For the question of xenobiotics biological monitoring

2017 ◽  
pp. 65-72
Author(s):  
Kudria M.Ya. ◽  
◽  
Lalymenko O.S. ◽  
Karachentsev Yu.I. ◽  
Zavhorodny I.V. ◽  
...  
Keyword(s):  
Biological Monitoring

Erythrocyte and reticulocyte parameters during biological monitoring of lead exposure to the body

2020 ◽  
Vol 60 (11) ◽  
pp. 873-876
Author(s):  
Anastasiya G. Khotuleva ◽  
Mariya S. Kozyreva
Keyword(s):  
Biological Monitoring ◽  
Hematological Parameters ◽  
Lead Level ◽  
Statistical Processing ◽  
Absorption Spectrometry ◽  
The Body ◽  
Control Group ◽  
Processing Plant ◽  
Hematological Disorders ◽  
Globin Synthesis

Introduction. The most susceptible to lead is the hematopoietic system of hematopoietic organs due to lead inhibition of heme and globin synthesis and cytotoxic effect on the membrane of Mature red blood cells. The aim of study was to evaluate the informative value of the study of erythrocyte and reticulocyte parameters determined on modern hematological analyzers in patients working in contact with lead during medical and biological monitoring. Materials and methods. 45 employees of the lead battery processing plant and 30 persons of control group were examined. The level of lead in the blood was determined by atomic absorption spectrometry, δ-ALA in the urine-by the reaction of pyrol formation with acetylacetone in terms of gram of creatinine, the study of hematological parameters was performed on a Sysmex HT-2000i analyzer. Statistical processing of the results was performed using the program STATISTICA 10.0. Results. Significant changes in erythrocytic (RDW) and reticulocytic (RET, IRF, LFR, MFR, HFR, RET-He) parameters, erythropoietin in workers in contact with lead compared to the control group, changes in MCV, MCH, RDW, RET indicators in the group working in dynamics after 2 years were revealed. Associations of hematological parameters with biomarkers of exposure and effect (lead level in blood and ALA in urine) were revealed. Conclusions. Assessment of erythrocyte (MCV, MCH, RDW) and reticulocyte parameters (RET% and their distribution by maturity) in dynamics during periodic medical examinations of workers in contact with lead allows us to detect the development of hematological disorders at early stages.

ON THE ROLE OF BIOMONITORING IN THE ASSESSMENT OF THE HEALTH OF THE POPULATION EXPOSED TO MERCURY

2017 ◽  
pp. 2-7
Author(s):  
L. V. Lukovnikova ◽  
G. I. Sidorin ◽  
L. A. Alikbaeva ◽  
A. V. Galochina
Keyword(s):  
High Risk ◽  
Biological Monitoring ◽  
Clinical Examination ◽  
Inorganic Compounds ◽  
Risk Groups ◽  
Comprehensive Approach ◽  
Chemical Monitoring ◽  
Environmental Objects

When examining the population exposed to organic and inorganic compounds of mercury, a comprehensive approach is proposed, including chemical monitoring of environmental objects, biological monitoring, clinical examination of persons exposed to mercury, identification of high-risk groups.

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