Distribution of Human Cystic Echinococcosis and Genotypes of Hydatid Cyst And Adult Worm of Echinococcus granulosus In Iran: A Systematic Review and Meta-Analysis

Human cystic echinococcosis (HCE), a zoonotic infection of the larval stage ofEchinococcus granulosus, has high effect on public health in human population all around the world. Iran is one of the most important endemic areas in the Middle East. This systematic review and meta-analysis was performed to evaluate the seroprevalence of HCE in Iranian population. An electronic search for articles from 1985 until April 2015 was performed using data bases PubMed, Scopus, Google Scholar, Magiran, IranMedex, Iran Doc, and Scientific Information Database (SID) both in English and in Persian. A random-effects meta-analysis was used to combine results from individual studies. The information was analyzed by STATA version 11.1. A total of 33 articles met our eligibility criteria and were included in a meta-analysis. The pooled estimate of the prevalence of HCE based on random-effects model was estimated 6.0% (95% CI: 4.0%, 7.0%). The prevalence of the disease significantly increased with age and prevalence rate in males was significantly lower than females (p<0.001). The using of CIE or CCIEP method was also significantly greater than the other methods (p<0.001). There was a publication bias in prevalence of studies. HCE is highly prevalent in Iran. Public education for preventive strategies and finally reducing transmission of the parasite and infection in population is needed.

Download Full-text

Human Cystic Echinococcosis in Lebanon: A Retrospective Study and Molecular Epidemiology

Acta Parasitologica ◽

10.1007/s11686-021-00453-w ◽

2021 ◽

Author(s):

Gaelle Joanny ◽

Maria Grazia Cappai ◽

Francesca Nonnis ◽

Claudia Tamponi ◽

Giorgia Dessì ◽

...

Keyword(s):

Echinococcus Granulosus ◽

Cystic Echinococcosis ◽

Epidemiological Data ◽

Sensu Stricto ◽

Control Measures ◽

Mediterranean Countries ◽

High Gene ◽

Human Infections ◽

And Control ◽

Human Cystic Echinococcosis

Abstract Purpose Human cystic echinococcosis (CE) is a zoonotic parasitic disease that constitutes a public health challenge and a socio-economic burden in endemic areas worldwide. No specific surveillance system of CE infections in humans exists in Lebanon. The incidence and trends over time have not been documented. The current study aimed to assess the demographic and epidemiologic features of human CE surgical cases over a 14-year period in the five main regions of Lebanon. Methods From 2005 to 2018, a total of 894 surgically confirmed cases of hydatidosis were recorded from five anatomy and pathology laboratories. Results The mean annual surgical incidence was 1.23/100,000 inhabitants. Over the span of these years, the incidence increased from 0.53 to 1.94 cases/100,000 inhabitants in 2005 and 2018, respectively. CE is present in Lebanon with an uneven distribution from one region to the other with higher prevalence in Bekaa (29.0%), a rural area where sheep raising is widespread. Human CE cases were more common in females (60.1%) than in males (39.9%) and a high burden of infection was reported for the age group of 30–39 years. Besides, 66.7% of the cases expressed only liver complications whereas, 20.5% showed predilection towards lungs. The 7.8% of cases presented cysts in other organs, and 1.3% showed multiple localizations. Additionally, predominant involvement of Echinococcus granulosus sensu stricto was recorded in human infections. Comparison of Echinococcus granulosus s.s. populations from different Mediterranean countries also revealed high gene flow among this region and sharing of alleles. Conclusion The current study is a step forward to fill the gap of knowledge for the hydatidosis in Lebanon where the lack of epidemiological data and control measures have resulted in higher incidence of human CE. Graphic Abstract

Download Full-text

Characterization of excretory–secretory products from protoscoleces of Echinococcus granulosus and evaluation of their potential for immunodiagnosis of human cystic echinococcosis

Parasitology ◽

10.1017/s0031182004005670 ◽

2004 ◽

Vol 129 (3) ◽

pp. 371-378 ◽

Cited By ~ 20

Author(s):

D. CARMENA ◽

J. MARTÍNEZ ◽

A. BENITO ◽

J. A. GUISANTES

Keyword(s):

Echinococcus Granulosus ◽

Cystic Echinococcosis ◽

Secretory Protein ◽

Major Protein ◽

Healthy Donors ◽

Secretory Products ◽

Protein Components ◽

Human Cystic Echinococcosis

This study describes, for the first time, the characterization of excretory–secretory antigens (ES-Ag) from Echinococcus granulosus protoscoleces, evaluating their usefulness in the immunodiagnosis of human cystic echinococcosis. ES-Ag were obtained from the first 50 h maintenance of protoscoleces in vitro. This preparation contained over 20 major protein components which could be distinguished by 1-dimensional SDS–PAGE with apparent masses between 9 and 300 kDa. The culture of of protoscoleces from liver produced a greater variety of excretory–secretory protein components than those from lung. Determination of enzymatic activities of secreted proteins revealed the presence of phosphatases, lipases and glucosidases, but no proteases. These findings were compared to those obtained from somatic extracts of protoscoleces and hydatid cyst fluid products. Immunochemical characterization was performed by immunoblotting with sera from individuals infected by cystic echinococcosis (n=15), non-hydatidic parasitoses (n=19), various liver diseases (n=24), lung neoplasia (n=16), and healthy donors (n=18). Antigens with apparent masses of 89, 74, 47/50, 32, and 20 kDa showed specificity for immunodiagnosis of human hydatidosis. The 89 and 74 kDa components corresponded to antigens not yet described in E. granulosus, whereas proteins of 41–43 kDa and 91–95 kDa were recognized by the majority of the non-hydatid sera studied.

Download Full-text

Commentary on “Percutaneous Versus Surgical Interventions for Hepatic Cystic Echinococcosis – A Systematic Review and Meta-Analysis”

CardioVascular and Interventional Radiology ◽

10.1007/s00270-021-02959-2 ◽

2021 ◽

Author(s):

Okan Akhan

Keyword(s):

Systematic Review ◽

Cystic Echinococcosis ◽

Meta Analysis ◽

Surgical Interventions

Download Full-text

Imported cystic echinococcosis in Spain: a systematic review

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/trab022 ◽

2021 ◽

Author(s):

Andrea Zabala ◽

Fernando Salvador ◽

Adrián Sánchez-Montalvá ◽

Pau Bosch-Nicolau ◽

Laura Escolà-Vergé ◽

...

Keyword(s):

Systematic Review ◽

Echinococcus Granulosus ◽

Cystic Echinococcosis ◽

Reporting System ◽

Neglected Tropical Disease ◽

Review Of The Literature ◽

Lack Of Information ◽

Reporting Systems ◽

Imported Cases ◽

Echinococcus Granulosus Sensu Lato

Abstract Background Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus granulosus (sensu lato). It is a neglected tropical disease with a global distribution, affecting an estimated 2–3 million people globally. Official reporting systems in Spain lack information concerning imported cases and their country of origin. Methods This is a systematic review of the literature that was performed to obtain published cases of immigrant patients diagnosed with CE in Spain. Results From the 21 included articles, a total of 84 cases of CE imported into Spain were documented from 1995 to 2018, with an average age of 33.2 years. The main countries of origin of the patients were Morocco with 30 cases (35.7%), Romania with 12 cases (14.3%) and Peru with 8 cases (9.5%). The most involved organ was the liver (28 cases [33.3%]). We found discrepancies between the published cases of imported CE in Spain and those reported by official authorities. Conclusions This review of the literature shows the lack of information and clarity in the mechanisms of CE notification in Spain. The disparity between these systems and the cases documented in the literature highlights a failure or shortcoming of the current reporting system.

Download Full-text