scholarly journals COMPLEXES OF SILVER, LEAD, CALCIUM WITH BISPHOSPHONIC LIGANDS

2018 ◽  
Vol 13 (5) ◽  
pp. 23-29
Author(s):  
A. V. Galantsev ◽  
M. .. Haukka ◽  
D. V. Drobot
Keyword(s):  
Solid State Nmr ◽  
Basic Structure ◽  
Side Chain ◽  
Amino Group ◽  
Chemical Research ◽  
Ir Spectrometry ◽  
Bisphosphonic Acid ◽  
Bisphosphonic Acids ◽  
New Applications ◽  
Physical And Chemical

It is interesting in chemical terms and promising in the applied production of new complexes of metals with bisphosphonic ligands with a popular set of consumer properties. To date, little has been studied chemistry of bisphosphonic acid complexes with the basic structure of 1-hydroxymethylene-bisphosphonic acid with a side chain containing 11 carbon atoms and ending with an amino group. The main objective is to obtain new bisphosphonates of s-, p -, d - and f-elements, their characterization by a complex of physical and chemical research methods (NMR and IR spectrometry, RSA, DTA, optical microscopy, laser diffraction) and to identify new applications of bisphosphonic acids and their salts. In the course of the work, complexes of Ag, Pb, Ca, with 1-hydroxymethylene-bisphosphonic acid (H2N(CH2)xC(OH)(H2PO3)2) and its derivatives, the side chain ends with an amino group, its length is 11 carbon atoms. Crystal structures of metal-bisphosphonate complexes with the general formula H2N(CH2)10C(OH)(HPO3)xM (M = Ag, Pb, Ca) were determined. The complexes were characterized by IR spectroscopy and 31P solid-state NMR spectroscopy, RSA. The areas of practical use of the complexes are outlined. It is shown, by the example of wastewater in Kuopio, Finland, that bisphosphonic acids can be used for wastewater treatment of enterprises from heavy metals (M =Pb, Zn, Cd, etc.).

Salt bridges in model peptides

1988 ◽  
Vol 53 (11) ◽  
pp. 2810-2824 ◽  
Author(s):  
Ilmars Sekacis ◽  
Mark Shenderovich ◽  
Gregory Nikiforovich ◽  
Edvards Liepinš ◽  
Ludmila Polevaya ◽  
...  
Keyword(s):  
Synthetic Peptides ◽  
Salt Bridge ◽  
Peptide Bond ◽  
Space Structure ◽  
Side Chain ◽  
Amino Group ◽  
Salt Bridges ◽  
Ionic Bond ◽  
Theoretical Conformational Analysis ◽  
H Nmr

A group of synthetic peptides including Boc-Lys-Phe-X-Y, X = Ala (I, III) or Thr (II), Y = Pro (I, II) or Ala (III) was studied by means of 1H NMR spectroscopy and theoretical conformational analysis. Compound I in DMSO shows two conformers with the trans- and cis-configuration of the peptide bond Ala-Pro. The salt bridge between the Lys ε-amino group and the C-terminal carboxyl is featured by magnetic nonequivalence of the Lys CεH2 protons. The space structure of I and II was found to possess a salt bridge fixed by an unusual turn in the chain formed by the Lys side chain and the C-terminal dipeptide with the trans-peptide bond X-Pro. Since a stable ionic bond in III and in the cis-conformer of I has not been observed, its contribution to stabilization of the space structure of the peptides in DMSO appears rather small.

Thermosetting Mechanism Study of Organosilicon Polymer Containing Carborane by Solid-State NMR Spectroscopy

1999 ◽  
Vol 576 ◽  
Author(s):  
H. Kimura ◽  
K. Okita ◽  
M. Ichitani ◽  
M. Yonezawa ◽  
T. Sugimoto
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Nmr Spectra ◽  
Main Chain ◽  
Addition Reaction ◽  
Side Chain ◽  
Mechanism Study ◽  
Nmr Method ◽  
Organosilicon Polymer ◽  
Thermal Stable

ABSTRACTThe thermosetting mechanism of an organosilicon polymer containing carborane has been studied utilizing the 13and 29Si solid-state NMR method. The polymer having C≡C bonds in the main chain and CH═CH2, Si-H bonds, and carborane in the bulky side chain, shows a very highly thermal stability in air by curing. From 13C and 29Si NMR spectra of the polymer, it was found that the intermolecular cross-linking reactions of the polymer was due to (1) the diene reaction between Ph-C≡C and C≡C and (2) the addition reaction between side chain terminal and Ph-C≡C and between CH═CH2 and Si–H, and a very highly thermal stable structure is formed.

scholarly journals Corrigendum: Solid-State NMR Measurements of Asymmetric Dipolar Couplings Provide Insight into Protein Side-Chain Motion

2012 ◽  
Vol 51 (40) ◽  
pp. 9959-9959
Author(s):  
Paul Schanda ◽  
Matthias Huber ◽  
Jérôme Boisbouvier ◽  
Beat H. Meier ◽  
Matthias Ernst
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Dipolar Couplings ◽  
Side Chain ◽  
Side Chain Motion ◽  
Insight Into

Preparation of (4-Amino-1-Hydroxybutylidene)bisphosphonic Acid Sodium Salt, MK-217 (Alendronate Sodium). An Improved Procedure for the Preparation of 1-Hydroxy-1,1-bisphosphonic Acids

1995 ◽  
Vol 60 (25) ◽  
pp. 8310-8312 ◽  
Author(s):  
Gerard R. Kieczykowski ◽  
Ronald B. Jobson ◽  
David G. Melillo ◽  
Donald. F. Reinhold ◽  
Victor J. Grenda ◽  
...  
Keyword(s):  
Sodium Salt ◽  
Alendronate Sodium ◽  
Bisphosphonic Acid ◽  
Acid Sodium Salt ◽  
Bisphosphonic Acids

Bacteriochlorophyll e : structure and stereochemistry of a new type of chlorophyll from Chlorobiaceae

1976 ◽  
Vol 273 (924) ◽  
pp. 277-285 ◽  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Oxidative Degradation ◽  
Chemical Properties ◽  
Structural Formula ◽  
Side Chain ◽  
Physical And Chemical Properties ◽  
New Type ◽  
Physical And Chemical ◽  
Bacteriochlorophyll E ◽  
And Chemical Properties

A so far unknown chlorophyll has been isolated from several strains of brown-coloured chlorobacteria and has been designated bacteriochlorophyll e . Comparison of the physical and chemical properties of the new chlorophyll with those of bacteriochlorophylls c and d ( Chlorbium chlorophylls) allows one to deduce its structural formula. The stereochemistry of the hydroxyethyl side chain of bacteriochlorophylls c, d and e can be determined by a modified Horeau analysis of these pigments, and the results thus obtained are in agreement with those derived from oxidative degradation experiments. The latter method allows one furthermore to prove the structure of bacteriochlorophylls c and d proposed by Holt, and to establish the absolute configuration at carbon atoms 7 and 8. The presence of a δ-methylsubstituent in bacteriochlorophylls c and e is unambiguously demonstrated by nuclear magnetic resonance.

Azoverdin -an Isopyoverdin

1996 ◽  
Vol 51 (11-12) ◽  
pp. 772-780 ◽  
Author(s):  
R Michalke ◽  
K Taraz ◽  
H Budzikiewiez
Keyword(s):  
Carboxylic Acid ◽  
Succinic Acid ◽  
Peptide Chain ◽  
Side Chain ◽  
Carboxyl Group ◽  
Amino Group ◽  
Present Evidence ◽  
N Terminus

For azoverdin, the siderophore of Azomonas macrocytogenes ATCC 12334, a pyoverdintype structure has been suggested. We now present evidence that it is actually an isopyoverdin. Also the sequence of the peptide chain has to be revised. Azoverdin comprises, therefore, the chromophore (3S)-5-amino-1,2-dihydro-8,9-dihydroxy-3H -pyrimido[1,2a]quinoline- 3-carboxylic acid whose amino group is bound to a succinamide residue while the carboxyl group is attached to the N -terminus of L-Hse-[2-(R-1-amino-3-hydroxypropyl)-3,4,5,6- tetrahydropyrimidine-65-carboxylic acid]-N5-acetyl-N5,-hydroxy-ᴅ-Orn-ᴅ-Ser-N5-acetyl-N5- hydroxy-ʟ-Orn. In addition to azoverdin congeners with succinic acid (azoverdin A ) and with ʟ-Glu (azoverdin G ), resp., instead of the succinamide side chain could be isolated.

scholarly journals Effect of ettringite morphology on the properties of expanding cement systems

2019 ◽  
Vol 110 ◽  
pp. 01037 ◽  
Author(s):  
Igor Kharchenco ◽  
Vyacheslav Alekseev
Keyword(s):  
Crystallization Process ◽  
Ph Value ◽  
Cement Stone ◽  
Chemical Research ◽  
Concrete Composition ◽  
Building Site ◽  
Reaction Solution ◽  
Physical And Chemical ◽  
Ready Mixed Concrete ◽  
Micro Fillers

The effect of the pH of the reaction solution on the crystallization process and the ettringite morphology is theoretically substantiated and experimentally proved. Using physical and chemical research methods, the dependence of the morphology of crystallizing ettringite on the pH value of the reaction solution was established. It has been established that by introducing mineral micro fillers into the composition of expanding cement, it is possible to actively influence the pH value, the morphology of the resulting ettringite, the expansion kinetics, and the strength of cement stone and concrete based on it. The studies of the technical properties of concrete on the basis of expanding cements of various types have shown that with the introduction of micro fillers into the concrete composition, which intensify volume expansion during hydration of cement stone at the building site or factories for the production of ready-mixed concrete, it is possible to control the kinetics and extent of expansion, expansion pressure, deformative and strength characteristics of concrete and reinforced concrete structures.

Morphology and side-chain dynamics in hydrated hard α-keratin fibres by 1H solid-state NMR

2009 ◽  
Vol 480 (4-6) ◽  
pp. 300-304 ◽  
Author(s):  
Claudiu Melian ◽  
Dan E. Demco ◽  
Monica Istrate ◽  
Andreea Balaceanu ◽  
Dumitrita Moldovan ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Side Chain ◽  
Chain Dynamics ◽  
Side Chain Dynamics ◽  
Keratin Fibres

scholarly journals Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Jakob Kljun ◽  
Saša Petriček ◽  
Dušan Žigon ◽  
Rosana Hudej ◽  
Damijan Miklavčič ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Side Chain ◽  
Synthesis And Characterization ◽  
Medical Applications ◽  
Amino Group ◽  
Heterocyclic Derivative ◽  
Biological Assays ◽  
X Ray ◽  
Protonated Amino Group

Novel ruthenium(III) complexes with histamine[RuCl4(dmso-S)(histamineH)]⋅O(1a) and[RuCl4(dmso-S)(histamineH)](1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound1bcombined with electroporation were performed to determine its potential for future medical applications in cancer treatment.

Proton Magnetic Resonance Spectra of Some Amphetamines and Related Compounds and Observations on Rotamer Populations

1971 ◽  
Vol 49 (19) ◽  
pp. 3143-3151 ◽  
Author(s):  
K. Bailey ◽  
A. W. By ◽  
K. C. Graham ◽  
D. Verner
Keyword(s):  
Hydrogen Bonding ◽  
Phenyl Ring ◽  
Proton Magnetic Resonance ◽  
Chemical Shifts ◽  
Coupling Constants ◽  
Side Chain ◽  
Amino Group ◽  
Ortho Position ◽  
Electronic Effects ◽  
Related Compounds

Data from the p.m.r. spectra of β-amino-, β-aminohydrochloride-, β-hydroxy-, and β-nitro-α-phenyl-propanes having methyl or methoxy substituants on the phenyl ring (37 compounds in all) are presented. The α and β protons of the side-chain give a pattern usually analyzable as ABX. The data are discussed in terms of correlations of coupling constants and chemical shifts with electronegativity of the substituent groups, steric and electronic effects, and apparent changes in rotamer populations. Hydrogen-bonding between the amino group of amphetamines and a methoxyl function at the ortho position in the phenyl ring is indicated for the salts but not the free bases.

Sign in / Sign up

Export Citation Format

Share Document