scholarly journals Myrid of histopathological features of malignancy in Xeroderma pigmentosum

2013 ◽  
Vol 3 (6) ◽  
pp. 472-475
Author(s):  
S Karki ◽  
G Pandey ◽  
N Bhattarai
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Xeroderma Pigmentosum ◽  
University Teaching ◽  
Computer Data ◽  
Female Ratio ◽  
Histopathological Features ◽  
Increased Risk ◽  
The Face

Background: Xeroderma pigmentosum is a rare autosomal recessively inherited disorder affecting 1 in 2,50,000 population. It shows genetic heterogeneity with at least ten different complementation groups identified which have different clinical presentations. They tend to have a more than 1000 fold increased risk of developing cancers in sun-exposed areas as a result of a DNA repair defect. This study presents a myriad of histopathological features of malignancies seen in individuals with this rare. Materials and Methods: Biopsies received from patients with a clinical diagnosis of Xeroderma Pigemntosa at the department of pathology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, from April 2008 to June 2012 were included in the study. Hematoxylin and eosin stained sections were examined. Clinical history was retrieved from the computer data base of the department. Results: During the study period, a total of eleven cases of Xeroderma pigmentosum presented with a biopsied lesion. All of these were malignant lesions. No benign lesions were seen. The age range of these patients was 6-30years with a mean of 18.8 years. The male to female ratio was 4.5:1. The most common malignancy seen was squamous cell carcinoma 7/11 (63.6%) followed by basal cell carcinoma 2/11 (27.2%). A single case presented with basal cell carcinoma of face and melanoma of trunk. The frequently observed site of malignancy was skin of the face followed by conjunctiva. Conclusion: In our population, non melanotic skin cancers affecting the face are more common in young individuals with Xeroderma pigmentosum. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8996   Journal of Pathology of Nepal (2013) Vol. 3, 472-475

scholarly journals Basal Cell Carcinoma in Cases with or without Xeroderma Pigmentosum

2017 ◽  
Vol 56 (208) ◽  
pp. 432-7
Author(s):  
Dilasma Ghartimagar ◽  
Arnab Ghosh ◽  
Sushil Ram Shrestha ◽  
Sachet Shrestha ◽  
Raghavan Narasimhan ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Xeroderma Pigmentosum ◽  
Age Groups ◽  
Cross Sectional ◽  
Female Ratio ◽  
Younger Age ◽  
Ethical Approval ◽  
Keywords Basal Cell Carcinoma

Introduction: Basal cell carcinoma is the most common form of cancer in humans and comprises the vast majority of skin cancers. It predominantly affects fair-skinned individuals, and its incidence is rapidly increasing. The objective of the study is to identify the epidemiology, its topography and different histological subtypes of basal cell carcinoma in patients with or without Xeroderma Pigmentosum. Methods: A cross-sectional descriptive study was conducted at Manipal Teaching Hospital, Pokhara from Jan 2009 to Dec 2016. Ethical approval was taken from MEMG/IRC/GA. The study included patients with a confirmed diagnosis of basal cell carcinoma irrespective of their age and sex. Results: This study showed 77 individuals with 91 biopsies of BCC including 5 cases of Xeroderma Pigmentosum. The predominant histological subtype was nodular with 41 (53.94%) cases, followed by the 14 (18.42%) cases of pigmented and 10 (13.15%) cases baso-squamous subtype. The most frequent sites of involvement were the head and neck, with predominance in the nasal and orbital region. The mean age was 57.68 years but the basal cell carcinoma in cases of Xeroderma Pigmentosum was seen more in younger age groups. There were 43 (55.84 %) male patients and 34 (44.16 %) female patients with a male to female ratio of 1.26:1. Conclusions: Nodular and pigmented varieties were the most frequent subtypes with nose being the commonest site of involvement. Basal cell carcinomas in cases of Xeroderma Pigmentosum were noted in younger age group with multiple lesions. Keywords:   basal cell carcinoma; recurrence; topography; xeroderma pigmentosum.

scholarly journals A Treatment of Basal cell Carcinoma on the Face of a Xeroderma Pigmentosum Patient: A Case Report

2020 ◽  
Vol 36 (1) ◽  
pp. 39-44
Author(s):  
Jaehyun Bae ◽  
Dongkeun Jun ◽  
Jeenam Kim ◽  
Myungchul Lee ◽  
Donghyeok Shin ◽  
...  
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Xeroderma Pigmentosum ◽  
The Face

scholarly journals Colonisation of basal cell carcinoma and actinic keratosis by malignant melanoma in situ in a patient with xeroderma pigmentosum variant

2012 ◽  
Vol 2 (2) ◽  
pp. 47 ◽  
Author(s):  
Louise J. Smith ◽  
Ehab A. Husain
Keyword(s):  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Actinic Keratosis ◽  
Xeroderma Pigmentosum ◽  
Clinical Impression ◽  
Anatomical Site ◽  
History Of

Although malignant melanoma (MM) and both basal cell carcinoma (BCC) and actinic keratosis (AK) are sun-induced lesions, the coexistence of these entities at the same anatomical site (collision tumour) is exceedingly rare. We report the case of a 54-year-old woman with a known history of xeroderma pigmentosum variant (XPV) who presented with 2 separate skin lesions over the middle and upper right forearm, respectively. The clinical impression was that of BCCs or squamous cell lesions. On histological examination, both specimens showed features of melanoma <em>in situ </em>(MIS). In the first lesion, MIS merged with and colonised a superficial and focally invasive BCC. In the second lesion, MIS merged with an AK. No separate invasive nests of malignant melanoma were seen in either specimen. The atypical melanocytes were highlighted by Melan-A and HMB-45 immunostaining, whereas the epithelial cells in both the BCC and AK stained with the pancytokeratin MNF-116. The patient had a previous history of multiple MMs and non-melanomatous skin cancers and finally developed widespread metastatic malignant melanoma, which proved fatal. The rare and interesting phenomenon of collision tumours may pose diagnostic difficulties. To our knowledge, this is the first reported simultaneous presentation of cytologically malignant collision tumours in a patient with XPV.

scholarly journals Basal cell carcinoma- a prospective clinico epidemiological and pathological study

2017 ◽  
Vol 5 (6) ◽  
pp. 2712 ◽  
Author(s):  
V. Ammasaigoundan ◽  
V. N. S. Ahamed Shariff ◽  
A. Ramesh
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Health Workers ◽  
Tertiary Care ◽  
Malignant Tumour ◽  
Care Hospital ◽  
Female Ratio ◽  
Histological Variant ◽  
Public Health Workers

Background: Basal cell carcinoma is the most common malignant tumour of the skin worldwide. The objective was to find out the age and sex incidence of basal cell carcinoma in patients attending the outpatient department of dermatology and to find out the various clinical and histopathological features of basal cell carcinoma.Methods: It was a prospective observational study carried out in a tertiary care hospital, Chennai, Tamilnadu, India. Patients with clinical diagnosis of basal cell carcinoma were included in the study after thorough history, clinical examination, routine and special investigations like skin biopsy.Results: Out of 20 patients with basal cell carcinoma 6 were males and 14 were females with a male to female ratio of 1:2.33. Most commonly affected age group was 50-70 years (70%). Distribution of BCC in our study was confined to head and neck area. Most common morphological subtype encountered in this study was nodular/nodulo-ulcerative BCC (70%), followed by pigmented type (25%) and superficial BCC (5%). The most common histological variant observed in present study was nodular type (55%), followed by pigmented variant (25%), adenoid (5%), basisquamous (5%), superficial BCC (5%) and BCC with sebaceous differentiation (5%).Conclusions: This study highlights a paradoxically increasing trend of BCC with female predilection. Early detection and treatment of lesions are crucial to decrease the functional and cosmetic disfigurement and also this study highlights the importance of improving awareness among general practitioners, public health workers and general population.

scholarly journals Large Basal Cell Carcinoma Defect Closure on The Lateral Cheek Using Multiple Advancement Flaps

2021 ◽  
pp. 1-7
Author(s):  
Siswanto Wahab ◽  
Khairuddin Djawad
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histopathological Examination ◽  
Skin Flap ◽  
Reconstruction Procedure ◽  
The Face ◽  
Advancement Flaps ◽  
Substantial Morbidity

Basal cell carcinoma (BCC) is the most common type of nonmelanoma skin cancer (NMSC). It grows slowly and very rarely metastasizes but can cause substantial morbidity due to its tendency to relapse and locally invasive nature, especially when located on the face. Excision surgery is still the gold standard treatment for primary BCC and is usually followed by reconstruction procedure. Skin flap techniques vary widely, one of which is flap advancement technique. The main benefit of flap advancement technique is the ability to hide the excision line, thus resulting in an aesthetically sound outcome. We report a case of 72-year-old female with hyperpigmented plaque brownish lump on the left lateral cheek. A diagnosis of igmented basal cell carcinoma had been confirmed through histopathological examination. The patient was treated with wide excision surgery and the defect was closed by multiple advancement flaps. Follow-up after three months showed excellent cosmetic and functional outcome.

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