Clinico-Radiological and Pathological Correlation of Breast Lesions in Patients Presenting to a Tertiary Hospital in Western Nepal

INTRODUCTION: Breast masses are frequently encountered problem, especially in females. Mammography and ultrasound are considered the standard imaging techniques for detection and evaluation of breast disease. The study was done to discuss the role of mammography and ultrasound in evaluation of breast mases with cytological correlation and to compare the sensitivity, specificity, positive predictive value and negative predictive value of ultrasonography6 with mammography in breast masses in different age groups and in patients with different breast density.MATERIALS AND METHODS: It was a non randomized prospective study carried out in Manipal teaching hospital Pokhara. The data for study was collected from patients with breast lump who attended the department of Radiology during the period from October 2013 to October 2014. Mammography and ultrasonography were performed on all cases presented with breast lump. A Fine needle aspiration cytology correlation was then performed with formed the basis for definitive judgement.RESULTS: The study analyzed 50 total numbers of patients presented to Radiology department who had breast lumps. Patients were aged between 20 and 75 years. Maximum numbe3r of patients were between 40 and 49 yrs constituting 40%. The mean age was 39.8 years ± 12.85 yrs. Ultrasound was significantly more sensitive than mammography in age less than 40 years. Mammogram had a significantly higher sensitivity than ultrasound in age group of more than 40 yrs. By using combined modalities (ultrasonography combined with mammogram), all benign cases were diagnosed correctly. For malignant breast masses, 10% were diagnosed as false negative but no cases were diagnosed false positive by combined modalities. Ultrasound was more sensitive than mammography in dense and heterogeneously dense breast whereas mammography was more sensitive than ultrasound in predominantly fatty breast.CONCLUSION: Combination of ultrasound and mammogram is more sensitive than other modality alone.Journal of Universal College of Medical Sciences, Vol. 5, No. 2, 2017, Page: 40-44

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Descriptive study of breast problems in women who present to the general outpatient of a tertiary hospital in eastern region of Nepal

Health Renaissance ◽

10.3126/hren.v11i1.7599 ◽

2013 ◽

Vol 11 (1) ◽

pp. 33-37

Author(s):

Rajani Giri ◽

R Bhandari ◽

I Mahato ◽

M Poudel ◽

S Kumari ◽

...

Keyword(s):

Age Groups ◽

Breast Disease ◽

Needle Aspiration ◽

Tertiary Hospital ◽

Outpatient Department ◽

Breast Diseases ◽

Eastern Region ◽

Breast Abscess ◽

Imaging Results ◽

Needle Aspiration Cytology

Background: Breast problems are common among female patient attending general outpatient. Although the problem is expected to have significant morbidity, patients usually hide or present late for breast related problems in Nepal. Objective: To measure the pattern of breast diseases and its frequency and distribution in different age groups among patients attending general outpatient department at BPKIHS, Nepal. Methods: A crosssectional study was conducted in general outpatient department (GOPD) of B.P.Koirala Institute of Health Sciences (BPKIHS) during a period of six months. Women of all age groups presenting with breast problem were included. Clinical assessment, fine needle aspiration cytology (FNAC) and radiology were done. Mammography being unavailable at the hospital, ultrasonography was the preferred method of imaging. Results: Hundred cases of breast diseases were assessed. The benign breast disease (BBD) was the commonest finding (96%). Among BBD, fibroadenoma was the commonest (32%) followed by breast abscess (26%) and mastalgia (22%) including cyclic and non cyclic. The common age groups of involvement were 30-39 years for fibroadenoma, 20-29 years for breast abscess, 30-39 years for cyclic mastalgia, 40- 49 years for non cyclic mastalgia and 70-79 years for breast cancer. Conclusion: BBD is the most common breast problem in women. Among BBD, fibroadenoma was the most common. Health Renaissance, January-April 2013; Vol. 11 No.1; 33-37 DOI: http://dx.doi.org/10.3126/hren.v11i1.7599

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A comparative clinicopathological study between ultrasonography, mammography, fine needle aspiration cytology and core needle biopsy of breast lump

International Surgery Journal ◽

10.18203/2349-2902.isj20202844 ◽

2020 ◽

Vol 7 (7) ◽

pp. 2325

Author(s):

Arnab Mandal ◽

Pradipta Jana ◽

Sabyasachi Bakshi ◽

Ram Krishna Mandal

Keyword(s):

Core Needle Biopsy ◽

Predictive Value ◽

Needle Biopsy ◽

Breast Disease ◽

Needle Aspiration ◽

Breast Lump ◽

Aspiration Cytology ◽

Core Needle ◽

Needle Aspiration Cytology ◽

Sensitivity Specificity

Background: Early presentation and prompt diagnosis is the essential key in treatment of different variety of neoplastic as well as non-neoplastic breast disease. In this study usefulness of high-resolution ultrasonography (HRUSG), mammography, fine needle aspiration cytology (FNAC) and core needle biopsy in correlation with histopathological pattern, was assessed.Methods: After matching the criteria, 212 cases, were taken for this prospective, single center, observational study.Results: Out of 212 cases, 163 (76.88%) were benign lesions, 49 (23.11%) were malignant and 1 (0.47%) were of inflammatory pathology. Benign to malignant breast disease ratio was 3.3:1. Out of 49 malignant cases, 45 (91.83%) were ductal cell carcinoma and 4 (8.16%) was apocrine carcinoma. Maximum numbers of cancer patients were found in the 51-60-year age groups. The sensitivity, specificity, positive predictive value and negative predictive value of mammography in detecting carcinoma breast were 87.76%, 64.71%, 87.76% and 64.71% respectively. The sensitivity, specificity, positive predictive value and negative predictive value of HRUSG in detecting carcinoma breast were 85.71%, 90.18%, 72.41% and 95.45% respectively. Among benign lesions, 47 (28.83%) were diagnosed by mammography and 147 (90.18%) were diagnosed by HRUSG. When these modalities were combined, >95% of the lesions was diagnosed accurately.Conclusions: Ultra sound used liberally as an adjunct to mammography, increase the cancer detection rate. Core needle biopsy is found more accurate but FNAC have limited value in evaluation of benign breast lump. This study also proves that preoperative categorization of breast lesions is utmost important for management of the patient and this will help to avoid unnecessary surgical treatment.

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Different Types of Breast Lump in Relation to Different Age Groups

Faridpur Medical College Journal ◽

10.3329/fmcj.v8i2.20369 ◽

2014 ◽

Vol 8 (2) ◽

pp. 56-58

Author(s):

ABM Zafar Sadik ◽

Md Mahmudul Hasan ◽

Nur-E-Zannat Afroza Haque ◽

Farid Uddin Ahmed ◽

Md Zahidul Kabir

Keyword(s):

Breast Carcinoma ◽

Age Groups ◽

Breast Disease ◽

Needle Aspiration ◽

Breast Lump ◽

College Hospital ◽

Medical College ◽

Group A ◽

Palpable Breast ◽

Needle Aspiration Cytology

This prospective observational study was carried out in the inpatient and outpatient department of surgery at Shaheed Ziaur Rahman Medical College Hospital, Bogra, during the period of 01.07.2008 to 31.12.2008 with a view to find out the incidence of breast carcinoma, fibroadenoma or other pathology in different age group. A total 130 patients with palpable breast lump were included in the study. Age of the patients was between 11 to 70 years. In most of the patients with breast lump Fine Needle Aspiration Cytology and biopsy were done. Sometimes ultrasonography, mammography and other routine investigations were also done. Among the study population 53.85% had benign lesions, Breast carcinoma accounted for 46.15% cases, fibroadenoma for 40.76% and fibroadenosis were in 10% cases. Fibroadenoma was common in second and third decade, while carcinoma of breast was common in third and fourth decade in this study. Here we attempted to find out the age incidence of breast lump and its correlation with clinical features, FNAC findings and histopathological report to improve the accuracy of diagnosis and management of breast disease. DOI: http://dx.doi.org/10.3329/fmcj.v8i2.20369 Faridpur Med. Coll. J. 2013;8(2): 56-58

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Accuracy of Fine Needle Aspiration Biopsy (F.N.A.B) in Diagnosis of Breast Lump

AL-Kindy College Medical Journal ◽

10.47723/kcmj.v15i2.152 ◽

2020 ◽

Vol 15 (2) ◽

pp. 9-12

Author(s):

Sarab K. Abedalrahman

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Biopsy ◽

False Negative ◽

Needle Aspiration ◽

Tertiary Hospital ◽

Aspiration Biopsy ◽

Test Accuracy ◽

Breast Lump ◽

Fine Needle ◽

Needle Aspiration Biopsy

Background: Breast cancer is the first one among Iraqi females. Most of them present later for diagnosis. Early detection center in tertiary hospital practice uses FNAB for early diagnosis. Publications on accuracy of this detection are scarce. Objective: To test the accuracy of FNAB in breast lump diagnosis. Methods: Diagnostic test accuracy study, on 204 women with breast lump, attending the oncology department in 2017. Results: Fine-needle aspiration biopsy diagnosis of histologically malignant cases were, malignant in 89 (87.3%), suspicious of malignancy in 5 (4.9%), and benign in 4 (3.9%). Complete sensitivity was 87.3%, and specificity was 100%, with 12.7% false negative results and no false positive cases. The accuracy was 94%.

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Diagnostic Accuracy of Fine Needle Aspiration Cytology of Thyroid Pathologies

Medical Journal of Shree Birendra Hospital ◽

10.3126/mjsbh.v19i2.27329 ◽

2020 ◽

Vol 19 (2) ◽

pp. 84-89

Author(s):

Shova Kunwar ◽

Barsha Bajracharya ◽

Kavita Karmacharya ◽

Amar Narayan Shrestha

Keyword(s):

Fine Needle Aspiration ◽

Predictive Value ◽

Fine Needle Aspiration Cytology ◽

False Negative ◽

False Negative Rate ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Thyroid Lesion ◽

Fine Needle ◽

Needle Aspiration Cytology

Introduction: Fine needle aspiration cytology is considered as the gold standard for the diagnosis of thyroid nodules. This study aimed to evaluate and compare the accuracy of fine-needle aspiration cytology in the diagnosis of thyroid lesion by comparing it with the corresponding histopathologic diagnosis after thyroidectomy. Methods: This is a retrospective study conducted over five years at a teaching hospital in Kathmandu. Eighty-nine cases of FNAC of thyroid nodule with subsequent histopathological reports were reviewed. The corresponding reports were compared and the accuracy of FNAC diagnosis was evaluated. Results: 87% of the cases were females and the majority of cases were in the age group 41 to 50 years. Among 89 cases, 55 were reported as benign on cytology and 34 were reported as malignant. On histopathological examination, out of 55 cases diagnosed as benign on cytology, 47 cases were diagnosed as benign whereas eight cases were diagnosed as malignant. HPE of 34 cases diagnosed as malignant on cytology showed that 29 were malignant and five were benign. The false-positive rate was 9.6% and the false-negative rate was 21.6%. The sensitivity was 78.3% and specificity was 90.3%. The positive predictive value and negative predictive value were 85.2% and 85.4% respectively. The accuracy of FNAC in differentiating benign from malignant thyroid lesions was 85.3%. Conclusions: The findings of this study showed that FNAC is a sensitive method for the diagnosis of a solid thyroid lesion

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A comparative clinicopathological study between ultrasonography, mammography, FNAC and core needle biopsy of breast lump

10.21203/rs.3.rs-28882/v1 ◽

2020 ◽

Author(s):

Arnab Mandal ◽

Pradipta Jana ◽

Sabyasachi Bakshi ◽

Ram Krishna Mandal

Keyword(s):

Core Needle Biopsy ◽

Predictive Value ◽

Needle Biopsy ◽

Breast Disease ◽

Ultra Sound ◽

Benign Lesions ◽

Breast Lump ◽

Core Needle ◽

Carcinoma Breast ◽

Sensitivity Specificity

Abstract BACKGROUND:Early presentation and prompt diagnosis is the essential key in treatment of different variety of neoplastic as well as non-neoplastic breast disease. In this study usefulness of HRUSG, Mammography, FNAC and Core Needle Biopsy in correlation with histopathological pattern, was assessed.METHODS:After matching the criteria, 212 cases, were taken for this prospective, single center, observational study. RESULTS:Out of 212 cases, 163(76.88 %%) were benign lesions, 49(23.11%) were malignant and 1(0.47%) were of inflammatory pathology. Benign to malignant breast disease ratio was 3.3:1. Out of 49 malignant cases, 45 (91.83%) were ductal cell carcinoma and 4 (8.16%) was apocrine carcinoma. Maximum numbers of cancer patients were found in the 51- 60 year age groups.The sensitivity, specificity, Positive predictive value and Negative Predictive value of mammography in detecting carcinoma breast were 87.76%, 64.71%, 87.76% and 64.71% respectively. The sensitivity, specificity, PPV and NPV of HRUSG in detecting carcinoma breast were 85.71%, 90.18%, 72.41% and 95.45% respectively.Among benign lesions, 47 (28.83) % were diagnosed by mammography and 147(90.18) % were diagnosed by HRUSG. When these modalities were combined, >95% of the lesions was diagnosed accurately.CONCLUSIONS:Ultra sound used liberally as an adjunct to mammography, increase the cancer detection rate. Core needle biopsy is found more accurate but FNAC have limited value in evaluation of benign breast lump. This study also proves that preoperative categorization of breast lesions is utmost important for management of the patient and this will help to avoid unnecessary surgical treatment.

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Reliability of fine needle aspiration biopsy in diagnosis of breast lump

AL-Kindy College Medical Journal ◽

10.47723/kcmj.v15i1.81 ◽

2019 ◽

Vol 15 (1) ◽

pp. 61-67

Author(s):

Sarab K. Abedalrahman

Keyword(s):

Breast Cancer ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Biopsy ◽

False Negative ◽

Screening Method ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Breast Lump ◽

Fine Needle ◽

Needle Aspiration Biopsy

Background: breast cancer is commonest cancer globally and the 1st cancer in Iraq among females, its management and prognosis depend on early diagnosis, the traditional method was excisional biopsy which is expensive and invasive leading to delayed diagnosis, FNAB is cheap nom invasive more acceptable to women, Aim of the study: to test the reliability of FNAB in preoperative diagnosis of breast lump. Methodology: This is a retrospective study of 204 cases, 102 breast cancer cases and 102 benign breast lesions, taken between Jan. 2017 – Nov. 2017. The sample taken from the breast cancer early detection center in Al-Alwiyaa maternity teaching hospital, during the year 2017 Results: Invasive ductal carcinoma (IDC) was found among 82(80.4%) of malignant cases, ILC was 14(13.7%) , fibroadenoma was the most common benign lesions 51(50%), The absolute sensitivity was 96% , specificity 100%, with 4% false negative the accuracy was 98%. The complete sensitivity was 96%, and specificity was 83%, with 4% false negative and 17% false positive cases, the accuracy was 90%, Conclusion and recommendation: fine-needle aspiration biopsy (FNAB) is accurate for breast lump diagnosis. With high sensitivity and specificity. FNAB is a good screening method and help in an improvement of treatment planning

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Correlation of fine needle aspiration cytology and histopathology of neck swellings

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20180986 ◽

2018 ◽

Vol 4 (3) ◽

pp. 648

Author(s):

C. S. Asha ◽

B. R. Suchit Roy

Keyword(s):

Salivary Gland ◽

Lymph Node ◽

Predictive Value ◽

Age Groups ◽

Invasive Procedure ◽

High Specificity ◽

Cost Effective ◽

Needle Aspiration ◽

Predictive Values ◽

Specificity And Sensitivity

Background: Neck swellings are a common clinical finding affecting all age groups. FNAC is a minimally invasive procedure helpful in the diagnosis of various neck swellings. The purpose of this study is to determine the accuracy of FNAC in the diagnosis of neck swellings by comparing it with the histopathology which is taken as the gold standard.Methods: A prospective study which included 90 patients who attended ENT and surgery departments of Government Medical College, Trivandrum with neck swellings from July 2006-2007. FNAC of the swelling was done and the FNAC results were compared with the histopathology results. The specificity, sensitivity, positive and negative predictive values and accuracy of FNAC were calculated. Results: Of the 90 patients, thyroid swelling formed the major group followed by lymph node, salivary gland and miscellaneous swellings. Thyroid swellings had a female predominance while the other three groups namely lymph node, salivary gland and miscellaneous groups showed a male preponderance. When the neck swellings namely thyroid, salivary gland, lymph node and miscellaneous group were taken into consideration as a whole, the sensitivity of FNAC for detecting malignancy was 64.3%. The specificity, positive predictive value, negative predictive value and accuracy were 97.4%, 81.8%, 93.7% and 92% respectively.Conclusions: FNAC can be rated as a safe, simple, reliable, cost effective and rapid diagnostic tool with high specificity and sensitivity for the initial evaluation of neck swellings.

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Role of Fine Needle Aspiration Cytology in Evaluation of Bony Lesions

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/47355.15141 ◽

2021 ◽

Author(s):

Arpita Singhvi ◽

SR Negi ◽

Hemant Jain ◽

Meeta Dewal ◽

Rajnee Joshi ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Predictive Value ◽

Fine Needle Aspiration Cytology ◽

False Negative ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Bony Lesions ◽

Needle Aspiration Cytology ◽

Standard Techniques

Introduction: Fine Needle Aspiration Cytology (FNAC) is increasingly being recognised for its diagnostic utility in evaluation of bone tumours. Though open surgical biopsy is the procedure of choice for diagnosis of bony tumours. Aim: To evaluate the efficacy and reliability of FNAC in diagnosis of bony tumours. Materials and Methods: This cross-sectional study included 40 patients with bony lesions from July 2018 to December 2019 in tertiary level centre of Rajasthan. The FNAC was performed after clinical and radiological assessment. The smears were stained using standard techniques. Also, open biopsy was performed in the patients who presented with bony lesions of patients and slides prepared for histopathological examination using standard techniques. The data was entered in Excel sheets and the results were evaluated using Statistical Package for Social Sciences (SPSS) software version 20.0. Results: Adequate material was obtained in FNAC in 29 (72.5%) cases. Out of 29 cases, FNAC results were accurate in 96.5% cases. False Negative report was obtained in one case with no false positives. Sensitivity of FNAC in diagnosing bony lesions comes to be 90% and Specificity was 100%. The Positive Predictive Value (PPV) was 100% and the Negative Predictive Value (NPV) 95.4%. Conclusion: The FNAC is invaluable tool in primary diagnosis of bony lesions. The technique of obtaining sufficient material though needs to be mastered and will definitely improve with more experience and radiologic correlation.

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Evaluation of Pancreatic Lesions With Endoscopic Ultrasound and Fine Needle Aspiration

Surgical Innovation ◽

10.1177/1553350620925321 ◽

2020 ◽

pp. 155335062092532

Author(s):

Yan Luk ◽

Wong Hoi She ◽

Felix Che Lok Chow ◽

Ka Wing Ma ◽

Simon Hing Yin Tsang ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Endoscopic Ultrasound ◽

Fine Needle Aspiration ◽

Predictive Value ◽

Diagnostic Yield ◽

False Negative ◽

Needle Aspiration ◽

Pancreatic Lesion ◽

Fine Needle ◽

Histopathological Findings

Background. Endoscopic ultrasound (EUS) and fine-needle aspiration (FNA) are commonly used for assessing pancreatic lesions. This study aimed to evaluate the diagnostic yield and accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in a single tertiary institution. Methods. Consecutive patients who underwent EUS-FNA of the pancreas at Queen Mary Hospital, Hong Kong, from January 2015 to March 2016 were retrospectively reviewed. Endoscopic findings and FNA results were analysed. For patients who subsequently underwent surgical resection of pancreatic lesion, EUS-FNA diagnoses were compared to histopathological findings of surgical specimens to determine its diagnostic accuracy. Results. One hundred twelve EUS-FNA were performed in 99 patients within the study time period and were included for analysis. Sixty-six (66.7%) pancreatic lesions were solid in nature and 33 (33.3%) were cystic. The overall diagnostic yield of EUS-FNA was 70.5% (n = 79). On multivariate analysis, more passes of needle were associated with a higher diagnostic yield (odds ratio = 2.000, P = .049). 57.1% (n = 64) of EUS-FNA results had an impact on management. Sixteen patients with diagnostic EUS-FNA subsequently underwent surgery for resection of the pancreatic lesion. Upon correlation to the histopathological findings of surgical specimens, there were 12 true-positive, 2 true-negative, 0 false-positive, and 2 false-negative cases. Sensitivity was 85.7%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 50%. The diagnostic accuracy of EUS-FNA was 87.5%. Conclusion. EUS-FNA is accurate and reliable for diagnosing pancreatic lesions.

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