scholarly journals Myelofibrosis in a Child with Tuberculosis: A Case Report

1970 ◽  
Vol 27 (2) ◽  
pp. 90-92
Author(s):  
K Malla ◽  
T Malla ◽  
A Thaplial
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Key Words ◽  
Poor Prognosis ◽  
Medical Literature ◽  
Acute Megakaryoblastic Leukemia ◽  
Diagnostic Dilemma ◽  
Megakaryoblastic Leukemia ◽  
Proper Diagnosis ◽  
Uncommon Condition

Myelofibrosis (MF), or fibrosis of the bone marrow, is an uncommon condition in children. Fewer than 100 cases have been described in the medical literature. Most cases in children arise secondary to other disease processes. We present a case of Myelofibrosis in a 12-year-old girl. The purpose of reporting this case is that this child had a diagnostic dilemma and was sent home with poor prognosis but with proper diagnosis and treatment she improved and may have a complete cure, as the myelofibrosis was secondary to tuberculosis. Key words: myelofibrosis, tuberculosis, acute megakaryoblastic leukemia (AMKL)   doi:10.3126/jnps.v27i2.1588 J. Nepal Paediatr. Soc. Vol.27(2) p.90-92

scholarly journals First reported case of acute megakaryoblastic leukemia successfully treated with decitabine and venetoclax combined with imatinib

2021 ◽  
Author(s):  
Wanzhuo Xie
Keyword(s):  
Bone Marrow ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Targeted Drugs ◽  
Acute Megakaryoblastic Leukemia ◽  
Rare Type ◽  
Megakaryoblastic Leukemia ◽  
First Case ◽  
Acute Megakaryocytic Leukemia ◽  
Acute Myeloid

Abstract Acute megakaryocytic leukemia (AMKL) is a rare type of acute myeloid leukemia (AML), which is characterized by its effect on megakaryocytes in bone marrow. Despite standard doses of anthracycline plus cytarabine based regimen, AMKL is notorious for its poor prognosis. With the continuous development of targeted drugs, the choice of chemotherapy regimens for AML patients has been gradually enriched. However, as far as we known, there is little data with this regimen in AMKL with decitabine and Bcl-2 inhibitor combined with imatinib. Herein, we reported the first case of adult AMKL with BCR-ABL positive successfully treated with decitabine and venetoclax combined with imatinib.

scholarly journals Hepatic myeloid sarcoma preceding acute megakaryoblastic leukemia with t(1;22) in an infant: Case report

2016 ◽  
Vol 1 (4) ◽  
pp. 80-82
Author(s):  
Zeynep Canan Özdemir ◽  
Ayşe Bozkurt Turhan ◽  
Beyhan Durak Aras ◽  
Berat Acu ◽  
Özcan Bör
Keyword(s):  
Case Report ◽  
Myeloid Sarcoma ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Infant Case

Bone marrow microenvironment in acute megakaryoblastic leukemia of children with down syndrome

2017 ◽  
Vol 53 ◽  
pp. S66
Author(s):  
Theresa Hack ◽  
Stephanie Sendker ◽  
Nils von Neuhoff ◽  
Dirk Reinhardt ◽  
Mareike Rasche
Keyword(s):  
Bone Marrow ◽  
Down Syndrome ◽  
Bone Marrow Microenvironment ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Children With Down Syndrome

scholarly journals The biology of pediatric acute megakaryoblastic leukemia

Blood ◽  
2015 ◽  
Vol 126 (8) ◽  
pp. 943-949 ◽  
Author(s):  
Tanja A. Gruber ◽  
James R. Downing
Keyword(s):  
Trisomy 21 ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Somatic Mutations ◽  
Newly Diagnosed ◽  
Acute Megakaryoblastic Leukemia ◽  
Pediatric Acute Myeloid Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Children With Down Syndrome ◽  
Gata1 Mutation

Abstract Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down syndrome (DS) is characterized by a founding GATA1 mutation that cooperates with trisomy 21, followed by the acquisition of additional somatic mutations. In contrast, non–DS-AMKL is characterized by chimeric oncogenes consisting of genes known to play a role in normal hematopoiesis. CBFA2T3-GLIS2 is the most frequent chimeric oncogene identified to date in this subset of patients and confers a poor prognosis.

Hypervitaminosis A: A Case Report

PEDIATRICS ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 112-115
Author(s):  
Melton B. James ◽  
Joe C. Leonard ◽  
John J. Fraser ◽  
John H. Stuemky
Keyword(s):  
Case Report ◽  
Vitamin A ◽  
Bone Scintigraphy ◽  
Medical Literature ◽  
Hypervitaminosis A ◽  
Diagnostic Dilemma ◽  
White Girl ◽  
X Ray ◽  
The Public

In his textbook, Pediatric X-Ray Diagnosis, Caffey1 makes the statement that "until the whole truth becomes available to the public, all authentic cases of Vitamin A poisoning be carefully recorded and widely published in the medical literature." Since Josephs2 first described this condition in children in 1944, more than 50 cases have appeared in the literature.3 The following case, initially viewed as a diagnostic dilemma, was subsequently recognized to have typical clinical, biochemical, and rediographic changes of hypervitaminosis A. In addition, bone scintigraphy demonstrated evidence of involvement in radiographically normal areas. CASE REPORT A 5-year-old, nonimmunized, white girl was diagnosed as having measles in late April 1980.

scholarly journals Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Rodney E. Shackelford ◽  
Pushpa Allam-Nandyala ◽  
Marilyn M. Bui ◽  
John V. Kiluk ◽  
Nicole Nicosia Esposito
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Colorectal Adenocarcinoma ◽  
Medical Literature ◽  
Rare Event ◽  
Poorly Differentiated ◽  
Disseminated Disease ◽  
Breast Malignancies

Metastases to the breast from extramammary primaries are uncommon and account for 0.5–6% of all breast malignancies (Georgiannos et al., 2001, and Vizcaíno et al., 2001). Malignant melanoma, lymphoma, and lung and gastric carcinomas are the most frequently encountered nonmammary metastases to the breast in adults (Georgiannos et al., 2001, and Chaignaud et al., 1994). Primary colorectal adenocarcinoma (CRC) metastatic to the breast is extremely rare, with the medical literature having only 19 recorded cases. Typically CRC metastatic to the breast is indicative of widely disseminated disease and a poor prognosis. Here we present a case of poorly differentiated colon cancer metastatic to the breast and review the current literature on this rare event.

Acute Megakaryoblastic Leukemia: Importance of Bone Marrow Biopsy in Diagnosis

1991 ◽  
Vol 4 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Irene Lorand-Metze ◽  
José Vassallo ◽  
Regina Yoko Aoki ◽  
Carmino Antonio De Souza
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia

scholarly journals Ocular Dirofilariasis - A Diagnostic Dilemma

2020 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Case Report ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
High Index ◽  
Diagnosis And Treatment ◽  
Care Hospital ◽  
Diagnostic Dilemma ◽  
Main Species ◽  
Proper Diagnosis ◽  
High Index Of Suspicion

Dirofilariasis is a zoonotic filariasis primarily affecting canines. It may infect humans causing pulmonary infarcts, subcutaneous and subconjunctival nodules. Dirofilaria repens is the main species inplicated in subconjunctival lesions. Proper diagnosis and treatment can cure the patient of all his symptoms. Hence it is important to have a high index of suspicion about this emerging zoonosis. This is a case report of ocular Dirofilariasis from a tertiary care hospital in Thrissur, Kerala.

scholarly journals Role for MKL1 in megakaryocytic maturation

Blood ◽  
2009 ◽  
Vol 113 (12) ◽  
pp. 2826-2834 ◽  
Author(s):  
Ee-chun Cheng ◽  
Qing Luo ◽  
Emanuela M. Bruscia ◽  
Matthew J. Renda ◽  
James A. Troy ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Serum Response Factor ◽  
Response Factor ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryocytic Differentiation ◽  
Megakaryoblastic Leukemia ◽  
Human Cd34 ◽  
Cd34 Cells ◽  
Serum Response ◽  
Cells Cultured

Abstract Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). Here we show that Mkl1 expression is up-regulated during murine megakaryocytic differentiation and that enforced overexpression of MKL1 enhances megakaryocytic differentiation. When the human erythroleukemia (HEL) cell line is induced to differentiate with 12-O-tetradecanoylphorbol 13-acetate, overexpression of MKL1 results in an increased number of megakaryocytes with a concurrent increase in ploidy. MKL1 overexpression also promotes megakaryocytic differentiation of primary human CD34+ cells cultured in the presence of thrombopoietin. The effect of MKL1 is abrogated when SRF is knocked down, suggesting that MKL1 acts through SRF. Consistent with these findings in human cells, knockout of Mkl1 in mice leads to reduced platelet counts in peripheral blood, and reduced ploidy in bone marrow megakaryocytes. In conclusion, MKL1 promotes physiologic maturation of human and murine megakaryocytes.

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