scholarly journals Shotguns Vs Lasers: Identifying Barriers and Facilitators to Scaling-Up Plant Molecular Farming for High-Value Health Products

2019 ◽  
Author(s):  
Jonathan Menary ◽  
Matthew Hobbs ◽  
Sara Mesquita de Albuqurque ◽  
Agata Pacho ◽  
Pascal M. W. Drake ◽  
...  
Keyword(s):  
Social Acceptance ◽  
Molecular Farming ◽  
Qualitative Interviews ◽  
Crop Improvement ◽  
Cost Effective ◽  
Scaling Up ◽  
Barriers And Facilitators ◽  
Horizon 2020 ◽  
Plant Molecular Farming ◽  
Health Products

Plant molecular farming (PMF) is a convenient and cost-effective way to produce high-value recombinant proteins that can be used in the production of a range of health products, from pharmaceutical therapeutics to cosmetic products. New plant breeding techniques (NPBTs) provide a means to enhance PMF systems more quickly and with greater precision than ever before, and have the potential to produce health and health-related products that are superior to current mammalian systems. However, the feasibility, regulatory standing and social acceptability of both PMF and NPBTs are in question. This paper qualitatively explores the perceptions of key stakeholders on two European Union (EU) Horizon 2020 programmes – Pharma-Factory and Newcotiana – towards the barriers and facilitators of PMF and NPBTs in Europe. One-on-one qualitative interviews were undertaken with N=20 individuals involved in one or both of the two projects at 16 institutions in seven countries (Belgium, France, Germany, Italy, Israel, Spain and the UK). The findings indicate that the current EU regulatory environment and the perception of the public towards biotechnology are seen as the main barriers to scaling-up PMF and NPBTs. Competition from existing systems and the lack of plant-specific regulations likewise present challenges for PMF developing beyond its current niche. However, respondents felt that the communication of the benefits and purpose of NPBT PMF could provide a platform for improving the social acceptance of genetic modification. The importance of the media in this process was highlighted. This article explores the justifications used by scientists for the use of NPBTs for crop improvement and suggests that the multi-level perspective framework is a useful tool for understanding the systemic factors that have shaped the development of PMF up until today.

scholarly journals Shotguns vs Lasers: Identifying barriers and facilitators to scaling-up plant molecular farming for high-value health products

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229952 ◽  
Author(s):  
Jonathan Menary ◽  
Matthew Hobbs ◽  
Sara Mesquita de Albuquerque ◽  
Agata Pacho ◽  
Pascal M. W. Drake ◽  
...  
Keyword(s):  
Molecular Farming ◽  
Scaling Up ◽  
Barriers And Facilitators ◽  
Plant Molecular Farming ◽  
Health Products

scholarly journals Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production

Plants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 842 ◽  
Author(s):  
Balamurugan Shanmugaraj ◽  
Christine Joy I. Bulaon ◽  
Waranyoo Phoolcharoen
Keyword(s):  
Recombinant Protein ◽  
Recombinant Protein Production ◽  
Protein Production ◽  
Molecular Farming ◽  
Expression System ◽  
Cost Effective ◽  
Biologically Active ◽  
Native Proteins ◽  
Plant Molecular Farming ◽  
Major Factors

The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing steadily, which is attracting global attention for the development of new recombinant protein production technologies and the engineering of conventional established expression systems based on bacteria or mammalian cell cultures. Since the advancements of plant genetic engineering in the 1980s, plants have been used for the production of economically valuable, biologically active non-native proteins or biopharmaceuticals, the concept termed as plant molecular farming (PMF). PMF is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. The development and improvement of the transient expression system has significantly reduced the protein production timeline and greatly improved the protein yield in plants. The major factors that drive the plant-based platform towards potential competitors for the conventional expression system are cost-effectiveness, scalability, flexibility, versatility, and robustness of the system. Many biopharmaceuticals including recombinant vaccine antigens, monoclonal antibodies, and other commercially viable proteins are produced in plants, some of which are in the pre-clinical and clinical pipeline. In this review, we consider the importance of a plant- based production system for recombinant protein production, and its potential to produce biopharmaceuticals is discussed.

Unfolding and characterizing the barriers and facilitators of scaling-up evidence-based interventions from the stakeholders’ perspective

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xiaoyan Zhang ◽  
Junqiang Zhao ◽  
XueJing Li ◽  
Lijiao Yan ◽  
Yufang Hao ◽  
...  
Keyword(s):  
Scaling Up ◽  
Barriers And Facilitators ◽  
Evidence Based

scholarly journals Stopping to Listen: Using Qualitative Methods to Inform a Web-Based Platform for Adults With Neurofibromatosis

2021 ◽  
Vol 8 ◽  
pp. 237437352110496
Author(s):  
Ethan G. Lester ◽  
Paula J. Popok ◽  
Victoria A. Grunberg ◽  
Alejandro Baez ◽  
Farahdeba Herrawi ◽  
...  
Keyword(s):  
Psychosocial Support ◽  
Qualitative Interviews ◽  
Psychosocial Care ◽  
Barriers And Facilitators ◽  
Web Based ◽  
Positive Attitudes ◽  
Efficient Access ◽  
Semistructured Interviews ◽  
Life Context ◽  
Specific Factors

Introduction: Psychosocial care for people with neurofibromatosis (NF) is challenging to access. Therefore, we sought to develop a self-guided web-based treatment platform for people with NF based on the live video relaxation response resiliency program for NF (3RP-NF). Here we report on qualitative interviews with adult patients who participated in the 3RP-NF to: (a) understand participant perceptions of the 3RP-NF program and (b) gather feedback for a self-guided web-based treatment platform (i.e., NF-Web). Methods: We conducted individual semistructured interviews ( N = 23; videoconferencing). We utilized both the Framework method and a hybrid deductive and inductive approach to analyze qualitative data. Results: We examined findings within the following themes for both 3RP-NF and NF-Web: (a) general attitudes, (b) barriers and facilitators, and (c) program-specific factors. Participants endorsed positive attitudes towards the 3RP-NF and NF-Web and described unique barriers and facilitators to each and provided suggestions regarding technology, NF-specific needs, and ways to promote social support virtually. Conclusions: This study highlights the importance of gathering participant feedback when designing novel, illness-specific interventions. In future studies, we aim to provide people with NF effective and efficient access to psychosocial support that matches their needs and life context. Results are informing NF-Web development.

scholarly journals Scaling-Up the Recognition of Indigenous and Community Land Rights: Opportunities, Costs and Climate Implications

2021 ◽  
Author(s):  
◽  
Keyword(s):  
Indigenous Peoples ◽  
Cost Effective ◽  
Land Rights ◽  
Scaling Up ◽  
Local Communities ◽  
Effective Strategy ◽  
Cost Effective Strategy ◽  
International Funding ◽  
Growing Body ◽  
Alternative Solutions

A growing body of evidence suggests that recognition of the collective tenure rights of Indigenous Peoples, local communities, and Afro-descendants is a powerful and cost-effective strategy for addressing the climate and biodiversity crises. In spite of this, international funding for rights recognition pales in comparison to donor mobilization around alternative solutions to these crises.

scholarly journals Engaging the Canadian Diaspora: Youth social identities in a Canadian border city1

2010 ◽  
Vol 44 (3) ◽  
pp. 405-433 ◽  
Author(s):  
S. Nombuso Dlamini ◽  
Barat Wolfe ◽  
Uzo Anucha ◽  
Miu Chung Yan
Keyword(s):  
African Descent ◽  
Qualitative Interviews ◽  
Immigrant Youth ◽  
Social Identities ◽  
Barriers And Facilitators ◽  
Important Resource ◽  
Final Settlement

Abstract This paper is based on qualitative interviews undertaken with immigrant youth of African descent in Windsor, Ontario; it describes their sojourner lives across geographic borders and their final settlement in Windsor. The paper also offers narrations of the activities that enabled them to formulate friendships and the barriers and facilitators to the development of friendships across races. Critical findings reported in this paper reveal the ways that youth use resources in their travels to construct and negotiate their identities and to formulate new friendships. An important resource used by the majority of the youth was that of an imagined homeland, which consequently impacted on how they viewed and acted on the racial boundary critical in the formation of friendships in the Diaspora.

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