STRUCTURAL FEATURES OF THE PANCREAS IN PATIENTS WITH VARIOUS CLINICAL AND MORPHOLOGICAL FORMS OF CHRONIC PANCREATITIS

The article presents the results of our own studies of structural changes in the pancreas according to computed tomography data in patients with various clinical and morphological forms of the disease. It was shown that the identification of structural changes in the pancreatic parenchyma using computed tomography with contrast (calcifications and calcifications, pancreatic cysts, fibrosis, expansion of pancreatic ducts) is a reliable confirmation of the diagnosis of chronic pancreatitis and allows to determine clinical and morphological form of the disease. Severe structural changes in the pancreatic parenchyma were found in 71.8% of the examined patients, in 18.5% of patients - moderate, in 8.7% - mild.

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Chronic pancreatitis: Risk Factors and Clinico-Radiological Profile

Nepal Medical College Journal ◽

10.3126/nmcj.v23i2.38526 ◽

2021 ◽

Vol 23 (2) ◽

pp. 153-158

Author(s):

Jiwan Thapa ◽

Ramila Shrestha ◽

Ram Krishna Tamang ◽

Shankar Baral ◽

Bhuwneshwer Yadav

Keyword(s):

Risk Factors ◽

Computed Tomography ◽

Chronic Pancreatitis ◽

Structural Changes ◽

Clinical Presentation ◽

Pain Abdomen ◽

Disease Condition ◽

Radiological Changes ◽

Male Patients ◽

Associated Risk Factors

Chronic pancreatitis is a disease condition characterized by progressive inflammation and fibrosis of pancreas. It manifests with pain abdomen, endocrine and exocrine dysfunction. Diagnosis is often difficult and is relied mostly on radiological examination. The aim of this study was to identify associated risk factors and correlate the clinical presentation with various radiological changes of the pancreas.We conducted a prospective hospital based observational study in patients presenting with abdominal pain and evaluated the etiology, clinical presentation and radiological changes of pancreas among 68 chronic pancreatitis patients visiting Gastroenterology Unit, Department of Medicine, National Academy of Medical Sciences, Bir Hospital during 1 year period (November 2019 to October 2020 AD). The results showed mean age of 35.75 ± 11.43 years with predominant male patients (76.4%). Pain abdomen was present in all patients with mean duration of 16.5 months, followed by diabetes in 27.9%. Alcohol was the major risk (n=42, 61.8%) and no cause was identified in 22 (32.3%) patients. Pancreatic parenchymal calcification in 65 (95.6%), duct dilation in 61 (89.7%) and gland atrophy in 39 (57.3%) were major structural changes detected in computed tomography scan, more reliably than ultrasonography. One third of patients had diabetes mellitus, which was significantly higher in female (63.2%) and had major radiological changes of chronic pancreatitis at diagnosis. Alcohol was the common risk of chronic pancreatitis. Structural changes suggestive of disease was demonstrated better by computed tomography.

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Structural features of pancreas in patients with various clinical and morphological forms of chronic pancreatitis

Medical alphabet ◽

10.33667/2078-5631-2019-2-13(388)-34-38 ◽

2019 ◽

Vol 2 (13) ◽

pp. 34-38

Author(s):

N. B. Gubergrits ◽

E. A. Krylova ◽

N. G. Gravirovskaya

Keyword(s):

Chronic Pancreatitis ◽

Structural Changes ◽

Structural Features ◽

Ultrasound Diagnostics

The article is devoted to the results of our own research into the possibilities of ultrasound diagnostics of various clinical and morphological forms of chronic pancreatitis (CP). It was shown that pronounced structural changes in the pancreas (pseudocysts, calcinates, wirsungolithiasis, pronounced fibrosis) make it possible to diagnose clinical and morphological forms of CP.

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Computed Tomography for the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice

Clinical Pancreatology for Practising Gastroenterologists and Surgeons ◽

10.1002/9781119570097.ch29 ◽

2021 ◽

pp. 218-226

Author(s):

Roberto García‐Figueiras ◽

Sandra Baleato‐González ◽

Gonzalo Tardáguila Fuente

Keyword(s):

Computed Tomography ◽

Clinical Practice ◽

Chronic Pancreatitis

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Interaction of Lactoferrin with Unsaturated Fatty Acids: In Vitro and In Vivo Study of Human Lactoferrin/Oleic Acid Complex Cytotoxicity

Materials ◽

10.3390/ma14071602 ◽

2021 ◽

Vol 14 (7) ◽

pp. 1602

Author(s):

Anna Elizarova ◽

Alexey Sokolov ◽

Valeria Kostevich ◽

Ekaterina Kisseleva ◽

Evgeny Zelenskiy ◽

...

Keyword(s):

Oleic Acid ◽

Structural Changes ◽

Unsaturated Fatty Acids ◽

Structural Features ◽

Control Group ◽

Acid Complex ◽

Hepatoma 22A ◽

Constitutive Parameters

As shown recently, oleic acid (OA) in complex with lactoferrin (LF) causes the death of cancer cells, but no mechanism(s) of that toxicity have been disclosed. In this study, constitutive parameters of the antitumor effect of LF/OA complex were explored. Complex LF/OA was prepared by titrating recombinant human LF with OA. Spectral analysis was used to assess possible structural changes of LF within its complex with OA. Structural features of apo-LF did not change within the complex LF:OA = 1:8, which was toxic for hepatoma 22a cells. Cytotoxicity of the complex LF:OA = 1:8 was tested in cultured hepatoma 22a cells and in fresh erythrocytes. Its anticancer activity was tested in mice carrying hepatoma 22a. In mice injected daily with LF-8OA, the same tumor grew significantly slower. In 20% of animals, the tumors completely resolved. LF alone was less efficient, i.e., the tumor growth index was 0.14 for LF-8OA and 0.63 for LF as compared with 1.0 in the control animals. The results of testing from 48 days after the tumor inoculation showed that the survival rate among LF-8OA-treated animals was 70%, contrary to 0% rate in the control group and among the LF-treated mice. Our data allow us to regard the complex of LF and OA as a promising tool for cancer treatment.

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