35. Bone Ingrowth into Porous Coatings Attached to Prostheses of Differing Stiffness

Author(s):  
D.R. Sumner ◽  
T.M. Turner ◽  
R.M. Urban ◽  
J.O. Galante
1997 ◽  
Vol 12 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Murali Jasty ◽  
Charles R. Bragdon ◽  
Edward Zalenski ◽  
Daniel O'Connor ◽  
Alexandra Page ◽  
...  

Author(s):  
William M. Mihalko ◽  
Craig Howard ◽  
Fred Dimaano ◽  
Nena Dimaano ◽  
Monica Hawkins

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 724
Author(s):  
Amilton Iatecola ◽  
Guilherme Arthur Longhitano ◽  
Luiz Henrique Martinez Antunes ◽  
André Luiz Jardini ◽  
Emilio de Castro Miguel ◽  
...  

Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant.


2021 ◽  
Vol 33 (5) ◽  
pp. 054105
Author(s):  
Tiehan Long ◽  
Ying Dong ◽  
Rui Zhao ◽  
Chihyung Wen

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Claus Moseke ◽  
Katharina Wimmer ◽  
Markus Meininger ◽  
Julia Zerweck ◽  
Cornelia Wolf-Brandstetter ◽  
...  

AbstractTo develop implants with improved bone ingrowth, titanium substrates were coated with homogeneous and dense struvite (MgNH4PO4·6H2O) layers by means of electrochemically assisted deposition. Strontium nitrate was added to the coating electrolyte in various concentrations, in order to fabricate Sr-doped struvite coatings with Sr loading ranging from 10.6 to 115 μg/cm2. It was expected and observed that osteoclast activity surrounding the implant was inhibited. The cytocompatibility of the coatings and the effect of Sr-ions in different concentrations on osteoclast formation were analyzed in vitro. Osteoclast differentiation was elucidated on morphological, biochemical as well as on gene expression level. It could be shown that moderate concentrations of Sr2+ had an inhibitory effect on osteoclast formation, while the growth of osteoblastic cells was not negatively influenced compared to pure struvite surfaces. In summary, the electrochemically deposited Sr-doped struvite coatings are a promising approach to improve bone implant ingrowth.


1998 ◽  
Vol 31 ◽  
pp. 26
Author(s):  
L. Labey ◽  
H. Van Campenhout ◽  
J. Vander Sloten ◽  
R. Van Audekercke ◽  
G. Van der Perre ◽  
...  

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