SQUAMOUS CELL CARCINOMA AS A LATE COMPLICATION OF CHRONIC OSTEOMYELITIS

ABSTRACTSquamous cell carcinoma is a rare but well documented complication of chronic osteomyelitis. With theadvent of antibiotics, better health care delivery to the people and improving socioeconomic conditions, theincidence of squamous cell carcinoma arising as a late complication of acute haematogenous osteomyelitishas become increasingly less. Occasional difficulty in the differential diagnosis of a pseudoepitheliomatoushyperplasia and well differentiated squamous cell carcinoma can be troublesome. These two cases arepresented to remind the clinician of this now increasingly rare complication of chronic osteomyelitis andthe occasional diagnostic dilemma involved in its histopathological diagnosis.Key Words: Squamous Cell Carcinoma, Chronic Osteomyelitis.

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Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x19847359 ◽

2019 ◽

Vol 7 ◽

pp. 2050313X1984735 ◽

Cited By ~ 2

Author(s):

Catherine F Roy ◽

Simon F Roy ◽

Feras M Ghazawi ◽

Erica Patocskai ◽

Annie Bélisle ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hidradenitis Suppurativa ◽

Rare Complication ◽

Excisional Biopsy ◽

Necrosis Factor Alpha ◽

Spindle Cells ◽

Poorly Differentiated ◽

Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

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Squamous cell carcinoma in mature cystic teratoma of the ovary

Medicinski pregled ◽

10.2298/mpns1210429a ◽

2012 ◽

Vol 65 (9-10) ◽

pp. 429-431 ◽

Cited By ~ 2

Author(s):

Jelena Amidzic ◽

Matilda Djolai ◽

Mihaela Mocko-Kacanski ◽

Aleksandar Gluhovic ◽

Jelena Ilic ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Rare Complication ◽

Cystic Teratoma ◽

Internal Surface ◽

Cystic Mass ◽

Mature Cystic Teratoma ◽

Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

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Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa

Cancers ◽

10.3390/cancers13051153 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1153

Author(s):

Elysia Racanelli ◽

Abdulhadi Jfri ◽

Amnah Gefri ◽

Elizabeth O’Brien ◽

Ivan Litvinov ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hidradenitis Suppurativa ◽

Case Reports ◽

Rare Complication ◽

Cox Proportional Hazards ◽

Cutaneous Squamous Cell Carcinoma ◽

Statistical Hypothesis ◽

Statistical Hypothesis Testing

Background: Cutaneous squamous cell carcinoma (cSCC) is a rare complication of hidradenitis suppurativa (HS). Objectives: To conduct a systematic review and an individual patient data (IPD) meta-analysis to describe the clinical characteristics of HS patients developing cSCC and determine predictors of poor outcome. Methods: Medline/PubMed, Embase, and Web of Science were searched for studies reporting cSCC arising in patients with HS from inception to December 2019. A routine descriptive analysis, statistical hypothesis testing, and Kaplan–Meier survival curves/Cox proportional hazards regression models were performed. Results: A total of 34 case reports and series including 138 patients were included in the study. The majority of patients were males (81.6%), White (83.3%), and smokers (n = 22/27 reported) with a mean age of 53.5 years. Most patients had gluteal (87.8%), Hurley stage 3 HS (88.6%). The mean time from the diagnosis of HS to the development of cSCC was 24.7 years. Human papillomavirus was identified in 12/38 patients tested. Almost 50% of individuals had nodal metastasis and 31.3% had distant metastases. Half of the patients succumbed to their disease. Conclusions: cSCC is a rare but life-threatening complication seen in HS patients, mainly occurring in White males who are smokers with severe, long-standing gluteal HS. Regular clinical examination and biopsy of any suspicious lesions in high-risk patients should be considered. The use of HPV vaccination as a preventive and possibly curative method needs to be explored.

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A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates

Journal of Drug Targeting ◽

10.1080/1061186x.2021.1929256 ◽

2021 ◽

pp. 1-31

Author(s):

Shinichiro Kina ◽

Reika Kawabata-Iwakawa ◽

Sho Miyamoto ◽

Akira Arasaki ◽

Hajime Sunakawa ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Resistance Mechanism ◽

Metronomic Chemotherapy ◽

Molecular Signature ◽

Well Differentiated ◽

Novel Therapeutic

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Retrospective analysis of Ca cervix postoperative: An institutional study

10.1055/s-0039-1685282 ◽

2016 ◽

Author(s):

Chandra Prakash

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Treatment Time ◽

Residual Disease ◽

Early Stage ◽

Treatment Length ◽

Recommended Treatment ◽

Carcinoma Of Cervix ◽

Well Differentiated

Introduction: Carcinoma of cervix is one of the leading causes of death worldwide and in developing countries like India. Cervical cancer is third most common cancer among women however there is a good chance of curability if diagnosed in early stage. Materials and Methods: We had analysed 78 patient of carcinoma of cervix post op who were registered from 2012 to 2015 at Dr. Ram Manohar Lohia Institute of Medical Sciences. Results: We analysed 78 patients between age of 32-70 years and median age is 50 year. Among all patients squamous cell carcinoma is most common (65 patient), adenocarcinoma were 12 and lieomyosarcoma was 1 patient. Among all patient 12 were of adenocarcinoma, 1 of lieomyosarcoma and 65 patient of squamous cell carcinoma. On examination 55 patients were NAD and 23 were residual. Among squamous cell carcinoma 35 were moderate differentiated, 18 were well differentiated and 12 were of poorly differentiated. On examination 55 patients were NAD rest were having disease. Gap between EBRT and SORBO ranging from 3 to 99 days and median is 27 days and median is 29 days. Treatment length varies from 4 cm to 8 cm and median is 6 cm. Ovoide size ranges from 2.5 cm to 3.5 cm and median is 2.5 cm. Dose per fraction ranges from 5 Gy to 9 Gy and median was 9 Gy. Median fraction of session were 2. Out of 78 patients 2 were developed metastasis and 6 having residual disease. 28 patients were NAD and rest were referral and send back to parent hospital. Conclusion: Due to lack of resources and awareness of disease maximum number of patient presented with advanced stage. The recommended treatment time could not be achieved due to scarcity of cancer centres, treatment time is prolonged. We have not found any relation between treatment length and outcome. We are still investigating to conclude to found out relation among these variables.

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Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

Case Reports in Dermatology ◽

10.1159/000487794 ◽

2018 ◽

Vol 10 (1) ◽

pp. 61-68 ◽

Cited By ~ 8

Author(s):

Ethan Frank ◽

David Macias ◽

Brian Hondorp ◽

Justin Kerstetter ◽

Jared C. Inman

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Low Cost ◽

Neck Mass ◽

Inclusion Cyst ◽

Neoplastic Change ◽

Epidermal Inclusion Cyst ◽

Hematoxylin And Eosin ◽

Well Differentiated

Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. The diagnosis was made incidentally after routine cyst bisection and hematoxylin and eosin staining. Given the potential for variable presentation and low cost of hematoxylin and eosin analysis, we recommend a low threshold for a comprehensive pathological search for malignancy in excised cysts when appropriate.

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