Neuroendoscopic biopsy of brain lesions: accuracy and complications

OBJECT The authors conducted a study to analyze the accuracy of neuroendoscopic biopsies of ventricular and periventricular lesions and record any difficulties or complications of the neuroendoscopic biopsy procedure. METHODS A total of 50 patients with different diseases consecutively underwent endoscopic biopsy procedures. The biopsy result was considered diagnostic if the pathologist reported any specific finding on which clinicians could base decisions about treatment or observation. The biopsy result was referred to as accurate if the results matched results of a sample obtained later or if the treatment response and disease evolution were compatible with the diagnosis. The biopsy result was considered inaccurate if results showed any relevant differences from those of the later sample or if the patient's disease did not evolve as expected. Complications were recorded and compared with those found in a literature review. RESULTS For 2 patients, the procedure had to be terminated. The biopsy diagnostic rate was 89.6%, and the accuracy rate was 86%. Complications associated with the procedure were 3 hemorrhages (6%), 2 infections (4%), and 1 death (2%); no reoperations were needed. CONCLUSIONS Endoscopic biopsy seems to be an accurate procedure with acceptable morbidity and mortality rates.

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Brain Lesions in Intrauterine Growth Restriction Assessed by Ultrasound Imaging: Focus on US Technique and Periventricular Lesions

Handbook of Growth and Growth Monitoring in Health and Disease ◽

10.1007/978-1-4419-1795-9_16 ◽

2011 ◽

pp. 263-274

Author(s):

Nelly Padilla ◽

Goya Enriquez ◽

Edgar Hernandez-Andrade ◽

Angela Arranz ◽

Ruthy Acosta-Rojas ◽

...

Keyword(s):

Ultrasound Imaging ◽

Intrauterine Growth Restriction ◽

Brain Lesions ◽

Growth Restriction ◽

Intrauterine Growth ◽

Periventricular Lesions

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Stroke occurring in patients with cognitive impairment or dementia

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20160187 ◽

2017 ◽

Vol 75 (2) ◽

pp. 117-121 ◽

Cited By ~ 1

Author(s):

Solène Moulin ◽

Didier Leys

Keyword(s):

Cognitive Impairment ◽

Systematic Approach ◽

Stroke Care ◽

The Elderly ◽

Mortality Rates ◽

Brain Lesions ◽

Optimal Management ◽

Cognitively Normal ◽

Search Results ◽

Mixed Origin

ABSTRACT One in six patients admitted for stroke was previously demented. These patients have less access to appropriate stroke care, although little is known about their optimal management. Objective To determine how pre-stroke cognitive impairment can be detected, its mechanism, and influence on outcome and management. Methods Literature search. Results (i) A systematic approach with the Informant Questionnaire of Cognitive Decline in the Elderly is recommended; (ii) Pre-stroke cognitive impairment may be due to brain lesions of vascular, degenerative, or mixed origin; (iii) Patients with pre-stroke dementia, have worse outcomes, more seizures, delirium, and depression, and higher mortality rates; they often need to be institutionalised after their stroke; (iv) Although the safety profile of treatment is not as good as that of cognitively normal patients, the risk:benefit ratio is in favour of treating these patients like others. Conclusion Patients with cognitive impairment who develop a stroke have worse outcomes, but should be treated like others.

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Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

Multiple Sclerosis Journal ◽

10.1177/1352458512441381 ◽

2012 ◽

Vol 18 (12) ◽

pp. 1721-1736 ◽

Cited By ~ 99

Author(s):

Hervé Perron ◽

Raphaëlle Germi ◽

Corinne Bernard ◽

Marta Garcia-Montojo ◽

Cécile Deluen ◽

...

Keyword(s):

Multiple Sclerosis ◽

Neurological Diseases ◽

Quantitative Polymerase Chain Reaction ◽

Brain Lesions ◽

Human Endogenous Retrovirus ◽

Enzyme Linked Immunosorbent Assay ◽

Disease Evolution ◽

Copy Numbers ◽

Vascular Elements ◽

Dna Copy Numbers

Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family ‘W’ (HERV-W), induces dysimmunity and inflammation. Objective: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. Methods: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals. Results: Env antigen was detected in a serum of 73% of patients with MS with similar prevalence in all clinical forms, and not in chronic infection, systemic lupus, most other neurological diseases and healthy donors ( p<0.01). Cases with chronic inflammatory demyelinating polyneuropathy (5/8) and rare HC (4/103) were positive. RNA expression in PBMC and DNA copy numbers were significantly elevated in patients with MS versus HC ( p<0.001). In patients with MS, DNA copy numbers were significantly increased in chronic progressive MS (secondary progressive MS vs relapsing–remitting MS (RRMS) p<0.001; primary progressive MS vs RRMS –<0.02). Env protein was evidenced in macrophages within MS brain lesions with particular concentrations around vascular elements. Conclusion: The association between MS disease and the MSRV-type HERV-W element now appears quite strong, as evidenced ex-vivo from serum and PBMC with post-mortem confirmation in brain lesions. Chronic progressive MS, RRMS and clinically isolated syndrome show different ELISA (Enzyme-Linked Immunosorbent Assay) and/or PCR profiles suggestive of an increase with disease evolution, and amplicon sequencing confirms the association with particular HERV-W elements.

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133: Comparisons of Prostate Cancer Mortality Rates with Changes in Dietary Practices in the United States from 1930 to 2000

The Journal of Urology ◽

10.1016/s0022-5347(18)32400-5 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 42-43

Author(s):

Jan L. Colli ◽

Albert Colli

Keyword(s):

Prostate Cancer ◽

United States ◽

Cancer Mortality ◽

The United States ◽

Mortality Rates ◽

Dietary Practices ◽

Prostate Cancer Mortality

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Inequalities and Impact of Socioeconomic-Cultural Factors in Suicide Rates Across Italy

Crisis ◽

10.1027/0227-5910/a000084 ◽

2011 ◽

Vol 32 (4) ◽

pp. 178-185 ◽

Cited By ~ 15

Author(s):

Maurizio Pompili ◽

Marco Innamorati ◽

Monica Vichi ◽

Maria Masocco ◽

Nicola Vanacore ◽

...

Keyword(s):

Suicide Rate ◽

Age Groups ◽

Premature Death ◽

Mortality Rates ◽

Mortality Data ◽

Italian Population ◽

Comprehensive Overview ◽

Suicide Rates ◽

Younger Age ◽

Age And Sex

Background: Suicide is a major cause of premature death in Italy and occurs at different rates in the various regions. Aims: The aim of the present study was to provide a comprehensive overview of suicide in the Italian population aged 15 years and older for the years 1980–2006. Methods: Mortality data were extracted from the Italian Mortality Database. Results: Mortality rates for suicide in Italy reached a peak in 1985 and declined thereafter. The different patterns observed by age and sex indicated that the decrease in the suicide rate in Italy was initially the result of declining rates in those aged 45+ while, from 1997 on, the decrease was attributable principally to a reduction in suicide rates among the younger age groups. It was found that socioeconomic factors underlined major differences in the suicide rate across regions. Conclusions: The present study confirmed that suicide is a multifaceted phenomenon that may be determined by an array of factors. Suicide prevention should, therefore, be targeted to identifiable high-risk sociocultural groups in each country.

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