scholarly journals EFFECT OF WATER-SOLUBLE QUERCETIN ON INDICATORS OF OXIDATIVE-NITROSATIVE STRESS IN TISSUES OF SUBMANDIBULAR SALIVARY GLANDS OF RATS UNDER LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE

2021 ◽  
Vol 21 (2) ◽  
pp. 175-181
Author(s):  
O.O. Shvaikovska ◽  
S.V. Denisenko ◽  
V.O. Kostenko
Keyword(s):  
Inflammatory Response ◽  
Salivary Glands ◽  
Nitrosative Stress ◽  
No Synthase ◽  
Systemic Inflammatory Response ◽  
Water Soluble ◽  
Male Rats ◽  
Soluble Form ◽  
Significant Shift ◽  
Submandibular Salivary Glands

The aim of this study was to investigate the effect of the water-soluble form of quercetin on the indicators of oxidative-nitrosative stress in the tissues of the submandibular salivary glands (SG) under conditions of lipopolysaccharide-induced systemic inflammatory response (SIR). The study was performed on 30 white Wistar male rats weighing 180-220 g, divided into 3 groups: 1st group included intact animals, 2nd group included animals, subjected to the systemic administration of lipopolysaccharide of Salmonella typhi, 3rd group involved animals, which received water-soluble quercetin complex with polyvinylpyrrolidone (corvitin) in a dosage of 100 mg/kg (10 mg/ g in terms of quercetin) intraperitoneally every 3 days, starting on the 30 day of the experiment with using S. typhi lipopolysaccharide. The latter was administered in a dose of 0.4 μg/kg body weight 3 times during the 1st week, and then once a week for the next 7 weeks. The study has demonstrated that applying quercetin under SIR restrains the production of reactive oxygen species in SG tissues: it reduces unstimulated production of superoxide anion radical and its induced generation with the administration of NADPH (by microsomes and NO-synthase), NADH (by mitochondria), S. typhi lipopolysaccharide (by leukocyte NADPH-oxidase). The administration of quercetin under SIR condition diminishes the signs of nitrosative stress in SG tissues, as evidenced by decrease in inducible NO-synthase activity without significant changes in ornithine decarboxylase activity and the level of coupling of constitutive isoform of NO-synthase, decreased concentration of highly active peroxynitrite, but, however, without significant shift in S-nitrosothiols content.

scholarly journals LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE ENHANCES THE DEVELOPMENT OF OXIDATIVE-NITROSATIVE STRESS IN SALIVARY GLANDS OF RATS UNDER ALCOHOL DAMAGE

2021 ◽  
Vol 67 (6) ◽  
pp. 60-67
Author(s):  
R.S. Kozaeva ◽  
◽  
M.O. Klymenko ◽  
V.О. Kostenko ◽  
◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Salivary Glands ◽  
Nitrosative Stress ◽  
Salmonella Typhi ◽  
No Synthase ◽  
Systemic Inflammatory Response ◽  
Aquaporin 5 ◽  
Superoxide Anion Production ◽  
Phagocyte Nadph Oxidase ◽  
Submandibular Salivary Glands

We addressed the role of lipopolysaccharide (LPS)-induced systemic inflammatory response (SIR) in the development of oxidative-nitrosative stress in the salivary glands of rats under the influence of alcohol. Ethanol (40%) at the dose of 24 mg/kg was administered intraperitoneally (ip) twice per day for 14 days. SIR was induced by ip administration of LPS (Salmonella typhi) at the dose 0.4 mg/kg for 1 week followed by a weekly LPS administration for 7 weeks. We found that long-term administration of ethanol in the back- ground of LPS-induced SIR increased the circulating level of proinflammatory markers (TNFa, IL-6) and C-reactive protein and this increase exceeded the respective values when LPS and alcohol were administered separately. Under these conditions, in submandibular salivary glands, the superoxide anion production by mitochondria respiratory chain was increased by 25.9 and 30.5%, by microsomal monooxygenases and NO synthase by 19.0 and 27,1%, by phagocyte NADPH-oxidase by 29.5 and 30.0%. The activity of inducible NO-synthase increased by 15.5 and 83.6%, the concentration of peroxynitrites of alkali and alkali-earth metals elevated by 32.5 and 58, 3%, and S- nitrosothiols raised by 20.2 and 22.7%. These changes were accompanied by a decrease in α-amylase activity and the aquaporin-5 concentration that impairs water and protein excretion by salivary glands. We conclude that adminis- tration of ethanol in the background of LPS-induced SIR results in more pronounced development of oxidative- nitrosative stress in the submandibular salivary glands and more marked dysfunction compared to separate use of LPS and alcohol.

scholarly journals QUERCETIN LIMITS THE DEVELOPMENT OF OXIDATIVE-NITROSATIVE STRESS IN PERIODONTAL TISSUES IN DIFFERENT MODELS SIMULATING SYSTEMIC INFLAMMATORY RESPONSE

2019 ◽  
Vol 19 (4) ◽  
pp. 83-87
Author(s):  
A.M. Yelins’ka ◽  
S.M. Nazarenko ◽  
V.O. Kostenko
Keyword(s):  
Inflammatory Response ◽  
Nadph Oxidase ◽  
Nitrosative Stress ◽  
Soft Tissues ◽  
Salmonella Typhi ◽  
No Synthase ◽  
Systemic Inflammatory Response ◽  
Water Soluble ◽  
Soluble Form ◽  
Periodontal Tissues

The study was carried out to investigate the effect produced by water-soluble form of quercetin (corvitin) on the indices of the development of oxidative-nitrosative stress in periodontal soft tissues of rats subjected to systemic inflammatory response. This condition was simulated by using two models: one was induced by the Salmonella typhi lipopolysaccharide (LPS) administration (in a dose of 0.4 μg / kg of body wt three times through the 1st week and once a week for the next 7 weeks), as well as on the 14th day after a moderate craniocerebral injury (CCI). Applying corvitin in a dose of 500 μg / kg (10 μg / kg recalculated as quercetin) every third day starting from the 30th day of the experiment with the use of pyrogenalum reduced the production of superoxide anion radical (.О) by NADPH-dependent electron transport chains (endoplasmic reticulum and NO-synthase) by 18.1%, but did not considerably affect the mitochondrial chain. .О production by leukocyte NADPH-oxidase was by 16.7% lower. The total NO synthase (NOS) activity in periodontal tissues decreased by 40.6%, and the content of peroxynitrite ions was inferior to the relevant result of the group received pyrogenalum by 13.9%. Administration of corvitin in a dose of 500 mg/kg for 7 days after CCI modeling reduced the (.О) production by NADPH-dependent chains by 20.9%, and by mitochondria by 31.7% on the 14th day of post-traumatic period. .О production by leukocyte NADPH-oxidase was by 35.8% lower. NOS activity in periodontal tissues decreased by 45.8%, the content of peroxynitrite ions was inferior to the relevant value in the group with modeled CCI by 25.7%. This suggests the conclusion that applying water-soluble form of quercetin in conditions of systemic inflammatory response limits the signs of oxidative-nitrosative stress in periodontal soft tissues of rats.

scholarly journals COMBINED EFFECTS OF QUERCETIN AND MODULATORS OF REDOX SENSITIVE FACTORS ON THE INDICATORS OF SYSTEMIC INFLAMMATORY RESPONSE, CARBOHYDRATE AND LIPID METABOLISM IN RATS EXPOSED TO INTRAPERITONEAL AND INTRAGINGIVAL ADMINISTRATION OF SALMONELLA TYPHI LIPOPOLY

2020 ◽  
Vol 20 (1) ◽  
pp. 13-18
Author(s):  
A.M. Yelins’ka ◽  
V.O. Kostenko
Keyword(s):  
Lipid Metabolism ◽  
Inflammatory Response ◽  
Systemic Inflammatory Response ◽  
Water Soluble ◽  
Soluble Form ◽  
Local Administration ◽  
Combined Effects ◽  
White Rats ◽  
Carbohydrate And Lipid Metabolism ◽  
Systemic And Local Administration

The experiment on 70 white rats was designed to investigate the effects of a water-soluble form of quercetin and modulators of AP-1 and Nrf2 transcription factors on the blood indicators of the systemic inflammatory response (SIR), and carbohydrate and lipid metabolism under the conditions of intraperitoneal and intra-gingival administration of S. typhi lipopolysaccharide (LPS). The animals were divided into 7 groups: the 1st group consisted of intact rats; the 2nd group included animals exposed to combined systemic and local administration of LPS - pyrogenal; the 3rd, 4th and 5th groups included the animals who were respectively injected with water-soluble complex of quercetin and polyvinylpyrrolidone (corvitin) in a dose of 100 mg/kg (10 mg/kg in terms of quercetin), an inhibitor of activation of AP-1 SR 11302 (in a dose of 1 mg / kg) and Keap1 / Nrf2 / antioxidant-responsive element (ARE) signaling pathway inducer epigallocatechin-3-gallate (EGCG, in a dose of 21.1 mg / kg) 3 times a week, starting on the 30th day since the experiment modeling. The 6th and 7th groups of the rats were subjected to combined effects of quercetin + SR 11302 and quercetin + EGCG, respectively. The study has demonstrated the combination of quercetin and SR 11302, or EGCG, in systemic and local administration of S. typhi lipopolysaccharide more effectively prevents the production of ceruloplasmin, a SIR marker, by-products of lipid peroxidation in rats’ blood, as well as increases its antioxidant potential compared to the separate application of these drugs. The combination of quercetin and SR 11302, or EGCG, under the experimental conditions has been found out to more effectively correct carbohydrate metabolism disorders (hyperinsulinemia, insulin resistance) than this occurs under separate usage of the agents, but does not reveal significant synergism in the correction of dyslipoproteinemia.

scholarly journals EFFECT OF MODULATORS OF REDOX-SENSITIVE TRANSCRIPTIONAL TRANSCRIPTION FACTORS ON MORPHOLOGICAL CHANGES IN PERIODONTIUM OF RATS DURING SYSTEM INFLAMMATORY RESPONSE

2019 ◽  
Vol 19 (3) ◽  
pp. 127-132
Author(s):  
A.M. Yelins’ka ◽  
I.I. Starchenko ◽  
V.O. Kostenko
Keyword(s):  
Inflammatory Response ◽  
Morphological Changes ◽  
Systemic Inflammatory Response ◽  
Water Soluble ◽  
Soluble Form ◽  
Alveolar Process ◽  
Experimental Conditions ◽  
Periodontal Tissues ◽  
White Rats ◽  
Destructive Processes

The experiment carried out on 30 white rats was aimed at studying pathomorphological changes in periodontal tissues during lipopolysaccharide-induced systemic inflammatory response and their nature when a water-soluble form of quercetin and epigallocatechin-3-gallate was administered to the animals. The rats were divided into 4 groups: the 1st group included animals after systemic administration of S. typhi lipopolysaccharide (pyrogenal); the 2nd and 3rd group involved animals, which were injected with a water-soluble form of quercetin (10 mg/kg) and epigallocatechin-3-gallate (21.1 mg/kg) intraperitoneally (every 3 days) starting from the 30th day of the experiment. Pyrogenal was administered in a dose of 0.4 μg/kg 3 times during the 1st week and once a week for the next 7 weeks. Sections of 4–6 μm thick were cut from paraffin blocks and stained with hematoxylin and eosin. It has been found out that experimental modeling of a systemic inflammatory response leads to the development of morphological signs of periodontitis, which are manifested by inflammation and destruction of periodontal pockets, the formation of pathological periodontal pockets, destructive changes in bone tissues of the alveolar process and in the cementum of the dental root. The use of the water-soluble form of quercetin and epigallocatechin-3-gallate in the experimental conditions changes the morphological picture of inflammatory and destructive processes in the periodontium: it prevents the formation of purulent exudate, reduces the intensity of the resorption of cementum and bone tissue of the alveolar process, accelerates the development and maturation of granulation tissue in the walls of periodontium, promotes the replacement of bone defects with connective tissue, and enhances the regeneration of cementum.

scholarly journals ROLE OF TRANSCRIPTIONAL FACTOR NF-κB IN DEVELOPMENT OF OXIDATIVE STRESS IN HEART OF RATS DURING SYSTEMIC INFLAMMATORY RESPONSE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE

2019 ◽  
Vol 19 (3) ◽  
pp. 108-112
Author(s):  
O.Ye. Akimov ◽  
A.Yu. Vetkina ◽  
A.I. Malyk ◽  
A.D. Shkodina ◽  
S.V. Denysenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Inflammatory Response ◽  
Catalase Activity ◽  
No Synthase ◽  
Systemic Inflammatory Response ◽  
Bacterial Lipopolysaccharide ◽  
Male Rats ◽  
Nuclear Transcription Factor ◽  
Basic Production

Systemic inflammatory response syndrome (SIRS) is a threatening complication that can lead to myocardial infarction. Activation of the nuclear transcription factor κB (NF-κB) plays an unambiguous role in the SIRS development. The purpose of this study is to determine the effect of NF-κB nuclear transcription factor activation on production of superoxide anion radical (O2•-), superoxide dismutase (SOD) and catalase activity, concentration of free malondialdehyde (MDA) in the heart of rats during SIRS modelling. The experiment was performed on 24 mature Wistar male rats weighing 180-220 g. Animals were divided into 3 groups consisting of 8 animals (control, SIRS group, NF-κB blockade group). SIRS was modelled by intraperitoneal administration of bacterial lipopolysaccharide (Pyrogenal) in a dose of 0.4 μg / kg 3 times a week in the first week; then once a week for 2 months. The blockade of NF-κB was performed by administration of ammonium pyrrolidine dithiocarbamate (PDTC) in a dose of 76 mg / kg. Production of O2•-, activities of SOD and catalase, concentration of MDA was investigated in 10% heart tissues homogenate. Induction of SIRS by Pyrogenal increases basic production of O2•- by 54.6% compared to the control group. Production of O2•- by microsomal electron transport chain (ETC) and NO synthase increases by 52.9%; production of O2•- by mitochondrial ETC increases by 38,9%. Activity of SOD increases by 1.86 times, activity of catalase increases by 1.53 times. The concentration of free MDA in heart tissues has grown by 81.2%. Blockade of the transcription factor NF-κB reduces basic production of O2•- by 38.9%; by microsomal ETC and NO synthase by 41%; by mitochondrial ETC by 22.2% compared to SIRS group. SOD activity decreases by 56.7%, while catalase activity does not statistically significantly change. The concentration of free MDA in heart tissues decreases by 31.4%. Activation of the nuclear transcription factor NF-κB in the heart of rats during SIRS induced by Pyrogenal leads to an increase in O2•- production with subsequent development of oxidative stress. Compensatory activation of antioxidant enzymes under these conditions is not able to prevent the development of oxidative stress in heart tissues.

QUERCETIN POTENTIATES ANTIRADICAL PROPERTIES OF EPIGALLOCATECHIN-3-GALLATE IN PERIODONTIUM OF RATS UNDER SYSTEMIC AND LOCAL ADMINISTRATION OF LIPOPOLISACCHARIDE OF SALMONELLA TYPHI

2019 ◽  
Vol 72 (8) ◽  
pp. 1499-1503
Author(s):  
Alina M. Yelins’ka ◽  
Lilia I. Liashenko ◽  
Vitalii O. Kostenko
Keyword(s):  
Nitrosative Stress ◽  
Salmonella Typhi ◽  
Water Soluble ◽  
Soluble Form ◽  
Tissue Homogenate ◽  
Local Administration ◽  
Related Factor ◽  
Periodontal Tissues ◽  
White Rats ◽  
Systemic And Local Administration

Introduction: There has been demonstrated that pharmaceutical effect of epigallocatechin-3-gallate (EGCG), a polyphenol, which is found in green tea (Camellia sinensis), is implemented through the activation of Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2).The importance of Keap1 / Nrf2 / antioxidant response element (ARE) system is determined by the fact that the state of NF-κB- and АР-1-associated pathways depends on its activity. Recent studies have demonstrated the property of quercetin to suppress ubiquitin-dependent proteolysis of complex of NF-κB and its inhibitory protein IκB. All this provides preconditions to eliminate the potentiality of NF-κB-dependent expression of the number of genes of pro-oxidant and pro-inflammatory proteins. However, co-effect produced by quercetin and EGCG on the oxidative nitrosative stress markers in the periodontal tissues is still unclear. The aim: To investigate the co-effect produced by quercetin and an inducer of the Keap1 / Nrf2 / ARE epigallocatechin-3-gallate on markers of oxidative-nitrosative stress in rats’ periodontium under the systemic and local administration of Salmonella typhi lipopolysaccharide (LPS). Materials and methods: The studies were conducted on 30 white rats of the Wistar line, divided into 5 groups: the 1st included intact animals, the 2nd was made up of animals after their exposure to combined systemic and local LPS administration, the 3rd and 4th groups included animals, which were given injections with water-soluble form of quercetin (corvitin) and EGCG respectively, and the 5th group involved rats, which were injected with co-administered corvitin and EGCG. The formation of superoxide anion radical (.О-2 ) was evaluated by a test with nitro blue tetrazolium using spectrophotometry of the periodontal soft tissue homogenate. The total activity of NO-synthase and concentration of peroxynitrite in the homogenate of the soft components of periodontium were evaluated spectrophotometrically. Results: Co-effect produced by corvitin and EGCG under systemic and local LPS administration is accompanied with reduced О-2 production by NADPH-dependent electron transport chains (microsomal and NOS) by 20.0 % (p<0.05) compared with values for the animals received separate corvitin during the experiment. .О-2 generation by the mitochondrial respiratory chain yielded to comparable data of the 3rd and 4th groups by 27.6 % (p<0.01) and 23.8 % (p<0.05) respectively. No differences were found between the groups exposed to combined or separate action of the above mentioned agents in the experiment when assessing О-2 generation by leukocyte NADPH-oxidase. Combined effect of corvitin and EGCG during systemic and local LSP administration showed the decrease in NOS activity and peroxynitrite concentration in periodontal tissues by 53.3 % (p<0.001) and 27.0 % (p<0.02) compared with the findings in the 3rd group, and by 42.0 % (p<0.01) and 22.3 % (p<0.01) in the 4th group. Conclusions: the co-administration of water-soluble form of quercetin and epigallocatechin-3-gallate under systemic and local introducing of lipopolysaccharide Salmonella typhi has been proven to be more effective means for preventing and correcting oxidative-nitrosative stress in the periodontal tissues than this occurs at separate administration of each of the polyphenols.

scholarly journals EFFECT OF TRANSCRIPTION FACTOR KAPPA B INHIBITORS ON METABOLIC AND STRUCTURAL DISORDERS IN BONE TISSUE UNDER COMBINED EXCESSIVE INTAKE OF FLUORIDE AND SODIUM NITRATE

2019 ◽  
Vol 19 (1) ◽  
pp. 65-70
Author(s):  
I.O. Kovalova ◽  
V.O. Kostenko
Keyword(s):  
Body Weight ◽  
Bone Mass ◽  
Sodium Nitrate ◽  
Nitrogen Monoxide ◽  
Total Activity ◽  
No Synthase ◽  
Water Soluble ◽  
Arginase Activity ◽  
Soluble Form ◽  
Structural Disorders

This experiment carried on 40 white Wistar rats aimed at studying the effect produced by inhibitors of the nuclear transcriptional factor kappa B (NF-κB) activation on the mechanisms of metabolic and structural disorders in the femoral bones and vertebrae under combined surplus fluoride and sodium nitrate intake. It has been found out that co-administration of sodium fluoride (10 mg/kg body weight) and sodium nitrate (500 mg/kg of body weight) for 30 days disrupts the autoregulation mechanism of nitrogen monoxide (NO) level in the femoral bones of the test rats that is manifested by an increase in the activity of total NO synthase and its inducible isoform against the background of a decrease in the total arginase activity and the activity of the constitutive NO synthase isoenzymes. Under these conditions, there has been observed the growth in the concentration of free hydroxyproline, N-acetylneuraminic and hexuronic acids in the femoral bones and vertebrae that is indicative of depolymerization of collagen, sialoglycoproteins and proteoglycans, decrease in bone mass, their density, mineral saturation, strength (the Simon index elevated). Inhibitors of NF-κB activation (ammonium pyrolidine dithiocarbamate and a water-soluble form of quercetin) restore the autoregulation mechanism of the NO level in the rats’ femoral bones that is accompanied by a decrease in the total activity of NO synthase, the activity of its inducible isoform, an increase in the total arginase activity and by limited peroxinitrite formation. Ammonium pyrolidine dithiocarbamate and a water-soluble form of quercetin have been shown to result in lowering in the content of free hydroxyproline, N-acetylneuraminic and hexuronic acids in bones that confirms their effectiveness as a means for correcting depolymerization of collagen, sialoglycoproteins and proteoglycans. There has been found their property to promote the growth of bone mass and density of the femurs and vertebrae.

scholarly journals QUERCETIN LIMITS THE PROGRESSION OF OXIDATIVE AND NITROSATIVE STRESS IN THE RATS’ TISSUES AFTER EXPERIMENTAL TRAUMATIC BRAIN INJURY

2020 ◽  
Vol 73 (10) ◽  
pp. 2127-2132
Author(s):  
Ivan V. Yavtushenko ◽  
Svitlana M. Nazarenko ◽  
Oleksandr V. Katrushov ◽  
Vitalii O. Kostenko
Keyword(s):  
Cerebral Hemisphere ◽  
Nitrosative Stress ◽  
Water Soluble ◽  
Cerebral Hemispheres ◽  
Soluble Form ◽  
Buffer Solution ◽  
Experimental Conditions ◽  
Oxidative And Nitrosative Stress ◽  
Periodontal Tissues ◽  
White Rats

The aim: To investigate the effect of water-soluble form of quercetin on the indices reflecting the progression of oxidative-nitrosative stress in the cerebral tissues and the periodontium of rats after experimental TBI. Materials and methods: The studies were conducted on 30 white rats of the Wistar line weighing 180-220 g, divided into 3 groups: the 1st group included pseudo-injured animals (subjected to ether anaesthesia, fixation without TBI modeling), the 2nd group included the animals exposed to modeled moderate TBI, the 3rd group involved the rats, which were given injections with water-soluble form of quercetin (corvitin, “Borshchahivskiy CPP”, Ukraine) intraperitoneally in a daily dose of 10 mg/kg recalculated for quercetin for 7 days following the TBI modeling. The formation of superoxide radical anion (.О2 -), activity of NO-synthase – total (NOS), its constitutive and inducible isoforms (cNOS, iNOS) – and concentration of peroxynitrite were evaluated spectrophotometrically. The level of lipid peroxidation (LPO) in the tissues was evaluated by the formationof a stained trimethine complex during the reaction of tiobarbituric acid (TBA). The activity of the antioxidant system was assessed by increasing in the concentration of TBA active products during 1.5 hour incubation in iron-ascorbate buffer solution, as well as by the activity of antioxidant enzymes – superoxide dismutase (SOD) and catalase. Results: The use of quercetin under the experimental conditions significantly reduced the О2 - generation by NADPH- and NADH-dependent electron transport chains by 30.2 and 35.0% (in the cerebral hemispheres) and by 23.5 and 32.5% (in the soft periodontal tissues), respectively, compared to the findings in the 2nd group. The production of this radical by leukocyte NADPH oxidase in these organs was inferior to the value of the 2nd group by 39.3 and 29.9%. We revealed that the use of quercetin in the experimental conditions probably reduced the activity of NOS, including iNOS, by 38.2 and 45.3% (in the cerebral hemispheres) and by 53.5 and 66.9% (in the soft periodontal tissues), respectively, compared with the findings in the 2nd group. Under these conditions, the cNOS activity went up by 50.0% and doubled, the peroxynitrite content was lower by 19.5 and 32.1% than that in the 2nd group. The administration of quercetin in the experimental conditions significantly reduced the concentration of TBA-active products in the homogenate of cerebral hemispheres and soft periodontal tissues. The development of decompensated LPO is also confirmed by a decrease in the activity of SOD and catalase. Conclusions: on the 7th day after modeling moderate TBI in rats the signs of oxidative-nitrosative stress are found not only in locus morbi (in the tissue of the cerebral hemisphere), but also in distant organs (periodontal tissues). Applying of water-soluble form of quercetin significantly reduces signs of oxidative-nitrosative stress in the tissue of the cerebral hemisphere of rats, as well as in periodontal tissues on the 7th day after moderate TBI modeling.

Protection by mTOR Inhibition on Zymosan-Induced Systemic Inflammatory Response and Oxidative/Nitrosative Stress: Contribution of mTOR/MEK1/ERK1/2/IKKβ/IκB-α/NF-κB Signalling Pathway

Inflammation ◽  
2017 ◽  
Vol 41 (1) ◽  
pp. 276-298 ◽  
Author(s):  
Seyhan Sahan-Firat ◽  
Meryem Temiz-Resitoglu ◽  
Demet Sinem Guden ◽  
Sefika Pinar Kucukkavruk ◽  
Bahar Tunctan ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Nitrosative Stress ◽  
Systemic Inflammatory Response ◽  
Signalling Pathway ◽  
Mtor Inhibition ◽  
Stress Contribution
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