scholarly journals The Application of Simulation Based Product Development Practices

2021 ◽  
Author(s):  
Brian Wamsher
Keyword(s):  
Product Development ◽  
Physical Properties ◽  
Process Modeling ◽  
Process Development ◽  
Modeling Tools ◽  
Component Testing ◽  
Development Costs ◽  
Simulation Based ◽  
Physical Components

Abstract The use of simulation-based process modeling tools with the intent of reducing iterative physical component testing and process development costs when designing new components was investigated. Several processing and testing phases were simulated to generate physical properties and geometries which could then be compared against how physical components put through the same processes reacted. These comparisons were repeated over several trials to validate their results. A good correlation between simulation and physical component response was found, and that iterative simulations could reliably be used in place of iterative physical component testing.

scholarly journals Pattern-Based Translation of BPMN Process Models to BPEL Web Services

2011 ◽  
pp. 545-566
Author(s):  
Chun Ouyang ◽  
Marlon Dumas ◽  
Arthur H.M. ter Hofstede ◽  
Wil M.P. van der Aalst
Keyword(s):  
Web Services ◽  
Business Process ◽  
Process Modeling ◽  
Process Development ◽  
Process Models ◽  
Modeling Tools ◽  
Business Process Execution ◽  
Business Process Modeling Notation ◽  
And Control ◽  
Block Structured

The business process modeling notation (BPMN) is a graph-oriented language primarily targeted at domain analysts and supported by many modeling tools. The business process execution language for Web services (BPEL) on the other hand is a mainly block-structured language targeted at software developers and supported by several execution platforms. Translating BPMN models into BPEL code is a necessary step towards standards-based business process development environments. This translation is challenging since BPMN and BPEL represent two fundamentally different classes of languages. Existing BPMN-to-BPEL translations rely on the identification of block-structured patterns in BPMN models that are mapped onto structured BPEL constructs. This article advances the state of the art in BPMN-to-BPEL translation by defining methods for identifying not only perfectly block-structured fragments in BPMN models, but quasi-structured fragments that can be turned into perfectly structured ones and flow-based acyclic fragments that can be mapped onto a combination of structured constructs and control links. Beyond its direct relevance in the context of BPMN and BPEL, this article addresses issues that arise generally when translating between graph-oriented and block-structured flow definition languages.

scholarly journals Experimental and theoretical explorations of nanocarriers’ multistep delivery performance for rational design and anticancer prediction

2021 ◽  
Vol 7 (6) ◽  
pp. eaba2458
Author(s):  
Weier Bao ◽  
Falin Tian ◽  
Chengliang Lyu ◽  
Bin Liu ◽  
Bin Li ◽  
...  
Keyword(s):  
Physical Properties ◽  
Rational Design ◽  
Theoretical Models ◽  
Cell Uptake ◽  
Anticancer Efficacy ◽  
Delivery Performance ◽  
Simulation Based ◽  
Multistep Process

The poor understanding of the complex multistep process taken by nanocarriers during the delivery process limits the delivery efficiencies and further hinders the translation of these systems into medicine. Here, we describe a series of six self-assembled nanocarrier types with systematically altered physical properties including size, shape, and rigidity, as well as both in vitro and in vivo analyses of their performance in blood circulation, tumor penetration, cancer cell uptake, and anticancer efficacy. We also developed both data and simulation-based models for understanding the influence of physical properties, both individually and considered together, on each delivery step and overall delivery process. Thus, beyond finding that nanocarriers that are simultaneously endowed with tubular shape, short length, and low rigidity outperformed the other types, we now have a suit of theoretical models that can predict how nanocarrier properties will individually and collectively perform in the multistep delivery of anticancer therapies.

Numerical Simulation of Bubble Growth During Nanofluid Flow Boiling in a Microchannel

2014 ◽  
Author(s):  
Arman Khalighi ◽  
Matthew Blomquist ◽  
Abhijit Mukherjee
Keyword(s):  
Heat Transfer ◽  
Physical Properties ◽  
Heat Dissipation ◽  
Flow Boiling ◽  
Contact Angles ◽  
Electronic Systems ◽  
Simulation Based ◽  
Fluid Media ◽  
Thermo Physical Properties ◽  
Current Heat

In recent years, heat dissipation in micro-electronic systems has become a significant design limitation for many component manufactures. As electronic devices become smaller, the amount of heat generation per unit area increases significantly. Current heat dissipation systems have implemented forced convection with both air and fluid media. However, nanofluids may present an advantageous and ideal cooling solution. In the present study, a model has been developed to estimate the enhancement of the heat transfer when nanoparticles are added to a base fluid, in a single microchannel. The model assumes a homogeneous nanofluid mixture, with thermo-physical properties based on previous experimental and simulation based data. The effect of nanofluid concentration on the dynamics of the bubble has been simulated. The results show the change in bubble contact angles due to deposition of the nanoparticles has more effect on the wall heat transfer compared to the effect of thermo-physical properties change by using nanofluid.

SIMULATION-BASED SOFTWARE PROCESS MODELING AND EVALUATION

2005 ◽  
pp. 333-364 ◽  
Author(s):  
OVE ARMBRUST ◽  
THOMAS BERLAGE ◽  
THOMAS HANNE ◽  
PATRICK LANG ◽  
JÜRGEN MÜNCH ◽  
...  
Keyword(s):  
Process Modeling ◽  
Software Process ◽  
Software Process Modeling ◽  
Simulation Based

Introducing the Industrial Product Realization Process Into Mechanical Engineering Design Education

1995 ◽  
Author(s):  
Vance D. Browne
Keyword(s):  
Product Development ◽  
Engineering Design ◽  
Design Education ◽  
Process Development ◽  
Project Planning ◽  
Concept Generation ◽  
Engineering Project ◽  
Engineering Design Education ◽  
Realization Process ◽  
Product Realization

Abstract The process by which new products are brought to market — the product realization process, or PRP — can be introduced in engineering design education. In industry, the PRP has been evolving to concurrent engineering and product teams. The PRP includes components such as concept generation, analysis, manufacturing process development and customer interaction. Also, it involves the sequencing of the components and their connections which includes teamwork, project planning, meetings, reports and presentations. A capstone senior engineering project, along with classroom lectures and presentations can be structured to provide knowledge and experience to the students in many of the PRP components and the connections. This paper will give an overview of the PRP and a project/lecture structure at the author’s university. The instructor recently joined the academic ranks after years in industry with responsibility for directing product development and R&D and for leading product development teams.

Potential Ethical Concerns in Nanotechnology

2010 ◽  
pp. 261-271
Author(s):  
Chi Anyansi-Archibong ◽  
Silvanus J. Udoka
Keyword(s):  
Product Development ◽  
Physical Properties ◽  
Human Health ◽  
Exposure Assessment ◽  
Ethical Issues ◽  
Science Review ◽  
Atoms And Molecules ◽  
Size Scale ◽  
Ethical Concerns ◽  
State Of The Science

Nanotechnology is science at the size of individual atoms and molecules. At that size scale, materials have different chemical and physical properties than those of the same materials in bulk. Research has shown that nanotechnology offers opportunities to create revolutionary advances in product development. It also has the potential to improve assessment, management, and prevention of environmental risks. There are however, unanswered questions about the impacts of nanomaterials and nanoproducts on human health and the environment. This chapter describes state-of the-science review, exposure assessment and mitigation, and potential macro ethical issues that must be considered to mitigate risk implications of emerging technologies such as nanotechnology.

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