scholarly journals Diagnostic utility of imprint cytology of endoscopic gastric biopsy: A cyto-histo correlation study

2019 ◽  
Vol 9 (2) ◽  
pp. 1542-1544
Author(s):  
Prabesh Kumar Choudhary ◽  
Niraj Nepal ◽  
Rishab Shrestha ◽  
Utsav Adhikari
Keyword(s):  
Diagnostic Tool ◽  
Histopathological Examination ◽  
Correlation Study ◽  
Gastric Biopsy ◽  
Upper Gastrointestinal Endoscopy ◽  
Imprint Cytology ◽  
Kappa Score ◽  
Common Procedure ◽  
Sensitivity Specificity ◽  
Upper Gastrointestinal

Background: Upper gastrointestinal endoscopy is a common procedure done for suspected cases of gastric malignancies. Histopathological examination of gastric tissue has been a gold standard for the diagnosis. Imprint smears of the gastric biopsy specimen is a useful and rapid alternative diagnostic tool. This study was conducted to assess the accuracy of gastric biopsy imprint cytology as compared to the histopathology. Materials and Methods: Imprint smears were made from all cases of gastric biopsy specimens taken from suspected cases of gastric malignancies. They were evaluated by three pathologists and categorized in to negative for malignancy, suspicious of malignancy and positive for malignancy. The diagnosis given by imprint smears was compared with histopathology. With the help of sensitivity, specificity & accuracy and Kappa score, the agreement between the imprint smear and histopathology was determined. Results: Among the total 79 cases, 49 cases were chronic non specific gastritis and 22 were adenocarcinoma. The sensitivity, specificity, and overall accuracy of gastric biopsy imprint smear were 92.0%, 98.11% and 94.93% respectively. Kappa core was 0.88. Conclusions: The gastric biopsy imprint smears is a rapid diagnostic tool and can be used routinely as an adjunct to histopathology in the diagnosis of gastric malignancies.

scholarly journals Narrow Band Imaging with Magnification Endoscopy for Celiac Disease: Results from a Prospective, Single-Center Study

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
L. De Luca ◽  
L. Ricciardiello ◽  
M. B. L. Rocchi ◽  
M. T. Fabi ◽  
M. L. Bianchi ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Villous Atrophy ◽  
Upper Gastrointestinal Endoscopy ◽  
Kappa Score ◽  
Biopsy Specimens ◽  
Surface Patterns ◽  
Sensitivity Specificity

In celiac disease (CD), the intestinal lesions can be patchy and partial villous atrophy may elude detection at standard endoscopy (SE). Narrow Band Imaging (NBI) system in combination with a magnifying endoscope (ME) is a simple tool able to obtain targeted biopsy specimens. The aim of the study was to assess the correlation between NBI-ME and histology in CD diagnosis and to compare diagnostic accuracy between NBI-ME and SE in detecting villous abnormalities in CD. Forty-four consecutive patients with suspected CD undergoing upper gastrointestinal endoscopy have been prospectively evaluated. Utilizing both SE and NBI-ME, observed surface patterns were compared with histological results obtained from biopsy specimens using the k-Cohen agreement coefficient. NBI-ME identified partial villous atrophy in 12 patients in whom SE was normal, with sensitivity, specificity, and accuracy of 100%, 92.6%, and 95%, respectively. The overall agreement between NBI-ME and histology was significantly higher when compared with SE and histology (kappa score: 0.90 versus 0.46; P=0.001) in diagnosing CD. NBI-ME could help identify partial mucosal atrophy in the routine endoscopic practice, potentially reducing the need for blind biopsies. NBI-ME was superior to SE and can reliably predict in vivo the villous changes of CD.

Endoscopic Diagnosis of a Pylorogastric Intussusception with Spontaneous ResolutionS

2011 ◽  
Vol 47 (6) ◽  
pp. e156-e161 ◽  
Author(s):  
Joao Felipe de Brito Galvao ◽  
Susan E. Johnson ◽  
Robert G. Sherding ◽  
Mieke Baan ◽  
Rebecca L. Ball ◽  
...  
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Gastric Biopsy ◽  
Spontaneous Resolution ◽  
Upper Gastrointestinal Endoscopy ◽  
Intact Female ◽  
Endoscopic Appearance ◽  
Vascular Congestion ◽  
Abdominal Radiographs ◽  
Upper Gastrointestinal

A 7 mo old intact female golden retriever was evaluated for acute vomiting. Abdominal radiographs revealed a possible gastric foreign body. Upper gastrointestinal endoscopy revealed an edematous, tubular antral mass, which on further evaluation was determined to be a pylorogastric intussusception based on radiographic, endoscopic, and surgical findings. Spontaneous resolution of the intussusception occurred upon surgical exploration of the abdomen. Histopathology of a full-thickness gastric biopsy revealed vascular congestion consistent with an intussusception, but did not indicate the primary cause. The dog recovered uneventfully from surgery and had no further vomiting during the 6 mo follow-up period. This case was significant as it was the first report of pylorogastric intussusception diagnosed using endoscopy. This description of the unique endoscopic appearance of pylorogastric intussusception will be useful for the veterinary endoscopist.

scholarly journals A surgically treated case of severe upper gastrointestinal hemorrhage with gastritis cystica polyposa

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Masaaki Yoshikawa ◽  
Hiroki Kinoshita ◽  
Naoki Nishimura ◽  
Rieko Takai ◽  
Takuya Matsuda ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Postoperative Recovery ◽  
Endoscopic Hemostasis ◽  
Resected Specimen ◽  
Upper Gastrointestinal Endoscopy ◽  
Gastric Glands ◽  
Duodenal Ulcers ◽  
Billroth Ii Reconstruction ◽  
Severe Hemorrhage ◽  
Upper Gastrointestinal

Abstract Background Gastritis cystica polyposa (GCP) is a recently recognized entity histologically characterized by hyperplasia and cystic dilatation of the gastric glands spreading through the submucosal layer. Its symptoms include those affecting the upper gastrointestinal tract, such as upper abdominal pain, nausea, and anorexia, although some patients might be asymptomatic. GCP rarely causes severe hemorrhage. Recently, we encountered a GCP case that exhibited severe hemorrhage. Case presentation A 53 year-old man visited the emergency department complaining of hematemesis. He underwent distal gastrectomy and Billroth II reconstruction for duodenal ulcers 32 years ago. Upper gastrointestinal endoscopy detected bleeding from the reddened mucosa at the anastomosis; thus, tentative endoscopic hemostasis was conducted. Despite medical treatment with transfusion, melena with significant hemodynamic impairment persisted. He was treated again with endoscopic hemostasis and interventional radiology (IVR) but remained unresponsive to these procedures. He eventually underwent partial resection of the anastomosis site with Roux-en-Y reconstruction and finally achieved excellent postoperative recovery. Histopathological examination of the resected specimen suggested a GCP bleeding. Conclusions GCP can indeed cause severe hemorrhage. Hemorrhage caused by GCP may not respond to endoscopic hemostasis or IVR; therefore, surgical treatment should be decided without delay.

scholarly journals Comparative Study of Clinico-Pathological Profiles of Patients with Proximal Versus Distal Gastric Adenocarcinoma

2020 ◽  
pp. 107-113
Author(s):  
Ashwini Krishnamoorthy ◽  
Shreya Rajkumar ◽  
K. Kuberan
Keyword(s):  
Gastric Adenocarcinoma ◽  
Gastrointestinal Endoscopy ◽  
Histopathological Examination ◽  
Clinical Pathology ◽  
Western Hemisphere ◽  
Upper Gastrointestinal Endoscopy ◽  
Medical College ◽  
Gastric Adenocarcinomas ◽  
Stomach Adenocarcinoma ◽  
Upper Gastrointestinal

Background: Stomach adenocarcinoma has been a major source of malignant development through the greater part of the 20th century. In different parts of the world, the prevalence of this disease has decreased, mostly due to changes in diet and some other natural constituents. Aim: To examine the clinical pathology of patients with proximal and distal gastric adenocarcinomas. Methodology: This was the prospective work carried out with gastric adenocarcinoma patients treated at Sree Balaji Medical College and Hospital (SBMCH), Chennai, Tamilnadu, India. All patients were undergone upper gastrointestinal endoscopy and an imaging. In endoscopy, biopsies will be taken from the lesion and biopsies were subjected to histopathological examination. Results: The most striking epidemiologic perceptions were the increasing frequency of adenocarcinomas of the proximal stomach and distal throat. We found that the occurrence of proximal gastric adenocarcinomas isn't expanding in our populace when contrasted with the rising rate of such proximal tumors in the Western Hemisphere. Conclusion: In our investigation distal gastric adenocarcinomas were a more incessant finding than the proximal gastric adenocarcinomas.

scholarly journals Performance of RoutineHelicobacter pyloriInvasive Tests in Patients with Dyspepsia

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Hsi-Chang Lee ◽  
Ting-Chang Huang ◽  
Chin-Lin Lin ◽  
Kuan-Yang Chen ◽  
Chung-Kwe Wang ◽  
...  
Keyword(s):  
Predictive Value ◽  
Gastrointestinal Endoscopy ◽  
Positive Culture ◽  
Upper Gastrointestinal Endoscopy ◽  
Rapid Urease Test ◽  
Urease Test ◽  
H Pylori ◽  
Sensitivity Specificity ◽  
Upper Gastrointestinal ◽  
Antral Biopsy

Background. This study was designed to compare the accuracy of three different invasive methods for the detection ofHelicobacter pylori (H. pylori)infection in patients with dyspepsia. These tests included culture, histology, and the rapid urease test (CLO test).Methods.H. pyloriinfection was diagnosed prospectively in 246 untreated dyspeptic patients who underwent upper gastrointestinal endoscopy. The gold standard forH. pyloriinfection was based on a positive culture or both a positive histological examination and a CLO test.Results.H. pyloriwas diagnosed in 33.3% of the patients. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy were as follows: histology from the antrum (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the antrum and corpus (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the corpus (76.83; 96.95; 92.65; 89.33; 90.24%); culture (91.46; 100; 100; 95.91; 97.15%); a CLO test from the antrum and corpus (85.59; 100; 100; 93.71; 95.52%); a CLO test from the antrum (64.63; 100; 100; 84.97; 88.21%); a CLO test from the corpus (69.51; 100; 100; 96.77; 89.83%), respectively.Conclusions. Antral biopsy histology and culture are the best methods for the diagnosis ofH. pyloriinfection in our cohort of patients with dyspepsia.

scholarly journals Endoscopic and Histologic Diagnosis of Upper Gastrointestinal Lesions, Experience in a Port City of Bangladesh

2014 ◽  
Vol 13 (3) ◽  
pp. 11-14
Author(s):  
Sk Md Jaynul Islam ◽  
A S M Mostaque Ahmed ◽  
M Sahab Uddin Ahmad ◽  
SAMMA Hafiz
Keyword(s):  
Hyperplastic Polyp ◽  
Histopathological Examination ◽  
Clinical Information ◽  
Endoscopic Biopsy ◽  
Histologic Diagnosis ◽  
Common Procedure ◽  
Gastrointestinal Lesions ◽  
Diagnostic Center ◽  
Upper Gastrointestinal ◽  
Duodenal Biopsies

Background: For upper gastrointestinal tract disorders endoscopic biopsy is common procedure performed in the hospital for a variety of benign and malignant lesions. Endoscopy is incomplete without biopsy and histopathology is the gold standard for the diagnosis of endoscopically detected lesions.Methods: A prospective study was carried out at a private histopathology diagnostic center at Chittagong from October 2012 to September 2013. All the upper GIT endoscopic biopsy samples received during the period were included in the study. The endoscopy was done by a skilled endoscopist and his detail endoscopic findings were noted. After conventional tissue processing H&E stained slides are examined under light microscope by three competent histopathologists.Results: Among total 110 upper GIT endoscopic biopsy samples 22 (20%) were oesophageal, 73 (66.36%) gastric and 15 (13.64%) duodenal biopsies. Among oesophageal biopsies 18 (81.82%) were histologically neoplastic of which 13 (81.25%) were SCC and 03 (18.75%) adenocarcinoma. Rest 02 (9.09%) were leiomyoma. Among all the oesophageal carcinomas, 10 (62.5%) were provisionally diagnosed as carcinoma by endoscopists. Among 73 endoscopic biopsies from stomach, the mean age was 54.63 yrs. On histopathology among 73 patients, adenocarcinoma-33 (45.20%), gastric ulcer-11 (15.07%), gastritis-15 (20.55%) and hyperplastic polyp-14 (19.18%). Among 33 adenocarcinoma of stomach 23 (69.69%) were clinically diagnosed or suspected as carcinoma by the endoscopist. Among 15 duodenal biopsies 11 (73.33%) were diagnosed histologically as hyperplastic polyp, 02 (13.33%) as adenocarcinoma, 02 (13.33%) as ulcer. Among 110 UGIT biopsies total 51 (46.36%) were malignant. Mean age 59.49 yrs ranges from 22 Yrs to 82 Yrs. M:F ratio is 1.4:1. Among all 33 (64.7%) were gastric carcinoma, 16 (31.37%) oesophageal carcinoma and 02 (3.92%) duodenal carcinoma. Among 51, 35 (68.63%) were clinically diagnosed or suspected as carcinoma by endoscopist. No clinical information was available in 03 (5.88%) cases and rest 13 (25.49%) cases were clinically diagnosed as non neoplastic conditions by the endoscopist. Conclusion:Endoscopy followed by histopathological examination play important role for diagnosis and management of UGIT lesions.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i3.20997

scholarly journals Intramural duodenal haematoma with mucosal prolapse causing intestinal obstruction

2019 ◽  
Vol 12 (4) ◽  
pp. e228276
Author(s):  
Arun Kumar Loganathan ◽  
Harshjeet Singh Bal
Keyword(s):  
Small Bowel ◽  
Intestinal Obstruction ◽  
Gastrointestinal Endoscopy ◽  
Histopathological Examination ◽  
Vascular Malformations ◽  
Duplication Cyst ◽  
Upper Gastrointestinal Endoscopy ◽  
Proximal Jejunum ◽  
Upper Gastrointestinal ◽  
Duodenal Haematoma

Intramural small bowel haematoma is a rare cause of intestinal obstruction in children. Coagulation disorders or anticoagulant therapy are the most common cause followed by blunt trauma. A one and half-year-old boy, with known case of gastro-oesophageal reflux disease had undergone upper gastrointestinal endoscopy and biopsy. Four days later, he presented to us with clinical features of small bowel obstruction. CT of the abdomen showed features suggestive of haemorrhagic duplication cyst. Explorative laparotomy revealed 15–20 cm of bowel from the third part of the duodenum to proximal jejunum filled with clotted blood and thinned out serosa. There was no evidence of intraluminal blood in the distal bowel loops. Resection of the involved bowel with primary anastomoses was done. Histopathological examination of bowel revealed intramural haematoma associated with prolapse of the mucosa. There was no evidence of duplication cyst or vascular malformations. Postoperative period was uneventful.

scholarly journals Mixed adenoneuroendocrine carcinoma of proximal stomach; a rare but sinister pathology

2020 ◽  
Vol 10 (2) ◽  
pp. 1772-1775
Author(s):  
Deepshikha Gaire ◽  
Daisy Maharjan ◽  
Nisha Sharma
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Histopathological Examination ◽  
Gastroesophageal Junction ◽  
Upper Gastrointestinal Endoscopy ◽  
Radiological Findings ◽  
Proximal Stomach ◽  
History Of ◽  
Adenocarcinoma Component ◽  
Physical Findings ◽  
Upper Gastrointestinal

Mixed adeno-neuroendocrine carcinoma is a rare tumor of the gastrointestinal tract comprising of both epithelial and neuroendocrine components, each representing at least 30% of the tumor. Diagnosis is based on clinical evaluation, radiological findings, histopathological features in conjunction with immunostaining with specific neuroendocrine markers such as chromogranin, synaptophysin, CD56, and markers of epithelial differentiation such as cytokeratin, CDX2, and carcinoembryonic antigen. A 50-year-old female presented with a history of dysphagia, chest pain, anorexia, and significant weight loss with normal physical findings and baseline investigations. Upper Gastrointestinal endoscopy showed growth at the gastroesophageal junction involving cardia of the stomach. Histopathological examination of the resected mass showed both adenocarcinoma and neuroendocrine carcinomatous components each involving more than 30% of total mass examined. Identifying adenocarcinoma component admixed with a high-grade neuroendocrine component is significant as the prognosis and survival of patients differ from pure adenocarcinoma.

scholarly journals 1228 Massive Gastrointestinal Bleeding Secondary to Bleeding Jejunal Diverticulum

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
A. Mukhtar A Mukhtar ◽  
B.A. Abdalaziz Alshareif ◽  
M. Gareeballah Yousif Hijazi ◽  
M Y Ibrahim
Keyword(s):  
Histopathological Examination ◽  
Primary Anastomosis ◽  
Exploratory Laparotomy ◽  
Intestinal Bleeding ◽  
Upper Gastrointestinal Endoscopy ◽  
Jejunal Diverticulum ◽  
Massive Gastrointestinal Bleeding ◽  
Blood Clots ◽  
Lower Endoscopy ◽  
Upper Gastrointestinal

Abstract Usually, the Jejunal diverticula appeared multiple and vary in size. These false diverticula lack the muscular coat of the normal intestinal walls, and most patients presented with it were asymptomatic. Although 10% of all patients develop complications such as perforation, obstruction, or bleeding, which then requires surgical intervention, but bleeding is relatively rare among these complications. A case of 74 years old lady was referred to our hospital because of persistent hematemesis and fresh melena. Her previous and recent upper gastrointestinal endoscopy both revealed only gastric erosions without any active bleeding. Also, previous, and recent colonoscopy was done but not completed due to the presents of fresh blood and blood clots along the colon, which led to improper visualization. Her selective mesenteric angiography was done together with upper and lower endoscopy, but none of them revealed the source of bleeding. Emergency exploratory laparotomy was undertaken, and a prominent single jejunal diverticulum with a prominent vessel entering it was noted, and no bleeding from other sites detected. Enterotomy was performed, and enteroscopy confirmed ulceration at the jejunal diverticulum site. Resection of the portion containing the diverticulum and primary anastomosis was done, and this cured the patient. The histopathological examination of the specimen showed an ulcerative lesion with an exposed vessel suggestive of the source of bleeding. Although jejunal diverticula incidence is rare, it is important to look for such lesions in patients with intestinal bleeding. Keywords: jejunal diverticulum, small intestine, intestinal bleeding.

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