scholarly journals DIAGNOSTIC ROLE OF BONE SCINTIGRAPHY IN EARLY PROGNOSIS OF PARAENDOPROSTHETIC COMPLICATIONS IN ARTHROPLASTY OF HIP AND KNIEE JOINTS

2018 ◽  
pp. 73-78
Author(s):  
P. Korol ◽  
M. Tkachenko
Keyword(s):  
Bone Scintigraphy ◽  
Inflammatory Diseases ◽  
Knee Joints ◽  
Three Phase ◽  
Static Phase ◽  
Diagnostic Role ◽  
Specific Accumulation ◽  
Inflammatory Processes ◽  
Kinetics Of

For 10 years, we studied the diagnostic role of three-phase bone scintigraphy (3-f BS) in the early prognosis of paraendoprosthetic complications in patients with degenerative-dystrophic and infectious-inflammatory diseases of the hip and knee joints. Using 3-f BS, the kinetic radionuclide parameters of inclusion and distribution of radiopharmaceutical (RP) in the projection of affected joints were evaluated. It was determined that the kinetics of osteotropic RP in the foci of fixation of affected joints in infectious and inflammatory processes is characterized by the predominance of retention and specific accumulation of the drug in the early and delayed static phase of 3-f BS in comparison with foci of fixing RP in degenerative-dystrophic lesions, which correlates with the differences destructively-reparative processes in them.According to the results of the analysis of the kinetic parameters, a radionuclide model of the dynamics of inclusion and distribution of RP in septic and aseptic joint lesions has been developed.

scholarly journals DIAGNOSTIC ROLE OF BONE SCINTIGRAPHY IN EARLY PROGNOSIS OF PARAENDOPROSTHETIC COMPLICATIONS IN ARTHROPLASTY OF HIP AND KNIEE JOINTS

2018 ◽  
pp. 73-78
Author(s):  
P. Korol ◽  
M. Tkachenko
Keyword(s):  
Bone Scintigraphy ◽  
Inflammatory Diseases ◽  
Knee Joints ◽  
Three Phase ◽  
Static Phase ◽  
Diagnostic Role ◽  
Specific Accumulation ◽  
Inflammatory Processes ◽  
Kinetics Of

For 10 years, we studied the diagnostic role of three-phase bone scintigraphy (3-f BS) in the early prognosis of paraendoprosthetic complications in patients with degenerative-dystrophic and infectious-inflammatory diseases of the hip and knee joints. Using 3-f BS, the kinetic radionuclide parameters of inclusion and distribution of radiopharmaceutical (RP) in the projection of affected joints were evaluated. It was determined that the kinetics of osteotropic RP in the foci of fixation of affected joints in infectious and inflammatory processes is characterized by the predominance of retention and specific accumulation of the drug in the early and delayed static phase of 3-f BS in comparison with foci of fixing RP in degenerative-dystrophic lesions, which correlates with the differences destructively-reparative processes in them.According to the results of the analysis of the kinetic parameters, a radionuclide model of the dynamics of inclusion and distribution of RP in septic and aseptic joint lesions has been developed.

scholarly journals PREDICTION OF PARANENDOPROSTHETIC COMPLICATIONS OF PATIENTS WITH THE PATHOLOGY OF HIP AND KNEE JOINTS OF VARIOUS GENESIS

2017 ◽  
Vol 13 (1-2) ◽  
pp. 66-73
Author(s):  
М.М. Tkachenko ◽  
P.O. Korol
Keyword(s):  
Bone Scintigraphy ◽  
Quantitative Characteristic ◽  
Infectious Agent ◽  
Knee Joints ◽  
Diagnostic Process ◽  
Osteoblastic Activity ◽  
Arterial Blood ◽  
Three Phase ◽  
Static Phase ◽  
Active Inflammation

Relevance. The issue of degenerative-dystrophic lesions of the hip and knee joints is becoming urgent in Ukraine. To date, in order to visualize degenerative-dystrophic and infectious-inflammatory lesions in the treatment and diagnostic process, the three-phase bone scintigraphy method is actively used, with the help of which it is possible to obtain a quantitative characteristic of metabolic changes and the morphological status of the organism. Objective. To determine the specific radionuclide parameters of three-phase bone scintigraphy for optimizing the prediction of paraendoprosthetic complications in pathological lesions of hip and knee joints of different genesis. Material and methods. The retrospective analysis of 455 patients with diseases of hip and knee joints of various genesis (including 274 women and 181 men), aged from 17 to 85 years, was conducted in the work. All patients underwent three-phase bone scintigraphy according to the standard protocol. Results. In the early static phase of bone scintigraphy, a gradual increase in the percentage of inclusion and distribution of radiopharmaceutical in degenerative-dystrophic and infectious-inflammatory foci is observed. The increase in accumulation of the indicator in the delayed static phase in the infectious-inflammatory foci of deforming osteoarthrosis is caused by an increase in the intensity of blood flow in the angiographic phase, which indicated the intensification of the arterial blood supply of such foci, due to active inflammation, exposure to an infectious agent or increased osteoblastic activity. Conclusion. The determination of the kinetic parameters of bone scintigraphy and the application of the radionuclide model of «dual time point imaging» contribute to the early detection of paraendoprosthetic complications in the postoperative period, the reduction of the number of revision procedures and the reduction in the duration of rehabilitation and recovery measures after endoprosthetics.

scholarly journals The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Samuel García ◽  
Carmen Conde
Keyword(s):  
Rheumatoid Arthritis ◽  
Septic Shock ◽  
Dna Repair ◽  
Beneficial Effect ◽  
Current Knowledge ◽  
Inflammatory Diseases ◽  
Genomic Stability ◽  
Inflammatory Processes ◽  
Parp 1

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. In recent years, we have studied the role of PARP-1 in rheumatoid arthritis, as have other researchers, and the results have shown that PARP-1 has an important function in the development of this disease. This review summarizes current knowledge on the effects of PARP-1 in rheumatoid arthritis.

scholarly journals Diagnostic role of whole body bone scintigraphy in atypical skeletal tuberculosis resembling multiple metastases: a case report

2009 ◽  
Vol 3 (1) ◽  
Author(s):  
Majid Assadi ◽  
Iraj Nabipour ◽  
Mohammad Eftekhari ◽  
Abdolali Ebrahimi ◽  
Seyed-Reza Abotorab ◽  
...  
Keyword(s):  
Case Report ◽  
Bone Scintigraphy ◽  
Whole Body ◽  
Skeletal Tuberculosis ◽  
Multiple Metastases ◽  
Diagnostic Role ◽  
Body Bone

scholarly journals Midkine in Inflammation

2011 ◽  
Vol 11 ◽  
pp. 2491-2505 ◽  
Author(s):  
Ludwig T. Weckbach ◽  
Takashi Muramatsu ◽  
Barbara Walzog
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Animal Models ◽  
Regulatory T Cells ◽  
Proinflammatory Cytokines ◽  
Inflammatory Diseases ◽  
Autoimmune Encephalitis ◽  
Heparin Binding ◽  
Inflammatory Processes

The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases including nephritis, arthritis, atherosclerosis, colitis, and autoimmune encephalitis have been shown to be alleviated in the absence of MK in animal models. Reduced leukocyte recruitment to the sites of inflammation was found to be one important mechanism attenuating chronic inflammation when MK was absent. Furthermore, MK was found to modulate expression of proinflammatory cytokines and the expansion of regulatory T-cells. Here, we review the current understanding of the role of MK in different inflammatory disorders and summarize the knowledge of MK biology.

Role of three-phase bone scintigraphy in paediatric osteoid osteoma eligible for radiofrequency ablation

2013 ◽  
Vol 34 (7) ◽  
pp. 638-644 ◽  
Author(s):  
Maria F. Villani ◽  
Piergiorgio Falappa ◽  
Milena Pizzoferro ◽  
Renato M. Toniolo ◽  
Antonio Lembo ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Bone Scintigraphy ◽  
Osteoid Osteoma ◽  
Three Phase
Sign in / Sign up

Export Citation Format

Share Document