scholarly journals Study on the complications by chronic diabetes mellitus type II in Quetta Balochistan

2020 ◽  
Vol 2 (3) ◽  
pp. 65-68 ◽  
Author(s):  
Mohsin Jamal Buzdar ◽  
Furqan Ahmed ◽  
Alam Mengal ◽  
Tahir Hameed ◽  
Farhat Abbas ◽  
...  

Due to worl wide increase in Diabetes Mellitus, a rise community consciousness about influence of hyperglycemiea and its most common complications ike stroke, hypertension, nephropathy, amputation, neuropathy, cardiovascular and retinopathy etc is required. Awareness on adoption of good diet,  physical activities as well as a healthy life-style is required for a healthy long life . Therefore, this study has been designed to investigate the burden of complications of chronic diabetes mellitus in diabetic patients of Quetta city, in order to improve the health status and life style of diabetic patients living in Quetta. Details of all the complications caused by diabetes mellitus were collected from the patients and the bllood glucose was permormed by standard method. This study reaveled the frequency percentage of comorbidities in this order crdiovascular conditions 30% > neuropathy conditions 17.8% > Ocular conditions 14.8% > Nephropathy conditions 10.7% > Cerebrovascular 6.8% > Feet conditions 1.5% > Amputations 0.1%. These results are in agreement to previous studies which showed the highest prevelance of cardiovascular diseases (CVDs) in diabetic patients with hyperglycemia, hypertension, smoking habits and unhealthy life styles.

2020 ◽  
Vol 21 (7) ◽  
Author(s):  
Roghayeh Zare ◽  
Mesbah Shams ◽  
Mojtaba Heydari ◽  
Azadeh Najarzadeh ◽  
Mehdi Zarshenas

Background: Conflicting results have been obtained from the studies on the hypoglycemic effect of cinnamon in patients with diabetes mellitus type II (T2DM). Objectives: This research aimed at assessing the effect of applying the syndrome differentiation model based on traditional Persian medicine (TPM) to identify the patients who benefit more from cinnamon supplementation. Methods: This study was a randomized, triple-blind, placebo-controlled trial based on a parallel design. One hundred and forty eligible patients referring to the Diabetes Clinic of Yazd University of Medical Sciences, who were diagnosed with T2DM, were randomly divided into the cinnamon and placebo groups. Then, 500-mg capsules of cinnamon bark powder or placebo were administered to them twice a day for three months. All the participants completed a standard questionnaire for syndrome diagnosis in traditional Persian medicine (TPM). Fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), fasting insulin (FI), and insulin resistance (IR), calorie intake, and physical activity were measured before and after the interventions. The glycemic outcomes were analyzed according to the TPM syndrome. Results: There was no statistically significant difference between the patients’ demographic and clinical features in the two groups. Glycemic indices were improved in patients receiving cinnamon supplementation compared to placebo group (-13.1 ± 1.7, -1.7 ± 1.9, P < 0.001 for change in FPG and -0.27 ± 0.039 vs. 0.001 ± 0.019, P < 0.001 for change in HbA1C respectively). All the outcomes were more improved in the patients with wet syndrome compared to dry ones, which was compatible with Persian syndrome differentiation (P < 0.05). Conclusions: Diabetic patients with wet syndrome based on TPM benefit more form cinnamon supplementation.


1969 ◽  
Vol 3 (2) ◽  
pp. 346-349
Author(s):  
HARESH KUMAR ◽  
MONA RANI ◽  
MOHAMMAD HANIF ◽  
KHEMOMAL A. KARIRA ◽  
MOHAMMAD MUNIB ◽  
...  

BACKGROUND: Hair is a dead tissue and is composed of keratin and related proteins. Hair is a protein offew growing cells at the base of the hair root. If the patient is diabetic glycosylation occurs in these growingcells.Since the extent of glycation of hair protein varies with the distance from the hair root, we hypothesizedthat glycation of hair protein might provide insight into blood glucose level over a period of several mouthsto one year.So hemoglobin Ale (HbAIc) may be established as an indicator of long-term blood glucosecontrol in diabetic patients. It is formed by non-enzymatic reaction of glucose with Hb.The objective of thisstudy was to estimate the furosine(an intermediate in the breaking down of amadori compounds likeglycosylated proteins) level by HPLC of glycosylated hair proteins, to find interrelation of fasting glucosewith HbAIc and furosine in diabetic patients, to determine the efficacy of Glycosylation of HbA,c andfurosinemay be a reliable marker in diabetic patients.STUDY DESIGN: This study was carried out in the department of Biochemistry Basic Medical SciencesInstitute (BMSI) Jinnah Postgraduate Medical Centre Karachi.METHODS: A total of 200 subjects were included in the study. 100 diagnosed type II and 100 controlnormal subjects. Hair from the scalp 12 cm long and 50 mg in weight was collected from each subject tomeasure furosine level. Furosine level was determined by HPLC and HbAIc, FBSand serumprotein byenzymatic kit method.RESULTS: When the mean values were compared with that of control it depicted significantly high level(0.001) of furosine, HbAIc and FBS.CONCLUSION: The furosine, HbAIc and FBS levels increases in diabetic patients while total serumprotein were unaffected. Weight and BMI increases in diabetic but height was unaffected.KEYWORDS: Diabetes mellitus type II, furosine, HbAIc, fasting blood sugar, glycation ofhair protein


Author(s):  
HRZ Chudhary ◽  
A Amin ◽  
MH Malik ◽  
MM Hafeez ◽  
MA Rana ◽  
...  

The aim of current study is the risk assessment of biochemical variables of medical importance, vitamin D and calcium, in pathogenesis of Diabetes Mellitus Type II (T2DM) human beings and the risk assessment due to variation of these biochemical variables in diabetic patients. One hundred subjects (n=100) were recruited from different hospitals in Lahore (31.5204° N, 74.3587° E) after taken informed consents individually. This study was approved by the ethical committee of Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore. Subjects were equally divide in two groups; diabetic (case group; n=50) and non-diabetic (control; n=50). Calcium and vitamin D levels were measured by the biochemical laboratory of Hospitals. Finally the data was statistically analyzed by using SPSS software (Version 16). A total of 52 % males and 48 % females were investigated for changes in serum calcium and vitamin D in relation to their biochemical importance in Diabetes Mellitus. Both calcium and vitamin D levels were significantly low in diabetic group (p=0.003 and p=0.001 respectively) as compare to control group. Persons correlation showed calcium and vitamin D were directly proportional to each other (R2= 0.577). Odds ratio showed that the low vitamin D and low Calcium levels were 3.47 and 3.17 time more prevalent in diabetic group as compare to the non- diabetic group. Diabetes Mellitus is an increasing health issue in world causing severe morbidity and mortality. So it is important to investigate the non-conventional risk factors of Diabetes Mellitus. Thus, the current study illuminates the risk assessment of altered levels of vitamin D and calcium, their possible pathogenesis in Diabetes Mellitus. It can be concluded from this study that supplementation of vitamin D and calcium till to the normal physiological limits can help not only lowering the risk of diabetes but may also prevent its progression.


Author(s):  
Liudmila Liutsko ◽  
Alexander Veraksa ◽  
Irina S. Polikanova ◽  
Sergey Leonov

The purpose of this article was to check the effects on health of various types of physical activities, diet, BMI, smoking and alcohol consumption and their interrelationships with control for age, sex and level of education. The study was based on epidemiological data (9617 participants from 19 to 81 years old for whom we have health indicators over a period of 11 years) together with questionnaires about diet, alcohol, tobacco and the frequency of different types of physical activities. Descriptive statistics and non-parametric correlational analysis of epidemiological data was performed with use of SPSS v.19. Our results indicate the existence of the significant relationship between leading a healthy life style (type of physical activities, limitations of fats consume and weight maintenance). However, the different categories of physical activities were analysed separately and showed slight differences on health indicators impacts. Our findings confirm that leading a healthy life style (all types of physical activities, limitations of fats consume and weight maintenance) is an important issue since it has a significant relationship with physical and mental health indicators, but outdoor physical activities and practicing sport in group have shown slightly higher impact on health.


2019 ◽  
Vol 9 (04) ◽  
pp. 711-714
Author(s):  
Ezzate H. Ajeena ◽  
Mohammad A. Alfawaz ◽  
Alaa S. Tajaldeen ◽  
Sami R. Alkatib

This study aims to examine the effects of anemia on patients with diabetes mellitus type II (DM). The cross-sectional study included 75 patients with (DM). They were divided into two groups according to the presence of anemia. The first group includes 50 diabetic patients suffering from anemia, while the second group contains only 25 patients with diabetes only. There was no specification in gender; the patients included both sexes and their ages were above 20 years. A blood sample was collected from each patient to measure (fasting blood glucose, hemoglobin, glycosylated hemoglobin, and ferritin). The results revealed an increase in anemia in females with diabetes mellitus more than males while the levels of HbA1c was on the contrary; it increased in males and decreased in females. A significant negative correlation is confirmed between ferritin and HbA1c in anemic diabetic women. Diabetic patients suffering from anemia recorded a sharp decrease in the levels of ferritin compared with patients with diabetes only. In conclusion, the incidence of anemia increase in diabetic patients with increased levels of HbA1c.


Author(s):  
Haydarova Pardaxol Bobaqulovna ◽  
Abdullayeva Dilfuza Rixsixodjayevna ◽  
Raimov Sodiq Sobirovich

Sign in / Sign up

Export Citation Format

Share Document