scholarly journals Food-dependent exercise-induced anaphylaxis following intake of nuts

2020 ◽  
Vol 11 (4) ◽  
pp. 87-90
Author(s):  
Robin George Manappallil ◽  
Thushara Anand
Keyword(s):  
Food Intake ◽  
Allergic Reaction ◽  
Severe Form ◽  
Allergic Reactions ◽  
History Taking ◽  
Life Threatening ◽  
Exercise Induced ◽  
Specific Food

Allergic reactions can be mild or life threatening. Food-dependent exercise-induced anaphylaxis (FDEIA) is a severe form of allergic reaction in which symptoms develop only after exercising within a few hours of eating a specific food. The condition is, at times, underdiagnosed. Proper history taking is essential, especially when patients present with allergic reactions after exertion and food intake. The patient being described developed FDEIA because of exercising after eating nuts. 

scholarly journals Nonspecific food dependant exercise-induced anaphylaxis with seizure: a case report

2020 ◽  
Vol 11 (4) ◽  
pp. 94-97
Author(s):  
Ummer Karadan ◽  
Robin George Manappallil ◽  
Ivin Panakkel Zacharia ◽  
Thushara Anand
Keyword(s):  
Case Report ◽  
Food Item ◽  
History Taking ◽  
Predisposing Factor ◽  
Systemic Reactions ◽  
Life Threatening ◽  
Exercise Induced ◽  
Specific Food

Exercise has been associated with several systemic reactions. These reactions can vary from mild symptoms to life threatening situations like anaphylaxis. In many of these cases, a predisposing factor in the form of food has been noticed. People may develop anaphylaxis on exercising after consumption of a nonspecific or specific food item. The patient being described developed anaphylaxis with seizure on exercising after having his meal. Nonspecific food dependant exercise-induced anaphylaxis is a rare scenario. Proper history taking is essential, as it can be lifesaving.

scholarly journals Incidence and patient demographics of pre-hospital anaphylaxis in Tasmania

2015 ◽  
Vol 12 (3) ◽  
Author(s):  
Melanie Blackhall ◽  
Dale Edwards
Keyword(s):  
Data Mining ◽  
Allergic Reaction ◽  
Primary Diagnosis ◽  
Severe Form ◽  
Recording System ◽  
Patient Demographics ◽  
Paediatric Patients ◽  
Life Threatening ◽  
Electronic Recording

IntroductionAnaphylaxis is widely accepted to be an increasing problem worldwide. This inquiry into pre-hospital incidence and patient demographics is useful to determine status of anaphylaxis in Tasmania. Our main goal was to determine the incidence of pre-hospital anaphylaxis in Tasmania and identify trends in characteristics of affected patients.MethodsRaw data was searched and extracted from Ambulance Tasmania electronic recording system and case records for the period 1st January 2007 to 31st December 2011. This involved data mining 279,482 cases with the search parameters of anaphylaxis and allergy/ allergic reaction.ResultsThere were 1,570 patients were classified as having allergic reaction (including the most severe form of anaphylaxis). 379 (24.1%) of the atopic group were given a final primary diagnosis of anaphylaxis. The adult cases distribution was female at 219 (57.8%) versus males at 160 cases (42.2%). Interestingly 21.1% of the total anaphylaxis cases were paediatric (n=80) with a greater percentage of male (n=46) to female (n=34) paediatric patients. Aetiology was identified in 85.5% of the cases accordingly: envenomation (insects) 141 (37.2%), food 118 (31.1%), medication 58 (15.3%), known other 4 (1.1%), exercise 3 ( ConclusionThese findings suggest that almost a quarter of all calls for allergy or allergic reaction are of a severe potentially life-threatening nature, with the most common aetiology envenomation from insects (jack jumper bites).

scholarly journals A Suspected Allergic Reaction to Boal Fish (Wallago Attu)

2020 ◽  
Vol 4 (9) ◽  
pp. CR1-CR4
Author(s):  
Ramesh Puri ◽  
Jayati Batra
Keyword(s):  
Immune System ◽  
Contact Dermatitis ◽  
Allergic Reaction ◽  
Nutritional Value ◽  
Allergic Reactions ◽  
Quick Recovery ◽  
Wallago Attu ◽  
Life Threatening

Consumption of fish has increased around the globe due to its high nutritional value and this has led to an increase in incidence of allergic reactions to fish. Reactions to fish are not only mediated by the immune system causing allergies but are often caused by proteins, metals, various toxins and parasites. Allergic reactions to fish can range from being mild and self-limiting to serious and life threatening. We report a case of an adult with suspected allergic reaction to Boal fish (Wallago Attu) who developed contact dermatitis during marinating process. Application of steroids and administration of oral antihistaminic led to a quick recovery.

scholarly journals Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA

2021 ◽  
Author(s):  
Ludger Klimek ◽  
Natalija Novak ◽  
Eckard Hamelmann ◽  
Thomas Werfel ◽  
Martin Wagenmann ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Allergic Reaction ◽  
Repeated Administration ◽  
Phase Iii ◽  
Foreign Protein ◽  
Severe Allergic Reaction ◽  
Allergic Reactions ◽  
Pivotal Phase ◽  
Other Substances ◽  
Life Threatening

SummaryTwo employees of the National Health Service (NHS) in England developed severe allergic reactions following administration of BNT162b2 vaccine against COVID-19 (coronavirus disease 2019). The British SmPC for the BNT162b2 vaccine already includes reference to a contraindication for use in individuals who have had an allergic reaction to the vaccine or any of its components. As a precautionary measure, the Medicines and Healthcare products Regulatory Agency (MHRA) has issued interim guidance to the NHS not to vaccinate in principle in “patients with severe allergies”. Allergic reactions to vaccines are very rare, but vaccine components are known to cause allergic reactions. BNT162b2 is a vaccine based on an mRNA embedded in lipid nanoparticles and blended with other substances to enable its transport into the cells. In the pivotal phase III clinical trial, the BNT162b2 vaccine was generally well tolerated, but this large clinical trial, used to support vaccine approval by the MHRA and US Food and Drug Administration, excluded individuals with a “history of a severe adverse reaction related to the vaccine and/or a severe allergic reaction (e.g., anaphylaxis) to a component of the study medication”. Vaccines are recognized as one of the most effective public health interventions. This repeated administration of a foreign protein (antigen) necessitates a careful allergological history before each application and diagnostic clarification and a risk–benefit assessment before each injection. Severe allergic reactions to vaccines are rare but can be life-threatening, and it is prudent to raise awareness of this hazard among vaccination teams and to take adequate precautions while more experience is gained with this new vaccine.

Clinical and immunological characteristics of sensitization to tropomyosins

2021 ◽  
Vol 18 (1) ◽  
pp. 73-78
Author(s):  
Marina A. Mokronosova ◽  
Tatiana M. Zheltikova
Keyword(s):  
Food Allergy ◽  
Allergic Reaction ◽  
Clinical Case ◽  
Oral Allergy Syndrome ◽  
Allergic Reactions ◽  
Allergenic Proteins ◽  
Primary Sensitization ◽  
Life Threatening ◽  
Reaction Severity ◽  
High Concentrations

Tropomyosins are a family of allergenic proteins found in large quantities in all invertebrates. Tropomyosins sensitization causes a life-threatening allergic reaction up to anaphylaxis after eating seafood. Identifying the source of primary sensitization is important to predict the allergic reaction severity. This article describes a clinical case of chronic recurrent urticaria in an 8-year-old boy with tropomyosins sensitization. An 8-year-old boy was diagnosed with the following: controlled atopic phenotype bronchial asthma, food allergy (oral allergy syndrome), and chronic recurrent spontaneous urticaria. Component diagnostics revealed IgE-aB to tropomyosins in high concentrations from 38.79 to 43.38 kUA/l and cat and dog uteroglobin and lipocalins in high concentrations from 7.79 to 43.38 kUA/l. It is necessary to specify the primary sensitizer to analyze the clinical significance of allergens that provoke sensitization to various groups of allergens. In this case, sensitization to tropomyosins is most likely described as caused by either a helminthic invasion or midge bites. Therefore, food allergic reactions to tropomyosins caused from crustaceans were not observed.

scholarly journals Myths, facts and controversies in the diagnosis and management of anaphylaxis

2018 ◽  
Vol 104 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Katherine Anagnostou ◽  
Paul J Turner
Keyword(s):  
Allergic Reaction ◽  
Healthcare Professionals ◽  
Allergic Reactions ◽  
International Guidelines ◽  
Diagnosis And Management ◽  
Systemic Allergic Reaction ◽  
Consensus Statements ◽  
Life Threatening ◽  
Optimal Approach ◽  
Common Misconceptions

Anaphylaxis is a serious systemic allergic reaction that is rapid in onset and may cause death. Despite numerous national and international guidelines and consensus statements, common misconceptions still persist in terms of diagnosis and appropriate management, both among healthcare professionals and patient/carers. We address some of these misconceptions and highlight the optimal approach for patients who experience potentially life-threatening allergic reactions.

scholarly journals A Severe Case of Wheat-Dependent Exercise-Induced Anaphylaxis in Adulthood

2014 ◽  
Vol 2 (3) ◽  
pp. 491-493
Author(s):  
Mehmet Hoxha ◽  
Albana Deliu ◽  
Elida Nikolla ◽  
Gjustina Loloci ◽  
Tritan Kalo
Keyword(s):  
Physical Exercise ◽  
Severe Case ◽  
Severe Form ◽  
Crucial Importance ◽  
Ige Antibodies ◽  
Triggering Factors ◽  
Exercise Induced ◽  
Specific Food

Food-dependent exercise-induced anaphylaxis (FDEIA), is a severe form of allergy for which the ingestion of a specific food, usually before physical exercise induces symptoms of anaphylaxis. Patients typically have IgE antibodies to the food that triggers the reactions; however, the symptoms appear only if the co-factors act together. The most common reported cause of these reactions seems to be wheat. In some cases FDEIA is displayed even when the food is eaten immediately after exercise, showing that in FDEIA, not the sequence but rather the coincidence of triggering factors use, is of crucial importance. The risk to develop anaphylaxis in these patients depends on the presence and, in some cases, on the amount of cofactors of anaphylaxis. There are lots of evidences about the role of NSAIDs as cofactors of anaphylaxis.

scholarly journals Lidocaine: A Local Anesthetic, Its Adverse Effects and Management

Medicina ◽  
2021 ◽  
Vol 57 (8) ◽  
pp. 782
Author(s):  
Entaz Bahar ◽  
Hyonok Yoon
Keyword(s):  
Adverse Effects ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Adverse Reactions ◽  
Rapid Diagnosis ◽  
Diagnosis And Treatment ◽  
Allergic Reactions ◽  
Life Threatening

The most widely used medications in dentistry are local anesthetics (LA), especially lidocaine, and the number of recorded adverse allergic responses, particularly of hazardous responses, is quite low. However, allergic reactions can range from moderate to life-threatening, requiring rapid diagnosis and treatment. This article serves as a review to provide information on LA, their adverse reactions, causes, and management.

scholarly journals Recombinant factor XIII: a safe and novel treatment for congenital factor XIII deficiency

Blood ◽  
2012 ◽  
Vol 119 (22) ◽  
pp. 5111-5117 ◽  
Author(s):  
Aida Inbal ◽  
Johannes Oldenburg ◽  
Manuel Carcao ◽  
Anders Rosholm ◽  
Ramin Tehranchi ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Autosomal Recessive Disorder ◽  
Allergic Reactions ◽  
Open Label ◽  
Impaired Wound Healing ◽  
Bleeding Rate ◽  
Life Threatening ◽  
A Subunit ◽  
Bleeding Episodes ◽  
Congenital Factor

Congenital factor XIII (FXIII) deficiency is a rare, autosomal-recessive disorder, with most patients having an A-subunit (FXIII-A) deficiency. Patients experience life-threatening bleeds, impaired wound healing, and spontaneous abortions. In many countries, only plasma or cryoprecipitate treatments are available, but these carry a risk for allergic reactions and infection with blood-borne pathogens. The present study was a multinational, open-label, single-arm, phase 3 prophylaxis trial evaluating the efficacy and safety of a novel recombinant FXIII (rFXIII) in congenital FXIII-A subunit deficiency. Forty-one patients ≥ 6 years of age (mean, 26.4; range, 7-60) with congenital FXIII-A subunit deficiency were enrolled. Throughout the rFXIII prophylaxis, only 5 bleeding episodes (all trauma induced) in 4 patients were treated with FXIII-containing products. The crude mean bleeding rate was significantly lower than the historic bleeding rate (0.138 vs 2.91 bleeds/patient/year, respectively) for on-demand treatment. Transient, non-neutralizing, low-titer anti-rFXIII Abs developed in 4 patients, none of whom experienced allergic reactions, any bleeds requiring treatment, or changes in FXIII pharmacokinetics during the trial or follow-up. These non-neutralizing Abs declined below detection limits in all 4 patients despite further exposure to rFXIII or other FXIII-containing products. We conclude that rFXIII is safe and effective in preventing bleeding episodes in patients with congenital FXIII-A subunit deficiency. This study is registered at http://www..clinicaltrials.gov as number NCT00713648.

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