Presentation of central nervous system sarcoidosis as intracranial tumors

1985 ◽  
Vol 63 (6) ◽  
pp. 851-856 ◽  
Author(s):  
W. Craig Clark ◽  
James D. Acker ◽  
F. Curtis Dohan ◽  
Jon H. Robertson

✓ Five cases of sarcoid presenting as an intracranial tumor are reported. In one instance, the lesion presented as a tumor in the cerebellopontine angle, a site not previously reported for the initial presentation of sarcoid isolated to the central nervous system. The role of computerized tomography, surgery, and steroid therapy is discussed. In the absence of pulmonary involvement, serum angiotensin-converting enzyme levels do not appear to be helpful in predicting steroid response.

1974 ◽  
Vol 40 (1) ◽  
pp. 34-36 ◽  
Author(s):  
Richard J. Wurtman ◽  
Nicholas T. Zervas

✓ The authors, at the invitation of the Editorial Board, have outlined their general interpretation of the role of monoamine neurotransmitters following injury to the central nervous system. Their work on experimental stroke is discussed, and its relevance to spinal cord injuries accompanied by comparable hemorrhage and ischemia involving neurons is implied.


Neurosurgery ◽  
1981 ◽  
Vol 9 (6) ◽  
pp. 706-709 ◽  
Author(s):  
Elizabeth Bullitt ◽  
Barbara J. Crain

Abstract A 10-month-old infant with a small. unilateral, peripheral retinal lesion also had a large. well-encapsulated. suprasellar retinoblastoma. The primary vs. the metastatic nature of the intracranial tumor is considered. It is postulated that primary intracranial tumors may arise within areas of the central nervous system embryologically related to the retina in patients with the genetic form of retinoblastoma.


1971 ◽  
Vol 34 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Harold A. Wilkinson ◽  
Ernest J. Ferris ◽  
Albert L. Muggia ◽  
Robert C. Cantu

✓ The authors report their experience with four recent cases of tuberculosis affecting the central nervous system (CNS), including tuberculous meningitis and tuberculomas of both the cerebrum and the cerebellum. They emphasize that antituberculous drugs have given the neurosurgeon a role of increased importance and effectiveness in the management of CNS tuberculosis. Shunts, radical excisions, and fusion have new significance. Angiography and brain scans may reveal operable lesions. The authors believe that CNS tuberculosis should always include triple therapy with INH, PAS, and streptomycin plus corticosteroids to control cerebral edema and help to minimize basilar adhesions and hydrocephalus in tuberculous meningitis.


1973 ◽  
Vol 38 (5) ◽  
pp. 627-630
Author(s):  
Jean Pecker ◽  
Jacques Simon ◽  
Gilles Guy ◽  
Michel Carsin ◽  
Michel Jan

✓ The authors present two cases of intracranial tumors that metastasized through the CSF to the spinal cord and its roots, and discuss the value and hazards of radiological studies in making the diagnosis. Medulloblastomas, pinealomas, and ependymomas are the most common intracranial tumors to metastasize in this fashion. The metastases usually locate in the dural fundus and roots of the cauda equina due to the hydrodynamics of the CSF.


2020 ◽  
pp. 49-56
Author(s):  
T. Shirshova

Disorders of the musculoskeletal system in school-age children occupy 1-2 places in the structure of functional abnormalities. Cognitive impairment without organic damage to the central nervous system is detected in 30-56% of healthy school children. Along with the increase in the incidence rate, the demand for rehabilitation systems, which allow patients to return to normal life as soon as possible and maintain the motivation for the rehabilitation process, is also growing. Adaptation of rehabilitation techniques, ease of equipment management, availability of specially trained personnel and availability of technical support for complexes becomes important.


2019 ◽  
Vol 20 (7) ◽  
pp. 750-758 ◽  
Author(s):  
Yi Wu ◽  
Hengxun He ◽  
Zhibin Cheng ◽  
Yueyu Bai ◽  
Xi Ma

Obesity is one of the main challenges of public health in the 21st century. Obesity can induce a series of chronic metabolic diseases, such as diabetes, dyslipidemia, hypertension and nonalcoholic fatty liver, which seriously affect human health. Gut-brain axis, the two-direction pathway formed between enteric nervous system and central nervous system, plays a vital role in the occurrence and development of obesity. Gastrointestinal signals are projected through the gut-brain axis to nervous system, and respond to various gastrointestinal stimulation. The central nervous system regulates visceral activity through the gut-brain axis. Brain-gut peptides have important regulatory roles in the gut-brain axis. The brain-gut peptides of the gastrointestinal system and the nervous system regulate the gastrointestinal movement, feeling, secretion, absorption and other complex functions through endocrine, neurosecretion and paracrine to secrete peptides. Both neuropeptide Y and peptide YY belong to the pancreatic polypeptide family and are important brain-gut peptides. Neuropeptide Y and peptide YY have functions that are closely related to appetite regulation and obesity formation. This review describes the role of the gutbrain axis in regulating appetite and maintaining energy balance, and the functions of brain-gut peptides neuropeptide Y and peptide YY in obesity. The relationship between NPY and PYY and the interaction between the NPY-PYY signaling with the gut microbiota are also described in this review.


2018 ◽  
Vol 17 (4) ◽  
pp. 272-279 ◽  
Author(s):  
Yudan Zhu ◽  
Shuzhang Zhang ◽  
Yijun Feng ◽  
Qian Xiao ◽  
Jiwei Cheng ◽  
...  

Background & Objective: The large conductance calcium-activated potassium (BK) channel, extensively distributed in the central nervous system (CNS), is considered as a vital player in the pathogenesis of epilepsy, with evidence implicating derangement of K+ as well as regulating action potential shape and duration. However, unlike other channels implicated in epilepsy whose function in neurons could clearly be labeled “excitatory” or “inhibitory”, the unique physiological behavior of the BK channel allows it to both augment and decrease the excitability of neurons. Thus, the role of BK in epilepsy is controversial so far, and a growing area of intense investigation. Conclusion: Here, this review aims to highlight recent discoveries on the dichotomous role of BK channels in epilepsy, focusing on relevant BK-dependent pro- as well as antiepileptic pathways, and discuss the potential of BK specific modulators for the treatment of epilepsy.


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