Prevalence of p-16 Positive Laryngeal and Pharyngeal Tumors in Nepalese Population: A Hospital based Cross-sectional Study

Introduction: P16 overexpression is considered as a good prognostic marker for oropharyngeal squamous cell carcinoma. However, there are very few literatures on the prevalence and outcomes of p16 overexpression in non-oropharyngeal squamous cell carcinoma and benign head and neck tumors. The aim of our study was to estimate the hospital based prevalence of p16 positive laryngeal and pharyngeal tumors and to compare it with the prevalence of p16 expression in the non tumor tissue (tonsils). Methods: This was a descriptive cross-sectional study. Cases of all genders >15 years presenting with malignant or benign tumors of larynx and all the subsites of pharynx were included in the study for evaluation of p16 expression by immunohistochemistry. Tonsillar tissue of cases undergoing tonsillectomy for recurrent acute tonsillitis were taken as non-tumorous tissue to evaluate for p16 expression. Results: A total of 48 cases were included in our study with 24 cases having different tumors of head and neck region and 24 cases having recurrent acute tonsillitis who were kept under non-tumor group. Eight cases (33.3%) in the tumor group showed positive stain for p16 in IHC. In non tumor group, 7 cases (29.1%) showed positive IHC staining for p16. Conclusions: P16 expression can be present in both benign and malignant tumors of various subsites of head and neck region and also in tonsillar tissue affected by inflammation.

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Role of Ultrasound in the Diagnosis and Differentiation between Inflammatory and Cystic Swellings of Head and Neck Region

Journal of Contemporary Dentistry ◽

10.5005/jp-journals-10031-1155 ◽

2016 ◽

Vol 6 (2) ◽

pp. 117-124

Keyword(s):

Head And Neck ◽

Neck Region ◽

Cross Sectional Study ◽

Cross Sectional ◽

Head And Neck Region ◽

Ultrasonographic Diagnosis ◽

Intergroup Comparison ◽

Neck Lesion ◽

Solid Lesions

ABSTRACT Ultrasound means the form of sound energy beyond the audible range. Ultrasonography (USG) is a safe and reliable method of examination that causes little patient discomfort and provides valuable information concerning size, location, internal nature of soft tissue masses in oral and neck lesion. Ultrasound is capable of differentiating cystic from solid lesions. The aim of this study was to compare the ultrasonographic differentiation of inflammatory swelling and cystic swelling with each other in head and neck regions. Intergroup comparison was also carried out in the study. For this single-blind cross-sectional study, 45 cases with clinically obvious swelling in head and neck region were selected randomly. Following clinical and ultrasonographic diagnosis and appropriate further investigations, surgical intervention was carried out. After considering the results of all 45 cases of the present study, it can be concluded that clinical diagnosis had a sensitivity and accuracy of 85.71%, whereas ultrasonographic diagnosis had a sensitivity and accuracy of 98.57%. How to cite this article Chandak RM, Chandak MG, Rawlani SM. Role of Ultrasound in the Diagnosis and Differentiation between Inflammatory and Cystic Swellings of Head and Neck Region. J Contemp Dent 2016;6(2):117-124.

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A study on clinical profile of non otogenic otalgia

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20174326 ◽

2017 ◽

Vol 3 (4) ◽

pp. 1027

Author(s):

Valli Rajasekaran ◽

Sharath Kumar B. V.

Keyword(s):

Cervical Spondylosis ◽

Neck Region ◽

Cross Sectional Study ◽

Age Group ◽

Sectional Study ◽

Diagnostic Challenge ◽

Cross Sectional ◽

Temporomandibular Joint Dysfunction ◽

Head And Neck Region ◽

Detailed Evaluation

Background: Ear pain can be because of pathologies in the ear or in the surrounding head and neck region. This is because of rich innervations of the ear. Sometimes it poses a diagnostic challenge.Methods: A cross sectional study was conducted in our institute where patients with ear pain were evaluated. Those with non otogenic causes were included in the study. 59 patients were identified and studied for the underlying cause. The sociodemographic profiles of the patients with varying etiologies were studied. Results: The most common cause for referred pain was temporomandibular joint dysfunction. This was more common in 15-45 years and in older age group cervical spondylosis was more common. There was no significant sex predominance.Conclusions: Careful detailed evaluation of the patient should be done to identify the exact underlying cause and treat effectively.

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A clinical study of tuberculous cervical lymphadenopathy: surgeon’s perspectives

International Surgery Journal ◽

10.18203/2349-2902.isj20190407 ◽

2019 ◽

Vol 6 (2) ◽

pp. 581 ◽

Cited By ~ 2

Author(s):

Kiran Patel

Keyword(s):

Head And Neck ◽

Economic Status ◽

Cervical Lymphadenopathy ◽

Severity Of Illness ◽

Neck Region ◽

Cross Sectional Study ◽

Excision Biopsy ◽

Primary Malignancy ◽

Cross Sectional ◽

Head And Neck Region

Background: Cervical lymphadenopathy is common in this country. There are many causes of cervical lymphadenopathy like, malignancies, infections, autoimmune disorders, iatrogenic, and other miscellaneous conditions. There are more chances of wrong clinical diagnosis in case of lymphadenopathy than any other diseases. The present study was planned with the objective to study the clinical presentation of tuberculous cervical lymphadenopathy.Methods: A prospective, cross-sectional study was undertaken with inclusion of all cases of cervical lymphadenopathy attending the department of general surgery. The patients with cervical lymphadenopathy irrespective of age, sex, caste, religion, socio-economic status, duration and severity of illness were included in this study. The patients with primary malignancy, patients with clinical features of suspected malignancy like obvious growth or ulcer in head and neck region and pregnant women were excluded from the study.Results: Total 130 patients presented with cervical lymphadenopathy during the study duration. Infective etiology was the commonest (55, 42.31%) cause for the cervical lymphadenopathy followed by TB (50, 38.46%). The commonest age group affected by tuberculous cervical lymphadenopathy (TCL) was 20-35 years. The females (29, 58.00%) were more affected with TCL as compared to males (21, 42.00%). A majority of the patients (45, 90.00%) had unilateral TCL. Commonly involved lymph node group was level V (26, 52.00%). Other than excision biopsy (12 patients), no other type of surgery was needed in patients.Conclusions: Though, anti-tuberculous chemotherapy is the mainstay of treatment for TCL, surgical treatment is more useful in selected cases. In this regard, early diagnosis and treatment are critical in lowering the overall prevalence. Therefore, it is important that surgeons are aware of tuberculosis in the head and neck region.

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Patterns of stress coping and depression among patients with head and neck cancer: A Japanese cross-sectional study

Psycho-Oncology ◽

10.1002/pon.4549 ◽

2017 ◽

Vol 27 (2) ◽

pp. 556-562 ◽

Cited By ~ 3

Author(s):

Kanako Ichikura ◽

Aya Yamashita ◽

Taro Sugimoto ◽

Seiji Kishimoto ◽

Eisuke Matsushima

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Cross Sectional Study ◽

Stress Coping ◽

Sectional Study ◽

Cross Sectional

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Subjective and objective appearance of head and neck cancer patients following microsurgical reconstruction and associated quality of life─A cross-sectional study

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/j.jcms.2018.05.024 ◽

2018 ◽

Vol 46 (8) ◽

pp. 1275-1284 ◽

Cited By ~ 5

Author(s):

Katinka Kansy ◽

Jürgen Hoffmann ◽

Obada Alhalabi ◽

Nicole Mistele ◽

Kolja Freier ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Microsurgical Reconstruction

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Prevalence of Salivary Gland Neoplasms in the Head and Neck in Educational Hospitals in Cairo Governorate (Retrospective Cross Sectional Study) v1 (protocols.io.67ahhie)

protocols.io ◽

10.17504/protocols.io.67ahhie ◽

2019 ◽

Author(s):

wegdan sayed

Keyword(s):

Salivary Gland ◽

Head And Neck ◽

Cross Sectional Study ◽

Salivary Gland Neoplasms ◽

Sectional Study ◽

Cross Sectional

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Epidemiology of Traumatic Injuries in the Northeast Region of Haiti: A Cross-sectional Study

Prehospital and Disaster Medicine ◽

10.1017/s1049023x15005361 ◽

2015 ◽

Vol 30 (6) ◽

pp. 599-605 ◽

Cited By ~ 7

Author(s):

Adam R. Aluisio ◽

Annelies De Wulf ◽

Ambert Louis ◽

Christina Bloem

Keyword(s):

Emergency Department ◽

Head And Neck ◽

Traffic Accidents ◽

Road Traffic ◽

Cross Sectional Study ◽

Road Traffic Accidents ◽

Sectional Study ◽

Cross Sectional ◽

Traumatic Injuries ◽

Northeast Region

AbstractIntroductionMore than 90% of traumatic morbidity and mortality occurs in low- and middle-income countries (LMIC). Haiti is the poorest country in the Western Hemisphere and lacks contemporary statistics on the epidemiology of traumatic injuries. This study aimed to characterize the burden of traumatic injuries among emergency department patients in the Northeast region of Haiti.MethodsData were collected from the emergency departments of all public hospitals in the Northeast region of Haiti, which included the Fort Liberté, Ouanaminthe, and Trou du Nord sites. All patients presenting for emergent care of traumatic injuries were included. Data were obtained via review of emergency department registries and patient records from October 1, 2013 through November 30, 2013. Data on demographics, mechanisms of trauma, and anatomical regions of injury were gathered using a standardized tool and analyzed using descriptive statistics. Temporal analysis of injury frequency was explored using regression modeling.ResultsData from 383 patient encounters were accrued. Ouanaminthe Hospital treated the majority of emergent injuries (59.3%), followed by Fort Liberté (30.3%) and Trou du Nord (10.4%). The median age in years was 23 with 23.1% of patients being less than 15 years of age. Road traffic accidents (RTAs) and interpersonal violence accounted for 65.8% and 30.1% of all traumatic mechanisms, respectively. Extremity trauma was the most frequently observed anatomical region of injury (38.9%), followed by head and neck (30.3%) and facial (19.1%) injuries. Trauma due to RTA resulted in a single injury (83.8%) to either an extremity or the head and neck regions most frequently. A minority of patients had medical record documentation (37.9%). Blood pressure, respiratory rate, and mental status were documented in 19.3%, 4.1%, and 0.0% of records, respectively. There were 6.3 injuries/day during the data collection period with no correlation between the frequency of emergent trauma cases and day of the week (R^2=0.01).ConclusionsTraumatic injuries are a common emergent presentation in the Northeast region of Haiti with characteristics similar to other LMIC. Documentation and associated data to adequately characterize the burden of disease in this region are lacking. Road traffic accidents are the predominate mechanism of injury, suggesting that interventions addressing prevention and treatment of this common occurrence may provide public health benefits in this setting.AluisioAR,De WulfA,LouisA,BloemC.Epidemiology of traumatic injuries in the Northeast region of Haiti: a cross-sectional study.Prehosp Disaster Med.2015;30(6):599–605.

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