Thirteen-year follow-up of parasellar intravascular papillary endothelial hyperplasia successfully treated by surgical excision: case report

Intracranial intravascular papillary endothelial hyperplasia (IPEH) is very rare, and to our knowledge long-term follow-up results have not been previously published. An 11-year-old boy presented with a 6-month history of progressive visual impairment in the right eye. Magnetic resonance imaging revealed a well-enhanced, large parasellar mass involving the cavernous sinus, right frontal skull base, and ethmoid and sphenoid sinuses. Frontotemporal craniotomy and subtotal resection were performed, and the diagnosis of IPEH was confirmed. The mass increased in size during the following 3 months. A second operation was performed via frontotemporal craniotomy combined with a transsphenoidal approach, and gross-total resection of the tumor was achieved. Adjuvant radiotherapy (5040 cGy) and chemotherapy with interferon were administered. The patient's visual symptoms improved, and there was no recurrence during a 13-year follow-up period. The results of this case indicate that intracranial IPEH can recur with subtotal resection; however, optimal resection with multimodal adjuvant treatment can control the disease for many years, if not permanently.

Download Full-text

Extramedullary Plasmacytoma of The Frontal Sinus: A Case Report

FACE ◽

10.1177/27325016211053640 ◽

2021 ◽

pp. 273250162110536

Author(s):

Joshua Harrison ◽

Samantha Marley ◽

Shawhin Shahriari ◽

Christian Bowers ◽

Anil Shetty

Keyword(s):

Frontal Sinus ◽

Surgical Excision ◽

Extramedullary Plasmacytoma ◽

High Rate ◽

Solitary Plasmacytoma ◽

Case Presentation ◽

Long Term Follow Up ◽

History Of

We report a rare case of an extramedullary plasmacytoma (EMP) in the frontal sinus with an indolent clinical presentation. Although a history of trauma was absent, the initial diagnosis was a mucocele, based on the radiological findings. Upon surgical excision, the patient was found to have an EMP. EMP, a form of solitary plasmacytoma, has a significantly high rate of conversion to multiple myeloma. This mandates long-term follow-up, even after successful radiotherapy and/or resection. While radiation therapy is generally considered a first line treatment for EMP, surgical intervention may provide optimal treatment in complicated cases. This case presentation highlights the prognosis of patients diagnosed with EMP.

Download Full-text

Oncocytic cyst of the larynx: a rare finding

BMJ Case Reports ◽

10.1136/bcr-2018-227214 ◽

2019 ◽

Vol 12 (1) ◽

pp. bcr-2018-227214 ◽

Cited By ~ 1

Author(s):

Samantha Baird ◽

Halina Mann ◽

Cesar M Salinas-La Rosa ◽

Halil Ozdemir

Keyword(s):

Social History ◽

Granular Eosinophilic Cytoplasm ◽

Eosinophilic Cytoplasm ◽

Long Term Follow Up ◽

History Of ◽

The Right ◽

False Vocal ◽

Columnar Cells

A 75-year-old woman presented with an 18-month history of severe, slowly worsening dysphonia. She was a smoker and known to have multiple benign cystic thyroid lesions. She reported no associated symptoms and other medical and social history was unremarkable. Fibreoptic nasendoscopy revealed a right-sided supraglottic cyst appearing to arise from the right false vocal cord. Further bedside examination was unremarkable. She underwent microlaryngoscopy and biopsy which showed a cyst originating from the right anterior ventricle, successfully removed without rupture using cold steel. Formal histopathology revealed a 14×10×7 mm unilocular, completely excised cyst lined by oncocytic epithelium and composed of columnar cells with darkly stained nuclei and abundant granular, eosinophilic cytoplasm. Three weeks postoperatively the patient’s voice had returned to normal. To date, 11 months postoperatively, there is no evidence of recurrence, and she will continue long-term follow-up.

Download Full-text

Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940611500303 ◽

2006 ◽

Vol 115 (3) ◽

pp. 175-181 ◽

Cited By ~ 22

Author(s):

Ana Nusa Naiman ◽

Darius Abedipour ◽

Sonia Ayari ◽

Elizabeth Fresnel ◽

Bruno Coulombeau ◽

...

Keyword(s):

Complete Remission ◽

Surgical Excision ◽

Intralesional Injection ◽

Adult Onset ◽

Laryngeal Papillomatosis ◽

Long Term Follow Up ◽

History Of ◽

A Prospective Study

Objectives: A prospective study was performed to assess the intermediate and long-term efficacy of intralesional cidofovir therapy associated with surgical excision in laryngeal papillomatosis in adults. Methods: Endoscopy with intralesional injection of cidofovir 5 mg/mL was performed 3 times at 4-week intervals. The concentration was later increased to 7.5 mg/mL and the interval between injections shortened to 2 weeks. Further treatment was performed at 3 or 6 months, depending on the evolution of the papillomas. After complete remission, the treatment was stopped and the patients were reviewed every 6 months. Results: Nineteen patients completed the protocol, with a mean of 4.5 injections each. Complete remission was obtained in 17 cases (89%) after a mean of 3.8 procedures. Remission was stable after a mean follow-up of 24 months (range, 8 to 57 months). With higher cidofovir concentrations at shorter intervals, patients needed fewer injections to achieve remission (mean, 2.1 versus 4.7 injections). Conclusions: The effectiveness of intralesional cidofovir therapy in adult-onset recurrent respiratory papillomatosis was impressive. Once obtained, complete remission was stable on intermediate or long-term follow-up. The concentration and the interval between injections seemed to influence the number of injections necessary to achieve remission.

Download Full-text

Pediatric case of presacral ganglioneuroma: diagnostic considerations and therapeutic strategy

Annals of Pediatric Surgery ◽

10.1186/s43159-021-00100-z ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Saloua Ammar ◽

Taycir Cheikhrouhou ◽

Mohamed Jallouli ◽

Rahma Chtourou ◽

Sahla Sellami ◽

...

Keyword(s):

Abdominal Mass ◽

Surgical Excision ◽

Residual Tumor ◽

Posterior Mediastinum ◽

Subtotal Resection ◽

Case Presentation ◽

Long Term Follow Up ◽

Neuroblastic Tumors

Abstract Background Ganglioneuroma (GN) is an uncommon tumor belonging to the neuroblastic tumors group and is often localized in the posterior mediastinum, retroperitoneum, and adrenal gland. Presacral (PS) location is extremely rare. Its management remains a challenge. Case presentation A 4-year-old child presented to our department for an isolated abdominal mass. Para-clinical exams concluded to PSGN. Subtotal surgical excision was performed through an anterior transperitoneal approach. The size of the residual tumor did not progress after the 6-year follow-up period and the patients were asymptomatic. Conclusions GN should be considered in the case of soft tissue presacral masses in pediatrics. Subtotal resection seems sufficient in case of an extension to the sacrum with low morbidity. The residual tumors are still stable and the prognosis seems conserved. Further, long-term follow-up in large studies is needed to confirm these findings.

Download Full-text

Case report of fibrous dysplasia in a pediatric patient: importance of adequate treatment to avoid malignization

10.5327/1516-3180.574 ◽

2021 ◽

Author(s):

João Victor Bezerra Ramos ◽

João Lucas Pordeus de Menezes ◽

Louyse Jerônimo de Morais ◽

Maurus Marques de Almeida Holanda

Keyword(s):

Fibrous Dysplasia ◽

Malignant Transformation ◽

Adequate Treatment ◽

Long Term Follow Up ◽

History Of ◽

Daily Headache ◽

The Right ◽

Temporal Bones

Background: Fibrous dysplasia is a congenital and benign bone tumor. There may be malignant transformation in some cases, with a mortality rate of 53.6%. Objectives and Methods: To describe a patient with fibrous dysplasia in childhood in the parietal and temporal bones, and to report the importance of surgical correction to prevent malignant transformation. The case was studied and came from a referral hospital – João Pesssoa, PB. Results: History of daily headache and bulging in the temporal and parietal regions on the right. Computed tomography revealed lesions in the aspect of “ground glass”. Surgery was performed with exposure of two lesions, with craniectomy, followed by cranioplasty. Such an approach should be recommended, since malignant transformation occurs in up to 1% of cases, but after radiotherapy this rate can reach 44% of cases, mainly osteosarcoma. In this case, the anatomopathological study revealed a diagnosis of fibrous dysplasia and the patient has been followed up for 20 years without recurrences, which are common in adolescence. Conclusions: It is important to make a differential diagnosis with malignant diseases, in addition to contraindicating radiotherapy to prevent malignant transformation; long-term follow-up is essential to avoid relapses and / or complications resulting from the disease.

Download Full-text

Lhermitte-Duclos disease and Cowden's syndrome in an adolescent patient

Journal of Neurosurgery ◽

10.3171/jns.1994.81.1.0133 ◽

1994 ◽

Vol 81 (1) ◽

pp. 133-136 ◽

Cited By ~ 32

Author(s):

Gregg B. Wells ◽

Todd M. Lasner ◽

David M. Yousem ◽

Eric L. Zager

Keyword(s):

Cystic Hygroma ◽

Content Type ◽

Adenomatous Goiter ◽

Cowden’S Syndrome ◽

Long Term Follow Up ◽

History Of ◽

The Right ◽

Multiple Hamartoma Syndrome

✓ Recent reports of seven cases of Lhermitte-Duclos disease occurring in adult patients with Cowden's syndrome (multiple hamartoma syndrome) strongly suggest that Lhermitte-Duclos disease is one of the types of neoplasia that characterize this syndrome. A case of Lhermitte-Duclos disease is reported in a 16-year-old girl with craniomegaly, choroidal hamartoma, and conjunctival papilloma of the right eye, and a history of bilateral multinodular adenomatous goiter and cystic hygroma. These findings strongly suggest a diagnosis of Cowden's syndrome. Although the syndrome traditionally has been defined by mucocutaneous criteria, it typically also involves hamartomas and neoplasia of internal organs, most commonly in the thyroid, breast, and female genitourinary tract. Because the mucocutaneous features may develop several decades after birth, the present case both supports the previously reported association between Lhermitte-Duclos disease and Cowden's syndrome and highlights the need for long-term follow-up monitoring of a pediatric patient with Lhermitte-Duclos disease because of the risk of malignancies associated with Cowden's syndrome.

Download Full-text

A Rare Case of Giant Mesenteric Lipoblastoma in a 6-Year-Old Child and Review of the Literature

Case Reports in Surgery ◽

10.1155/2020/3018065 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Maria Enrica Miscia ◽

Gabriele Lisi ◽

Giuseppe Lauriti ◽

Angela Riccio ◽

Dacia Di Renzo ◽

...

Keyword(s):

Benign Tumor ◽

Malignant Tumors ◽

Surgical Excision ◽

Review Of The Literature ◽

Imaging Studies ◽

Long Term Follow Up ◽

Rare Benign Tumor ◽

History Of

Giant mesenteric lipoblastoma is a rare benign tumor arising from the adipocytes. It can mimic malignant tumors, and its diagnosis is difficult before surgery. Imaging studies could lead the diagnosis but not confirm it. Those tumors arising in the abdomen are usually larger and can cause symptoms of compression. Surgical excision is the treatment of choice, and a long-term follow-up is necessary to detect local recurrences. Only a few cases of lipoblastomas arising from the mesentery are reported in literature. We present a case of a rare giant lipoblastoma arising from the mesentery of a 6-year-old girl, with a history of postprandial abdominal pain.

Download Full-text

Report of A Case of Papillary Thyroid Carcinoma Following Intracranial Germinoma

International Journal of Diabetes & Metabolic Disorders ◽

10.33140/ijdmd.06.02.07 ◽

2021 ◽

Vol 6 (2) ◽

Keyword(s):

Second Primary ◽

Intracranial Germinoma ◽

Adult Cancer Survivors ◽

Long Term Follow Up ◽

History Of ◽

The Right ◽

Brain Radiation ◽

Hypoechoic Nodule

Introduction The occurrence of second primary thyroid malignancy should be noticed in survivors of brain germinoma treated by irradiation. Case Report A patient with a history of intracranial germinoma who underwent chemoradiotherapy was referred to our endocrine clinic due to impotency and infertility. The patient received replacement therapy due to hypopituitarism. He returned to us 11 years after brain radiation with enlargement of the thyroid gland. Thyroid ultrasonography showed enlargement with a dominant 62*37 mm solid hypoechoic nodule in the right thyroid lobe. Several lymph nodes at both sides of the neck were seen. Total thyroidectomy revealed PTC with regional metastasis. Conclusion Endocrine disruption must be considered in adult cancer survivors and the importance of long-term follow-up should be emphasized in these patients.

Download Full-text