Optimization and Evaluation of Developed Topical Ointment Formulation Containing Cefadroxil and Its Antibacterial Activity

2021 ◽  
Vol 13 (02) ◽  
Keyword(s):  
Antibacterial Activity ◽  
Ointment Formulation

scholarly journals (Ointment Formulation from N-Hexane Extract of Majapahit Leaves (Crescentia cujete l.) and its Antibacterial Activity Evaluation against Pseudomonas aeruginosa)

MEDULA ◽  
2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Fery I Armadany ◽  
Andi E.P. Putri ◽  
Erlina D. Sasmin ◽  
Mallarangeng Andi N.T.A. Mallarangeng
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Liquid Paraffin ◽  
Inhibition Zone ◽  
Hexane Extract ◽  
Test Method ◽  
Diffusion Method ◽  
Ointment Formulation ◽  
Crescentia Cujete

ABSTRACT Background:  Majapahit leaves (Crescentia cujete L.) are known to contain biochemical compounds namely tannins, terpenoids, alkaloids, and saponins which are effective as antimicrobials. Objective(s): This study aimed to formulate ointment from n-hexane extract of majapahit leaves and to known its antimicrobial activity against P. aeruginosa. Methods: ointment ingredients are vaselin, cera alba, liquid paraffin, and menthol and 2% of Majapahit leaves n-hexane extract. Ointment stability test included organoleptic, homogeneity, viscosity, pH, and irritation tests. Evaluation of stability of ointment was obtained by using cycling test method. The irritation test was carried out by open patch test on 6 panellists. Diffusion method is used to obtain antimicrobial activity. Results: The antimicrobial   activity    (diameter   inhibition   zone)   of    the    ointment    against Pseudomonas aeruginosa bacteria was 11 mm and the positive control was 13 mm. The formula showed no change on texture, colour, aroma, viscosity, homogeneity, but there was slight increase in viscosity and pH. The ointment showed non-irritating for panellists thus the ointment formulation is safe for topical use. Conclusion: 2% n-hexane extract of Majapahit leaves can be formulated into ointment with good stability with strong antibacterial activity and non-irritating. Keywords:  antibacterial  activity,  majapahit  leaves,  N-hexane  extract,  ointment,  Pseudomonas aeruginosa

scholarly journals FORMULATION OF OINTMENT OF ANTIBACTERY ETHANOL EXTRACT OF TORCH GINGER (Etlingera elatior) AGAINST BACTERIA Staphylococcus aureus

2018 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Ainil Fithri Pulungan ◽  
Debi Dinha Octora Sitepu ◽  
Devi Mariana Sinaga
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Diffusion Method ◽  
Ointment Base ◽  
Ointment Formulation ◽  
Inhibitory Power ◽  
Made In ◽  
Etlingera Elatior

One of the causes of infection was bacteria, such as Staphylococcus aureus. Torch ginger has been widely used to treat dwaseases caused by bacteria. Torch ginger has been studied to have antibacterial activity against Staphylococcus aureus bacteria. The purpose of thwas study was to formulate an ointment preparation of ethanol extract of torch ginger and to see if the ointment preparations had antibacterial activity against Staphylococcus aureus bacteria. The research method used in thwas research was experimental True, covering the stages: making of ethanol extract of kecombrang flower with maceration method using 96% ethanol solvent, ointment formulation made with ointment base: vaseline, adeps lanae, and propylene glycol. Made in three concentrations of extracts namely: F I with 100 mg, F II with 200 mg, and F III with 300 mg. Furthermore, the evaluation of the preparation of evaluation of physical stability and homogeneity, and test of antibacterial activity against Staphylococcus aureus bacteria with diffusion method to use Kirby odor dwasc paper. The results showed that the ointment had good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial activity test of the ointment shows that the inhibitory diameter F I has an average of 16.45 mm, F II has an average of 18.60 mm and F III has an average of 21.12 mm. Based on the results obtained it can be concluded that the preparation of the ethanol extract of torch ginger has an inhibitory power to Staphylococcus aureus bacteria. In the next research was expected to pay attention to the growing area of ​​torch ginger  and to compare the antibacterial activity between petal flowers and flower seeds using Staphylococcus aureus bacteria.

Antibacterial activity of herbal preparation to treat sore throats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
J Reichling ◽  
U Suschke ◽  
A Suter
Keyword(s):  
Antibacterial Activity ◽  
Herbal Preparation

Antibacterial activity of Celastrol against Bacillus subtilis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
N Padilla-Montaño ◽  
IL Bazzocchi ◽  
L Moujir
Keyword(s):  
Antibacterial Activity ◽  
Bacillus Subtilis

Antibacterial Activity of Rhinacanthin Rich Rhinacanthus nasutus Extract

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
P Panichayupakaranant ◽  
P Puttarak
Keyword(s):  
Antibacterial Activity ◽  
Rhinacanthus Nasutus

Antibacterial activity comparison of several Portuguese Thymus essential oils

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
SA Dandlen ◽  
AC Figueiredo ◽  
LG Pedro ◽  
JG Barroso ◽  
MG Miguel ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Essential Oils ◽  
Activity Comparison

Chemical composition and antibacterial activity of essential oils from different populations of Artemisia incana (Asteraceae) from Iran

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
M Atri ◽  
A Chehregani ◽  
S Yousefi ◽  
F Jalal
Keyword(s):  
Antibacterial Activity ◽  
Chemical Composition ◽  
Essential Oils ◽  
Different Populations

Antibacterial activity of acyl and epoxide derivatives of β-sitosterol and cycloartanes

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
N Oliveira ◽  
A Duarte ◽  
A Madureira
Keyword(s):  
Antibacterial Activity ◽  
Derivatives Of

Searching for iridoids from tropical plants: detection, isolation and antibacterial activity

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
M Litaudon ◽  
E Le Borgne ◽  
P Teres ◽  
B Deguin ◽  
M Lecsö Bornet ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Tropical Plants
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