scholarly journals Platelet Rich Fibrin and Bone Graft in the Treatment of Intrabony Defect in Periodontitis Patients

2018 ◽  
Vol 2 (2) ◽  
pp. 49-55
Author(s):  
Shilu Shrestha ◽  
Surendra Man Shrestha ◽  
Ameena Pradhan ◽  
Shreeya Aryal
Keyword(s):  
Bone Graft ◽  
Graft Material ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Porous Hydroxyapatite ◽  
Platelet Rich Fibrin ◽  
Polypeptide Growth Factors ◽  
Radiographic Outcomes ◽  
Probing Depth ◽  
Depth Reduction

Background: Porous hydroxyapatite and β-tricalcium phosphate (β-TCP + HA) bone grafting material has resulted in clinically acceptable responses when used to fill the periodontal intrabony defects. PRF is an autologous leukocyte and platelet preparation that concentrates various polypeptide growth factors which therefore holds potential to be used as regenerative treatment for periodontal defects. Aim: The purpose of this study was to evaluate clinical and radiographic outcomes in periodontal intrabony defects treated with platelet rich fibrin compared to alloplastic bone graft material. Materials and Methods: Twenty subjects (10 subject per group, one site/subject) were treated either with platelet rich fibrin or alloplastic bone graft (30% β-TCP+ 70% HA). Primary clinical parameters: PD, CAL were taken at baseline, three months, six months and nine months post-operatively. Standardised radiographic data were collected at baseline, six months and nine months postoperatively. Results: Preoperative parameters were similar for both groups. Postsurgical measurements revealed a greater reduction in pocket depth in bone graft group (2.5 mm), greater CAL gain (2.2 mm) and greater defect fill (1.30 mm) as compared to platelet rich fibrin group (1.50 mm, 1.6 mm and 0.80 mm respectively ) at nine months. Conclusion: Treatment of intrabony defects with alloplast (30% β TCP+ 70% HA) or platelet rich fibrin both resulted in a significant probing depth reduction, CAL gain and bone depth reduction, with significantly better improvement in bone graft group.

scholarly journals Differences in results of infrabony pocket treatment with addition of platelet rich fibrin and platelet rich plasma gel in DFDBA bone graft

2019 ◽  
Vol 1 (1) ◽  
pp. 29
Author(s):  
Netta Anggraini ◽  
Sri Pramestri Lastianny ◽  
Al Sri Koes Soesilowati
Keyword(s):  
Bone Graft ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Bone Allograft ◽  
Graft Material ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Freeze Dried ◽  
Bone Height ◽  
Prp Gel

Treatment of infrabony pocket makes use of bone graft material demineralized freeze dried bone allograft (DFDBA) from different individuals which has undergone demineralization process and it is osteoinductive. Enhancement of growth factor was done by adding platelet rich fibrin (PRF) and platelet rich plasma (PRP). PRP is activated with an addition of calcium chloride CaCl2) to form gel. The method used to apply the bone grafting material is open flap debridement OFD). This research aimed to reveal the differences in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA. The sample was taken from 20 infrabony pocket points divided into 2 groups, 10 infrabony pocket were treated with OFD+DFDBA+PRF and the other were treated with OFD+DFDBA+PRP gel. Pocket depth (PD) was measured on the baseline and the first and third month after treatment. Alveolar bone height was measured using cone beam computed tomography (CBCT) radiograph on the baseline to the third month after treatment. The results of this research showed that there was difference in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA which could be observed from a reduction in PD from the baseline, month 1 and month 3 as well as reduction in alveolar bone height from the baseline to month 3. This research concluded that infrabony pocket treatment PRF application yields better results than PRP gel application in terms of PD and alveolar bone height reduction.

scholarly journals Evaluation of intrabony defects treated with platelet-rich fibrin or autogenous bone graft: A comparative analysis

2015 ◽  
Vol 09 (01) ◽  
pp. 100-108 ◽  
Author(s):  
Ashish Mathur ◽  
Vivek Kumar Bains ◽  
Vivek Gupta ◽  
Rajesh Jhingran ◽  
G. P. Singh
Keyword(s):  
Bone Graft ◽  
Primary Objective ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Probing Pocket Depth ◽  
Bivariate Correlation ◽  
Open Flap Debridement

ABSTRACT Objective: The primary objective of this study was to compare clinically and radiographically the efficacy of autologous platelet rich fibrin (PRF) and autogenous bone graft (ABG) obtained using bone scrapper in the treatment of intrabony periodontal defects. Materials and Methods: Thirty-eight intrabony defects (IBDs) were treated with either open flap debridement (OFD) with PRF or OFD with ABG. Clinical parameters were recorded at baseline and 6 months postoperatively. The defect-fill and defect resolution at baseline and 6 months were calculated radiographically (intraoral periapical radiographs [IOPA] and orthopantomogram [OPG]). Results: Significant probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, defect fill and defect resolution at both PRF and ABG treated sites with OFD was observed. However, inter-group comparison was non-significant (P > 0.05). The bivariate correlation results revealed that any of the two radiographic techniques (IOPA and OPG) can be used for analysis of the regenerative therapy in IBDs. Conclusion: The use of either PRF or ABG were effective in the treatment of three wall IBDs with an uneventful healing of the sites.

scholarly journals Evaluation of the Efficiency of Modified Bone Graft in Putty Consistency in Treatment of Angular Bone Defect - A Pilot Study

2019 ◽  
Vol 4 (12) ◽  
Author(s):  
Ramnath Elangovan ◽  
Mejalla Muthiah Amaladhas ◽  
Ramakrishnan Theyagarajan ◽  
Sivaranjani Pandithurai
Keyword(s):  
Pilot Study ◽  
Bone Graft ◽  
Bone Defects ◽  
Graft Material ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Bone Level ◽  
Distal Aspect ◽  
Attachment Level ◽  
Depth Reduction

Background: Periodontitis is the inflammatory disease of the periodontium which leads to destruction of the supporting bone and periodontium. Colocast is a bovine derived bone graft. This colocast when processed in a putty consistency constitutes the modified colocast. Aim: The aim is to evaluate the clinical efficiency of consistency modified bone graft material in the treatment of angular bone defects. Materials and Methods: Five patients with angular bone defects were included in this study. Bone defects were treated with bone grafts in putty consistency. Probing depth, clinical attachment level along with mesial and distal bone level were evaluated at baseline and three months after surgery. Results: There was a clinically and statistically considerable Probing depth reduction, Clinical Attachment Level gain and increase in bone formation at both mesial and distal aspect of treated teeth. Conclusions: The Modified bone graft in putty consistency has been proven to be effective in managing angular bone defects along with ease at handling the graft in this study.

scholarly journals Use of Platelet-Rich Fibrin in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Liang Chen ◽  
Yi Ding ◽  
Guoping Cheng ◽  
Shu Meng
Keyword(s):  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Periodontal Regeneration ◽  
Risk Of Bias ◽  
Secondary Outcome ◽  
Intrabony Defects ◽  
Platelet Rich Fibrin ◽  
Probing Depth ◽  
Autologous Platelet Concentrate ◽  
Depth Reduction

Background. Platelet-rich fibrin (PRF) is a kind of autologous platelet concentrate which is easy to obtain and cheap. In recent years, it has been studied to improve the effect of periodontal regeneration. However, few studies have systematically evaluated the complementary effect of PRF in the treatment of intrabony defects. The present review is aimed at systematically assessing the effects of PRF on clinical and radiological outcomes of the surgical treatment of periodontal intrabony defects. Methods. The protocol was registered at PROSPERO (International Prospective Register of Systematic Reviews) as CRD42020206056. An electronic search was conducted in MEDLINE, Cochrane, and EMBASE databases. Only randomized clinical trials were selected. Systematically healthy patients with two or three walls of intrabony defects were considered. Intrabony defect (IBD) depth reduction and bone fill (BF) % were set as primary outcomes while probing depth (PD) reduction, clinical attachment level (CAL) gain, and gingival margin level (GML) gain were considered as the secondary outcome. When possible, a meta-analysis was performed. Results. Eighteen articles fulfilled the inclusion criteria, and seventeen studies were quantitatively analyzed. Of 17 studies, four were rated as high risk of bias and thirteen as the moderate risk of bias. Two comparisons were set: (1) open flap debridement (OFD) combined with PRF and OFD alone and (2) bone grafting (BG) combined with PRF and BG alone. Compared to OFD alone, OFD+PRF showed significantly greater in all primary and secondary outcomes. Compared to BG alone, BG+PRF showed significantly greater in IBD depth reduction, PD reduction, CAL gain, and GML gain. Conclusions. The use of PRF was significantly effective in the treatment of periodontal intrabony defects. The benefit of OFD+PRF may be greater than BG+PRF. PRF can promote early wound healing in periodontal surgery. As all included studies were not at low risk of bias, well-designed RCTs having a high methodological quality are needed to clarify the additional effectiveness of PRF in the treatment of intrabony defects in the future.

scholarly journals Efficacy of a New-generation Platelet-rich Fibrin in the Treatment of Periodontal Intrabony Defects: a Randomized Clinical Trial

2021 ◽  
Author(s):  
Boroka Klara Csifo-Nagy ◽  
Eleonora Solyom ◽  
Vera Lili Bognar ◽  
Annamaria Nevelits ◽  
Ferenc Dori
Keyword(s):  
Positive Impact ◽  
Test Group ◽  
Gingival Recession ◽  
Control Group ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Registration Number ◽  
Enamel Matrix Derivatives ◽  
New Generation

Abstract Background: The aim of the study was to clinically evaluate the healing of intrabony defects after treatment with a new generation of platelet-rich fibrin (A-PRF+) respect to enamel matrix derivatives (EMD). Methods: Thirty (30) intrabony defects of 18 patients (9 males, 9 females) were randomly treated with A-PRF+ (test, n=15) or EMD (control, n=15). The following clinical parameters were recorded at baseline and 6 months after surgery: pocket depth (PD), gingival recession (GR) and clinical attachment level (CAL). After debridement the intrabony defects were filled with A-PRF+ in the test group, respectively with EMD in the control group, and fixed with sutures to ensure wound closure and stability.Results: Both treatment methods resulted in statistically significant PD reductions, respectively CAL gains six months post-operatively. No statistically significant differences were found between the two groups as the mean CAL gain was 2.33±1.58 mm in the A-PRF+ group, respectively 2.60±1.18 mm in the EMD group (p < 0.001).Conclusion: Within the limits of this study the new-generation platelet-rich fibrin seems to be as clinically effective as EMD in the surgical treatment of intrabony defects. Treatment with A-PRF+ or EMD resulted in reliable clinical outcomes. The use of A-PRF+ as a human autologous product can give a positive impact on periodontal healing.Clinical Relevance: A-PRF+ may be suitable for the treatment of intrabony periodontal defects. Trial registration number (TRN): NCT04404374 (ClinicalTrials.gov ID)Date of registration: 19.05.2020., retrospectively registered

A Novel Approach to Restore a Decayed Mandibular Posterior Tooth by Immediate Implant Placement Using Autogenous Tooth Graft Material Mixed with Platelet-Rich Fibrin: A Case Report

2021 ◽  
Author(s):  
Amit Khunger
Keyword(s):  
Case Report ◽  
Bone Graft ◽  
Graft Material ◽  
Present Case Report ◽  
Platelet Rich Fibrin ◽  
Implant Placement ◽  
Novel Approach ◽  
Decayed Tooth ◽  
Immediate Implant ◽  
Missing Tooth

A dental implant is the most accepted treatment option to replace the badly decayed tooth or missing tooth. The jumping gap left after the placement of the implant in the socket will require augmentation of bone graft material. In this case report, the extracted root stumps are used as an autogenous tooth graft material after its preparation. And PRF is mixed with graft material for additive advantage. So, the present case report discusses the feasibility of the use of autogenous tooth graft material along with PRF for the better osseointegration of the implant.

What is the Efficacy of Beta-tricalcium Phosphate as Graft Material in Periodontal Infra-bony Defects? Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Reham Al-Jasser ◽  
Abdulelah AlSubaie ◽  
Fayez Alshehri
Keyword(s):  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Controlled Study ◽  
Bony Defect ◽  
Graft Material ◽  
Inclusion Criteria ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Attachment Level ◽  
Depth Reduction

Abstract Background: β-TCP is a synthetic grafting material (alloplasts)that can be used as allografts and xenografts in peridontal periodontal infra-bony defect. However, it is important to compare this material outcomes in such treatments when comparted to others Therefore, the aim of this review is to evaluate the effectiveness of β-TCP in the regeneration of periodontal infra-bony defect. Methods: Three electronic databases (Cochrane, Pubmed, Embase) were searched up to March 2020. The inclusion criteria consist of regeneration of periodontal infra-bony defect via implementation of β-TCP in combination with other bone graft materials. Outcomes consisted of pocket depth reduction, clinical attachment level gain and bone fill. Results: Five studies were included according to inclusion criteria. β-TCP found to be superior than debridement alone while it shown comparable result to other bone grafts materials in term of pocket depth reduction, clinical attachment level gain and bone fill. the outcomes of the regenerative procedures of periodontal infra-bony defect with the use of β-TCP in combination with other growth factors seems to be superior than alone. Conclusion: β-TCP seems to be a promising material to be used in periodontal infra-bony defect regeneration. However, randomized clinical trials with larger sample size and more controlled study design are needed to support the findings.

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