Enhanced stability of uncemented canine femoral components by bone ingrowth into the porous coatings

Abstract:: Medicinal chemists have continuously shown interest in new curcuminoid derivatives, the diarylpentadienones, owing to their enhanced stability feature and easy preparation using a one-pot synthesis. Thus far, methods such as Claisen-Schmidt condensation and Julia-Kocienski olefination have been utilised for the synthesis of these compounds. Diarylpentadienones possess a high potential as a chemical source for designing and developing new and effective drugs for the treatment of diseases, including inflammation, cancer, and malaria. In brief, this review article focuses on the broad pharmacological applications and the summary of the structure-activity relationship of molecules which can be employed to further explore the structure of diarylpentadienone. The current methodological developments towards the synthesis of diarylpentadienones are also discussed.

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Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Current Topics in Medicinal Chemistry ◽

10.2174/1568026618666180608125344 ◽

2018 ◽

Vol 18 (10) ◽

pp. 857-880 ◽

Cited By ~ 3

Author(s):

Salma E. Ahmed ◽

Nahid Awad ◽

Vinod Paul ◽

Hesham G. Moussa ◽

Ghaleb A. Husseini

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Special Focus ◽

Nano Drug Delivery ◽

Medical Researchers ◽

History Of ◽

Overall Performance ◽

Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

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Cyclooxytocin, an oxytocin analogue with an enhanced stability of the secondary structure

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19773500 ◽

1977 ◽

Vol 42 (12) ◽

pp. 3500-3509 ◽

Cited By ~ 8

Author(s):

M. Zaoral ◽

V. Krchňák

Keyword(s):

Secondary Structure ◽

Enhanced Stability

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Enhanced stability of SnSb/graphene anode through alternative binder and electrolyte additive for lithium ion batteries application

Journal of Power Sources ◽

10.1016/j.jpowsour.2015.06.065 ◽

2015 ◽

Vol 294 ◽

pp. 248-253 ◽

Cited By ~ 33

Author(s):

Agnese Birrozzi ◽

Fabio Maroni ◽

Rinaldo Raccichini ◽

Roberto Tossici ◽

Roberto Marassi ◽

...

Keyword(s):

Lithium Ion Batteries ◽

Lithium Ion ◽

Electrolyte Additive ◽

Enhanced Stability

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Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

Pharmaceutics ◽

10.3390/pharmaceutics13050724 ◽

2021 ◽

Vol 13 (5) ◽

pp. 724

Author(s):

Amilton Iatecola ◽

Guilherme Arthur Longhitano ◽

Luiz Henrique Martinez Antunes ◽

André Luiz Jardini ◽

Emilio de Castro Miguel ◽

...

Keyword(s):

Surface Modification ◽

Additive Manufacturing ◽

Bone Ingrowth ◽

Orthopedic Implants ◽

Coated Sample ◽

High Mechanical Strength ◽

Coated Surface ◽

Surface Modification Techniques ◽

Almost All ◽

Cobalt Base

Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant.

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