scholarly journals Gastrointestinal manifestations as early symptoms to diagnose COVID-19 paediatric cases

2021 ◽  
Vol 8 (1) ◽  
pp. 5-7
Author(s):  
J Robinson ◽  
I Banerjee ◽  
A Leclézio
Keyword(s):  
Gastrointestinal Tract ◽  
Admission Rate ◽  
Virus Infections ◽  
Gastrointestinal Manifestations ◽  
Demographic Profile ◽  
Early Symptoms ◽  
Trivial Group ◽  
Form Part ◽  
Stark Contrast ◽  
Inflammatory Syndrome

Background: The international situation surrounding the COVID-19 pandemic is seeing multiple countries battle various waves of the SARS-CoV-2 virus infections, with millions of individuals being infected globally. COVID-19 cases initially involved the immuno-compromised and elderly. As the virus has infected millions globally, the demographic profile of cases has shifted with more children being infected; this increase in younger individuals contracting the infection has resulted in new symptoms with altered manifestations and presentations of the disease in the young. In comparison to the severe symptoms of COVID-19 in adults children present with a more trivial group of symptoms. The majority of children develop mild symptoms or remain asymptomatic. This is in stark contrast to adults who have a higher admission rate with severe symptoms. A sign of great importance and now incidence in pediatric cases with COVID-19 is that of the gastrointestinal tract. The virus has a tropism for the GIT due to the presence of ACE2 receptors, which facilitate the entry of the virus into the cell. Conclusion: It is now established that the GIT symptoms form part of a newly recognized multisystem inflammatory syndrome (MIS-C) which occurs as a result and or manifestation of the COVID-19 infection. The innate difficulty in correctly and accurately diagnosing such a case is that the symptoms very close mimic gastroenteritis and acute abdominal pathologies. Therefore, physicians need to be aware of the various manners in which the COVID-19 infection manifests itself in children to diagnose better and isolate the cases. 

scholarly journals Gastrointestinal Hemorrhage in Patient with Granulomatosis with Polyangitis

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Nikhil Madan ◽  
Vipul Patel
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Hemorrhage ◽  
Lower Respiratory Tract ◽  
Rare Presentation ◽  
Bowel Infarction ◽  
Small Arteries ◽  
Gastrointestinal Manifestations ◽  
Granulomatous Vasculitis ◽  
Pulmonary Renal Syndrome ◽  
Arteries And Veins

Granulomatosis with polyangitis (GPA) is characterized by a necrotizing granulomatous vasculitis of small arteries and veins. It most commonly affects the upper and lower respiratory tract and kidneys. However, other organs including the gastrointestinal tract can be affected. Gastrointestinal manifestations of GPA are rare and can include ischemia, bowel infarction, and perforation. Hemorrhage is an extremely rare presentation of GPA. We present a case of a woman with GPA and pulmonary renal syndrome on treatment who presents with severe gastrointestinal hemorrhage.

Gastrointestinal Manifestations of Systemic Lupus Erythematosus and Scleroderma

2009 ◽  
Vol 2 ◽  
pp. CGast.S2264 ◽  
Author(s):  
Cherag Daruwala ◽  
Giancarlo Mercogliano ◽  
Thomas P. Harder
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Fecal Incontinence ◽  
Lupus Erythematosus ◽  
Diagnostic Tests ◽  
Systemic Lupus ◽  
Gastrointestinal Manifestations ◽  
Oral Ulcers

In this review, we analyze the effects of systemic lupus erythematosus and scleroderma on the gastrointestinal tract. There is a wide variation of gastrointestinal manifestations from these autoimmune disorders including but not limited to: oral ulcers, dysphagia, gastroesophageal reflux disease, abdominal pain, constipation, diarrhea, fecal incontinence, pseudo-obstruction, perforation and gastrointestinal bleeding. The purpose of this review is to discuss these manifestations, the appropriate diagnostic tests, and treatment.

scholarly journals COVID-19 and the Gastrointestinal Tract

2021 ◽  
Vol 12 (4) ◽  
pp. 394-404
Author(s):  
María-Jimena Mucino-Bermejo
Keyword(s):  
Public Health ◽  
Critical Care ◽  
Gastrointestinal Tract ◽  
Severe Acute Respiratory Syndrome ◽  
Healthcare Team ◽  
Healthy Individuals ◽  
Gastrointestinal Involvement ◽  
Gastrointestinal Manifestations ◽  
Public Health Threat ◽  
Common Clinical Finding

Since it was discovered at the end of 2019; the pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health threat worldwide, with over 175 million confirmed cases reported globally. Even when COVID-19 was initially considered a respiratory disease, it was actually known to be multisystemic, with gastrointestinal involvement a common clinical finding. Furthermore, COVID-19 may affect patients with gastrointestinal comorbidities, being the clinical intersectionality of utmost interest for gastroenterologists; critical care physicians and all the healthcare team taking care of COVID-19 patients. The present article presents a brief review of the reported gastrointestinal manifestations of COVID-19 disease in both previously healthy individuals and in patients with gastrointestinal comorbidities.

scholarly journals Cystic fibrosis and the gut

2020 ◽  
pp. flgastro-2020-101610
Author(s):  
Mordechai Slae ◽  
Michael Wilschanski
Keyword(s):  
Cystic Fibrosis ◽  
Gastrointestinal Tract ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Gastrointestinal Malignancy ◽  
Gastrointestinal Manifestations ◽  
Adult Disease ◽  
Novel Treatments ◽  
Cftr Protein ◽  
Cf Transmembrane Conductance Regulator

Cystic fibrosis (CF) is a recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The gene product, CFTR protein, has important manifestations in the intestine, pancreas and hepatobiliary system. Increased survival has caused CF to be primarily an adult disease today. Physicians must be knowledgeable as to the varied phenotype in the gastrointestinal tract. This review will outline the main gastrointestinal manifestations including a section on gastrointestinal malignancy in CF. Novel treatments treating the basic effect in CF are now being introduced and their effects on the gastrointestinal tract are discussed.

The globus syndrome: value of flexible endoscopy of the upper gastrointestinal tract

1993 ◽  
Vol 107 (6) ◽  
pp. 535-537 ◽  
Author(s):  
Reinhard Lorenz ◽  
Gabriele Jorysz ◽  
Meinihard Clasen
Keyword(s):  
Gastrointestinal Tract ◽  
Prospective Trial ◽  
Flexible Endoscopy ◽  
Upper Gastrointestinal Tract ◽  
Radiographic Examination ◽  
Causative Relationship ◽  
Form Part ◽  
Pathologic Lesions ◽  
Endoscopic Assessment ◽  
Upper Gastrointestinal

Flexible endoscopy of the upper gastrointestinal tract usually does not form part of the primary diagnostic evaluation of the globus syndrome. In a prospective trial, a flexible endoscopy was performed in 51 globus patients with normal results of the laryngologic and radiographic examination. Pathologic findings requiring therapy were diagnosed in 70.6 per cent of cases. The most frequent findings were reflux oesophagitis (n = 24; 47 per cent) and hiatial hernia (n = 25; 49 per cent). In 16 cases (31,4 per cent) these were accompanied by other pathologic lesions. A total of 32 patients (62.7 per cent) suffered from oesophageal diseases as sole aetiologic factors of the globus syndrome, which led us to postulate a causative relationship in these cases. Flexible endoscopy therefore can contribute significantly to the differential diagnosis of the globus syndrome. It must be kept in mind, however, that there is a ‘blind zone’ for endoscopic assessment in a region of the hypopharynx, thus some indications may require rigid endoscopy.

scholarly journals Gastrointestinal tract diseases at different stages of COVID-19 in children

2021 ◽  
Vol 1 (6) ◽  
pp. 18-28
Author(s):  
G. S. Karpovich ◽  
I. V. Kuimova ◽  
A. E. SHestakov ◽  
I. Ya. Izvekova ◽  
L. M. Panasenko ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Laboratory Tests ◽  
Pediatric Patients ◽  
Clinical Signs ◽  
Pain Syndrome ◽  
Immune Development ◽  
Icd 10 ◽  
One Year ◽  
Inflammatory Syndrome

Purpose of the study. To investigate the features of lesions of the gastrointestinal tract in diff erent variants of the course of COVID-19 in children.Materials and methods. A single-center prospective study was carried out to study the clinical and laboratory manifestations of gastrointestinal tract (GIT) lesions in different variants of the course of COVID-19 in children. The study was carried out in the following groups: group No. 1 — pediatric patients with a verified diagnosis (according to ICD 10) “U07.1. COVID-19 virus identified, confirmed by laboratory tests, regardless of the severity of clinical signs or symptoms ”, n = 524; group No. 2 — pediatric patients with a verified diagnosis (according to ICD 10) “U10.9 Multisystem inflammatory syndrome associated with COVID-19, unspecified”, n = 46. The article provides a brief description of the observations of the development of autoimmune pathologies (ulcerative colitis, autoimmune hepatitis) in pediatric patients, for whom a postponed COVID-19 infection could be a probable trigger.Results. The leading symptoms of the gastrointestinal tract in patients of group No. 1 were symptoms of acute gastroenteritis, registered in 37.6% of cases. Diarrhea was detected in 21.2% of cases, vomiting — in 16.5%; abdominal pain syndrome — 9.2%. These manifestations were statistically more significant in patients under one year of age, as well as in children of the first three years of life (p≤0.05). Gastrointestinal syndrome in patients of group No. 2 was registered in 67.4% of cases, with vomiting — 60.9% of cases, diarrheal syndrome — 23.9% of cases, abdominal pain syndrome — 82.6%. Other manifestations of the gastrointestinal tract in patients of this group were: reactive hepatitis — 69.6% of cases (average ALT — 98 (47; 347); AST — 107 (34; 347)), reactive pancreatitis — 60.8% of cases (average values of amylase — 127 (28; 269); lipase — 196 (47; 107)). These lesions were of a reactive inflammatory nature, with a probable immune development mechanism.

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