The Influence of Trace-Mineralized Salt upon the Vitamin B12 and Folic Acid Content of Goat's Milk

1. Groups of kids were reared from birth to 5 d on goat's milk. On the 6th day five of the kids received by bottle a morning feed of goat's milk with [3H]folic acid added to saturate the folate-binding proteins (FBP) (Expt 1); three kids received raw goat's milk containing only the endogenous folate and hence a large surplus folate-binding capacity (FBC) (Expt 2). The contents of the stomach, duodenum, jejunum and ileum were recovered by washing out 1·5 h after feeding (Expt 1) or at 0·5, 1 and 3·5 h after feeding (Expt 2).2. Recovery of [3H]folic acid 1·5 h after feeding (Expt 1) in all segments was 58·4%, mainly in a soluble form, most of this being in the stomach (37·0%) and ileum (14·3%). No surplus FBC was found in any gut segment. Sephadex G-75 chromatography of the soluble fractions of the contents of the various gut segments showed that [3H]folic acid remained bound to FBP throughout the stomach and small intestine. The bound [3H]folic acid exhibited a molecular weight of 81000 in stomach contents, similar to that in the milk feed, presumably representing an aggregated form of the FBP, whereas in the intestinal contents its molecular weight was 39000 indicating dissociation to monomer due to dilution in the recovery process.3. In Expt 2, the total recovery of free FBP in all four gut segments was 67, 54 and 23% respectively at 0·5, 1 and 3·5 h after the milk feed, and the distribution of FBP along the gut at 1 h was similar to that of [3H]folic acid-labelled FBP at 1·5 h in Expt 1. In mature goat's milk the endogenous 5-methyltetrahydrofolate was shown to be associated with species of molecular weight 80000 and 38000.4. The results indicate that goat's-milk FBP is relatively resistant to digestionby gastric and intestinal enzymes in vivo in the kid and survives along the length of thesmall intestine.5. The implications of the findings are discussed in relation to the possible influence of FBP on uptake of folate by mucosal cells and their relevance to neonatal folate nutrition.

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The folic acid activity of some milk foods for babies

Journal of Dairy Research ◽

10.1017/s0022029900018811 ◽

1968 ◽

Vol 35 (1) ◽

pp. 85-90 ◽

Cited By ~ 26

Author(s):

J. E. Ford ◽

K. J. Scott

Keyword(s):

Folic Acid ◽

Breast Milk ◽

Human Milk ◽

Folic Acid Supplementation ◽

Cow’S Milk ◽

Acid Supplementation ◽

Cow's Milk ◽

Goat’S Milk ◽

Liquid Milk ◽

Goat's Milk

SummaryFolic acid activity was determined for National Dried Milk and for 5 proprietary dried milk foods for babies, for a proprietary liquid milk baby food and for 8 brands of tinned evaporated milk. For comparison, values were determined for mature breast milk, for raw bulk cow's milk, for bottled pasteurized cow's milk and for goat's milk.Human milk and raw and pasteurized cow's milk all had much the same folate activity, equivalent to about 54 µg folic acid/1. Values for goat's milk were much lower, around 6 µg/1.Values for the reconstituted baby milks ranged from 9 to 65 µg/1, though only 2 of the products had markedly lower values than breast milk. The question is discussed whether the folic acid requirement in infants can be met by formulas based on cow's milk without having recourse to folic acid supplementation.

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The N-acetyl neuraminic-acid content of the milk of various species

Journal of Dairy Research ◽

10.1017/s0022029900014795 ◽

1973 ◽

Vol 40 (3) ◽

pp. 421-425 ◽

Cited By ~ 26

Author(s):

P. A. Morrissey

Keyword(s):

Acid Content ◽

Neuraminic Acid ◽

Species Variation ◽

Goat’S Milk ◽

Goat's Milk

SummaryAverage N-acetyl neuraminic-acid (NANA) content of milk from cow, sheep, goat, mare, donkey and sow (about 10 samples from each species) was 17·7, 10·1, 6·4, 6·1, 12·0 and 64·0mg/100 ml, of which 14·2, 8·4, 3·2, 3·1, 5·0 and 53·7mg/100 ml respectively was in the casein fraction. The NANA content of casein showed marked species variation ranging from an average of 2·18 % for the sow to 0·09 % for the goat.About 28 % of the casein NANA of mare's milk was liberated in the fraction soluble in 12 % TCA by the action of rennin at pH 6·6 compared with 75 and around 100 % for donkey's and sow's milk respectively; about half the total NANA in the casein of cow's, sheep's and goat's milk was released under the same conditions.

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Vitamin B12 and Folic Acid Content of Raw and Cooked Turkey Muscle

Poultry Science ◽

10.3382/ps.0590303 ◽

1980 ◽

Vol 59 (2) ◽

pp. 303-307 ◽

Cited By ~ 4

Author(s):

BETH R. MOLONON ◽

JANE A. BOWERS ◽

ARTHUR D. DAYTON

Keyword(s):

Folic Acid ◽

Vitamin B12 ◽

Acid Content

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Effect of daily vitamin B12 and folic acid supplementation on fracture incidence in elderly with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial

Bone Abstracts ◽

10.1530/boneabs.3.oc2.2 ◽

2014 ◽

Author(s):

Wijngaarden JP van ◽

KMA Swart ◽

AW Enneman ◽

RAM Dhonukshe-Rutten ◽

Dijk SC van ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Folic Acid ◽

Vitamin B12 ◽

Homocysteine Level ◽

Controlled Trial ◽

Folic Acid Supplementation ◽

Plasma Homocysteine ◽

Elevated Plasma ◽

Plasma Homocysteine Level ◽

Randomized Controlled

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EXPERIENCE IN THE APPLICATION COMPLEX OF NUCLEOTIDES (URIDINE MONOPHOSPHATE), FOLIC ACID AND VITAMIN B12 AT EXACERBATION OF CHRONIC NONSPECIFIC LOW BACK PAIN

10.26226/morressier.5ab3c880a874c600265597b2 ◽

2018 ◽

Author(s):

Natalya Oliferuk

Keyword(s):

Low Back Pain ◽

Folic Acid ◽

Back Pain ◽

Vitamin B12 ◽

Low Back ◽

Uridine Monophosphate

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Estimation of Aflatoxin M1 Levels in Some Dairy Products Manufactured from Raw Milk Experimentally Inoculated with Toxin

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v43i1.471 ◽

2019 ◽

Vol 43 (1) ◽

pp. 50-58

Author(s):

H. S. Alnaemi

Keyword(s):

Dairy Products ◽

Raw Milk ◽

Aflatoxin M1 ◽

Consumer Health ◽

Goat’S Milk ◽

White Cheese ◽

Elisa Technique ◽

Permissible Levels ◽

Goat's Milk

Fate of AflatoxinM1 in soft white cheese and its by-product (whey) and in yogurt locally made from raw sheep's and goat's milk experimentally inoculated with 0.05 and 0.5 µg/l AflatoxinM1 were investigated using ELISA technique. Results reported that AflatoxinM1 was concentrated in cheese at levels significantly higher than that recorded in the raw milk that used for its processing, with a significant decrease in AflatoxinM1 levels in its by-product (whey) comparable to the raw milk used in manufacturing at both inoculated levels. Yogurt produced from raw sheep's milk at second inoculated level exerted AflatoxinM1concentration significantly lower than that present in the milk. Significant differences in AflatoxinM1distribution in cheese and whey produced from sheep's milk comparable to their counterparts produced from goat's milk were recorded. Finally, results revealed the efficacious role of the various dairy manufacturing processes in AflatoxinM1 distribution and the necessity to issue of local legislations concerning the maximum permissible limits for AflatoxinM1 in milk in order to stay within the universal permissible levels for AflatoxinM1 in dairy products to provide greater protection for consumer health.

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