Indolent granulomatous angiitis

1994 ◽  
Vol 81 (3) ◽  
pp. 472-476 ◽  
Author(s):  
Mahlon D. Johnson ◽  
Robert Maciunas ◽  
Jeffrey Creasy ◽  
Robert D. Collins
Keyword(s):  
Clinical Course ◽  
Cerebellar Infarction ◽  
Cortical Lesions ◽  
Pathological Findings ◽  
Central Nervous System Vasculitis ◽  
Granulomatous Angiitis ◽  
Content Type ◽  
Presenting Symptoms ◽  
Tissue Changes ◽  
Prompt Diagnosis

✓ Granulomatous angiitis is a rare, treatable central nervous system vasculitis. Prompt diagnosis may be thwarted by protean presenting symptoms, an indolent clinical course, and atypical neurological findings. The authors describe a case of indolent granulomatous angiitis in which the patient presented with cerebellar signs and tissue changes suggestive of an atypical cerebellar infarction. After several years of remissions and relapses, repeat evaluation and biopsy disclosed granulomatous angiitis both in remote infarctions and in new cortical lesions. The clinical course and neuroradiological and pathological findings are compared with previous reports of fulminant and indolent granulomatous angiitis.

Predictive value of perfusion defect size using N-isopropyl-(I-123)-p-iodoamphetamine emission tomography in acute stroke

1984 ◽  
Vol 61 (3) ◽  
pp. 449-452 ◽  
Author(s):  
Robert G. L. Lee ◽  
Thomas C. Hill ◽  
B. Leonard Holman ◽  
Henry D. Royal ◽  
Daniel H. O'Leary ◽  
...  
Keyword(s):  
Perfusion Defect ◽  
Clinical Course ◽  
Lesion Size ◽  
Defect Size ◽  
Emission Tomography ◽  
Perfusion Abnormality ◽  
Content Type ◽  
Brain Scans ◽  
Presenting Symptoms ◽  
Fine Print

✓ Sixteen patients with acute cerebral infarction who were studied with N-isopropyl-I-123-p-iodoamphetamine (IMP) brain scans were followed to determine if the extent of perfusion abnormality was predictive of the clinical course. Lesion size and diminished density on the scans appeared to correlate well with presenting symptoms, but were not predictive of outcome. When evaluated by IMP scanning in conjunction with computerized tomography, however, a group of patients could be identified in whom therapy may improve prognosis.

Multiple melanotic meningiomas of the cervical cord

1971 ◽  
Vol 34 (4) ◽  
pp. 555-559 ◽  
Author(s):  
Michael Scott ◽  
Vincent L. Ferrara ◽  
Augustin R. Peale
Keyword(s):  
Clinical Course ◽  
Cervical Cord ◽  
Pathological Findings ◽  
Content Type ◽  
History Of ◽  
Melanotic Tumors ◽  
Fine Print

✓ The clinical course and pathological findings are described in a patient who survived 17 years following her first operation for multiple encapsulated extradural and intradural melanotic meningiomas of the cervical meninges. Although the recurrence of these tumors suggested a malignant histological component, the long history of survival, the restricted location, and absence of melanotic tumors elsewhere, and the basic histological background all favored an uncommon variant of meningioma.

Fever in the returning traveller: Dual infection with SARS-CoV-2 and Plasmodium falciparum malaria

2020 ◽  
pp. 105-108
Author(s):  
MA Parker ◽  
E Nell ◽  
A Mowlana ◽  
MS Moolla ◽  
S Karamchand ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Clinical Course ◽  
Febrile Illness ◽  
Plasmodium Falciparum Malaria ◽  
Dual Infection ◽  
Pneumocystis Pneumonia ◽  
Case Presentation ◽  
Presenting Symptoms ◽  
Uncomplicated Plasmodium Falciparum Malaria

Background: More than 90% of the global 400 000 annual malaria deaths occur in Africa. The current SARS-CoV-2 pandemic has resulted in more than 830 000 deaths in its first 10 months. Case presentation: This case describes a patient who had travelled from Mozambique to Cape Town, presented with a mild febrile illness, and was diagnosed with both COVID-19 and uncomplicated Plasmodium falciparum malaria infection. She responded well to malaria treatment and had an uneventful COVID-19 admission. Her blood smear showed a low malaria parasitaemia and a relatively high gametocyte load. Conclusion: We postulate that her clinical course and abnormal smear could well be due to reciprocal disease-modifying effects of the infections. The presenting symptoms of COVID-19 may mimic endemic infectious diseases including malaria, tuberculosis, pneumocystis pneumonia and influenza thus there is a need for clinical vigilance to identify and treat such co-infections.

Adult neuronal ceroid lipofuscinosis with clinical findings consistent with a butterfly glioma

1998 ◽  
Vol 88 (2) ◽  
pp. 314-318 ◽  
Author(s):  
Stefanie Hammersen ◽  
Mario Brock ◽  
Jorge Cervós-Navarro
Keyword(s):  
Muscular Atrophy ◽  
Neuronal Ceroid Lipofuscinosis ◽  
Cerebral Atrophy ◽  
Brain Biopsy ◽  
Progressive Dementia ◽  
Ataxic Gait ◽  
Content Type ◽  
Presenting Symptoms ◽  
Ceroid Lipofuscinosis ◽  
Kufs Disease

✓ The authors report a case of neuronal ceroid lipofuscinosis (Kufs' disease) confirmed by stereotactically obtained brain biopsy findings and initially diagnosed as a butterfly glioma. The presenting symptoms in the 64-year-old patient were mental alterations with progressive dementia, followed by muscular atrophy and myoclonia with distal preponderance. The mild initial disturbances of coordination increased, and the patient developed a markedly ataxic gait. Computerized tomography (CT) scanning and magnetic resonance imaging revealed generalized cerebral atrophy and a bifrontal space-occupying lesion involving the callosum. The original “clearcut” diagnosis of glioblastoma multiforme, based on CT scans, was unexpectedly disproved by examination of stereotactically obtained brain biopsy specimens, which revealed a neuronal ceroid lipofuscinosis (Kufs' disease). To the authors' knowledge, this is the first report of a case presenting with both diffuse brain atrophy and localized accumulation of neuronal lipofuscin, mimicking a mass lesion on radiological studies.

Terminal ventriculostomy for syringomyelia

1977 ◽  
Vol 46 (5) ◽  
pp. 609-617 ◽  
Author(s):  
W. James Gardner ◽  
Herbert S. Bell ◽  
Pete N. Poolos ◽  
Donald F. Dohn ◽  
Marta Steinberg
Keyword(s):  
Clinical Course ◽  
Adult Life ◽  
Central Canal ◽  
Conus Medullaris ◽  
Fetal Life ◽  
Filum Terminale ◽  
Content Type ◽  
Fine Print

✓ The clinical course of 12 patients who underwent terminal ventriculostomy for syringomyelia is presented. Opening the central canal at the tip of the conus medullaris is a relatively benign procedure that improves the symptoms of syringomyelia and syringobulbia. This canal normally terminates at the tip of the conus, but in each of the 12 surgical specimens it continued into the filum terminale for distances up to 8 cm. In most cases the tip of the conus was located more caudally than normal, indicating some degree of tethering in fetal life. This belief is supported by the fact that the newborn, whose conus is tethered to a lipoma at the sacral level, may develop syringomyelia in adult life.

Angioplasty for basilar artery atherosclerosis

1992 ◽  
Vol 77 (6) ◽  
pp. 941-944 ◽  
Author(s):  
Arvind Ahuja ◽  
Lee R. Guterman ◽  
Leo N. Hopkins
Keyword(s):  
Basilar Artery ◽  
Balloon Angioplasty ◽  
Medical Management ◽  
Clinical Course ◽  
Anticoagulation Therapy ◽  
Transient Ischemic Attacks ◽  
Content Type ◽  
Severe Atherosclerosis ◽  
Percutaneous Transluminal ◽  
Fine Print

✓ A case is presented of severe atherosclerosis of the basilar artery, successfully treated with percutaneous transluminal balloon angioplasty. Crescendo daily transient ischemic attacks consisted of alternating hemiplegia and were refractory to medical management, including anticoagulation therapy. The clinical course, endovascular treatment, and results are described. Prior published experiences with this condition are reviewed.

scholarly journals Managing All the Genotypic Knowledge: Approach to a Septic Patient Colonized by Different Enterobacteriales with Unique Carbapenemases

2019 ◽  
Vol 63 (8) ◽  
Author(s):  
Stacy C. Park ◽  
Alexander M. Wailan ◽  
Katie E. Barry ◽  
Kasi Vegesana ◽  
Joanne Carroll ◽  
...  
Keyword(s):  
Septic Patient ◽  
Cirrhotic Patient ◽  
Clinical Course ◽  
Raoultella Planticola ◽  
Content Type

ABSTRACT The recent development of new antimicrobials active against carbapenemase-producing Enterobacteriales (CPE) has brought new hope for the treatment of infections due to these organisms. However, the evolving epidemiology of bacteria with carbapenemases may complicate management, as providers are faced with treating patients colonized by bacteria producing multiple carbapenemases. Here, we present the clinical course and treatment of Raoultella planticola bacteremia in a cirrhotic patient known to be colonized with both blaKPC- and blaOXA-48-carrying organisms.

Intracranial extension of an eccrine porocarcinoma

1999 ◽  
Vol 90 (1) ◽  
pp. 138-140 ◽  
Author(s):  
Ann M. Ritter ◽  
R. Scott Graham ◽  
Barbara Amaker ◽  
William C. Broaddus ◽  
Harold F. Young
Keyword(s):  
Soft Tissue ◽  
Malignant Tumor ◽  
Clinical Presentation ◽  
Intracranial Extension ◽  
Pathological Findings ◽  
Review Of The Literature ◽  
Radiographic Evidence ◽  
Content Type ◽  
Eccrine Porocarcinoma ◽  
Fine Print

✓ Eccrine porocarcinoma is a rare malignant tumor of the true sweat gland. It commonly presents in the lower extremities with lymphatic metastasis. The authors describe the clinical presentation, radiographic evidence, operative discoveries, and pathological findings in a patient with an eccrine porocarcinoma involving the soft tissue of the occiput, which had eroded through the cranium. A review of the literature failed to reveal any other such case. The discussion includes the epidemiology, pathogenesis, treatment, and outcome of eccrine porocarcinomas. The six reported cases of scalp eccrine tumors are reviewed.

Natural course of unoperated intracranial arteriovenous malformations: study of 50 cases

1989 ◽  
Vol 71 (6) ◽  
pp. 805-809 ◽  
Author(s):  
Youichi Itoyama ◽  
Syouzaburou Uemura ◽  
Yukitaka Ushio ◽  
Jun-Ichi Kuratsu ◽  
Nobuhito Nonaka ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
Poor Prognosis ◽  
Clinical Course ◽  
Initial Symptom ◽  
Intracranial Arteriovenous Malformations ◽  
Good Clinical Outcome ◽  
Content Type ◽  
Initial Rupture ◽  
High Incidence

✓ The clinical course of 50 patients with conservatively treated intracranial arteriovenous malformations (AVM's) was followed, most of them for more than 5 years. The average follow-up period was 13.4 years. The initial symptom was intracranial bleeding in 29 patients (58%) and seizure in 15 patients (30%). Small and deep-seated AVM's were associated with a high incidence of bleeding; however, repeated hemorrhages were not necessarily indicative of a poor prognosis. Children younger than 15 years had a better prognosis than adults. There was no correlation between pregnancy and bleeding. In the hemorrhage group, the incidence of rebleeding was 6.9% in the 1st year after initial rupture, 1.91% per year after 5 years, and 0.92% per year after 15 years. The overall incidence of rebleeding was 34.5% in the hemorrhage group. Of the 50 patients, 37 (74%) had a good clinical outcome, four (8%) had a fair outcome, and four (8%) had a poor outcome; five patients died.

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