scholarly journals PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Nurul Huda Mohamed Safri ◽  
Maizirwan Mel ◽  
Dominic C.Y. Foo ◽  
Denny K.S. Ng ◽  
Irene M.L. Chew

ABSTRACT: The main objective of this research work was to model and optimise the production of a locally-developed Infectious Coryza (IC) vaccine. The simulation work was performed using a commercially available batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost to benefit ratio (CBR) when the annual production was set to increase by 100%. Based on the economic analysis, the selected debottlenecking scheme has an annual predicted revenue of USD 240 million, with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition, the payback period of the selected scheme is estimated to be within three years. ABSTRAK: Objektif utama dalam penyelidikan ini adalah untuk memodelkan dan mengoptimumkan hasil pembuatan vaksin tempatan Coryza berjangkit. Kerja simulasi ini dijalankan menggunakan alat simulasi Super Pro Designer v5.5. Sebanyak enam (6) skema khusus diujikaji menggunakan analisis pemprosesan dan kos kepada nisbah faedah (CBR) apabila pembuatan tahunan meningkat kepada 100%. Berdasarkan analisis ekonomi yang telah dilakukan, sesuatu skema khusus yang dipilih mempunyai keuntungan sebanyak USD 240 juta dengan margin kasar 9.13% dan pulangan atas pelaburan (ROI) sebanyak 46.12%. Selain itu juga, tempoh pembayaran balik bagi skema yang dipilih dianggarkan dalam tempoh tiga(3) tahun.KEYWORDS: process simulation; modelling; debottlenecking; optimisation

1970 ◽  
Vol 3 (1) ◽  
Author(s):  
Fikri Fathurahman Aziz

This study aims to analyze financially (net present value, revenue cost ratio, internal rate of return, break event point, return on investment and payback period) feasibility of kampung super chicken farming Mr. Suparlan in Jojog village, district Pekalongan, East Lampung regency. The data used in the form of quantitative and qualitative data sourced from the primary data and secondary data which is then analyzed descriptively. Based on the analysis, it is known that kampung super farm is financially feasible to cultivate. This is indicated by the positive value of net present value (NPV) of Rp 186,568,517, revenue ratio (RCR) 1.59, internal rate of return (IRR) of 135.82%, return on investment (ROI) of 43%, and the value of payback period (PP) of 0.50. Keywords: financial feasibility, kampung chicken, chicken farm


2016 ◽  
Vol 1 (3) ◽  
pp. 183
Author(s):  
Cecilia Farrona Al Hadri ◽  
Ari Natalia Probandari ◽  
Rizaldi Taslim Pinzon

Latar Belakan: kematian akibat PTM (Penyakit Tidak Menular) diperkirakan akan terus meningkat di seluruh dunia, peningkatan terbesar akan terjadi di negara-negara berkembang. Mempertahankan konsumen dan berusaha mendapatkan konsumen baru merupakan strategi wajib yang harus di jalankan oleh rumah sakit. Keberadaan konsumen sangat penting bagi bisnis rumah sakit karena konsumen merupakan roda bisnis rumah sakit. Rumah Sakit Bethesda Yogyakarta, berencana untuk melakukan investasi laboratorium Angiografi untuk menunjang fasilitas kesehatan yang sudah ada. Sebelum melakukan investasi penting untuk mengetahui berapa besar unit cost dan tarif yang akan ditetapkan selain itu juga perlu diketahui kemauan membayar (Willingness to Pay) dan kemampuan membayar (Ability to Pay) pasien terhadap penggunaan layanan. Metode Penelitian: penelitian dilakukan dengan menggunakan rancangan studi kasus yang dilakukan di Rumah Sakit Bethesda Yogyakarta. Sebanyak 265 orang dipilih sebagai responden, yang diambil dari poliklinik saraf dan penyakit dalam. Data primer terdiri dari data kemauan dan kemampuan pasien untuk melakukan pelayanan laboratorium angiografi. Data sekunder di dapatkan dari rumah sakit, penelitian terdahulu dan lainnya. Analisis investasi dihitung menggunakan Net Present Value, Internal Ratr of Return, payback Period dan Return On Investment. Hasil: Perhitungan dengan menggunakan analisis Net Present Value menghasilkan nilai sebesar Rp.23.569.363.711,-. Jika dibandingkan dengan nilai modal, NPV bernilai positif sehingga investasi ini layak dilaksanakan. Analisis Internal Rate of Return menghasilkan nilai 29% yang berarti lebih besar dari faktor diskonto artinya dengan menggunakan analisis ini investasi juga layak dilakukan. Perhitungan menggunakan Payback Period diketahui masa balik modal investasi laboratorium angiografi adalah selama tiga tahun tujuh bulan dan Return On Invesment menunjukkan pelayanan laboratrium angiografi berkemampuan untuk menghasilkan laba sebesar 120%. Kesimpulan: hasil penelitian menunjukkan investasi laboratorium angiografi dari aspek keuangan layak dilakukan. Kemauan masyarakat untuk menggunakan layanan cukup tinggi namun dari segi kemampuan rata-rata masih rendah.


2019 ◽  
Vol 12 (2) ◽  
pp. 138
Author(s):  
Zineb Mcharfi ◽  
Bouchra El Asri

Software Product Lines represent a solution for massive development with minimum costs, while assuring product high quality and interesting time to market. In fact, Software Product Lines systems are used for massive productions, and are based on systematic reuse of commun components, while offering the ability to add specific development, in order to satisfy particular users or market needs. However, to maintain such complex and large-scale systems, it is mandatory to adopt a suitable tracing policy that satisfies the system constraints, especially cost and complexity. Unfortunately, tracing is rearly applied in Software Product Lines as it presents several constraints, especially its cost. Through our research work, we tried to come up with elements that would help break this prejudice. Therefore, we worked on a cost and Return on Investment estimation model that helps identify the optimal conditions (phase and policy) for implementing a tracing solution. As a result of our work, we found that implementing specific trace links, in a targeted approach that meets business goals, and starting from the Domain Engineering phase, costs less and presents the most interesting Return on Investment. To conduct this study and reach those findings, we followed the Design Science Research Methodology. In this article, we detail the steps of our research according to this methodology’s phases.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Apeesada Sompolgrunk ◽  
Saeed Banihashemi ◽  
Saeed Reza Mohandes

Purpose The purpose of this study is to identify and analyse the key measurable returning factors, value drivers and strategic benefits associated with building information modelling (BIM) return on investment (ROI). The findings of this study provide researchers and practitioners with up-to-date information in formulating appropriate strategies to quantify the monetary value of BIM. The suggested research agenda provided would also advance what is presently a limited body of knowledge relating to the evaluation of BIM ROI. Design/methodology/approach To fill the identified gap, this study develops a comprehensive systematic review of mainstream studies on factors affecting BIM ROI published from 2000 to 2020. A total of 23 academic records from different sources such as journals, conference proceedings, dissertation and PhD theses were identified and thoroughly reviewed. Findings The reported BIM ROI ranged greatly from −83.3% to 39,900%. A total of 5 returning factors, namely, schedule reduction and compliance, productivity improvement, request for information reduction, rework reduction and change orders reduction were identified as the most commonly reported factors that influence BIM ROI. Four quantification techniques including general assumptions-based theoretical model, perceived BIM ROI based on survey, factors affecting BIM ROI with no reported ROI and quantified BIM ROI based on a case study were observed and pointed out in the review, together with their limitations. Finally, three major gaps were raised as the lack of consideration on the likelihood of BIM assisting in a construction project, intangible returning factors influencing BIM-based projects and industry standards in benchmarking BIM ROI. Practical implications The outcomes of this study would assist practitioners by providing the current evaluation techniques that address the limitations with BIM investment and present issues relating to the economic evaluation of BIM in the construction industry. It is also expected that presenting a deeper and wider perspective of the research work performed until now will direct a more focussed approach on productivity improvement efforts in the construction industry. Originality/value This study identifies and analyses the key measurable returning factors, value drivers and strategic benefits associated with BIM ROI on an industry scale rather than a particular organisation or a project scale.


1998 ◽  
Vol 120 (2) ◽  
pp. 409-416 ◽  
Author(s):  
Sung-Gwang Chen ◽  
A. Galip Ulsoy ◽  
Yoram Koren

To improve productivity and quality in machining, it is necessary to understand the interactions among machine tool components and the cutting process. This paper presents a model that characterizes interactions among the subsystems of a computer numerically controlled (CNC) lathe. The model is combined with a cutting force model to obtain a comprehensive turning simulator that simulates the cutting forces and part dimensions. A series of calibration experiments are proposed and implemented for process simulation. The simulation results are good when compared with experimental measurements. The interactions among the subunits of a CNC lathe and the cutting process are found to be potentially important.


2014 ◽  
Vol 54 (10) ◽  
pp. 1694 ◽  
Author(s):  
S. M. Robertson ◽  
A. F. Southwell ◽  
M. A. Friend

Month of joining and lamb sale strategy influence both the quantity and so value of lamb produced, and the feed required, so are important management decisions contributing to the profitability of sheep systems. Simulation modelling was used to evaluate the impact on gross margins of three lamb sale strategies for different months of joining and varying stocking rates. A flock of purchased Merino ewes producing crossbred lambs in southern Australia was modelled between 1971 and 2011. April joining produced higher gross margins than November or January only if the number of ewes per hectare was increased to potential carrying capacity. At the optimum stocking rate for each month of joining, three sale policies – a flexible lamb sale policy (where lambs were sold depending on seasonal conditions); selling lambs in December; or selling at 45-kg liveweight, all produced a similar mean gross margin, but the feed resources required were least using the flexible strategy (April-joined mean 195 ± 253 s.d. kg/ha for flexible compared with 219 ± 270 kg/ha if selling December or 1085 ± 459 kg/ha if sold at 45 kg). Mean gross margin differed between sale strategies by up to AU$66/ha if the optimal stocking rate was not used. These results suggest that the most advantageous lamb sale strategy will vary with both month of joining and stocking rate used, and should be considered when optimising sheep management systems.


1996 ◽  
Vol 20 ◽  
pp. S1281-S1286 ◽  
Author(s):  
Konrad Wöllhaf ◽  
Martin Fritz ◽  
Christian Schulz ◽  
Sebastian Engell

2018 ◽  
pp. 777-802
Author(s):  
Radojko Lukic

In a very significant measure of the performance of trade companies, there is a return on investment. This applies in particular to the gross margin return on inventory investment. In this paper, in view of this, we especially investigate the trend and factors of the return on investment, with a special focus on the gross margin return on inventory investment of trade in Serbia. The efficiency of investment management in retail companies in Serbia is at a lower level than global retailers. In order to increase it in the future, it is certainly necessary to apply ?new business models? and modern technology.


Author(s):  
Samuel O. Igwe ◽  
Terhemba E. Chancha ◽  
Blessing G. Umbugadu ◽  
Beatrice G. Dauda

The study was carried out in Onitsha north and Onitsha south local government area of Anambra State Nigeria. The main objective of the study was to assess the profitability and viability of catfish marketing. Data were collected with structured questionnaires administered to 65 randomly selected catfish marketers.  Mean, frequency, percentages, gross margin, Net profit, Gross margin ratio, Operating ratio and Return on investment were all employed to analyze the objectives. The result revealed that transportation cost is the most militating factor against catfish marketing in Onitsha north and Onitsha south local government area of Anambra State Nigeria. The study also revealed that, catfish marketing in the study area was profitable and viable with return on Investment (ROI) of 22.17% and a Gross Margin ratio of 18.14%. The study therefore, recommends that government should provide storage facility and rehabilitate our roads to reduce the cost of transportation in marketing.


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