scholarly journals Polyamine Analogue SBP-101

2020 ◽  
Author(s):  
Keyword(s):  
Polyamine Analogue

scholarly journals The Novel Polyamine Analogue CGC-11093 Enhances the Antimyeloma Activity of Bortezomib

2008 ◽  
Vol 68 (12) ◽  
pp. 4783-4790 ◽  
Author(s):  
Jennifer S. Carew ◽  
Steffan T. Nawrocki ◽  
Venudhar K. Reddy ◽  
Dorothy Bush ◽  
Jerold E. Rehg ◽  
...  
Keyword(s):  
The Novel ◽  
Polyamine Analogue

scholarly journals Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue

1999 ◽  
Vol 338 (2) ◽  
pp. 311-316 ◽  
Author(s):  
Suvikki SUPPOLA ◽  
Marko PIETILÄ ◽  
Jyrki J. PARKKINEN ◽  
Veli-Pekka KORHONEN ◽  
Leena ALHONEN ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Transgenic Mice ◽  
Transgenic Mouse ◽  
Cell Injury ◽  
Mrna Level ◽  
Transgenic Animals ◽  
Ultrastructural Changes ◽  
Mouse Line ◽  
Transgenic Mouse Line ◽  
Polyamine Analogue

We recently generated a transgenic mouse line overexpressing spermidine/spermine N1-acetyltransferase (SSAT) gene under its own promoter. The tissue polyamine pools of these animals were profoundly affected and the mice were hairless from early age. We have now generated another transgenic-mouse line overexpressing the SSAT gene under the control of a heavy-metal-inducible mouse metallothionein I (MT) promoter. Even in the absence of heavy metals, changes in the tissue polyamine pools indicated that a marked activation of polyamine catabolism had occurred in the transgenic animals. As with the SSAT transgenic mice generated previously, the mice of the new line (MT-SSAT) suffered permanent hair loss, but this occurred considerably later than in the previous SSAT transgenic animals. Liver was the most affected tissue in the MT–SSAT transgenic animals, revealed by putrescine overaccumulation, significant decrease in spermidine concentration and > 90% reduction in the spermine pool. Even though hepatic SSAT mRNA accumulated to massive levels in non-induced transgenic animals, SSAT activity was only moderately elevated. Administration of ZnSO4 further elevated the level of hepatic SSAT message and induced enzyme activity, but not more than 2- to 3-fold. Treatment of the transgenic animals with the polyamine analogue N1,N11-diethylnorspermine (DENSPM) resulted in an immense induction, more than 40000-fold, of enzyme activity in the liver of transgenic animals, and minor changes in the SSAT mRNA level. Liver spermidine and spermine pools were virtually depleted within 1–2 days in response to the treatment with the analogue. The treatment also resulted in a marked mortality (up to 60%) among the transgenic animals which showed ultrastructural changes in the liver, most notably mitochondrial swelling, one of the earliest signs of cell injury. These results indicated that, even without its own promoter, SSAT is powerfully induced by the polyamine analogue through a mechanism that appears to involve a direct translational and/or heterogenous nuclear RNA processing control. It is likewise significant that overexpression of SSAT renders the animals extremely sensitive to polyamine analogues.

scholarly journals The Human Carnitine Transporter SLC22A16 Mediates High Affinity Uptake of the Anticancer Polyamine Analogue Bleomycin-A5

2009 ◽  
Vol 285 (9) ◽  
pp. 6275-6284 ◽  
Author(s):  
Mustapha Aouida ◽  
Richard Poulin ◽  
Dindial Ramotar
Keyword(s):  
Carnitine Transporter ◽  
High Affinity ◽  
High Affinity Uptake ◽  
Polyamine Analogue

scholarly journals The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines

2009 ◽  
Vol 65 (6) ◽  
pp. 1067-1081 ◽  
Author(s):  
Allison Pledgie-Tracy ◽  
Madhavi Billam ◽  
Amy Hacker ◽  
Michele D. Sobolewski ◽  
Patrick M. Woster ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Synergistic Effects ◽  
Chemotherapeutic Agents ◽  
Human Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Catabolic Enzymes ◽  
Polyamine Analogue

scholarly journals In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells

2008 ◽  
Vol 63 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Amy Hacker ◽  
Laurence J. Marton ◽  
Michelle Sobolewski ◽  
Robert A. Casero
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Small Cell ◽  
Small Cell Lung ◽  
Conformationally Restricted ◽  
Polyamine Analogue ◽  
In Vivo Effects

Plasma pharmacokinetics and urinary excretion of the polyamine analogue 1, 19-bis(ethylamino)-5, 10, 15-triazanonadecane in CD 2 F 1 mice

1996 ◽  
Vol 38 (1) ◽  
pp. 13-20 ◽  
Author(s):  
J. L. Eiseman ◽  
Zhi-Min Yuan ◽  
Natalie D. Eddington ◽  
Dorothy L. Sentz ◽  
Patrick S. Callery ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Polyamine Analogue ◽  
Plasma Pharmacokinetics

Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway

1998 ◽  
Vol 26 (4) ◽  
pp. 609-614 ◽  
Author(s):  
D. L. Kramer ◽  
S. Vujcic ◽  
P. Diegelman ◽  
C. White ◽  
J. D. Black ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Regulatory Pathway ◽  
Human Melanoma Cells ◽  
Polyamine Analogue
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