Dietary Zinc Deficiency Decreases Plasma Concentrations of Vitamin E

Rationale: Cystic fibrosis (CF), caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leads to impaired pancreatic function and therefore reduced intestinal absorption of lipids and fat-soluble vitamins especially in patients with CF developing pancreatic insufficiency (PI). Previous studies showed that CFTR modulator therapy with lumacaftor-ivacaftor (LUM/IVA) in Phe508del-homozygous patients with CF results in improvement of pulmonary disease and thriving. However, the effects of LUM/IVA on plasma concentration of the lipid soluble vitamins A and E remain unknown. Objectives: To investigate the course of plasma vitamin A and E in patients with CF under LUM/IVA therapy. Methods: Data from annual follow-up examinations of patients with CF were obtained to assess clinical outcomes including pulmonary function status, body mass index (BMI), and clinical chemistry as well as fat-soluble vitamins in Phe508del-homozygous CF patients before initiation and during LUM/IVA therapy. Results: Patients with CF receiving LUM/IVA improved substantially, including improvement in pulmonary inflammation, associated with a decrease in blood immunoglobulin G (IgG) from 9.4 to 8.2 g/L after two years (p < 0.001). During the same time, plasma vitamin A increased significantly from 1.2 to 1.6 µmol/L (p < 0.05), however, levels above the upper limit of normal were not detected in any of the patients. In contrast, plasma vitamin E as vitamin E/cholesterol ratio decreased moderately over the same time from 6.2 to 5.5 µmol/L (p < 0.01). Conclusions: CFTR modulator therapy with LUM/IVA alters concentrations of vitamins A and vitamin E in plasma. The increase of vitamin A must be monitored critically to avoid hypervitaminosis A in patients with CF.

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Effect of vitamin E intake from food and supplement sources on plasma α- and γ-tocopherol concentrations in a healthy Irish adult population

British Journal Of Nutrition ◽

10.1017/s0007114514002438 ◽

2014 ◽

Vol 112 (9) ◽

pp. 1575-1585 ◽

Cited By ~ 20

Author(s):

Yang Zhao ◽

Frank J. Monahan ◽

Breige A. McNulty ◽

Mike J. Gibney ◽

Eileen R. Gibney

Keyword(s):

Vitamin E ◽

Adult Population ◽

Plasma Concentrations ◽

Fats And Oils ◽

Food Sources ◽

Dietary Vitamin ◽

Plasma Vitamin ◽

Institute Of Medicine ◽

Nutrition Survey ◽

Plasma Vitamin E

Vitamin E is believed to play a preventive role in diseases associated with oxidative stress. The aims of the present study were to quantify vitamin E intake levels and plasma concentrations and to assess dietary vitamin E adequacy in Irish adults. Intake data from the National Adult Nutrition Survey were used; plasma samples were obtained from a representative cohort of survey participants. Plasma α- and γ-tocopherol concentrations were measured by HPLC. The main sources of vitamin E in the diet were ‘butter, spreadable fats and oils’ and ‘vegetables and vegetable dishes’. When vitamin E intake from supplements was taken into account, supplements were found to be the main contributor, making a contribution of 29·2 % to vitamin E intake in the total population. Supplement consumers had significantly higher plasma α-tocopherol concentrations and lower plasma γ-tocopherol concentrations when compared with non-consumers. Consumers of ‘vitamin E’ supplements had significantly higher vitamin E intake levels and plasma α-tocopherol concentrations compared with consumers of other types of supplements, such as multivitamin and fish oil. Comparison with the Institute of Medicine Estimated Average Requirement of 12 mg/d indicated that when vitamin E intake from food and supplement sources was taken into account, 100 % of the study participants achieved the recommended intake levels. When vitamin E intake from food sources was taken into account, only 68·4 % of the females were found to achieve the recommended intake levels compared with 99·2 % of the males. The results of the present study show that dietary vitamin E intake has a significant effect on plasma α- and γ-tocopherol concentrations. Furthermore, they show that the consumption of supplements is a major contributor to overall intake and has a significant effect on plasma vitamin E concentrations in the Irish population.

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The Effects of Dietary Zinc Deficiency on Voluntary Alcohol Drinking in Rats

Alcoholism Clinical and Experimental Research ◽

10.1111/j.1530-0277.1984.tb05729.x ◽

1984 ◽

Vol 8 (6) ◽

pp. 556-559 ◽

Cited By ~ 5

Author(s):

P. J. Collipp ◽

V. K. Kris ◽

M. Castro-Magana ◽

A. Shih ◽

S. Y. Chen ◽

...

Keyword(s):

Zinc Deficiency ◽

Alcohol Drinking ◽

Dietary Zinc

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MORPHOMETRIC AND HISTOPATHOLOGICAL CHANGES INDUCED BY MODERATE AND SEVERE DIETARY ZINC DEFICIENCY IN TESTES OF MALE ALBINO RATS

Mansoura Medical Journal ◽

10.21608/mjmu.2001.127101 ◽

2001 ◽

Vol 30 (2) ◽

pp. 269-279

Author(s):

Osama Ibrahim Nasif

Keyword(s):

Zinc Deficiency ◽

Albino Rats ◽

Histopathological Changes ◽

Dietary Zinc

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Protection Against Zinc Deficiency by Prior Excess Dietary Zinc in Young Japanese Quail

Journal of Nutrition ◽

10.1093/jn/105.12.1509 ◽

1975 ◽

Vol 105 (12) ◽

pp. 1509-1518 ◽

Cited By ~ 19

Author(s):

B. F. Harland ◽

M. R. Spivey Fox ◽

Bert E. Fry

Keyword(s):

Zinc Deficiency ◽

Japanese Quail ◽

Dietary Zinc

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Vitamin E Inadequacy Observed in a Group of 2- to 6-Year-Old Children Living in Kwangju, Republic of Korea

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.78.3.148 ◽

2008 ◽

Vol 78 (3) ◽

pp. 148-155 ◽

Cited By ~ 6

Author(s):

Giraud ◽

Kim ◽

Cho ◽

Driskell

Keyword(s):

Vitamin E ◽

High Performance ◽

Plasma Concentrations ◽

Age Groups ◽

Republic Of Korea ◽

Dietary Intakes ◽

Korean Children ◽

Trained Interviewer ◽

And Gender ◽

Vitamin E Status

Studies on the vitamin E status of Korean children are lacking. Dietary intakes and plasma concentrations of tocopherols of healthy 2- to 6-year-olds living in Kwangju, Republic of Korea, were determined and their vitamin E status evaluated. Subjects included 66 girls and 65 boys, with 21–32 subjects per age group. Subjects’ intakes were recorded by a trained interviewer for foods eaten at preschool/kindergarten; otherwise, three consecutive 24-hour food recalls were obtained from parents. Plasma tocopherol concentrations were determined using high-performance liquid chromatography. Intakes of energy and total monounsaturated and polyunsaturated fats were significantly different (p < 0.05) among age groups, not gender, with 2- and 3-year-olds having lower intakes. Alpha- and γ-tocopherol intakes were similar by age and gender. Sixty-seven percent consumed less than the Korean Adequate Intakes for vitamin E, and 77% had α-tocopherol intakes less than USA/Canadian Estimated Average Requirements. Plasma α-tocopherol concentrations, but not γ-tocopherol, were significantly higher (p < 0.05) for 2-year-olds. Two-thirds of subjects had plasma α-tocopherol concentrations less than 12 μmol/L, which is indicative of vitamin E inadequacy in adults; guidelines for children do not exist. Many of the Korean children had inadequate intakes and likely inadequate plasma concentrations of vitamin E.

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