scholarly journals Leiomiosarcoma of the Subcutaneous Tissue the Difficulties of Clinical Diagnosis: Description of a Case

2020 ◽  
pp. 1-5
Author(s):  
Alessandro Crisci ◽  
Alessandro Crisci ◽  
Michela Crisci ◽  
Raffaele D’Adamo
Keyword(s):  
Clinical Diagnosis ◽  
Clinical Presentation ◽  
Malignant Tumors ◽  
Subcutaneous Tissue ◽  
Soft Tissue Sarcomas ◽  
Review Of The Literature ◽  
Long Period ◽  
The Right ◽  
Slow Growing

Aims: Leiomyosarcomas are infrequent malignant tumors of smooth muscle, mainly derived from blood vessels or viscera. Superficial leiomyosarcomas are rare soft tissue sarcomas resulting from the dermis or subcutaneous tissue. They show a preference for proximal ends and tend to be slow-growing. They clearly show different histological and prognostic characteristics depending on whether they are cutaneous or subcutaneous. Case Report: We reported the case of subcutaneous leiomyosarcoma resulting in the medial subinguinal region of the right thigh in a 58-year-old female. Leiomyosarcoma is an entity whose clinical presentation may appear non-specific, making diagnosis difficult. We discussed the case with a brief review of the literature and the difficulties of a first approach clinical diagnosis. Conclusion: In conclusion, a long period of patient follow-up is recommended to capture a subsequent malignant progression of the disease.

scholarly journals Dermatofibrosarcoma protuberans – a wolf in sheep’s clothing: a case report and review of the literature

2021 ◽  
Vol 11 (3) ◽  
pp. 246-249
Author(s):  
Mohammad Kamrul Ahsan ◽  
Md Rashedul Islam
Keyword(s):  
Subcutaneous Tissue ◽  
Skin Flap ◽  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Diagnostic Work ◽  
Work Up ◽  
Slow Growing

Dermatofibrosarcoma protuberans (DFSP) is a locally invasive and slow growing tumor of the subcutaneous tissue. It rarely metastasizes but progressive and recurs frequently after surgical excision. The trunk and proximal extremities are the most common sites of the disease. A 53-year-old woman presented to dermatology outpatient department with a 3-cm, firm, violaceous and multinodular mass located on the left upper shoulder. Diagnostic work-up including magnetic resonance imaging and histopathological findings of biopsy were consistent with DFSP. The patient underwent wide local excision with skin flap reconstruction. No recurrence has been observed during ten months of follow-up. BIRDEM Med J 2021; 11(3): 246-249

scholarly journals Heterogeneity of the Clinical Presentation of the MEN1 LRG_509 c.781C>T (p.Leu261Phe) Variant Within a Three-Generation Family

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 512
Author(s):  
Aleksandra Gilis-Januszewska ◽  
Anna Bogusławska ◽  
Kornelia Hasse-Lazar ◽  
Beata Jurecka-Lubieniecka ◽  
Barbara Jarząb ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Clinical Presentation ◽  
Age Of Onset ◽  
Malignant Tumors ◽  
Genetic Disorder ◽  
Family Members ◽  
Pancreatic Neuroendocrine Tumor ◽  
Index Patient ◽  
Generation Family

Multiple neuroendocrine neoplasia type 1 (MEN1) is a rare genetic disorder with an autosomal dominant inheritance, predisposing carriers to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localization, age of onset, and clinical aggressiveness, even between affected members within the same family. We describe a heterogenic phenotype of the MEN1 variant c.781C>T (LRG_509t1), which was previously reported only once in a family with isolated hyperparathyroidism. A heterozygous missense variant in exon 4 of the gene was identified in the sequence of the MEN1 gene, i.e., c.781C>T, leading to the amino acid change p.Leu261Phe in a three-generation family. In the screened family, 5/6 affected members had already developed hyperparathyroidism. In the index patient and two other family members, an aggressive course of pancreatic neuroendocrine tumor (insulinoma and non-functioning neuroendocrine tumors) with dissemination was diagnosed. In the index patient, late diagnosis and slow progression of the disseminated neuroendocrine tumor have been observed (24 years of follow-up). The very rare variant of MEN1, LRG_509t1 c.781C>T /p.Leu261Phe (LRG_509p1), diagnosed within a three-generation family has a heterogenic clinical presentation. Further follow-up of the family members should be carried out to confirm the spectrum and exact time of clinical presentation.

scholarly journals Oral myopericytoma: a rare pediatric case report and a review of the literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dalit Porat Ben Amy ◽  
Victoria Yaffe ◽  
Rawan Kawar ◽  
Sharon Akrish ◽  
Imad Abu El-Naaj
Keyword(s):  
Subcutaneous Tissue ◽  
Maxillofacial Surgery ◽  
Young Patients ◽  
Conservative Approach ◽  
Case Presentation ◽  
Mesenchymal Neoplasm ◽  
The Right ◽  
Surgery Department ◽  
Histology And Immunohistochemistry

Abstract Background Myopericytoma is a rare mesenchymal neoplasm with perivascular myoid differentiation that arises most commonly in middle adulthood. The lesion generally involves the subcutaneous tissue of distal extremities. Myopericytoma of the oral cavity is extremely rare. Herein we report a case of oral myopericytoma in a pediatric patient, who was treated via a conservative approach with a follow up of 8 years. The case is followed by a literature review. To our knowledge this is the first documented case of oral myopericytoma affecting a patient of such a young age. Case presentation A 6 years old boy was referred to the maxillofacial surgery department for the evaluation of a solitary growth of the right maxillary buccal and palatal gingiva. Histology and immunohistochemistry confirmed the diagnosis of myopericytoma. Conclusions Our patient was treated by local excision with no recurrence in 8 years of follow up. Conservative approach should be considered for the treatment oral myopericytoma especially in young patients in tooth bearing areas.

scholarly journals Bilateral angiomyolipoma of the kidney in patient with tuberous sclerosis

2005 ◽  
Vol 133 (9-10) ◽  
pp. 433-437
Author(s):  
Radoje Colovic ◽  
Natasa Colovic ◽  
Nikica Grubor ◽  
Vladimir Radak ◽  
Marijan Micev ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Complete Loss ◽  
Hla Typing ◽  
Uneventful Recovery ◽  
Loss Of Function ◽  
Kidney Tumors ◽  
Benign Nature ◽  
The Right ◽  
Slow Growing

Angiomyolipomas are relatively frequent tumors of the kidney. It is believed that about 10 million people worldwide have such a tumor. About 1/10 of these 10 million are patients who suffer from tuberous sclerosis. The tumors are frequently bilateral, slow growing, and usually a symptomatic, as well as being rare in children. Due to the benign nature of angiomyolipomas, surgical treatment and embolisation of the tumors are generally not recommended, unless renal function is endangered, the symptoms are severe, or the kidney in question becomes completely dysfunctional. This is particularly the case in patients with tuberous sclerosis in whom these tumors are either already bilateral or may become so. We present a 24-year-old woman with tuberous sclerosis in whom bilateral kidney tumors were diagnosed 7 years earlier and in whom we carried out a left nephrectomy of a 5300 gram angiomyolipoma, which caused pain and complete loss of function. Although timorous, the right kidney was functional, so it was left untouched. After an uneventful recovery, a close follow-up was recommended, as well as HLA typing, as it is highly probable that the right kidney will gradually become inadequate or completely dysfunctional, so that haemodialysis and/or kidney transplantation along with nephrectomy will become necessary.

scholarly journals Angiosarcoma of the Heart: Case Report

2020 ◽  
Vol 3 (11) ◽  
pp. 01-07
Author(s):  
Marc Vanderheyden ◽  
Sofie Dhaeyer ◽  
Chirik Wah Lau ◽  
Vanessa Meert ◽  
Jan Leeman ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Tumors ◽  
Local Relapse ◽  
Review Of The Literature ◽  
Poor Survival ◽  
Right Heart ◽  
Course Of Disease ◽  
Metastatic Recurrence ◽  
Primary Angiosarcoma ◽  
The Right

Cardiac angiosarcomas are rare malignant tumors, predominantly affecting the right heart with poor survival outcomes. The current mainstay of treatment consists of surgery with or without chemotherapy, but often yields limited results with local relapse or metastatic recurrence. This case report describes 2 patients with primary angiosarcoma located in the right atrium. One patient received neo-adjuvant and adjuvant chemotherapy; both were scheduled for surgical resection. The course of disease is described followed by a comprehensive review of the literature.

scholarly journals Unusual coexistence of first and second branchial fistulas: clinical case and review of the literature

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094430
Author(s):  
Danqing Liu ◽  
Guangqi Li ◽  
Jun Qiu ◽  
Jianyan Wang ◽  
Genwang Pei
Keyword(s):  
Clinical Signs ◽  
Preoperative Imaging ◽  
Review Of The Literature ◽  
False Positive Diagnosis ◽  
Fistula Recurrence ◽  
History Of ◽  
Physical Examinations ◽  
Missed Diagnosis ◽  
The Right

Branchial fistulas are uncommon in the clinical setting. The coexistence of first and second branchial fistulas has not been previously reported. We herein describe a 12-year-old girl who presented with a 2-year history of repeated swelling and purulence behind the right earlobe and neck. According to the patient’s physical and auxiliary examination findings, she was diagnosed with coexisting first and second branchial fistulas, both of which were completely removed by surgery. No clinical signs of fistula recurrence were present at the patient’s 20-month postoperative follow-up. Ipsilateral coexisting first and second branchial fistulas are very rare; thus, a false-positive diagnosis can easily occur if the doctor does not carefully perform specialized physical examinations. Surgery is an effective method for treating this condition. Adequate preoperative imaging preparation is imperative to ensure the most effective course of treatment. The purpose of this article is to improve clinicians’ awareness of this disease, thereby effectively reducing the rates of missed diagnosis and recurrence.

scholarly journals Giant Muscle Invasive Dermatofibroma Clinically Mimicking a Malignant Tumor

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Hideyuki Kinoshita ◽  
Takeshi Ishii ◽  
Hiroto Kamoda ◽  
Toshinori Tsukanishi ◽  
Sumihisa Orita ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Present Report ◽  
Wide Resection ◽  
Large Size ◽  
Muscle Invasive ◽  
Muscle Invasion ◽  
The Right ◽  
Slow Growing ◽  
Muscle Invasive Tumor

Dermatofibromas are common benign fibrohistiocytic lesions, usually appearing as slow growing firm dermal nodules with a predilection for the extremities (mostly the lower legs). They are found mostly in middle-aged women and are usually smaller than 2 cm in diameter. Giant dermatofibromas exceeding 5 cm in diameter are rare. In recent years, reports have suggested a relationship between the primary size of dermatofibromas and rates of local recurrence and metastases after surgery. This relationship is however debated. The present report describes the case of a giant muscle invasive tumor in a 51-year-old female patient who presented with a large ulcerated mass in the right upper arm. The tumor appeared clinically malignant, measuring approximately 12 cm × 6 cm in size, with ulceration and invasion of surrounding muscle. Wide resection of the tumor was performed with myocutaneous flap-plasty. Histopathological examination showed evidence of a dermatofibroma. No recurrence, metastases, or other complications were noted at 5 years after surgery. The present case demonstrates that although dermatofibromas are essentially benign, they may present with atypical features including large size, ulceration, and muscle invasion, clinically mimicking malignant tumors.

scholarly journals Olfactory Neuroblastoma: A Case Report and Review of the Literature

2005 ◽  
Vol 84 (3) ◽  
pp. 150-152 ◽  
Author(s):  
Shehzad Ghaffar ◽  
Iftikhar Salahuddin
Keyword(s):  
Case Report ◽  
Facial Pain ◽  
Elderly Woman ◽  
Malignant Tumors ◽  
Olfactory Neuroblastoma ◽  
Lateral Rhinotomy ◽  
Review Of The Literature ◽  
Postoperative Radiation ◽  
History Of

Malignant tumors of the nasal cavity are rare. We report the case of an elderly woman who consulted us with a 4-year history of progressive nasal obstruction, occasional epistaxis, facial pain, and watering of the eyes. A diagnosis of olfactory neuroblastoma was established by histopathology and confirmed by immunohistochemistry. On staging, the mass was classified as a Kadish stage B tumor. The mass was excised via a lateral rhinotomy approach, and the tumor was peeled away completely from the cribriform plate with endoscopes. The patient underwent postoperative radiation, and she was free of recurrence at follow-up 15 months later.

scholarly journals Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

2017 ◽  
Vol 2 (2) ◽  
pp. 1-15 ◽  
Author(s):  
Juliana Maria de Almeida Vital ◽  
Terence Pires de Farias ◽  
Fernando Luiz Dias ◽  
Juliana Fernandes de Oliveira ◽  
José Gabriel Miranda da Paixão ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Literature Review ◽  
Nasal Cavity ◽  
Rare Case ◽  
Bleeding Risk ◽  
Preoperative Embolization ◽  
Long Period ◽  
Radiologic Investigation ◽  
The Right

Paragangliomas can be found from the skull base to the sacrum. Sinonasal paragangliomas are infrequent. A 16-year-old female reported spontaneous discrete bilateral epistaxis once a month beginning when she was 3 years of age. Computed tomography showed an expansive hypervascular mass occupying the right nasal cavity and nasopharynx. Sinonasal paragangliomas usually occur in middle-aged women. Radiologic investigation is essential for the diagnosis of sinonasal paragangliomas and evaluating extension of the lesion. Endoscopic and conventional approaches are effective, and preoperative embolization is paramount for reducing bleeding risk. Histopathological features cannot differentiate benign from malignant paragangliomas, and since metastasis may eventually occur, follow-up must be carried out for a long period of time.

scholarly journals Acute appendicitis: a 2- year review of clinical presentation and histopathology

1970 ◽  
Vol 1 (2) ◽  
pp. 104-107 ◽  
Author(s):  
N Subedi ◽  
US Dangol ◽  
MB Adhikary ◽  
S Pudasaini ◽  
R Baral
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Iliac Fossa ◽  
Operative Procedure ◽  
Lymphoid Hyperplasia ◽  
Negative Appendectomy ◽  
Histopathological Correlation ◽  
The Right

Background: Acute appendicitis is the most common surgical emergency. Obstruction of the lumen by fecolith is the usual cause of acute appendicitis.The aim of the study was to analyze clinical presentation of acute appendicitis and its histopathological correlation. Materials and Methods: A retrospective study of acute appendicitis was done in the Department of Surgery of Helping Hands Community Hospital from January 2009 to December 2010. Three hundred forty five patients out of 415 patients with clinical diagnosis of appendicitis underwent operative treatment. The histopathological reports were reviewed and correlated with clinical diagnosis. Results: Out of 345 patients who underwent operative procedure 98% (n= 338) came with chief complaint of pain in the periumbilical region migrating to the right iliac fossa. The mean age of presentation was 42 years. Increased leucocyte count was seen in only 65% cases. Acute appendicitis was more commonly seen in male patients (214 cases, 62%). The most common per operative finding was acutely inflammed appendix (84%) followed by perforated appendix (7.5%), gangrenous appendix (3.5%) and appendicular lump (1.5%). However, histopathological diagnoses were acute appendicitis (91.9%), resolving appendicitis (3.5%), lymphoid hyperplasia (2.6%), mucocele (0.3%) and carcinoid (0.3%). Normal histology was seen in 1.4% cases. Conclusion: Though there are other causes of acute abdomen, acute appendicitis still stands first amongst all the emergencies. Histopathological examination of appendectomy specimen should not be omitted in order to see the incidence negative appendectomy rate and to avoid complications relating to malignant conditions. Keywords: Acute appendicitis; Appendectomy; Appendicular perforation; Histopathology DOI: http://dx.doi.org/10.3126/jpn.v1i2.5402 JPN 2011; 1(2): 104-107

Sign in / Sign up

Export Citation Format

Share Document