Drug-mediated inhibition of ERBB2 signaling

Reactome ◽  
2020 ◽  
Author(s):  
Ron Bose ◽  
Rama Krishna Kancha ◽  
Anagha Krishna
Keyword(s):  
Erbb2 Signaling

scholarly journals Trastuzumab Modulates the Protein Cargo of Extracellular Vesicles Released by ERBB2+ Breast Cancer Cells

Membranes ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 199
Author(s):  
Silvia Marconi ◽  
Sara Santamaria ◽  
Martina Bartolucci ◽  
Sara Stigliani ◽  
Cinzia Aiello ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Breast Cancer Cells ◽  
Culture Supernatant ◽  
High Resolution Mass Spectrometry ◽  
Recombinant Antibody ◽  
Target Cells ◽  
Cellular Processes ◽  
Erbb2 Signaling

Cancers overexpressing the ERBB2 oncogene are aggressive and associated with a poor prognosis. Trastuzumab is an ERBB2 specific recombinant antibody employed for the treatment of these diseases since it blocks ERBB2 signaling causing growth arrest and survival inhibition. While the effects of Trastuzumab on ERBB2 cancer cells are well known, those on the extracellular vesicles (EVs) released from these cells are scarce. This study focused on ERBB2+ breast cancer cells and aimed to establish what type of EVs they release and whether Trastuzumab affects their morphology and molecular composition. To these aims, we performed immunoelectron microscopy, immunoblot, and high-resolution mass spectrometry analyses on EVs purified by differential centrifugation of culture supernatant. Here, we show that EVs released from ERBB2+ breast cancer cells are polymorphic in size and appearance and that ERBB2 is preferentially associated with large (120 nm) EVs. Moreover, we report that Trastuzumab (Tz) induces the expression of a specific glycosylated 50 kDa isoform of the CD63 tetraspanin and modulates the expression of 51 EVs proteins, including TOP1. Because these proteins are functionally associated with organelle organization, cytokinesis, and response to lipids, we suggest that Tz may influence these cellular processes in target cells at distant sites via modified EVs.

scholarly journals The Role of ErbB2 Signaling in the Onset of Terminal Differentiation of OligodendrocytesIn Vivo

2003 ◽  
Vol 23 (13) ◽  
pp. 5561-5571 ◽  
Author(s):  
Ju Young Kim ◽  
Qin Sun ◽  
Michael Oglesbee ◽  
Sung Ok Yoon
Keyword(s):  
Terminal Differentiation ◽  
Erbb2 Signaling

The impact of glucocorticoids on Neuregulin-1/ERBB2 signaling in cardiomyocyte proliferation and heart regeneration

2020 ◽  
Vol 140 ◽  
pp. 30
Author(s):  
Nicola Pianca ◽  
Francesca Pontis ◽  
Alla Aharonov ◽  
Chiara Bongiovanni ◽  
Martina Mazzeschi ◽  
...  
Keyword(s):  
Heart Regeneration ◽  
Cardiomyocyte Proliferation ◽  
Neuregulin 1 ◽  
The Impact ◽  
Erbb2 Signaling

scholarly journals A dual role for ErbB2 signaling in cardiac trabeculation

Development ◽  
2010 ◽  
Vol 137 (22) ◽  
pp. 3867-3875 ◽  
Author(s):  
J. Liu ◽  
M. Bressan ◽  
D. Hassel ◽  
J. Huisken ◽  
D. Staudt ◽  
...  
Keyword(s):  
Dual Role ◽  
Erbb2 Signaling

scholarly journals To Determine Pivotal Genes Driven by Methylated DNA in Obstructive Sleep Apnea Hypopnea Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yan Li ◽  
Yajuan Zhang
Keyword(s):  
Dna Methylation ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Molecular Mechanisms ◽  
Sleep Apnea Syndrome ◽  
Respiratory Dysfunction ◽  
Obstructive Sleep ◽  
Hypopnea Syndrome ◽  
First Time ◽  
Erbb2 Signaling

Obstructive sleep apnea syndrome (OSAHS) is a widespread respiratory dysfunction that has attracted more and more attention in recent years. Recently, a large number of studies have shown that abnormal DNA methylation epigenetically silences genes necessary for the pathogenesis of human diseases. However, the exact mechanism of abnormal DNA methylation in OSAHS is still elusive. In this study, we downloaded the OSAHS data from the GEO database. Our data for the first time revealed 520 hypermethylated genes and 889 hypomethylated genes in OSAHS. Bioinformatics analysis revealed that these abnormal methylated genes exhibited an association with the regulation of angiogenesis, apoptosis, Wnt, and ERBB2 signaling pathways. PPI network analysis displayed the interactions among these genes and validated several hub genes, such as GPSM2, CCR8, TAS2R20, TAS2R4, and TAS2R5, which were related to regulating liganded Gi-activating GPCR and the transition of mitotic metaphase/anaphase. In conclusion, our study offers a new hint of understanding the molecular mechanisms in OSAHS progression and will provide OSAHS with newly generated innovative biomarkers.

scholarly journals Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility in SKBr3 breast cancer cells

2015 ◽  
Vol 35 (2) ◽  
pp. 1147-1152 ◽  
Author(s):  
HYE YOUNG CHOI ◽  
NAMMI PARK ◽  
JAE BOEM NA ◽  
EUN SOOK KO ◽  
JAE-YONG PARK ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Direct Binding ◽  
Erbb2 Signaling

Abstract 1661: Knockdown of Nrf2 in cancer cells suppresses tumor growth: implication for the inhibitory role in HIF-1α and ErbB2 signaling

2011 ◽  
Author(s):  
Mi-Kyoung Kwak ◽  
Eu-gene Hur ◽  
Tae-Hyoung Kim ◽  
Sarala Manandhar ◽  
Bo-Hyun Choi ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cancer Cells ◽  
Inhibitory Role ◽  
Erbb2 Signaling

scholarly journals The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells

Biology Open ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. bio038323 ◽  
Author(s):  
Carolina D'Alesio ◽  
Grazia Bellese ◽  
Maria Cristina Gagliani ◽  
Anastasia Lechiara ◽  
Martina Dameri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Erbb2 Signaling
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