The article presents a methodology for implementing the project technology used in the educational process of students of the natural science direction of grades 6-8, 10, in order to introduce them to science. Also, the course and stages of the organization of research work with their application in the learning process were reflected. The methods of implementation of the project in the classroom, in extra-curricular time, the derivation of the project results, the criteria for its evaluation, and the stages of the lesson were analyzed. During the implementation of the project work, the formation of the student's skills of organizing research, identifying problems and the ability to solve them independently were improved. The analysis of the forms of organizing a biology lesson using technology and methods of studying the laws of genetics, research of species of medicinal plants, the formation of cytological, physiological concepts using a mono-project was carried out. Criteria for protection, argumentation, and assessment of project results are given.