scholarly journals Classification of mucinous appendiceal neoplasm and pseudomyoxma peritonei

2018 ◽  
Vol 8 (1) ◽  
pp. 1301-1307
Author(s):  
Arnab Ghosh
Keyword(s):  
Goblet Cell ◽  
Wide Spectrum ◽  
Low Grade ◽  
Controversial Issues ◽  
High Grade ◽  
Goblet Cell Carcinoid ◽  
Signet Ring Cells ◽  
Mucinous Neoplasm ◽  
Signet Ring

Mucinous appendiceal tumors are uncommon and include a wide spectrum of tumors whose classification remained controversial. Some of these mucin producing appendiceal tumors can disseminate to the peritoneal cavity leading to pseudomyxoma peritonei (PMP). Despite several attempts to classify mucinous tumors of appendix and PMP by different authors in the past, no universally accepted classification system was present. The controversial issues were discussed at the 2012 World Congress of the Peritoneal Surface Oncology Group International (PSOGI) in Berlin. A panel of 71 experts from 13 different countries was formed under the lead co-ordinator Norman J. Carr. A total of 4 rounds of questionnaires and one meeting were held. The opinion of the majority was taken into account. Importance of intactness of muscularis mucosae, pushing invasion and infiltrative invasion were emphasized. The entities Low grade appendiceal mucinous neoplasm (LAMN) and High grade appendiceal mucinous neoplasm (HAMN) were defined.. The terminologies suggested for Goblet cell carcinoid and adenoneuroendocrine carcinoma were goblet cell tumor and adenocarcinoma ex goblet cell carcinoid. Acellular mucin in peritoneum was not classified under PMP which was classified into 3 categories depending upon low grade , high grade cytologic features and presence of signet ring cells. It was suggested to report the extent of mucin and cells separately. A reporting format solely for mucinous appendiceal tumors was formulated by the panel. However, there are some grey areas which may have to be addressed in future.

Impact of multidisciplinary therapy on high-grade appendiceal adenocarcinoma (AA).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 4134-4134
Author(s):  
Karen A. Beaty ◽  
Richard E. Royal ◽  
Keith F. Fournier ◽  
Melissa W. Taggart ◽  
Michael J. Overman ◽  
...  
Keyword(s):  
Treatment Plan ◽  
Tumor Biology ◽  
Low Grade ◽  
High Grade ◽  
Multidisciplinary Therapy ◽  
Peritoneal Disease ◽  
Signet Ring Cells ◽  
Heated Intraperitoneal Chemotherapy ◽  
Signet Ring ◽  
The Impact

4134 Background: AA is a rare malignancy ranging from well-differentiated to poorly differentiated carcinoma, including those with signet ring cells. Optimal therapy for low grade peritoneal disease is cytoreductive surgery (CRS) combined with heated intraperitoneal chemotherapy (HIPEC). However, some patients (pts) are suboptimal for CRS/HIPEC, and are considered for systemic chemotherapy (SC) alone, or SC + CRS. In light of our previously reported overall survival (OS) benefits for the role of SC in metastatic AA, here we explore the impact of surgical intervention on OS in these pts. Our aim was to clarify the OS benefit of multidisciplinary therapy (SC + CRS + HIPEC) in those pts with aggressive tumor biology. Methods: A retrospective chart review of AA pts registered in our tumor registry between Jan. 2005 to Dec. 2009 was undertaken to identify patients with AA who received SC. Electronic medical records (EMR) were reviewed for CRS, HIPEC, histology, SC, and OS. The K-M method and Log-Rank test were used for statistical analysis. Results: Of 143 AA pts, 52 (36%) pts were high grade with 33 (23%) having signet ring cells. After a median follow-up of 35M, high grade tumors were noted to have worse OS overall (24M vs 56M, p<.001). When comparing treatment received, and adjusting for tumor biology, those pts with high grade disease again fared worse, and experienced comparatively worse OS. However, those treated with SC + CRS + HIPEC experienced the longest median survival. Conclusions: Pts with peritoneal disease from high grade AA who completed SC with CRS + HIPEC experienced prolonged OS compared to those treated by SC +/- CRS. Our data suggest that SC + palliative CRS offers minimal benefit for high grade disease. Selection bias influences these results heavily; as those who do well proceed to complete all components of therapy. A treatment plan that includes SC + CRS + HIPEC can result in durable survival, and is a strategy that warrants further study emphasizing the importance of multidisciplinary management. [Table: see text]

scholarly journals Combined goblet cell carcinoid and low grade appendiceal mucinous neoplasm: A case report

2018 ◽  
Vol 14 ◽  
pp. 38-40
Author(s):  
Naoko Sato ◽  
Koji Irie ◽  
Shinji Yotsumoto ◽  
Shinsaku Honda ◽  
Takashi Tasaki ◽  
...  
Keyword(s):  
Case Report ◽  
Goblet Cell ◽  
Low Grade ◽  
Goblet Cell Carcinoid ◽  
Mucinous Neoplasm

scholarly journals An Appendiceal Goblet Cell Carcinoid with a Low-Grade Appendiceal Mucinous Neoplasm

2019 ◽  
Vol 52 (4) ◽  
pp. 220-226
Author(s):  
Yoshinao Chinen ◽  
Masami Ueda ◽  
Masakazu Ikenaga ◽  
Yujiro Tsuda ◽  
Shinsuke Nakashima ◽  
...  
Keyword(s):  
Goblet Cell ◽  
Low Grade ◽  
Goblet Cell Carcinoid ◽  
Mucinous Neoplasm

scholarly journals Interobserver reproducibility of The Paris System for Reporting Urinary Cytology

CytoJournal ◽  
2017 ◽  
Vol 14 ◽  
pp. 17 ◽  
Author(s):  
Theresa Long ◽  
Lester J. Layfield ◽  
Magda Esebua ◽  
Shellaine R. Frazier ◽  
D. Tamar Giorgadze ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Urinary Cytology ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Cells ◽  
Urothelial Carcinomas ◽  
Absolute Agreement ◽  
Potential Impact ◽  
Urine Specimens

Background: The Paris System for Reporting Urinary Cytology represents a significant improvement in classification of urinary specimens. The system acknowledges the difficulty in cytologically diagnosing low-grade urothelial carcinomas and has developed categories to deal with this issue. The system uses six categories: unsatisfactory, negative for high-grade urothelial carcinoma (NHGUC), atypical urothelial cells, suspicious for high-grade urothelial carcinoma, high-grade urothelial carcinoma, other malignancies and a seventh subcategory (low-grade urothelial neoplasm). Methods: Three hundred and fifty-seven urine specimens were independently reviewed by four cytopathologists unaware of the previous diagnoses. Each cytopathologist rendered a diagnosis according to the Paris System categories. Agreement was assessed using absolute agreement and weighted chance-corrected agreement (kappa). Disagreements were classified as low impact and high impact based on the potential impact of a misclassification on clinical management. Results: The average absolute agreement was 65% with an average expected agreement of 44%. The average chance-corrected agreement (kappa) was 0.32. Nine hundred and ninety-nine of 1902 comparisons between rater pairs were in agreement, but 12% of comparisons differed by two or more categories for the category NHGUC. Approximately 15% of the disagreements were classified as high clinical impact. Conclusions: Our findings indicated that the scheme recommended by the Paris System shows adequate precision for the category NHGUC, but the other categories demonstrated unacceptable interobserver variability. This low level of diagnostic precision may negatively impact the applicability of the Paris System for widespread clinical application.

Triple Synchronous Tumors of the Appendix: Carcinoid, Goblet Cell Carcinoma and Low-Grade Mucinous Neoplasm

2020 ◽  
pp. 000313482095484
Author(s):  
Fabio Carboni ◽  
Renato Covello ◽  
Maria Grazia Diodoro ◽  
Enrico Vizza ◽  
Mario Valle
Keyword(s):  
Cell Carcinoma ◽  
Goblet Cell ◽  
Low Grade ◽  
Synchronous Tumors ◽  
Mucinous Neoplasm

scholarly journals Amphicrine carcinoma of the stomach and intestine: a clinicopathologic and pan-cancer transcriptome analysis of a distinct entity

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Dan Huang ◽  
Fei Ren ◽  
Shujuan Ni ◽  
Cong Tan ◽  
Weiwei Weng ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Expression Patterns ◽  
Biological Behavior ◽  
Low Grade ◽  
High Grade ◽  
Clinicopathologic Characteristics ◽  
Signet Ring ◽  
Cancer Transcriptome ◽  
Male Patients ◽  
Pan Cancer

Abstract Background and aim Amphicrine carcinoma, in which endocrine and epithelial cell constituents are present within the same cell, is very rare. This study characterized the clinicopathologic and survival analysis of this tumor, further compared the genetic diversities among amphicrine carcinoma and other tumors. Materials and methods The clinicopathologic characteristics and survival outcomes of amphicrine carcinoma in this study were analyzed. The pan-cancer transcriptome assay was utilized to compare the genetic expression profile of this entity with that of conventional adenocarcinoma or neuroendocrine tumors. Results Ten cases (all in male patients) were identified in the stomach or intestine, with a median patient age of 62 years. There were characteristic patterns in the tumors: tubular, fusion or single-file growth of goblet- or signet ring-like cells. Four tumors were classified as low-grade and 6 as high-grade according to the histologic architecture. All cases were positive for neuroendocrine markers (synaptophysin and chromogranin A) and showed intracellular mucin in the amphicrine components. Four cases exhibited mRNA expression patterns showing transcriptional homogeneity with conventional adenocarcinomas and genetic diversity from neuroendocrine tumors. During the follow-up period, 3 patients died of disease, all of whom had high-grade tumors. Patients with high-grade amphicrine carcinoma had worse outcomes than those with low-grade tumors. Conclusions This study confirms the morphological, immunostaining and transcriptome alterations in amphicrine carcinoma distinct from those in conventional adenocarcinomas and neuroendocrine tumors, but additional studies are warranted to determine the biological behavior and therapeutic response.

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