Assessment of pentraxin 3 in a systemic inflammatory response occurring with neonatal bacterial infection

INTRODUCTION: In the developing countries, neonatal sepsis is the most common complication in neonatal period. It is as a systemic inflammatory response because of infection. Laboratory indicators, do not have satisfactory sensitivity. Thus, early identification of sepsis is still needed. Because PTX3 may be a faster acute-phase protein that is not liver-dependent, it is probable that it is superior to traditional biomarkers for mirroring rapid inflammatory courses. METHODS: A prospective case control study design was used to determine the sensitivity of pentraxin 3 in the diagnosis of neonatal sepsis to allow early diagnostic tool. This study was carried out on neonatal ICU unit in Suez Canal University Hospital and the studied population were divided into two groups, including patients diagnosed with neonatal sepsis, based on clinical, laboratory and positive blood culture results, and control group RESULTS: The study found that there was statistically significant differences between both groups in serum CRP values in diseased and control group (Mean = 49.3±37.4 mg/L, 26.8±17.2 mg/L, p < 0.05), and pentraxin values in diseased and control group (Mean = 5.2±3.7 mg/L, 2.3±0.78 mg/L, p < 0.0001). In addition, there were statistically significant correlations between pentraxin and serum CRP concentrations (p < 0.05) in diseased group. ROC curve showed that serum CRP demonstrated good diagnostic accuracy in predicting neonatal sepsis AUC = 0.875 with sensitivity of 100% and specificity of 92.3%. CONCLUSION: Serum PTX3 may be a promising acute-phase protein for interpretation of affected newborns with symptoms and signs of sepsis.

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FETUIN, A NEGATIVE ACUTE PHASE PROTEIN, ATTENUATES TNF SYNTHESIS AND THE INNATE INFLAMMATORY RESPONSE TO CARRAGEENAN

Shock ◽

10.1097/00024382-200115030-00004 ◽

2001 ◽

Vol 15 (3) ◽

pp. 181-185 ◽

Cited By ~ 78

Author(s):

Michael Ombrellino ◽

Haichao Wang ◽

Huan Yang ◽

Minghuang Zhang ◽

Jaideep Vishnubhakat ◽

...

Keyword(s):

Inflammatory Response ◽

Acute Phase ◽

Acute Phase Protein ◽

Fetuin A ◽

Phase Protein

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Prepartum milking effects on parlour behaviour, endocrine and immune responses in Holstein heifers

Journal of Dairy Research ◽

10.1017/s0022029907002695 ◽

2007 ◽

Vol 74 (4) ◽

pp. 417-424 ◽

Cited By ~ 4

Author(s):

Susan D Eicher ◽

Michael Schutz ◽

Francis Kearney ◽

Scott Willard ◽

Susan Bowers ◽

...

Keyword(s):

Acute Phase ◽

Acute Phase Protein ◽

Multiple Stressors ◽

Post Partum ◽

Control Group ◽

Protein Determination ◽

Housing Systems ◽

Grazing System ◽

Phase Protein ◽

Confinement System

Transition of primiparous heifers to the milking herd is a period with multiple stressors. The objective of these studies was to determine effects of parlour experience and prepartum milking (pre-milking) on behavioural and physiological indicators of stress after calving. Two experiments were conducted, one was in a free-stall housing confinement system and the second was in a modified grazing system. Forty-eight first-calf heifers were assigned to three treatments: control; experienced heifers taken through the parlour without milking; or pre-milk heifers milked for 3 weeks prior to estimated parturition. Blood was collected within 24 h of parturition and on days 3, 5, 7, 10 and 14 following parturition for cortisol and acute phase protein determination. In the grazing system, 20 heifers were assigned to a prepartum milked or control group as in the confinement system and behaviour observations included days −21, −14, −7, −5, −3 and −1 relative to calving and days 1, 3, 7, 9, 14, and 16 post-calving. Milk production was greatest for prepartum milked heifers in both housing systems. However, somatic cell score was reduced by prepartum milking only in the confinement system. Balking occurred least in parlour-experienced heifers. In confinement housing, shifting while in the parlour was the only behaviour that was greater at first milking in control heifers. Kicking was most frequent for parlour experienced heifers on day 2. Grazing system pre-milked heifers shifted more at their first milking (day −21) than did the controls at their first milking (day 1). Shifting within cow was greatest on day −21 compared with day −5 (P<0·05). Pre-milked heifers shifted more on day 1 post-calving than did the control heifers (P<0·05). These results showed that shifting was the most indicative behaviour of restlessness, was transient, and decreased by day 5 prior to calving. Cortisol and α1-acid glycoprotein concentrations were not different; however, haptoglobin increased for all treatments up to and including day 3 and haptoglobin concentrations of pre-milked heifers began to decrease by day 5 post-calving. Pre-milked heifers had lower haptoglobin concentrations than the control heifers and tended to have lower concentrations than experienced heifers on day 10 post partum. By day 14 post partum, all haptoglobin concentrations were <200 μg/ml, but the haptoglobin concentration of control heifers was greater than that of pre-milked and experienced heifers. These results showed that prepartum milking and parlour experience shorten some acute phase protein responses, but minimally affect early parlour behaviours.

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Hemopexin as an acute phase protein regulates the inflammatory response against bacterial infection of Nile tilapia (Oreochromis niloticus)

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2021.07.109 ◽

2021 ◽

Author(s):

Xiaoxue Yin ◽

Xiaoyu Li ◽

Nuo Chen ◽

Liangliang Mu ◽

Hairong Wu ◽

...

Keyword(s):

Inflammatory Response ◽

Bacterial Infection ◽

Acute Phase ◽

Oreochromis Niloticus ◽

Nile Tilapia ◽

Acute Phase Protein ◽

Nile Tilapia Oreochromis Niloticus ◽

Phase Protein

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Plasma levels of pentraxin-3, an acute phase protein, are increased during sickle cell painful crisis

Blood Cells Molecules and Diseases ◽

10.1016/j.bcmd.2010.10.016 ◽

2011 ◽

Vol 46 (3) ◽

pp. 189-194 ◽

Cited By ~ 13

Author(s):

Erfan Nur ◽

Eduard J. van Beers ◽

Shuena Martina ◽

Ivan Cuccovillo ◽

Hans-Martin Otten ◽

...

Keyword(s):

Sickle Cell ◽

Acute Phase ◽

Plasma Levels ◽

Acute Phase Protein ◽

Pentraxin 3 ◽

Phase Protein ◽

Painful Crisis

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Leucogram and serum acute phase protein concentrations in queens submitted to conventional or videolaparoscopic ovariectomy

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/s0102-09352010000100012 ◽

2010 ◽

Vol 62 (1) ◽

pp. 86-91 ◽

Cited By ~ 4

Author(s):

A.E. Alves ◽

A.P.C. Ribeiro ◽

P.A. Di Filippo ◽

M.F. Apparicio ◽

J.J. Fagliari ◽

...

Keyword(s):

Inflammatory Response ◽

Acute Phase ◽

Surgical Procedures ◽

Acute Phase Proteins ◽

Acute Phase Protein ◽

White Blood Cells ◽

Conventional Technique ◽

Blood Cell Count ◽

Serum Samples ◽

Phase Protein

Thirty health queens were submitted to ovariectomy by conventional technique or by videolaparoscopy. In order to study the intensity of inflammatory response by means of acute phase protein analysis and white blood cell count, serum samples were taken before and until 144 hours after the surgical procedures. The protein concentrations that were significantly increased 24 hours after surgical procedures were: ceruloplasmin, hemopexin, haptoglobin, and α1-acid glycoprotein, 69.8%, 103.5%, 117.3%, and 199.0%, respectively, for conventional ovariectomy; and 22.3%, 46.1%, 79.8%, and 74.6%, respectively, for laparoscopic ovariectomy. Therefore, inflammatory response was more intense in queens submitted to conventional ovariectomy. Results indicate that the increase or decrease in acute phase proteins, as well as in white blood cells count, may be useful in the evaluation of inflammatory response induced by these surgical procedures.

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