A Significance Assessment of Diabetes Diagnostic Biomarkers Using Machine Learning

2021 ◽  
Author(s):  
Ran Cui ◽  
Elena Daskalaki ◽  
Md Zakir Hossain ◽  
Artem Lenskiy ◽  
Christopher J Nolan ◽  
...  
Keyword(s):  
Machine Learning ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Hemoglobin A1c ◽  
Diagnostic Algorithm ◽  
Fasting Insulin ◽  
Blood Biomarkers ◽  
Diagnostic Biomarkers ◽  
Fasting Plasma

Diabetes can be diagnosed by either Fasting Plasma Glucose or Hemoglobin A1c. The aim of our study was to explore the differences between the two criteria through the development of a machine learning based diabetes diagnostic algorithm and analysing the predictive contribution of each input biomarker. Our study concludes that fasting insulin is predictive of diabetes defined by FPG, but not by HbA1c. Besides, 28 other fasting blood biomarkers were not significant predictors of diabetes.

scholarly journals Prevalence of prediabetes according to hemoglobin A1c versus fasting plasma glucose criteria in healthy adults

2014 ◽  
Vol 52 (3) ◽  
pp. 631-632 ◽  
Author(s):  
Jonas Blum ◽  
Stefanie Aeschbacher ◽  
Tobias Schoen ◽  
Matthias Bossard ◽  
Katrin Pumpol ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Hemoglobin A1c ◽  
Healthy Adults ◽  
Fasting Plasma

scholarly journals Use of Hemoglobin A1c and Fasting Plasma Glucose to Diagnose Type 2 Diabetes in the Real World

2012 ◽  
Vol 6 (3) ◽  
pp. 721-722
Author(s):  
B. Shivananda Nayak ◽  
Kameel Mungrue ◽  
Shawn Seepersad ◽  
Justin Sookram ◽  
Shalina Singh ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Real World ◽  
Fasting Plasma Glucose ◽  
Hemoglobin A1c ◽  
The Real ◽  
Fasting Plasma

scholarly journals Dissociation of serum fructosamine from fasting plasma glucose or hemoglobin A1c in diabetics.

1990 ◽  
Vol 29 (2) ◽  
pp. 132-137 ◽  
Author(s):  
Hiroshi SOBAJIMA ◽  
Masahiko SHIKANO ◽  
Makoto TANIKAWA ◽  
Toyoo Niwa ◽  
Tetsuo HAYAKAWA
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Hemoglobin A1c ◽  
Fasting Plasma ◽  
Serum Fructosamine

scholarly journals Use of hemoglobin A1C to detect Haitian-Americans with undiagnosed Type 2 diabetes

2012 ◽  
Vol 56 (7) ◽  
pp. 449-455 ◽  
Author(s):  
Joel C. Exebio ◽  
Gustavo G. Zarini ◽  
Joan A. Vaccaro ◽  
Cristobal Exebio ◽  
Fatma G. Huffman
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Roc Analysis ◽  
Hemoglobin A1c ◽  
Cutoff Point ◽  
Operating Characteristics ◽  
Fasting Plasma ◽  
Haitian Americans

OBJECTIVE: To evaluate the validity of hemoglobin A1C (A1C) as a diagnostic tool for type 2 diabetes and to determine the most appropriate A1C cutoff point for diagnosis in a sample of Haitian-Americans. SUBJECTS AND METHODS: Subjects (n = 128) were recruited from Miami-Dade and Broward counties, FL. Receiver operating characteristics (ROC) analysis was run in order to measure sensitivity and specificity of A1C for detecting diabetes at different cutoff points. RESULTS: The area under the ROC curve was 0.86 using fasting plasma glucose ≥ 7.0 mmol/L as the gold standard. An A1C cutoff point of 6.26% had sensitivity of 80% and specificity of 74%, whereas an A1C cutoff point of 6.50% (recommended by the American Diabetes Association - ADA) had sensitivity of 73% and specificity of 89%. CONCLUSIONS: A1C is a reliable alternative to fasting plasma glucose in detecting diabetes in this sample of Haitian-Americans. A cutoff point of 6.26% was the optimum value to detect type 2 diabetes.

scholarly journals Usefulness of the index calculated as the product of levels of fasting plasma glucose and hemoglobin A1c for insulinoma screening

2020 ◽  
Vol 67 (5) ◽  
pp. 509-513 ◽  
Author(s):  
Keiichi Torimoto ◽  
Yosuke Okada ◽  
Yoshiya Tanaka ◽  
Atsuko Matsuoka ◽  
Yushi Hirota ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Hemoglobin A1c ◽  
Fasting Plasma

scholarly journals Diabetes Screening With Hemoglobin A1c Versus Fasting Plasma Glucose in a Multiethnic Middle-School Cohort

Diabetes Care ◽  
2012 ◽  
Vol 36 (2) ◽  
pp. 429-435 ◽  
Author(s):  
J. B. Buse ◽  
F. R. Kaufman ◽  
B. Linder ◽  
K. Hirst ◽  
L. El ghormli ◽  
...  
Keyword(s):  
Middle School ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Hemoglobin A1c ◽  
Diabetes Screening ◽  
Fasting Plasma

scholarly journals Prevalence of prediabetes in healthy adults using hemoglobin A1c versus fasting plasma glucose - The GAPP study

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4290-P4290
Author(s):  
J. Blum ◽  
S. Aeschbacher ◽  
T. Schoen ◽  
K. Pumpol ◽  
M. Risch ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Hemoglobin A1c ◽  
Healthy Adults ◽  
Fasting Plasma
Sign in / Sign up

Export Citation Format

Share Document