Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis

AbstractPrevalence rates for folate deficiency and hyperhomocysteinemia have been markedly reduced following the introduction of folic acid fortification in the United States. We report the prevalence of hyperhomocysteinemia in a population of community-dwelling elderly Latinos in the post-folic acid fortification era. We measured homocysteine, total vitamin B

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Mandatory fortification with folic acid in the United States appears to have adverse effects on histone methylation in women with pre-cancer but not in women free of pre-cancer

International Journal of Women s Health ◽

10.2147/ijwh.s6521 ◽

2009 ◽

pp. 131 ◽

Cited By ~ 1

Author(s):

Piyathilake

Keyword(s):

United States ◽

Folic Acid ◽

Adverse Effects ◽

Histone Methylation ◽

The United States

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No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine

PLoS ONE ◽

10.1371/journal.pone.0024976 ◽

2011 ◽

Vol 6 (9) ◽

pp. e24976 ◽

Cited By ~ 31

Author(s):

Audrey Y. Jung ◽

Yvo Smulders ◽

Petra Verhoef ◽

Frans J. Kok ◽

Henk Blom ◽

...

Keyword(s):

Dna Methylation ◽

Folic Acid ◽

Folic Acid Supplementation ◽

Global Dna Methylation ◽

Men And Women ◽

Acid Supplementation

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Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix

Nutrition ◽

10.1016/j.nut.2007.10.007 ◽

2008 ◽

Vol 24 (1) ◽

pp. 94-99 ◽

Cited By ~ 16

Author(s):

Chandrika J. Piyathilake ◽

Jorge E. Celedonio ◽

Maurizio Macaluso ◽

Walter C. Bell ◽

Maria Azrad ◽

...

Keyword(s):

United States ◽

Folic Acid ◽

Dna Methyltransferase ◽

The United States ◽

Dna Methyltransferase 1 ◽

Methyltransferase 1

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DNA methylation and cognitive functioning in healthy older adults

British Journal Of Nutrition ◽

10.1017/s0007114511003576 ◽

2011 ◽

Vol 107 (5) ◽

pp. 744-748 ◽

Cited By ~ 9

Author(s):

Olga J. G. Schiepers ◽

Martin P. J. van Boxtel ◽

Renate H. M. de Groot ◽

Jelle Jolles ◽

Frans J. Kok ◽

...

Keyword(s):

Older Adults ◽

Dna Methylation ◽

Folic Acid ◽

Cognitive Functioning ◽

Cognitive Performance ◽

Global Dna Methylation ◽

Older Individuals ◽

Healthy Older Adults ◽

Study Results ◽

The Relationship

Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status and non-pathological cognitive functioning in human subjects has not yet been investigated. The present study investigated the associations between global DNA methylation and key domains of cognitive functioning in healthy older adults. Global DNA methylation, defined as the percentage of methylated cytosine to total cytosine, was measured in leucocytes by liquid chromatography–MS/MS, in 215 men and women, aged 50–70 years, who participated in the Folic Acid and Carotid Intima-Media Thickness (FACIT) study (clinical trial registration number NCT00110604). Cognitive performance was assessed by means of the Visual Verbal Word Learning Task, the Stroop Colour-Word Interference Test, the Concept Shifting Test, the Letter–Digit Substitution Test and the Verbal Fluency Test. Using hierarchical linear regression analyses adjusted for age, sex, level of education, alcohol consumption, smoking status, physical activity, erythrocyte folate concentration and 5,10-methylenetetrahydrofolate reductase 677 C → T genotype, we found that global DNA methylation was not related to cognitive performance on any of the domains measured. The present study results do not support the hypothesis that global DNA methylation, as measured in leucocytes, might be associated with cognitive functioning in healthy older individuals.

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