scholarly journals A rare case of Gingival Myeloid sarcoma in a child

2017 ◽  
Vol 7 (2) ◽  
pp. 1227-1230
Author(s):  
Meghashree Vishwanath ◽  
Purnima S Rao ◽  
Muktha R Pai
Keyword(s):  
Lymph Node ◽  
Rare Case ◽  
Soft Tissues ◽  
Myeloid Cells ◽  
Myeloid Sarcoma ◽  
Rare Tumour ◽  
Immature Myeloid Cells

Myeloid sarcoma is a rare tumour composed of immature myeloid cells. Its occurrence in childhood is rare. Only a few cases of intraoral myeloid sarcoma have been reported in literature. We present a case of myeloid sarcoma with simultaneous involvement of intraoral soft tissues and lymph node. Here, importance is given to suspect this frequently misdiagnosed disease. 

scholarly journals Myeloid Sarcoma Developing in Prexisting Hydroxyurea-Induced Leg Ulcer in a Polycythemia Vera Patient

2013 ◽  
Vol 2013 ◽  
pp. 1-2 ◽  
Author(s):  
Hatim Nafil ◽  
Illias Tazi ◽  
Lahoucine Mahmal
Keyword(s):  
Polycythemia Vera ◽  
Rare Case ◽  
Myeloid Cells ◽  
Leg Ulcer ◽  
Myeloid Sarcoma ◽  
Immature Myeloid Cells

Myeloid sarcoma (MS) is an extramedullary tumour consisting of myeloblasts or immature myeloid cells located in an extramedullary site. It may occur at presentation of AML, at relapse, or prior to the onset of frank leukemia. We report a rare case of MS developing in prexisting Hydroxyurea-induced leg Ulcer in a 70-year-old woman.

scholarly journals Co-Occurrence of Myeloid Sarcoma of the Lymph Node and Acute Monocytic Myeloid Leukemia: A Case Report and Literature Review

2018 ◽  
Vol 11 (3) ◽  
pp. 791-799 ◽  
Author(s):  
Misbahuddin Khaja ◽  
Toolsie Omesh ◽  
Masooma Niazi ◽  
Danial Shaikh ◽  
Sitarama Arvind Mudunuru ◽  
...  
Keyword(s):  
Lymph Node ◽  
Myeloid Leukemia ◽  
Soft Tissues ◽  
Myeloid Cells ◽  
Needle Aspiration ◽  
Myeloid Sarcoma ◽  
Monocytic Differentiation ◽  
Monocytic Leukemia ◽  
Extramedullary Tumor ◽  
Wbc Count

Background: Acute myeloid leukemia (AML) is the most common leukemia in adults. According to the French-American-British (FAB) system, monocytic leukemia is classified as M5. Myeloid sarcoma further occurs in 3–5% of AML. This is defined as an extramedullary tumor of myeloid cells in the lymph nodes, soft tissues, periosteum, bone, central nervous system (CNS), spinal cord, intestine, mediastinum, prostate, uterus, or ovaries. Case Presentation: Here, we describe the case of a 29-year-old female who presented with fever, swelling of gums, neck pain, and weakness, which had persisted for 1 week. The patient had a white blood cell (WBC) count of 53.5 K/μL, and a peripheral smear revealed a myeloid blast cell (blast) percentage of 8%. Computed tomography (CT) of the neck indicated lymphadenopathy. Fine needle aspiration of the cervical lymph node showed groups of atypical immature myeloid cells, mixed with occasional megakaryocytes, and infiltration of eosinophilic myeloid cells into the lymph node, consistent with myeloid sarcoma. Flow cytometry analysis revealed intermediate to large circulating blasts, with irregular nuclei, fine chromatin, and distinct nucleoli, indicative of AML, with monocytic differentiation. The patient responded well to chemotherapy with fludarabine, cytarabine, granulocyte colony stimulating factor (G-CSF), and idarubicin; WBC counts returned to normal and patient was discharged to home. Conclusion: Myeloid sarcoma of the lymph node is a rare co-occurrence with AML. Results of our study are consistent with the conclusion that early diagnosis and appropriate treatment improve survival.

scholarly journals A Rare Case of Myeloid Sarcoma Presenting as an Anorectal Ulcer

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Laxmi Parsa ◽  
Priti Bijpuria ◽  
Daniel Ringold ◽  
David Stein
Keyword(s):  
Immunohistochemical Staining ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
Soft Tissues ◽  
Histochemical Staining ◽  
Myeloid Sarcoma ◽  
Atypical Presentation ◽  
Rare Tumor ◽  
Gastrointestinal Complaint ◽  
Acute Myeloid

Myeloid Sarcoma is a rare tumor composed of myeloblasts occurring at an extramedullary site like bones, or various soft tissues. Myeloid sarcoma may involve the gastrointestinal tract very rarely either solitarily, or occurring simultaneously with acute myeloid leukemia. Its diagnosis is challenging and needs biopsy and immunohistochemical staining. We are describing a case of myeloid sarcoma which presented as a painful anal ulcer mimicking an atypical fissure. Its appearance resembled crohn’s disease on sigmoidoscopy. A biopsy of the ulcer along with histochemical staining led to the diagnosis of myeloid sarcoma. Our case demonstrates the need for aggressive evaluation of any common gastrointestinal complaint with an atypical presentation.

scholarly journals Mesenchymal Chondrosarcoma of the Parotid Gland

2020 ◽  
Vol 26 (2) ◽  
pp. 158-160
Author(s):  
MA Matin ◽  
Md Abdullah Al Harun ◽  
Mohammad Saiful Islam ◽  
AKM Shaif Uddin ◽  
MA Sabur
Keyword(s):  
Parotid Gland ◽  
Head And Neck ◽  
Rare Case ◽  
Soft Tissues ◽  
Clinical Presentation ◽  
Mesenchymal Chondrosarcoma ◽  
Rare Tumour ◽  
Rare Tumours ◽  
Myxoid Matrix ◽  
Mesenchymal Chondrosarcomas

Mesenchymal Chondrosarcomas of the parotid are extremely rare tumours. They are broadly classified under extra skeletal form of mesenchymal chondrosarcomas and account for less than 1% of all sarcomas. It is characterized by a multinodular architecture, abundant myxoid matrix, and malignant chondroblast like cells arranged in cords. The tumor is an entity from chondrosarcomas of bones, commonly found in the soft tissues of the lower extremities at 80%. There are very limited reports of this tumor in the head and neck, especially in the parotid gland. We report a rare case of a parotid mesenchymal chondrosarcoma in a 55 years old man and discuss the pathogenesis, clinical presentation and management of such a rare tumour Bangladesh J Otorhinolaryngol; October 2020; 26(2): 158-160

scholarly journals Monoblastic Sarcoma- A Rare Case Report of Myeloid Sarcoma Variant

2021 ◽  
Author(s):  
Nupur Kaushik ◽  
Lalit Kumar ◽  
Pooja Agarwal ◽  
Harendra Kumar ◽  
Brijesh Sharma
Keyword(s):  
Rare Case ◽  
Histopathological Examination ◽  
Granulocytic Sarcoma ◽  
Myeloid Sarcoma ◽  
Cervical Region ◽  
Rare Manifestation ◽  
Rare Case Report ◽  
History Of ◽  
Immature Myeloid Cells ◽  
Normal Architecture

Myeloid sarcoma, also known as chloroma, granulocytic sarcoma, extramedullary Acute Myeloid Leukaemia (AML), myeloblastoma or extramedullary myeloid tumour, is a rare manifestation, characterised by the proliferation of immature myeloid cells, myeloblasts or monoblasts occurring as one or more tumour at an extramedullary site. It is associated with disruption of normal architecture of tissue in which it is found. Monoblastic sarcoma is a rare variant of myeloid sarcoma. Hereby, the authors report a rare case of primary monoblastic sarcoma in a 64-year-old male patient presented with complaint of swelling over right side lower cervical region. He had no history of AML. On physical examination, the swelling was over medial one-third of right clavicle measuring 6×5.8×3 cm. The swelling was excised and sent for histopathological examination, which was diagnosed as monoblastic sarcoma, and confirmed on immunohistochemistry.

Myeloid Sarcoma: a Clinical Report of 18 Cases

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4377-4377
Author(s):  
Xiujin Ye ◽  
Lixia Zhu ◽  
Jinjin Zhu ◽  
Li Li ◽  
Jingsong He ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Conflicts Of Interest ◽  
Bone Marrow Involvement ◽  
Myeloid Cells ◽  
Small Sample ◽  
Myeloid Sarcoma ◽  
Complete Disappearance ◽  
Clinical Report ◽  
Kaplan Meier

Abstract Abstract 4377 Background: Myeloid Sarcoma (MS) is a rare neoplasm composed of immature myeloid cells occurring in any extramedullary organ most commonly in the skin, bone and lymph node. It may develop independently or concurrently with acute myeloid leukemia (AML), myeloproliferative disorder (MPD) or myelodysplastic syndrome (MDS). Some reports have described MS while most of them were one case report. In this study we retrospectively analyzed the clinical characteristics, treatment approaches and prognosis of 18 MS patients in our single center. Methods: between January 2003 and March 2010, eighteen MS patients were included in this study. The diagnosis depends on histological features and immunohistochemical results. All pathology specimens were routinely processed and examined by morphology. Immunohistochemical stains were performed on paraffin-embedded sections with monoclonal antibodies including MPO, CD3, CD20, CD79a, CD45, CD34, CD117, CD43. At the same time bone marrow aspiration were routinely examined. Disease morphology was determined according to the French-American – British(FAB) classification. After patients had comfirmed diagnosis with MS, they received cytarabine plus idarubicin or homoharringtonine for induction and consolidation chemotherapy. All the statistical analyses were performed using Kaplan-Meier. Results: among the 18 patients, the proportion of male and female was 1:1. Median age at diagnosis was 31.5 years (range 18–67). The usual involvement sites were skin (25%), lymph node (20%), breast (15%), uterus and cervix (15%). In total ten of the eighteen patients (55.6%) preceded AML without abnormality in peripheral blood and bone marrow while five patients concurrently developed AML-M2 and three (22.2%) were initially misdiagnosed as two were mistaken for Non-Hodgkin's lymphoma and the other for myeloma. In total 14 of 18 patients were examined by immunohistochemistry. The positive rate of MPO was 92.9% and other myeloid related markers were also strongly positive whereas lymphoid related markers were negative which were accord with biologic properties of myeloid cells. All the patients received chemotherapy. 10 patients without bone marrow involvement achieved complete disappearance of MS. Of these, 5 (50%) patients still kept complete remission after 1 year, 3 progressed to AML after six, eight and sixty-two months respectively; 2 died after two months after definite diagnoses of AML. As for the 6 patients with bone-marrow involvement undgone chemotherapy, 5 (83.3%) achieved complete bone-marrow remission but 3 of them relapsed at the points of seven,eleven and eighteen months, respectively. 4-year EFS and OS were longer in non-leukemic MS patients than in MS cases with bone-marrow involvement using Kaplan-Meier analyses. Conclusion: this study showed myeloid sarcoma could develop in various kinds of populations with easy misdiagnosis. Non-leukemic MS should be the beginning stage of AML. It is necessary to treat patients who have non-leukemic MS by classic chemical therapy for AML as early as possible. As such a study is limited by relatively small sample size, more clinical prospective trials in multiple centers should be carried out worldwide. Disclosures: No relevant conflicts of interest to declare.

Myeloid Sarcoma Involving the Central Nervous System Without Evidence of Preexisting Hematologic Disease: A Case Report

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S48-S48
Author(s):  
C Marshall ◽  
A D Sandhu ◽  
A Mohanty
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Brain Mri ◽  
Myeloid Cells ◽  
Myeloid Sarcoma ◽  
Rare Presentation ◽  
Bone Marrow Biopsies ◽  
The Central Nervous System ◽  
Immature Myeloid Cells

Abstract Introduction/Objective Myeloid sarcoma within the central nervous system is a rare presentation of an infiltrative mass of immature myeloid cells. It is typically found in association with myeloid dysplastic syndrome, myeloproliferative disorder, or acute myeloid leukemia. Rarely, it can occur in the absence of these diseases. Methods We present the case of 68-year-old female with worsening nausea and headaches. Brain MRI showed diffuse pachymeningeal enhancement with numerous nodular enhancing extra-axial masses overlying both cerebral hemispheres. Results Open biopsy of these masses showed gelatinous, hemorrhagic, brown tissue measuring 3.0 x 2.0 x 0.7 cm. Histologically, the specimen shows a diffuse polymorphous atypical myeloid proliferation consisting of all three cell lineages. There are nodules composed predominantly of large blastoid cells with 1 to 2 prominent oblong nucleoli, consistent with erythroblasts and early erythroid precursors. In between the nodules there are myeloid cells in different stages of maturation, including numerous eosinophilic precursors. Scattered megakaryocytes are also identified. Immunohistochemistry shows positivity for E-cadherin, CD235a and spectrin which highlight the immature erythroid cells. MPO, muramidase, and CD33 are positive in myeloid elements. Eosinophilic peroxidase highlights numerous eosinophilic precursors. CD34 is positive in the endothelial cells and very rare hematopoietic cells. CD20 and PAX 5 highlights B-cells, CD3 highlights T-cells, and CD4 highlights monocytic precursors, monocytes, histiocytes and a subset of T-cells. Conclusion Additional work up at the time of biopsy including FLOW cytometry and bone marrow biopsies showed no evidence of hematologic pathology. In summary the histologic and immunohistochemical findings demonstrate a tumor composed of proliferating immature myeloid cells most consistent with myeloid sarcoma without any evidence of hematological disease.

scholarly journals Isolated myeloid sarcoma

2015 ◽  
Vol 4 (3) ◽  
pp. 46-48
Author(s):  
B P Rauniyar ◽  
X Liu ◽  
J Shrestha ◽  
K R Devkota ◽  
S Poudel ◽  
...  
Keyword(s):  
Lymph Node ◽  
Case Reports ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Myeloid Sarcoma ◽  
Tumour Mass ◽  
Medical College ◽  
Node Biopsy ◽  
Immature Myeloid Cells ◽  
Prospective Trials

Myeloid Sarcoma (MS) is a tumour mass of myeloblasts or immature myeloid cells in an extra-medullary site. Isolated MS is a red disease found only seen in case reports. Here, we present the case of a 25years old man with bilateral cervical lymphadenopathy who was diagnosed as MS on the basis of lymph node biopsy and immunohistochemistry. There is no definite consensus on management of MS and needs prospective trials. DOI: http://dx.doi.org/10.3126/jcmc.v4i3.11941Journal of Chitwan Medical College 2014; 4(3):46-48 

scholarly journals Rare Case of Mediastinal Myeloid Sarcoma

2021 ◽  
Vol 6 (4) ◽  
pp. 533-537
Author(s):  
Kanta Devi ◽  
Salman Naseem Adil ◽  
Natasha Ali ◽  
Nasir Ali ◽  
Hammad Khan
Keyword(s):  
Myeloid Leukemia ◽  
Mediastinal Mass ◽  
Soft Tissues ◽  
Clinical Presentation ◽  
Bone Marrow Involvement ◽  
Young Female ◽  
Myeloid Sarcoma ◽  
Anterior Mediastinal Mass ◽  
Recommended Treatment ◽  
Immature Myeloid Cells

Myeloid sarcoma is a rare tumor mass with extra medullary growth pattern, composed of myeloblast or immature myeloid cells. Myeloid sarcoma (MS) is a distinct clinical presentation of acute myeloid leukemia (AML) where less than 1% of patients present with prominent extra medullary disease which most commonly involves the bone, skin, lymph node, soft tissues, gastrointestinal tract or testes. The recommended treatment regimen in isolated myeloid sarcoma or with bone marrow involvement is upfront systemic chemotherapy. We report a case of a young female with anterior mediastinal mass diagnosed as myeloid sarcoma which was refractory to chemotherapy.

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