scholarly journals Comparative Study of Sesame Lignans (Sesamin, Episesamin and Sesamolin) Affecting Gene Expression Profile and Fatty Acid Oxidation in Rat Liver

2009 ◽  
Vol 55 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Takashi IDE ◽  
Jin Seon LIM ◽  
Tseye-Oidov ODBAYAR ◽  
Yasutaka NAKASHIMA
2002 ◽  
Vol 13 (5) ◽  
pp. 289-295 ◽  
Author(s):  
Masayo Kushiro ◽  
Takeshi Masaoka ◽  
Shinji Hageshita ◽  
Yoko Takahashi ◽  
Takashi Ide ◽  
...  

Author(s):  
Takashi Ide ◽  
Hideyuki Kobayashi ◽  
Lakshmikuttyamma Ashakumary ◽  
Isabelle A. Rouyer ◽  
Yoko Takahashi ◽  
...  

1989 ◽  
Vol 257 (4) ◽  
pp. R822-R828 ◽  
Author(s):  
M. J. Azain ◽  
J. A. Ontko

These studies were undertaken to further characterize and explain the differences in hepatic fatty acid metabolism between lean and obese Zucker rats. It was shown that the rate of palmitate or octanoate oxidation and the inhibition of palmitate oxidation by malonyl CoA in mitochondria isolated from lean and obese Zucker rats were similar. Cytochrome oxidase activity was similar in lean and obese rat livers. It was found that the addition of cytosol from the obese rat liver inhibited palmitate oxidation by 20-30% in mitochondria isolated from lean or obese rat livers and thus reproduced the conditions observed in the intact cell. Increased concentrations of metabolites such as malonyl CoA and glycerophosphate in the liver of the obese rat are likely contributors to this inhibitory effect. These results are extrapolated to the intact cell and suggest that decreased hepatic fatty acid oxidation in the obese rat can be accounted for by cytosolic influences on the mitochondria. The decreased rate of fatty acid oxidation observed in the intact hepatocyte or perfused liver cannot be explained by a defect in the capacity of mitochondria to oxidize substrate or by a decrease in mitochondrial number in the obese rat liver.


PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0122024 ◽  
Author(s):  
Linyi Li ◽  
Hisae Yoshitomi ◽  
Ying Wei ◽  
Lingling Qin ◽  
Jingxin Zhou ◽  
...  

Heart Rhythm ◽  
2016 ◽  
Vol 13 (12) ◽  
pp. 2368-2376 ◽  
Author(s):  
Takanori Yaegashi ◽  
Takeshi Kato ◽  
Soichiro Usui ◽  
Naomi Kanamori ◽  
Hiroshi Furusho ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document