Lumbar disc rehydration postimplantation of a posterior dynamic stabilization system

2010 ◽  
Vol 13 (5) ◽  
pp. 576-580 ◽  
Author(s):  
Bo Young Cho ◽  
Judith Murovic ◽  
Kyung Woo Park ◽  
Jon Park
Keyword(s):  
Disc Degeneration ◽  
Lumbar Disc ◽  
Young Male ◽  
Dynamic Stabilization ◽  
Disc Height ◽  
Physiological Status ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
Mechanical Approach ◽  
Posterior Dynamic Stabilization

Biological attempts at disc regeneration are promising; however, disc degeneration is closely related to other predisposing factors such as alteration of disc height, intradiscal pressure, load distribution, and motion. The restoration of the physiological status of the affected spinal segment is thus necessary prior to attempts at disc regeneration. Dynamic stabilization systems now offer the potential of a mechanical approach to intervertebral disc regeneration.The authors used decompression and placement of the BioFlex dynamic stabilization device to treat a young male patient with disc degeneration. This patient underwent follow-up, and he was found to gradually improve both neurologically and radiographically. On MR imaging performed 1 year postoperatively, he had an increase in disc height and disc rehydration. This case and the concept of disc rehydration are presented in this paper.

Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration

2011 ◽  
Vol 14 (3) ◽  
pp. 322-329 ◽  
Author(s):  
Ganjun Feng ◽  
Xianfeng Zhao ◽  
Hao Liu ◽  
Huina Zhang ◽  
Xiangjun Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Signal Intensity ◽  
Disc Height ◽  
Nucleus Pulposus Cells ◽  
Disc Regeneration ◽  
Disc Model

Object The aim of this study was to compare transplanted mesenchymal stem cells (MSCs) with nucleus pulposus cells (NPCs) in a degenerative disc model in rabbits to determine the better candidate for disc cell therapy. Methods Mesenchymal stem cells and NPCs were transplanted in a rabbit model of disc degeneration. Changes in disc height, according to plain radiography, T2-weighted signal intensity on MR imaging, histology, sulfated glycosaminoglycan (sGAG)/DNA, and associated gene expression levels, were evaluated among healthy controls without surgery, sham-operated animals in which only disc degeneration was induced, MSC-transplanted animals, and NPC-transplanted animals for a 16-week period. Results Sixteen weeks after cell transplantation, in the MSC- and NPC-transplanted groups, the decline in the disc height index was reduced and T2-weighted signal intensity increased compared with the sham-operated group. Safranin O staining showed a high GAG content, which was also supported by sGAG/DNA assessment. Disc regeneration was also confirmed at the gene expression level using real-time polymerase chain reaction. However, no significant differences in expression were found between the NPC- and MSC-transplanted groups. Conclusions Study data showed that MSC transplantation is effective for the treatment of disc degeneration and seems to be an ideal substitute for NPCs.

scholarly journals Disc Height and Sagittal Alignment in Operated and Non-Operated Levels in the Lumbar Spine at Long-Term Follow-Up: A Case-Control Study

2013 ◽  
Vol 7 (1) ◽  
pp. 258-263 ◽  
Author(s):  
Anne Froholdt ◽  
Jens Ivar Brox ◽  
Olav Reikerås ◽  
Gunnar Leivseth
Keyword(s):  
Back Pain ◽  
Disc Degeneration ◽  
Sagittal Alignment ◽  
Lumbar Fusion ◽  
Lumbar Disc ◽  
Disc Height ◽  
Secondary Outcome ◽  
Lumbar Disc Degeneration ◽  
Long Term Follow Up

Purpose: To compare lumbar disc degeneration at 9-year follow-up in patients with chronic low back pain who had instrumented lumbar fusion or no fusion. Material and methodology: The main outcomes were disc height and sagittal alignment measured by Distortion Compensated Roentgen Analysis (DCRA). Secondary outcome included the Oswestry Disability Index and VAS back pain. Results: Forty-eight patients with baseline and 9-year radiographs from L2- S1 were included. Twenty-three had lumbar fusion and 25 had no fusion. Disc height was reduced at all levels independent of fusion. No difference in disc height and sagittal alignment was observed between patients fused and not fused. There were weak correlations, ranging from 0.04 to 0.36, between clinical and radiological parameters. Conclusion: Lumbar disc degeneration increased at all measured levels independent of fusion and correlated poorly with clinical outcome.

Intervertebral disc regeneration after implantation of a cell-free bioresorbable implant in a rabbit disc degeneration model

Biomaterials ◽  
2010 ◽  
Vol 31 (22) ◽  
pp. 5836-5841 ◽  
Author(s):  
Michaela Endres ◽  
Alexander Abbushi ◽  
Ulrich W. Thomale ◽  
Mario Cabraja ◽  
Stefan N. Kroppenstedt ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
A Cell

scholarly journals Full-Endoscopic Lumbar Interbody Fusion for Treating Lumbar Disc Degeneration Involving Disc Height Loss: Technical Report

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 478
Author(s):  
Tsuyoshi Harakuni ◽  
Hiroki Iwai ◽  
Yasushi Oshima ◽  
Hirokazu Inoue ◽  
Tomoaki Kitagawa ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
Interbody Fusion ◽  
Rating Scale ◽  
Lumbar Disc ◽  
Disc Height ◽  
Height Loss ◽  
Foraminal Stenosis ◽  
Lumbar Interbody Fusion ◽  
Lumbar Disc Degeneration ◽  
The Mean

Background and Objectives: Lumbar disc degeneration (LDD) is the main cause of lower back pain and leads to corresponding disc height loss. Although lumbar interbody fusion (LIF) is commonly used for treating LDD, several different treatment strategies are available. We performed a minimally invasive full-endoscopic LIF (FELIF) using a uniportal full-endoscopic system. Materials and Methods: FELIF was performed for 12 patients with LDD with disc-height loss using a 4.1 mm working channel endoscope and a newly developed slider for cage insertion. The mean age of the patients was 68.3 years; the patients presented with single vertebral level involvement. The Brandner’s disc index was used for evaluating the postoperative increase in the disc height. Preoperative and postoperative leg pain was evaluated using the numerical rating scale (NRS) score. Results: The mean operation time for FELIF was 109.4 min. The mean duration of hospital stay after FELIF was 7.7 days. There were no operative and postoperative complications, even without drainage during the mean follow-up period of 6.2 months (range, 2–10 months). The Brandner’s disc index improved statistically significant (p > 0.01). The mean preoperative and postoperative NRS scores were 6.5 and 1.2, respectively. Conclusions: FELIF using a 4.1 mm working channel endoscope can be used for treating LDD with disc height loss. Radiculopathy caused by foraminal stenosis was the most suitable operative indication for FELIF.

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