Serum-derived Bovine Immunoglobulin Effect on Mucositis

Author(s):  
2017 ◽  
Vol 01 (01) ◽  
Author(s):  
Larry Good ◽  
Audrey Shaw ◽  
David Wei ◽  
Rene E. Vasquez ◽  
Raymond Panas ◽  
...  

1995 ◽  
Vol 78 (12) ◽  
pp. 2745-2752 ◽  
Author(s):  
G.M. Tomita ◽  
D.A. Todhunter ◽  
J.S. Hogan ◽  
K.L. Smith

2017 ◽  
Vol 11 (2) ◽  
pp. 335-343 ◽  
Author(s):  
Rachelle A. Soriano ◽  
Asuncion G. Ramos-Soriano

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is particularly troublesome for pediatric patients, as current therapeutic options consist of biologic agents and steroids which alter the immune response and have the harmful side effect of leaving the patient more susceptible to opportunistic infections and eventual surgery. Another option for therapy exists in the form of serum-derived bovine immunoglobulin/protein isolate (SBI), the key ingredient in a medical food, EnteraGam®. The FDA has reviewed the safety of SBI and issued a no challenge letter to the generally recognized as safe (GRAS) findings for this medical food. The product also has no known food or drug interactions, no significant adverse effects, and no contraindications, save for beef allergy. SBI has been shown to induce clinical remission in adult populations and to decrease markers of inflammation in pediatric patients. Here, we present a detailed case of pediatric UC, including documentation of mucosal healing and decrease in pediatric UC activity index in a difficult to treat pediatric patient, after the addition of SBI to this patient’s treatment regimen.


2003 ◽  
Vol 278 (37) ◽  
pp. 35024-35032 ◽  
Author(s):  
Yaofeng Zhao ◽  
Imre Kacskovics ◽  
Hodjattallah Rabbani ◽  
Lennart Hammarström

1997 ◽  
Vol 25 (2) ◽  
pp. 326S-326S ◽  
Author(s):  
ROBERT AITKEN ◽  
JANICE GILCHRIST ◽  
M. CATHERINE SINCLAIR

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