520 ◽

2019 ◽

Vol 28 (2) ◽

pp. 177-182 ◽

Cited By ~ 2

Author(s):

Karl-Heinz T. Bäuml

Keyword(s):

Memory Retrieval ◽

Critical Role ◽

Temporal Context ◽

Critical Component ◽

Memory Research ◽

Item Repetition ◽

Induced Forgetting

Selective retrieval often impairs recall of nonretrieved items, a finding referred to as retrieval-induced forgetting. In this article, I review recent research showing that selective retrieval can also improve recall of other items. This research points to a critical role of context retrieval in selective memory retrieval. The concept of context retrieval, which has played a prominent role in other lines of memory research, suggests that selective retrieval can reactivate the retrieved items’ temporal context during study, facilitating recall of other items that had a similar context at study. Such facilitatory effects on recall can arise both when selective item repetition occurs via retrieval and when it occurs via restudy, which suggests a link to the reminding literature. The findings offer new perspectives for investigating and understanding the effects of selective memory retrieval.

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Critical Role of Plasma Corticosteroid-Binding-Globulin During Stress to Promote Glucocorticoid Delivery to the Brain: Impact on Memory Retrieval

Endocrinology ◽

10.1210/en.2012-1485 ◽

2012 ◽

Vol 153 (10) ◽

pp. 4766-4774 ◽

Cited By ~ 27

Author(s):

Amandine M. Minni ◽

Rodolphe Dorey ◽

Christophe Piérard ◽

Gaëlle Dominguez ◽

Jean-Christophe Helbling ◽

...

Keyword(s):

Memory Retrieval ◽

Critical Role ◽

Corticosteroid Binding Globulin ◽

The Brain

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Memory retrieval in rats: Critical role of contextual similarity between training and testing

Behavioural Brain Research ◽

10.1016/0166-4328(82)90106-1 ◽

1982 ◽

Vol 5 (1) ◽

pp. 97-98 ◽

Cited By ~ 2

Author(s):

B. Deweer

Keyword(s):

Memory Retrieval ◽

Critical Role

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NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy

Current Pharmaceutical Design ◽

10.2174/1381612825666191011102444 ◽

2019 ◽

Vol 25 (33) ◽

pp. 3506-3518 ◽

Cited By ~ 32

Author(s):

Md. Tanvir Kabir ◽

Mohammad A. Sufian ◽

Md. Sahab Uddin ◽

Mst. Marium Begum ◽

Shammi Akhter ◽

...

Keyword(s):

Nmda Receptor ◽

Nmda Receptors ◽

Symptomatic Relief ◽

Critical Role ◽

Nmda Receptor Antagonists ◽

Receptor Antagonists ◽

Disease Condition ◽

And Behavior ◽

With Memory

: Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes problems with memory, thinking, and behavior. Currently, there is no drug that can reduce the pathological events of this degenerative disease but symptomatic relief is possible that can abate the disease condition. N-methyl-D-aspartate (NMDA) receptors exert a critical role for synaptic plasticity as well as transmission. Overstimulation of glutamate receptors, predominantly NMDA type, may cause excitotoxic effects on neurons and is recommended as a mechanism for neurodegeneration. Atypical activation of the NMDA receptor has been suggested for AD by synaptic dysfunction. NMDA receptor antagonists especially memantine block the NMDA receptor and can reduce the influx of calcium (Ca2+) ions into neuron, thus, toxic intracellular events are not activated. This review represents the role of NMDA receptors antagonists as potential therapeutic agents to reduce AD. Moreover, this review highlights the repositioning of memantine as a potential novel therapeutic multitargeting agent for AD.

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Phase-based coordination of hippocampal and neocortical oscillations during human sleep

Communications Biology ◽

10.1038/s42003-020-0913-5 ◽

2020 ◽

Vol 3 (1) ◽

Cited By ~ 4

Author(s):

Roy Cox ◽

Theodor Rüber ◽

Bernhard P. Staresina ◽

Juergen Fell

Keyword(s):

Eye Movement ◽

Neural Oscillations ◽

Rapid Eye Movement ◽

Physiological Basis ◽

Slow Oscillations ◽

Neurosurgical Patients ◽

High Gamma ◽

Phase Amplitude ◽

Frequency Phase

AbstractDuring sleep, new memories undergo a gradual transfer from hippocampal (HPC) to neocortical (NC) sites. Precisely timed neural oscillations are thought to mediate this sleep-dependent memory consolidation, but exactly how sleep oscillations instantiate the HPC-NC dialog remains elusive. Employing overnight invasive electroencephalography in ten neurosurgical patients, we identified three broad classes of phase-based communication between HPC and lateral temporal NC. First, we observed interregional phase synchrony for non-rapid eye movement (NREM) spindles, and N2 and rapid eye movement (REM) theta activity. Second, we found asymmetrical N3 cross-frequency phase-amplitude coupling between HPC slow oscillations (SOs) and NC activity spanning the delta to high-gamma/ripple bands, but not in the opposite direction. Lastly, N2 theta and NREM spindle synchrony were themselves modulated by HPC SOs. These forms of interregional communication emphasize the role of HPC SOs in the HPC-NC dialog, and may offer a physiological basis for the sleep-dependent reorganization of mnemonic content.

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The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

Perspectives on Language Learning and Education ◽

10.1044/lle15.2.50 ◽

2008 ◽

Vol 15 (2) ◽

pp. 50-59 ◽

Cited By ~ 1

Author(s):

Amy Philofsky

Keyword(s):

Language Development ◽

Critical Role ◽

Children With Autism ◽

Autism Spectrum ◽

Children With Asd ◽

Prevalence Estimates ◽

Notable Increase ◽

Screening Assessment ◽

Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

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