Copper and Zinc in the Amniotic Fluid and Serum from High-Risk Pregnant Women

1979 ◽  
Vol 161 (3) ◽  
pp. 382-385 ◽  
Author(s):  
T. R. Shearer ◽  
E. W. Lis ◽  
K. S. Johnson ◽  
J. R. Johnson ◽  
G. H. Prescott
Keyword(s):  
High Risk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Copper And Zinc

Amniotic fluid composition in pregnant women at high risk of preterm birth

2020 ◽  
Vol 8_2020 ◽  
pp. 82-87
Author(s):  
Khodzhaeva Z.S. Khodzhaeva ◽  
Gorina K.A. Gorina ◽  
Muminova K.T. Muminova ◽  
Ivanets T.Yu. Ivanets ◽  
Kessler Yu.V. Kessler ◽  
...  
Keyword(s):  
Preterm Birth ◽  
High Risk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Fluid Composition

scholarly journals The Presence of Mycotoxins in Human Amniotic Fluid

Toxins ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 409
Author(s):  
Karolina Gromadzka ◽  
Jakub Pankiewicz ◽  
Monika Beszterda ◽  
Magdalena Paczkowska ◽  
Beata Nowakowska ◽  
...  
Keyword(s):  
High Risk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Prenatal Screening ◽  
Genetic Defects ◽  
Chromosomal Anomalies ◽  
Risk Characterization ◽  
Fusarium Mycotoxins ◽  
Human Amniotic Fluid ◽  
Toxic Metabolites

Mycotoxin exposure assessments through biomonitoring studies, based on the analysis of amniotic fluid, provides useful information about potential exposure of mothers and fetuses to ubiquitous toxic metabolites that are routinely found in food and the environment. In this study, amniotic fluid samples (n = 86) were collected via abdominal amniocentesis at 15–22 weeks of gestation from pregnant women with a high risk of chromosomal anomalies or genetic fetal defects detected during 1st trimester prenatal screening. These samples were analyzed for the presence of the most typical Aspergillus, Penicillium and Fusarium mycotoxins, with a focus on aflatoxins, ochratoxins and trichothecenes, using the LC-FLD/DAD method. The results showed that the toxin was present in over 75% of all the tested samples and in 73% of amniotic fluid samples from fetuses with genetic defects. The most frequently identified toxins were nivalenol (33.7%) ranging from <LOQ to 4037.6 ng/mL, and aflatoxins (31.4%), including aflatoxin G1, ranging from <LOQ to 0.4 ng/mL. Ochratoxin A and deoxynivalenol were identified in 26.7% and 27.9% of samples, respectively. Bearing in mind the above, the detection of mycotoxin levels in amniotic fluid is useful for the estimation of overall risk characterization with an attempt to link the occurrence of fetal abnormalities with exposure to mycotoxins in utero.

scholarly journals EVALUATION OF THE BRAIN PLACENTA INDEX AND THE AMNIOTIC LIQUID IN HIGH RISK PREGNANCY AS A PREDICTOR OF LOW APGAR

2020 ◽  
Vol 8 (1) ◽  
pp. 12-17
Author(s):  
Jorge Elias Daher Nader ◽  
Aldo Guzman Soria ◽  
Maikel Leyva Vázquez ◽  
Xavier Chan Gomez ◽  
Marlene Isabel Hernandez Navarro
Keyword(s):  
High Risk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Fetal Distress ◽  
Well Being ◽  
High Risk Pregnancy ◽  
Amniotic Fluid Index ◽  
Risk Pregnancy ◽  
The Brain ◽  
Doppler Echography

Fetal distress is an alteration of the fetus maternal exchange with disorder in the metabolism due to complications of high-risk pregnancies that affect the well-being of the fetus, Evaluation by Doppler echography and amniotic fluid index can help us to diagnose fetal distress; the Objective of the research was to analyze the Brain placenta index and amniotic fluid index in high-risk pregnancies as a predictor of low Apgar; We investigated pregnant women who attended the hospital Alfredo G Paulson performing Doppler ultrasounds, the result when evaluating the pathologies of high Risk comparing ALI with Apgar was (p.208) and BPI with Apgar was (p.064) which indicates that there are differences so we came to the conclusion that they do not predict if the fetus at the time of birth would present Apgar bass.

scholarly journals Cervical Length Measurement in Obstetrics: From Academic Luxury to Clinical Practice

2012 ◽  
Vol 6 (1) ◽  
pp. 93-96
Author(s):  
Badreldeen Ahmed ◽  
Zohra Hasnani
Keyword(s):  
Clinical Practice ◽  
Preterm Birth ◽  
High Risk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Preterm Labor ◽  
Cervical Length ◽  
Length Measurement ◽  
Cervical Length Measurement

ABSTRACT Preterm birth is the main cause of perinatal mortality and morbidity and can be very costly to the healthcare system. Although improvements in neonatal care have led to higher survival of very premature infants, there is a need for the development of a sensitive method with which to identify women at high risk of preterm delivery and find an effective strategy for the prevention of preterm labor.1 Considering the increased incidence of preterm birth, it has become more important now to be able to early diagnose this problem. The measurement of cervical length to predict the risk of preterm birth can be extremely useful in diagnosing this condition. The use of transvaginal ultrasound in measuring cervical length is safe, reliable and well accepted by women.2 The use of vaginal progesterone has shown to be effective in the prevention of preterm delivery in women with short cervix. Tocolytics are used to delay labor for a minimum of 24 to 48 hours3 for up to 1 week but they have not shown to improve neonatal outcomes and most have undesirable side effects. Steroids can assist with fetal lung maturity when the diagnosis of preterm labor is made,3 they can be used unnecessarily when preterm labor is misdiagnosed. The measurement of cervical length can also be helpful in patients with preterm premature rupture of membrane and in patients with the presence of amniotic fluid (AF) sluge.4 Therefore, performing cervical length measurements in all pregnant women and use it as a screening tool at around 20 weeks of pregnancy to identify patients at high risk of preterm labor can assist with true diagnosis. There is a great expectation from cervical assessment and subsequent addition of progesterone to reduce preterm birth and have better neonatal outcomes. The aim of this review is to bring forward evidence that highlights the importance of performing cervical length measurement in midpregnancy in all pregnant women to predict the risk of preterm birth. Medline, PubMed, MD Consult and Science Direct were searched using the terms cervical length measurement, ‘preterm delivery’, ‘amniotic fluid sludge’ and ‘treatment for preterm birth’. How to cite this article Ahmed B, Hasnani Z. Cervical Length Measurement in Obstetrics: From Academic Luxury to Clinical Practice. Donald School J Ultrasound Obstet Gynecol 2012;6(1):93-96.

scholarly journals Cytogenetic Analysis of Amniotic Fluid Cells in 4206 Cases of High-Risk Pregnant Women

2019 ◽  
Author(s):  
Huafeng LI ◽  
Yongli LI ◽  
Rui ZHAO ◽  
Yanli ZHANG
Keyword(s):  
High Risk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Detection Rate ◽  
Chromosomal Abnormalities ◽  
Chromosome Abnormalities ◽  
Chromosome Polymorphism ◽  
Fetal Malformation ◽  
Autosomal Aneuploidy ◽  
Amniotic Fluid Cells

Background: We aimed to assess the frequency and structure of chromosomal abnormalities as well as the distribution of the indications of prenatal diagnosis in 4206 cases of high-risk pregnant women. Methods: A retrospective analysis of cytogenetic studies of 4206 pregnant women with indications of amniocentesis, referred to Linyi Women and Children’s Hospital, Shandong Province, Linyi, China in 2016-2017, was performed. Among those, 4191 amniotic fluid specimens were successfully extracted and cultured, and received karyotype diagnosis. Results: A total of 358 abnormal karyotypes were detected and the abnormal rate was 8.54%. Among them, autosomal aneuploidy was the most common pattern occupied 64.53% and the detection rate was 5.51%, of which 173 (48.32%) cases were 21-trisomy, which was the main type of abnormal karyotypes, followed by 18-trisomy (14.25%). There were 38 cases with sex chromosome aneuploidy, including 47, XXY, 47, XXX, 47, XYY, 69, XXX and 45, X0, accounting for 10.61% of the total chromosome abnormalities and the detection rate was 0.91%. Chromosome structural disorders occupied 10.61% (38/358) of the chromosome abnormalities, including Robertson translocation (16 cases), balance translocation (14 cases), inversion (3 cases), deletion (3 cases), and so on. Chromosome polymorphism was 10.61% too. Other uncommon abnormal karyotypes included mosaicism (11/358), marker chromosome (1.3%). Advanced age and serological screening for high risk were the major prenatal diagnostic indications for pregnant women with chromosomal abnormalities. Conclusion: The karyotype analysis of amniotic fluid cells in pregnant women with different amniocentisis indications can effectively prevent the birth of fetuses with chromosomal diseases and reduce the risk of fetal malformation.

scholarly journals Screening for Cytomegalovirus during Pregnancy

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Stuart P. Adler
Keyword(s):  
High Risk ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Cmv Infection ◽  
Blood Samples ◽  
High Risk Women ◽  
Effective Interventions ◽  
Fetal Infection ◽  
Recent Developments ◽  
Serologic Screening

The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the availability of accurate methods for the serologic diagnosis of a primary CMV infection using either single or serial blood samples, accurate methods for the diagnosis of fetal infection via amniotic fluid, sensitive fetal and placental indicators for neonatal outcomes, and the availability of potentially effective interventions.

Dual and multiple trisomies: analysis of 38 cases from 13 thousand karyotyped embryos and fetuses

2017 ◽  
pp. 109-115
Author(s):  
N.P. Veropotvelyan ◽  
Keyword(s):  
Prenatal Diagnosis ◽  
High Risk ◽  
Pregnant Women ◽  
Maternal Age ◽  
Chromosomal Abnormalities ◽  
Chorionic Villus ◽  
Primary Group ◽  
Chorionic Villus Sampling ◽  
Missed Abortion ◽  
Reproductive Losses

The study presents data of different authors, as well as its own data on the frequency of multiple trisomies among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of chromosomal abnormalities (CA) in I and II trimesters of gestation. The objective: determining the frequency of occurrence of double (DT) and multiple trisomies (MT) among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of occurrence of HA in I and II trimesters of gestation; establishment of the most common combinations of diesel fuel and the timing of their deaths compared with single regular trisomy; comparative assessment materinskogo age with single, double and multiple trisomies. Patients and methods. During the period from 1997 to 2016, the first (primary) group of products in 1808 the concept of missed abortion (ST) of I trimester was formed from women who live in Dnepropetrovsk, Zaporozhye, Kirovograd, Cherkasy, Kherson, Mykolaiv regions. The average term of the ST was 8±3 weeks. The average age of women was 29±2 years. The second group (control) consisted of 1572 sample product concepts received during medical abortion in women (mostly residents of Krivoy Rog) in the period of 5-11 weeks of pregnancy, the average age was 32 years. The third group was made prenatally karyotyped fruits (n = 9689) pregnant women with high risk of HA of the above regions of Ukraine, directed the Centre to invasive prenatal diagnosis for individual indications: maternal age, changes in the fetus by ultrasound (characteristic malformations and echo markers HA) and high risk of HA on the results of the combined prenatal screening I and II trimesters. From 11 th to 14 th week of pregnancy, chorionic villus sampling was performed (n=1329), with the 16th week – platsentotsentez (n=2240), 18 th and 24 th week – amniocentesis (n=6120). Results. A comparative evaluation of maternal age and the prevalence anembriony among multiple trisomies. Analyzed 13,069 karyotyped embryonic and fetal I-II trimester of which have found 40 cases of multiple trisomies – 31 cases in the group in 1808 missed abortion (2.84% of total HA), 3 cases including 1 572 induced medabortov and 7 cases during 9689 prenatal research (0.51% of HA). Determined to share the double trisomies preembrionalny, fetal, early, middle and late periods of fetal development. Conclusion. There were no significant differences either in terms of destruction of single and multiple trisomies or in maternal age or in fractions anembrionalnyh pregnancies in these groups. Key words: multiple trisomies, double trisomy, missed abortion, prenatal diagnosis.

scholarly journals Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zhu ◽  
Xiaoxiao Jin ◽  
Yuqing Xu ◽  
Weihua Zhang ◽  
Xiaodan Liu ◽  
...  
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Predictive Value ◽  
Trisomy 21 ◽  
Maternal Age ◽  
Prenatal Screening ◽  
Advanced Maternal Age ◽  
Youden Index ◽  
Non Invasive ◽  
Sensitivity Specificity

Abstract Background Non-invasive prenatal screening (NIPS) is widely used as the alternative choice for pregnant women at high-risk of fetal aneuploidy. However, whether NIPS has a good detective efficiency for pregnant women at advanced maternal age (AMA) has not been fully studied especially in Chinese women. Methods Twenty-nine thousand three hundred forty-three pregnant women at AMA with singleton pregnancy who received NIPS and followed-up were recruited. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), receiver operating characteristic (ROC) curves and the Youden Index for detecting fetal chromosomal aneuploidies were analyzed. The relationship between maternal age and common fetal chromosomal aneuploidy was observed. Results The sensitivity, specificity, PPV, NPV of NIPS for detecting fetal trisomy 21 were 99.11, 99.96, 90.98, and 100%, respectively. These same parameters for detecting fetal trisomy 18 were 100, 99.94, 67.92, and 100%, respectively. Finally, these parameters for detecting trisomy 13 were 100, 99.96, 27.78, and 100%, respectively. The prevalence of fetal trisomy 21 increased exponentially with maternal age. The high-risk percentage incidence rate of fetal trisomy 21 was significantly higher in the pregnant women at 37 years old or above than that in pregnant women at 35 to 37 years old. (Youden index = 37). Conclusion It is indicated that NIPS is an effective prenatal screening method for pregnant women at AMA.

Sign in / Sign up

Export Citation Format

Share Document