scholarly journals ASSESSMENT OF THE STATE OF THE HEMOSTASIS SYSTEM IN PATIENTS WITH CORONAVIRUS INFECTION USING A THROMBIN GENERATION TEST

2021 ◽  
pp. 95-98
Author(s):  
O.Yu. Matvienko ◽  
O.A. Smirnova ◽  
A.A. Lerner ◽  
T.N. Shvedova ◽  
O.G. Golovina ◽  
...  
Keyword(s):  
Thrombin Generation ◽  
The State ◽  
Hemostasis System ◽  
Coronavirus Infection ◽  
Generation Test

Experimental Studies on a Recombinant Hirudin, CGP 39393

1991 ◽  
Vol 65 (04) ◽  
pp. 355-359 ◽  
Author(s):  
E Gray ◽  
J Watton ◽  
S Cesmeli ◽  
T W Barrowcliffe ◽  
D P Thomas
Keyword(s):  
Thrombin Generation ◽  
Bleeding Time ◽  
Thrombus Formation ◽  
Experimental Studies ◽  
Venous Stasis ◽  
Antithrombotic Agent ◽  
Recombinant Hirudin ◽  
Excessive Bleeding ◽  
Generation Test

SummaryThe in vitro anticoagulant activities of recombinant desulphatohirudin (r-hirudin) were studied in the activated partial thromboplastin time (APTT) and the thrombin generation test : systems. In the APTT at concentrations below 5 μg/ml, r-hirudin showed a dose-response curye. At concentrations above 5 μg/ml, the plasma became unclottable, but in the thrombin generation test , at least 10 μg/ml of r-hirudin was required for full inhibition of thrombin generation. The antithrombotic effect was assessed using a rabbit venous stasis model; 150 μg/ml r-hirudin completely prevented thrombus formation at 10 and 20 min stasis. At antithrombotic dose, the mean bleeding time ratio measured in a rabbit ear template model, was not prolonged over control values. At higher doses, the bleeding time ratios were higher than those observed for the same dosage of heparin. These data indicate that while r-hirudin is an effective antithrombotic agent, antithrombotic doses have to be carefully titrated to avoid excessive bleeding.

The Ability of Thrombin Inhibitors to Reduce the Thrombin Activity Generated in Plasma on Extrinsic and Intrinsic Activation

1997 ◽  
Vol 77 (03) ◽  
pp. 498-503 ◽  
Author(s):  
D Prasa ◽  
L Svendsen ◽  
J Stürzebecher
Keyword(s):  
Active Site ◽  
Thrombin Generation ◽  
Anion Binding ◽  
Thrombin Inhibitors ◽  
Coagulation System ◽  
Thrombin Activity ◽  
Continuous Registration ◽  
High Concentrations ◽  
20 Nm ◽  
Generation Test

SummaryIn a thrombin generation test with continuous registration of thrombin activity in plasma we studied the ability of a variety of thrombin inhibitors of different type and mechanism of action to influence the activity of thrombin after activation of the coagulation system. Depending on the inhibitor, the peak of thrombin activity is delayed and/or reduced.By blocking the active site of generated thrombin inhibitors cause a concentration dependent reduction of the thrombin peak and inhibit feed-back reactions of thrombin resulting in a delay of thrombin generation. Highly potent synthetic active-site directed inhibitors (Ki ≤ 20 nM) reduce the thrombin activity formed in plasma after extrinsic or intrinsic activation with the same efficiency (IC50 0.1 - 0.6 μM) as hirudin. The delay and reduction of thrombin generation by inhibitors of the anion-binding exosite 1 of thrombin is only attributed to an inhibition of feed-back reactions of thrombin. For a 50% reduction of thrombin activity in plasma by this type of inhibitors relatively high concentrations were determined.

Budgetary Regulation in the Context of Preventing the Consequences of the Spread of a New Coronavirus Infection in the Russian Federation

Lex Russica ◽  
2021 ◽  
Vol 74 (2) ◽  
pp. 64-79
Author(s):  
R. V. Tkachenko
Keyword(s):  
Public Relations ◽  
Russian Federation ◽  
The State ◽  
Russian Society ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
Legal Forms ◽  
The Impact ◽  
Budget System

The paper is devoted to the examination of issues related to the increasing importance of budgetary regulation for the proper functioning of a modern innovative society. The key role of the budgetary regulation in the financial process of the State is particularly acute in the context of systemic crises that include socio-economic consequences caused by the spread of a new coronavirus infection (COVID-19) in Russia. In the course of the study, the features of changes in the state financial policy caused by the above-mentioned crisis phenomena are highlighted. The paper describes various approaches to the interpretation of the budgetary regulation as a category of financial law, explores various types and legal forms of methods of the budgetary regulation, analyses mechanisms and the impact of the State on the budget system through the existing legal structure of the budgetary regulation. It is determined that the rules of financial law governing the whole complex of public relations concerning the distribution and redistribution of the national product between the levels of the budget system of the Russian Federation constitute the institution of financial law, namely: the budgetary regulation. The author concludes that the approach based on the concentration of basic powers in the financial field at the federal level significantly slows down the dynamics of development of economic activity in the majority of regions of Russia, while the need for breakthrough innovative development of Russian society determinates the expansion of long-term tax sources of income for regional budgets. In this regard, it is proposed to consolidate additional regulation for revenues gained by regional and local budgets in the form of targeted deductions from federal taxes on a long-term basis.

Thrombin generation test for evaluating hemostatic effects of Brazilian snake venoms

Toxicon ◽  
2019 ◽  
Vol 163 ◽  
pp. 36-43 ◽  
Author(s):  
Rita Carolina Figueiredo Duarte ◽  
Danyelle Romana Alves Rios ◽  
Paula Mendonça Leite ◽  
Luan Carlos Alves ◽  
Henrique Pimenta Barroso Magalhães ◽  
...  
Keyword(s):  
Thrombin Generation ◽  
Snake Venoms ◽  
Hemostatic Effects ◽  
Generation Test

scholarly journals Terms of Forced Return and Expulsion of Foreigners and Stateless Persons by Bodies of the Border Guard Service in a Pandemic

2020 ◽  
pp. 66-77
Author(s):  
Nadia DEMCHYK ◽  
Ruslan HRYNKO
Keyword(s):  
The State ◽  
Immigration Detention ◽  
Temporal Regulation ◽  
Occupied Territory ◽  
Legal Nature ◽  
Administrative Punishment ◽  
Coronavirus Infection ◽  
Russian Law ◽  
Forced Return ◽  
Administrative Proceedings

The article examines the doctrinal approaches to determining the legal nature of the terms of forced return and expulsion of foreigners and stateless persons by bodies of the border guard service. The analysis of domestic and foreign scientific views on time measurement in administrative proceedings has been carried out. The rules of the American and European system of termination of illegal stay of third-country nationals in connection with immigration detention, which is distinguished by its purpose and duration. The place of administrative deportation in the system of migration measures under Russian law is explained by the fact that it is an administrative punishment of foreign citizens and stateless persons who are subject to detention and are kept in specially designated premises. The peculiarities of temporal regulation and its significance in the application of coercive measures aimed at the return of a migrant in the context of the global spread of coronavirus infection are clarified. The allocation of material and procedural terms within the framework of which the state border guards exercise the powers of forced return and expulsion from the territory of Ukraine is reasoned. The focus on achieving the migration result reflects the material content of the terms allotted for departure and / or ensuring the departure of an illegal migrant from the country. The material expulsion terms are also associated with detention, which is applied according to the rules of administrative proceedings and is characterized by a significant duration, especially in a pandemic. The appointment of procedural terms is justified on the basis of the current norms of administrative-procedural legislation and is associated with the performance of the procedural actions necessary to be applied to the court and the phasing of administrative-jurisdictional proceedings. During the quarantine it is allowed to review the procedural terms in contrast to the material ones. Among the prospects of elaboration of the chosen topic, a comprehensive study of the normative regulation of time characteristics of immigration detention in accordance with the new administrative legislation and the return of foreigners (stateless persons) detected during their crossing the state border and entering the temporarily occupied territory of Ukraine is proposed.

Experience in the use of telerehabilitation after a COVID-19 infection at the polyclinic stage in Tyumen

2021 ◽  
Vol 22 (2) ◽  
pp. 84-88
Author(s):  
T. I. Kutergina ◽  
◽  
O. V. Andreeva ◽  
E. F. Turovinina ◽  
T. M. Kleshchevnikova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
The State ◽  
Medical Rehabilitation ◽  
Medical Institution ◽  
Shortness Of Breath ◽  
Early Start ◽  
Coronavirus Infection ◽  
Medical University

Aim. To evaluate the effectiveness of the early start of medical rehabilitation, after a coronavirus infection, with the use of telemedicine technologies at the polyclinic stage. Material and methods. A study was conducted on the basis of the State Medical Institution “City Polyclinic No. 17” with the participation of 65 patients who had pneumonia against the background of COVID-19 infection at the age of 29 to 81 years inclusive, the average age was 54 ± 13.0 years, receiving rehabilitation at the 3rd stage using telemedicine technologies. Results. The Department of Medical Prevention and Rehabilitation of the INPR of the Tyumen State Medical University has developed a “Program of medical rehabilitation of patients who have suffered a new coronavirus infection at the polyclinic stage with the use of telemedicine technologies”. Implemented and implemented on the basis of the State Medical Institution “City Polyclinic No. 17” in Tyumen. Earlier, the beginning of rehabilitation measures at the outpatient stage in patients after pneumonia on the background of COVID-19 infection eliminates shortness of breath in patients with a mild course, with a moderate-severe and severe course restores by 60%. Recovery of muscle strength was noted in all patients. Positive dynamics in the normalization of the psychoemotional background and improvement of the quality of life were reliably obtained. Conclusion. Medical rehabilitation with the use of telemedicine technologies is an effective approach of the healthcare system in restoring the health status of patients who have suffered a coronavirus infection.

New coronavirus infection as an occupational disease: complex expert cases

2021 ◽  
Vol 61 (11) ◽  
pp. 720-725
Author(s):  
Railya V. Garipova ◽  
Leonid A. Strizhakov ◽  
Yuri Yu. Gorblyansky ◽  
Sergey A. Babanov
Keyword(s):  
Russian Federation ◽  
Healthcare Workers ◽  
Occupational Diseases ◽  
The State ◽  
Production Factor ◽  
Professional Activity ◽  
Production Environment ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
The Impact

Introduction. The professional activity of medical workers (MW) is in close contact with daily contact with various factors of the production environment: physical, chemical, biological, and labor processes. Until 2020, tuberculosis and viral hepatitis prevailed in the structure of occupational diseases (OD) of the medical workers in the Russian Federation. According to the State report "On the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2020," the first ranking the second place in the structure of occupational diseases, depending on the impact of harmful production factor took the illnesses associated with the action of biological factors - 20,19%, while the main reason for the growth in the incidence of healthcare workers in coronavirus infection COVID-19 (further COVID-19). The study aims were to identify problematic aspects in the establishment of the COVID-19 work from MW. Materials and methods. We have given descriptions of clinical cases, as well as a retrospective analysis of issues of OD according to the patient registers of the following medical institutions: the Center of Occupational Pathology of Sechenov University, the Republican Center of Occupational Pathology of the Ministry of Health, Republic of Tatarstan, the Regional Center of Occupational Pathology of the Samara Region. Results. In 2020, COVID-19 was the most common OD with fatal outcomes and complications in healthcare workers. Today, difficulties in determining the connection of COVID-19 with the profession arise when assessing the epidemiological history, the consequences after a coronavirus infection, and the formulation of the diagnosis. Conclusions. For a qualitative examination of the connection of COVID-19 with the profession, it is necessary to develop a list of clinical conditions with the definition of the timing of complications.

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