scholarly journals Camptocormia treated with bilateral pallidal stimulation

2002 ◽  
Vol 12 (2) ◽  
pp. 1-6 ◽  
Author(s):  
Dipankar Nandi ◽  
Simon Parkin ◽  
Richard Scott ◽  
Jonathan L. Winter ◽  
Carole Joint ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Temporal Correlation ◽  
Functional Improvement ◽  
Field Potentials ◽  
Neuropsychological Effects ◽  
Functional Benefit ◽  
Pallidal Stimulation ◽  
Significant Functional Improvement ◽  
Deep Brain

The authors report the neurological, neurophysiological, and neuropsychological effects of using chronic bilateral pallidal high-frequency deep brain stimulation (DBS) in a case of disabling camptocormia. Deep brain stimulation electrodes were implanted stereotactically to target the globus pallidus internus (GPi) bilaterally. Local field potentials (FPs) were recorded using the DBS electrodes and concurrent abdominal flexor elec-tromyography (EMG) potentials during camptocormic episodes. Videotaped assessments of the movement disorder and neuropsychological evaluation before implantation and at 6 months after initiation of pallidal stimulation were recorded. There was significant functional improvement following chronic pallidal stimulation, and some improvement was noted in neuropsychological scores. The GPi FPs showed temporal correlation with EMG-recorded rectus abdominis potentials. There were no treatment-related adverse effects. The authors have found that chronic pallidal stimulation was safe and offered functional benefit in this severely disabling condition. The physiological studies may help further the understanding of the pathophysiology of this rare entity.

Camptocormia treated with bilateral pallidal stimulation

2002 ◽  
Vol 97 (2) ◽  
pp. 461-466 ◽  
Author(s):  
Dipankar Nandi ◽  
Simon Parkin ◽  
Richard Scott ◽  
Jonathan L. Winter ◽  
Carole Joint ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Functional Improvement ◽  
Content Type ◽  
Functional Benefit ◽  
Pallidal Stimulation ◽  
Neuropsychological Evaluations ◽  
Fine Print ◽  
Deep Brain

✓ The authors report the neurological, neurophysiological, and neuropsychological effects of using long-term bilateral pallidal high-frequency deep brain stimulation (DBS) in a case of disabling camptocormia. Deep brain stimulation electrodes were implanted stereotactically to target the globus pallidus internus (GPi) bilaterally. Local field potentials (FPs) were recorded using the DBS electrodes and concurrent abdominal flexor electromyography (EMG) potentials during camptocormic episodes. Videotaped assessments of the movement disorder and neuropsychological evaluations of the patient before implantation and 6 months after initiation of pallidal stimulation were recorded. There was significant functional improvement following long-term pallidal stimulation, and some improvement was noted in neuropsychological scores. A temporal correlation between the GPi FPs and EMG-recorded rectus abdominis potentials was evident. There were no treatment-related adverse effects. The authors have found that long-term pallidal stimulation was safe and offered functional benefit to a patient with this severely disabling condition. The physiological studies may help further the understanding of the pathophysiology of this rare entity.

Basal ganglia local field potentials: applications in the development of new deep brain stimulation devices for movement disorders

2007 ◽  
Vol 4 (5) ◽  
pp. 605-614 ◽  
Author(s):  
Sara Marceglia ◽  
Lorenzo Rossi ◽  
Guglielmo Foffani ◽  
AnnaMaria Bianchi ◽  
Sergio Cerutti ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Local Field ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Local Field Potentials ◽  
Field Potentials ◽  
Deep Brain

scholarly journals Characteristics of local field potentials correlate with pain relief by deep brain stimulation

2016 ◽  
Vol 127 (7) ◽  
pp. 2573-2580 ◽  
Author(s):  
Yongzhi Huang ◽  
Huichun Luo ◽  
Alexander L. Green ◽  
Tipu Z. Aziz ◽  
Shouyan Wang
Keyword(s):  
Deep Brain Stimulation ◽  
Pain Relief ◽  
Local Field ◽  
Brain Stimulation ◽  
Local Field Potentials ◽  
Field Potentials ◽  
Deep Brain

A Method for Removal of Deep Brain Stimulation Artifact From Local Field Potentials

2017 ◽  
Vol 25 (12) ◽  
pp. 2217-2226 ◽  
Author(s):  
Xing Qian ◽  
Yue Chen ◽  
Yuan Feng ◽  
Bozhi Ma ◽  
Hongwei Hao ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Local Field ◽  
Brain Stimulation ◽  
Local Field Potentials ◽  
Field Potentials ◽  
Deep Brain

Neuropsychological Effects of Deep Brain Stimulation in Subjects with Early Stage Parkinson's Disease in a Randomized Clinical Trial

2015 ◽  
Vol 5 (1) ◽  
pp. 151-163 ◽  
Author(s):  
Michael G. Tramontana ◽  
Anna L. Molinari ◽  
Peter E. Konrad ◽  
Thomas L. Davis ◽  
Scott A. Wylie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Randomized Clinical Trial ◽  
Brain Stimulation ◽  
Early Stage ◽  
Neuropsychological Effects ◽  
Deep Brain

scholarly journals Unilateral thalamic and pallidal deep brain stimulation for idiopathic hemidystonia: results of individual and combined stimulations. Case report

2017 ◽  
Vol 43 (1) ◽  
pp. E2 ◽  
Author(s):  
Victor Goulenko ◽  
Paulo Luiz da Costa Cruz ◽  
Paulo Niemeyer Filho
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Multiple Target ◽  
Motor Pathways ◽  
Severity Rating ◽  
Pallidal Stimulation ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Pallidal stimulation has been the usual surgical treatment for dystonia in the last decades. The continuous investigation of the physiopathology and the motor pathways involved leads to the search for complementary targets to improve results. The authors present the case of a 37-year-old woman who had suffered from idiopathic hemidystonia with hyperkinetic and hypokinetic movements for 11 years, and who was treated with deep brain stimulation. A brief literature review is also provided. The globus pallidus internus and the ventral intermediate/ventral oral posterior complex of the thalamus were stimulated separately and simultaneously for 3 months and compared using the Burke-Fahn-Marsden Dystonia Rating Scale and the Global Dystonia Severity Rating Scale, with a 3.5-year follow-up. The synergism of multiple-target stimulation resulted in a complete improvement of the mixed dystonic symptoms.

scholarly journals Biophysical basis of subthalamic local field potentials recorded from deep brain stimulation electrodes

2018 ◽  
Vol 120 (4) ◽  
pp. 1932-1944 ◽  
Author(s):  
Nicholas Maling ◽  
Scott F. Lempka ◽  
Zack Blumenfeld ◽  
Helen Bronte-Stewart ◽  
Cameron C. McIntyre
Keyword(s):  
Deep Brain Stimulation ◽  
Local Field ◽  
Brain Stimulation ◽  
Local Field Potentials ◽  
Patient Specific ◽  
Beta Activity ◽  
Field Potentials ◽  
Clinical Biomarkers ◽  
Scientific Platform ◽  
Deep Brain

Clinical deep brain stimulation (DBS) technology is evolving to enable chronic recording of local field potentials (LFPs) that represent electrophysiological biomarkers of the underlying disease state. However, little is known about the biophysical basis of LFPs, or how the patient’s unique brain anatomy and electrode placement impact the recordings. Therefore, we developed a patient-specific computational framework to analyze LFP recordings within a clinical DBS context. We selected a subject with Parkinson’s disease implanted with a Medtronic Activa PC+S DBS system and reconstructed their subthalamic nucleus (STN) and DBS electrode location using medical imaging data. The patient-specific STN volume was populated with 235,280 multicompartment STN neuron models, providing a neuron density consistent with histological measurements. Each neuron received time-varying synaptic inputs and generated transmembrane currents that gave rise to the LFP signal recorded at DBS electrode contacts residing in a finite element volume conductor model. We then used the model to study the role of synchronous beta-band inputs to the STN neurons on the recorded power spectrum. Three bipolar pairs of simultaneous clinical LFP recordings were used in combination with an optimization algorithm to customize the neural activity parameters in the model to the patient. The optimized model predicted a 2.4-mm radius of beta-synchronous neurons located in the dorsolateral STN. These theoretical results enable biophysical dissection of the LFP signal at the cellular level with direct comparison to the clinical recordings, and the model system provides a scientific platform to help guide the design of DBS technology focused on the use of subthalamic beta activity in closed-loop algorithms. NEW & NOTEWORTHY The analysis of deep brain stimulation of local field potential (LFP) data is rapidly expanding from scientific curiosity to the basis for clinical biomarkers capable of improving the therapeutic efficacy of stimulation. With this growing clinical importance comes a growing need to understand the underlying electrophysiological fundamentals of the signals and the factors contributing to their modulation. Our model reconstructs the clinical LFP from first principles and highlights the importance of patient-specific factors in dictating the signals recorded.

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