Bio-Adhesive Nanomedicine for Targeted Drug Delivery

The bio/muco-adhesive auxiliary agents are considered as a promising strategy for the administration of various challenging drugs including peptides, proteins and oligosaccharides therapeutics. The delivery of such therapeutics is hampered due to rapid degradation, restricted uptake, short residence time, poor solubility and limited half-life. The recent emergence of nanomedicine based on bio/mucoadhesive auxiliary agents is offering new avenues to overcome these drawbacks. Hence, it is important to understand the mechanism of nanoscale bio/mucoadhesion, protocols for investigating bio/mucoadhesive potential at nanoscale. This chapter is an endeavor to focus on the mechanism of bio adhesion and the bio/mucoadhesive auxiliary agents that are used in the design of the targeted oral, nasal, ocular, vaginal, and buccal nanomedicine with their properties that affect the bio/mucoadhesion.

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NANOSUSPENSION: AN OVERVIEW

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017.v9i3.19584 ◽

2017 ◽

Vol 9 (3) ◽

pp. 19

Author(s):

Smita S. Aher ◽

Sagar T. Malsane ◽

R. B. Saudagar

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

High Pressure Homogenization ◽

Specific Drug ◽

Site Specific ◽

Promising Strategy ◽

Media Milling ◽

Efficient Delivery ◽

Targeted Drug ◽

Novel Drug

Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in theOcular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery.

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Recent Applications of Liposomes in Ophthalmic Drug Delivery

Journal of Drug Delivery ◽

10.1155/2011/863734 ◽

2011 ◽

Vol 2011 ◽

pp. 1-14 ◽

Cited By ~ 82

Author(s):

Gyan P. Mishra ◽

Mahuya Bagui ◽

Viral Tamboli ◽

Ashim K. Mitra

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Half Life ◽

Topical Delivery ◽

Posterior Segment ◽

Hydrophilic Polymers ◽

Ophthalmic Drug Delivery ◽

Liposomal Formulations ◽

Ophthalmic Drug ◽

Targeted Drug

Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. Current approaches for topical delivery of liposomes are focused on improving the corneal adhesion and permeation by incorporating various bioadhesive and penetration enhancing polymers. In the case of posterior segment disorders improvement in intravitreal half life and targeted drug delivery to the retina is achieved by liposomes. In this paper we have attempted to summarize the applications of liposomes in the field of ophthalmic drug delivery by citing numerous investigators over the last decade.

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