Changes in gamma-aminobutyric acid and somatostatin in epileptic cortex associated with low-grade gliomas

1992 ◽  
Vol 77 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Michael M. Haglund ◽  
Mitchel S. Berger ◽  
Dennis D. Kunkel ◽  
JoAnn E. Franck ◽  
Saadi Ghatan ◽  
...  
Keyword(s):  
Epileptiform Activity ◽  
Aminobutyric Acid ◽  
Low Grade ◽  
Tumor Infiltration ◽  
Gamma Aminobutyric Acid ◽  
Content Type ◽  
Low Grade Gliomas ◽  
Neuronal Populations ◽  
Significant Difference

✓ The role of specific neuronal populations in epileptic foci was studied by comparing epileptic and nonepileptic cortex removed from patients with low-grade gliomas. Epileptic and nearby (within 1 to 2 cm) nonepileptic temporal lobe neocortex was identified using electrocorticography. Cortical specimens taken from four patients identified as epileptic and nonepileptic were all void of tumor infiltration. Somatostatin- and γ-aminobutyric acid (GABAergic)-immunoreactive neurons were identified and counted. Although there was no significant difference in the overall cell count, the authors found a significant decrease in both somatostatin- and GABAergic-immunoreactive neurons (74% and 51 %, respectively) in the epileptic cortex compared to that in nonepileptic cortex from the same patient. It is suggested that these findings demonstrate changes in neuronal subpopulations that may account for the onset and propagation of epileptiform activity in patients with low-grade gliomas.

A randomized trial of radiotherapy versus radiotherapy plus CCNU for incompletely resected low-grade gliomas: a Southwest Oncology Group study

1993 ◽  
Vol 78 (6) ◽  
pp. 909-914 ◽  
Author(s):  
Harmon J. Eyre ◽  
John J. Crowley ◽  
Jeannette J. Townsend ◽  
James R. Eltringham ◽  
Robert A. Morantz ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Performance Status ◽  
Hematological Toxicity ◽  
Low Grade ◽  
Patient Age ◽  
Content Type ◽  
Low Grade Gliomas ◽  
Patient Âgé ◽  
Significant Difference ◽  
And Performance

✓ Sixty adult patients with incompletely excised low-grade gliomas were randomly assigned to receive radiotherapy (55 Gy over a total of 6½ to 7 weeks) either alone or with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; 100 mg/sq m every 6 weeks). Pathological review showed that six patients were ineligible for the study. Evaluation of patient age. extent of surgery, tumor grade, and performance status showed no significant differences between the treatment arms. The response rate, as judged by the disappearance or reduction in size of the tumor on computerized tomography scans, was 79% for radiation therapy alone versus 54% for irradiation plus CCNU. The median survival time was 4.45 years for all patients, with no significant difference between treatment arms (p = 0.7). For the group as a whole, patient age and performance status were the most important prognostic parameters. The majority of patients receiving chemotherapy experienced moderate hematological toxicity. This study demonstrates that CCNU chemotherapy does not improve the results of radiation therapy in the treatment of incompletely excised low-grade gliomas.

Brain amino acid concentrations during diving and acid-base stress in turtles

1985 ◽  
Vol 58 (6) ◽  
pp. 1751-1754 ◽  
Author(s):  
B. M. Hitzig ◽  
M. P. Kneussl ◽  
V. Shih ◽  
R. D. Brandstetter ◽  
H. Kazemi
Keyword(s):  
Amino Acid ◽  
Aminobutyric Acid ◽  
Breath Hold ◽  
Gamma Aminobutyric Acid ◽  
Amino Acid Neurotransmitters ◽  
Acid Base ◽  
Ventilatory Drive ◽  
Amino Acid Concentrations ◽  
Brain Amino Acid

To assess the role of brain amino acid neurotransmitters in the breath hold of diving animals, concentrations of free amino acids present in the brains of turtles immediately after 2 h of apneic diving (at 20 degrees C) were measured. Additionally, the same measurements were performed on four other groups of animals subjected to 2 h of hypercapnia (8% CO2 in air), anoxia (N2 breathing), anoxia plus hypercapnia (8% CO2–92% N2), or air breathing (control). Significant changes in the concentrations of the inhibitory amino acid neurotransmitters known to affect respiration [gamma-aminobutyric acid (GABA) and taurine] were seen. GABA increased significantly in those animals subjected to anoxia, whereas taurine decreased significantly in the diving animals and increased significantly in those subjected to anoxia plus hypercapnia. These results suggest that the attenuated central ventilatory drive during diving in these animals may be related to alterations in brain concentrations of GABA and taurine.

scholarly journals The role of clinical and molecular characteristics in low grade gliomas

2017 ◽  
Vol 28 ◽  
pp. vi75-vi76
Author(s):  
A. Mura ◽  
E. Franceschi ◽  
S. Minichillo ◽  
A. Tosoni ◽  
A. Fioravanti ◽  
...  
Keyword(s):  
Molecular Characteristics ◽  
Low Grade ◽  
Low Grade Gliomas

Exploring the role of inflammation in the malignant transformation of low-grade gliomas

2016 ◽  
Vol 297 ◽  
pp. 132-140 ◽  
Author(s):  
Nicole Michelson ◽  
Jordina Rincon-Torroella ◽  
Alfredo Quiñones-Hinojosa ◽  
Jeffrey P. Greenfield
Keyword(s):  
Malignant Transformation ◽  
Low Grade ◽  
Low Grade Gliomas

Store atmosphere and impulse: a cross-cultural study

2019 ◽  
Vol 47 (8) ◽  
pp. 817-835 ◽  
Author(s):  
Ludmila Bandeira Lima Barros ◽  
Martin de La Martinière Petroll ◽  
Cláudio Damacena ◽  
Marc Knoppe
Keyword(s):  
Structural Equation ◽  
Emotional Responses ◽  
Environment Design ◽  
Content Type ◽  
Significant Difference ◽  
Culture Characteristics ◽  
Impulse Purchase ◽  
Buying Behaviour ◽  
Moderating Role

Purpose The purpose of this paper is to investigate the influence of store atmosphere on consumers’ positive emotional responses and impulsive purchase behaviour. In addition, it analyses the moderating role of culture characteristics and situational variables on this influence. Design/methodology/approach The study carried out a quantitative face-to-face on-site survey of a retail fashion brand in two countries, Brazil and Germany. This paper extended the original model of Jung Chang et al. (2014) based on environment, design and social features (staff) by adding store atmosphere factors such as layout, music and lighting (Mohan et al., 2013), thereby defining store atmosphere as the way customers perceive and experience the combination of all those factors. Findings Data analysis from 313 consumers by structural equation modelling (PLS–SEM) showed that most factors influence consumers’ positive emotional responses, but no significant difference between countries. However, the effect of emotions on impulse purchase behaviour is stronger among collectivist consumers (Brazil) than among individualists (Germany). Originality/value This study sheds light on the links between store atmosphere and retail market in Brazil and Germany, framing its conclusions in the context of a comparison between cultures. The paper extends the growing research in the area by exploring the moderating role of the individualism–collectivism dimension of national culture in consumer buying behaviour by comparing the strength of various relationships across shoppers from individualistic vs collectivistic cultures.

Hydrocephalus associated with intramedullary low-grade gliomas

1995 ◽  
Vol 83 (3) ◽  
pp. 480-485 ◽  
Author(s):  
Giuseppe Cinalli ◽  
Christian Sainte-Rose ◽  
Arielle Lellouch-Tubiana ◽  
Guy Sebag ◽  
Dominique Renier ◽  
...  
Keyword(s):  
Spinal Tumor ◽  
Low Grade ◽  
Content Type ◽  
Low Grade Gliomas ◽  
Leptomeningeal Seeding ◽  
Secondary Implantation ◽  
Csf Hydrodynamics ◽  
Neuroradiological Examination ◽  
Subarachnoid Spaces ◽  
Fine Print

✓ Over the past 15 years, eight children affected by intramedullary low-grade gliomas associated with hydrocephalus were treated at l'Hôpital des Enfants Malades. In all cases the diagnosis of hydrocephalus was made prior to that of the spinal tumor. Neuroradiological examination of all patients revealed contrast enhancement of the intracranial subarachnoid spaces. In six cases this was progressive, suggesting subarachnoid spread of the tumor, which was confirmed in two cases by histological examination. The authors analyzed 38 cases of intramedullary low-grade glioma associated with hydrocephalus that were reported in the literature. Fifteen of the cases had intracranial leptomeningeal seeding. Several hypotheses have been proposed to explain this unusual association, such as 1) increase in cerebrospinal fluid (CSF) viscosity because of elevated fluid protein content; 2) obliteration of the cisterna magna due to a rostral extension of the tumor; and 3) blockage of the spinal subarachnoid pathways of CSF resorption. Two other theories seem of particular interest. Bamford and Labadie suggested that the abnormal presence of fibrinogen in the CSF and its transformation into fibrin at the level of the basal cisterns and Pacchioni's granulation may alter CSF hydrodynamics. This mechanism alone is sufficient to induce hydrocephalus of the communicating type. In addition, as suggested by Maurice-Williams and Lucey, the resulting leptomeningeal fibrosis might predispose secondary implantation of neoplastic elements in the subarachnoid spaces of the intracranial compartment.

Role of cholinergic system in modulating gamma-aminobutyric acid and dopamine functions in rat brain

1985 ◽  
Vol 6 (1) ◽  
pp. 47-54 ◽  
Author(s):  
S. K. Rastogi ◽  
R. B. Rastogi ◽  
R. L. Singhal ◽  
Y. D. Lapierre
Keyword(s):  
Rat Brain ◽  
Cholinergic System ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid
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